Neurofibromatosis type 2

Common Name(s)

Neurofibromatosis type 2, Neurofibromatosis 2 (NF2), Bilateral Acoustic Neurofibromatosis, BANF Acoustic Neurinoma

Neurofibromatosis type 2 is a disorder characterized by the growth of noncancerous tumors in the nervous system. The most common tumors associated with neurofibromatosis type 2 are called vestibular schwannomas or acoustic neuromas. These growths develop along the nerve that carries information from the inner ear to the brain (the auditory nerve). Tumors that occur on nerves in other areas of the brain or spinal cord are also commonly seen with this condition. Mutations in the NF2 gene cause neurofibromatosis type 2. Neurofibromatosis type 2 is considered to have an autosomal dominant pattern of inheritance.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Neurofibromatosis type 2" for support, advocacy or research.

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Children's Tumor Foundation, Inc.

Funds research, patient support and public awareness of the neurofibromatoses (NF1, NF2, and Schwannomatosis) - genetic disorders that cause random tumor growth throughout the body.

Last Updated: 14 Jan 2013

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Littlest Tumor Foundation

The Littlest Tumor Foundation is a nonprofit organization dedicated to finding preventative therapies and threatment for tumor growth in children and providing wellness scholarships to families dealing with Neurofibromatosis (NF). Our mission is to increase understanding of NF, to empower families dealing with the disorder, and to continue research of preventative therapies.

Last Updated: 4 Feb 2013

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Neurofibromatosis Mid-Atlantic

Neurofibromatosis Mid-Atlantic is a non profit organization dedicated to helping people with Neurofibromatosis and their loved ones make sense of the complex medical disorder. We provide reliable, complete, and up to date information about Neurofibromatosis. We provide education, support, and community. There is no charge for our services.

Last Updated: 22 Dec 2012

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Neurofibromatosis, Inc., Northeast

Our mission is to find treatments and the cure for neurofibromatosis by promoting scientific research, creating awareness, and providing hope and support to those who are affected by NF.

Last Updated: 5 May 2014

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Neurofibromatosis type 2" for support, advocacy or research.

Logo
Children's Tumor Foundation, Inc.

Funds research, patient support and public awareness of the neurofibromatoses (NF1, NF2, and Schwannomatosis) - genetic disorders that cause random tumor growth throughout the body.

https://www.ctf.org

Last Updated: 14 Jan 2013

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Littlest Tumor Foundation

The Littlest Tumor Foundation is a nonprofit organization dedicated to finding preventative therapies and threatment for tumor growth in children and providing wellness scholarships to families dealing with Neurofibromatosis (NF). Our mission is to increase understanding of NF, to empower families dealing with the disorder, and to continue research of preventative therapies.

http://www.littlesttumor.org

Last Updated: 4 Feb 2013

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Neurofibromatosis Mid-Atlantic

Neurofibromatosis Mid-Atlantic is a non profit organization dedicated to helping people with Neurofibromatosis and their loved ones make sense of the complex medical disorder. We provide reliable, complete, and up to date information about Neurofibromatosis. We provide education, support, and community. There is no charge for our services.

http://www.nfmidatlantic.org

Last Updated: 22 Dec 2012

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Neurofibromatosis, Inc., Northeast

Our mission is to find treatments and the cure for neurofibromatosis by promoting scientific research, creating awareness, and providing hope and support to those who are affected by NF.

http://www.nfincne.org

Last Updated: 5 May 2014

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Neurofibromatosis type 2" returned 84 free, full-text research articles on human participants. First 3 results:

Spinal intradural malignant peripheral nerve sheath tumor in a child with neurofibromatosis type 2: the first reported case and literature review.
 

Author(s): Liang Wu, Xiaofeng Deng, Chenlong Yang, Yulun Xu

Journal: Turk Neurosurg. 2014 ;24(1):135-9.

 

Spinal intradural malignant peripheral nerve sheath tumors (MPNSTs) in children are extremely rare, with only five reported cases in the literature. A 9-year-old female with neurofibromatosis type 2 (NF-2) presented with right hip pain and severe weakness of bilateral legs for 3 months. ...

Last Updated: 18 Feb 2014

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FRAX597, a small molecule inhibitor of the p21-activated kinases, inhibits tumorigenesis of neurofibromatosis type 2 (NF2)-associated Schwannomas.
 

Author(s): Silvia Licciulli, Jasna Maksimoska, Chun Zhou, Scott Troutman, Smitha Kota, Qin Liu, Sergio Duron, David Campbell, Jonathan Chernoff, Jeffrey Field, Ronen Marmorstein, Joseph L Kissil

Journal: J. Biol. Chem.. 2013 Oct;288(40):29105-14.

 

The p21-activated kinases (PAKs) are immediate downstream effectors of the Rac/Cdc42 small G-proteins and implicated in promoting tumorigenesis in various types of cancer including breast and lung carcinomas. Recent studies have established a requirement for the PAKs in the pathogenesis ...

Last Updated: 7 Oct 2013

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Therapeutic potential of HSP90 inhibition for neurofibromatosis type 2.
 

Author(s): Karo Tanaka, Ascia Eskin, Fabrice Chareyre, Walter J Jessen, Jan Manent, Michiko Niwa-Kawakita, Ruihong Chen, Cory H White, Jeremie Vitte, Zahara M Jaffer, Stanley F Nelson, Allan E Rubenstein, Marco Giovannini

Journal: Clin. Cancer Res.. 2013 Jul;19(14):3856-70.

 

The growth and survival of neurofibromatosis type 2 (NF2)-deficient cells are enhanced by the activation of multiple signaling pathways including ErbBs/IGF-1R/Met, PI3K/Akt, and Ras/Raf/Mek/Erk1/2. The chaperone protein HSP90 is essential for the stabilization of these signaling molecules. ...

Last Updated: 17 Jul 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Neurofibromatosis type 2" returned 9 free, full-text review articles on human participants. First 3 results:

Gastrinoma and neurofibromatosis type 2: the first case report and review of the literature.
 

Author(s): Sara Massironi, Alessandra Zilli, Roberta Elisa Rossi, Federica Cavalcoli, Dario Conte, Maddalena Peracchi

Journal:

 

Gastroenteropancreatic neuroendocrine tumors have occasionally been described in association with neurofibromatosis type 1, whereas an association with neurofibromatosis type 2 has never been reported.

Last Updated: 5 Jul 2014

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Neurofibromatosis type 2 protein, NF2: an uncoventional cell cycle regulator.
 

Author(s): Sarah Beltrami, Richard Kim, Jennifer Gordon

Journal: Anticancer Res.. 2013 Jan;33(1):1-11.

 

Neurofibromatosis type 2 protein (NF2) is an underappreciated tumor suppressor involved in a broad range of nervous system tumors. Inactivation of the NF2 gene leads to neurofibromatosis type-2, which is characterized by multiple benign nervous system tumors and mutations in the gene ...

Last Updated: 25 Dec 2012

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Tomotherapy for neurofibromatosis Type 2: case report and review of the literature.
 

Author(s): H-H Lee, S-L Lian, C-J Huang, M-Y Huang

Journal: Br J Radiol. 2010 Apr;83(988):e74-8.

 

Neurofibromatosis 2 (NF2) results in multiple central nervous system tumours. In this case report, the patient has one vestibular schwannoma, one trigeminal schwannoma and two meningiomas developed before the age of 30. Aiming to treat three targets at one fraction with minimal interaction ...

Last Updated: 25 Mar 2010

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Study of Axitinib in Patients With Neurofibromatosis Type 2 and Progressive Vestibular Schwannomas
 

Status: Recruiting

Condition Summary: Neurofibromatosis Type 2; Vestibular Schwannomas

 

Last Updated: 1 May 2014

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Phase 2 Study of Bevacizumab in Children and Young Adults With NF 2 and Progressive Vestibular Schwannomas
 

Status: Recruiting

Condition Summary: Neurofibromatosis Type 2; Progressive Vestibular Schwannomas

 

Last Updated: 20 Oct 2014

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Exploratory Evaluation of AR-42 Histone Deacetylase Inhibitor in the Treatment of Vestibular Schwannoma and Meningioma
 

Status: Not yet recruiting

Condition Summary: Vestibular Schwannoma; Meningioma; Acoustic Neuroma; Neurofibromatosis Type 2

 

Last Updated: 4 Nov 2014

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