Neuroblastoma

Common Name(s)

Neuroblastoma

Neuroblastoma is a tumor that develops from a nerve in a child, usually before the age of 5.  It occurs in the abdomen near the adrenal glands, but it can also occur in other parts of the body.  It is considered an aggressive tumor because it often spreads to other parts of the body (metastasizes).   The symptoms of a neuroblastoma may include a lump in the abdomen, pain, diarrhea, or generally feeling unwell.  It affects one out of 100,000 children.   The exact cause of this tumor is not yet known.  Neuroblastoma may be diagnosed by physical examination; specific blood tests; imaging tests such as x-rays, magnetic resonance imaging (MRI), or computed tomography (CT) scans; and a biopsy.   Treatment depends on the size and location of the tumor within the body, as well as the childÕs age. Surgery is often the first step of treatment, and may be followed by chemotherapy, radiation therapy, or a stem cell transplant in more severe cases.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Neuroblastoma" for support, advocacy or research.

National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

Last Updated: 20 Feb 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Neuroblastoma" for support, advocacy or research.

National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

http://www.nbmtlink.org

Last Updated: 20 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Neuroblastoma" returned 3243 free, full-text research articles on human participants. First 3 results:

Genetic predisposition to neuroblastoma mediated by a LMO1 super-enhancer polymorphism.
 

Author(s): Derek A Oldridge, Andrew C Wood, Nina Weichert-Leahey, Ian Crimmins, Robyn Sussman, Cynthia Winter, Lee D McDaniel, Maura Diamond, Lori S Hart, Shizhen Zhu, Adam D Durbin, Brian J Abraham, Lars Anders, Lifeng Tian, Shile Zhang, Jun S Wei, Javed Khan, Kelli Bramlett, Nazneen Rahman, Mario Capasso, Achille Iolascon, Daniela S Gerhard, Jaime M Guidry Auvil, Richard A Young, Hakon Hakonarson, Sharon J Diskin, A Thomas Look, John M Maris

Journal: Nature. 2015 Dec;528(7582):418-21.

 

Neuroblastoma is a paediatric malignancy that typically arises in early childhood, and is derived from the developing sympathetic nervous system. Clinical phenotypes range from localized tumours with excellent outcomes to widely metastatic disease in which long-term survival is approximately ...

Last Updated: 17 Dec 2015

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Elevated TrkA receptor expression is associated with all-trans retinoic acid-induced neuroblastoma differentiation.
 

Author(s): Q Gao, C F Chen, Q Dong, L Hou, X Chen, Y L Zhi, X Li, H T Lu, H Y Zhang

Journal:

 

Neuroblastoma is the most common and one of the deadliest among pediatric tumors; however, a subset of infants with neuroblastoma display spontaneous regression. The mechanism of spontaneous regression remains to be elucidated. TrkA plays an essential role in the differentiation and ...

Last Updated: 5 Nov 2015

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Heterogeneous nuclear ribonucleoprotein A1 post-transcriptionally regulates Drp1 expression in neuroblastoma cells.
 

Author(s): So Jung Park, Heejin Lee, Doo Shin Jo, Yoon Kyung Jo, Ji Hyun Shin, Han Byeol Kim, Hae Mi Seo, David C Rubinsztein, Jae-Young Koh, Eun Kyung Lee, Dong-Hyung Cho

Journal: Biochim. Biophys. Acta. 2015 Dec;1849(12):1423-31.

 

Excessive mitochondrial fission is associated with the pathogenesis of neurodegenerative diseases. Dynamin-related protein 1 (Drp1) possesses specific fission activity in the mitochondria and peroxisomes. Various post-translational modifications of Drp1 are known to modulate complex ...

Last Updated: 23 Nov 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Neuroblastoma" returned 99 free, full-text review articles on human participants. First 3 results:

123I-MIBG scintigraphy and 18F-FDG-PET imaging for diagnosing neuroblastoma.
 

Author(s): Gitta Bleeker, Godelieve A M Tytgat, Judit A Adam, Huib N Caron, Leontien C M Kremer, Lotty Hooft, Elvira C van Dalen

Journal:

 

Neuroblastoma is an embryonic tumour of childhood that originates in the neural crest. It is the second most common extracranial malignant solid tumour of childhood.Neuroblastoma cells have the unique capacity to accumulate Iodine-123-metaiodobenzylguanidine (¹²³I-MIBG), which ...

Last Updated: 1 Oct 2015

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Chemoresistance, cancer stem cells, and miRNA influences: the case for neuroblastoma.
 

Author(s): Alfred Buhagiar, Duncan Ayers

Journal: Anal Cell Pathol (Amst). 2015 ;2015():150634.

 

Neuroblastoma is a type of cancer that develops most often in infants and children under the age of five years. Neuroblastoma originates within the peripheral sympathetic ganglia, with 30% of the cases developing within the adrenal medulla, although it can also occur within other ...

Last Updated: 10 Aug 2015

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Neuroblastoma and nephroblastoma: a radiological review.
 

Author(s): Maureen Dumba, Noorulhuda Jawad, Kieran McHugh

Journal:

 

Neuroblastoma (NBL) is the most common extra-cranial tumour in childhood. It can present as an abdominal mass, but is usually metastatic at diagnosis so the symptomatology can be varied. Nephroblastoma, also more commonly known as a Wilms tumour, is the commonest renal tumour in childhood ...

Last Updated: 27 May 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Biomarkers in Tumor Tissue Samples From Patients With Newly Diagnosed Neuroblastoma or Ganglioneuroblastoma
 

Status: Recruiting

Condition Summary: Disseminated Neuroblastoma; Ganglioneuroblastoma; Localized Resectable Neuroblastoma; Localized Unresectable Neuroblastoma; Regional Neuroblastoma; Stage 4S Neuroblastoma

 

Last Updated: 12 Nov 2015

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Study of DNA in Blood Samples From Patients With Neuroblastoma
 

Status: Recruiting

Condition Summary: Disseminated Neuroblastoma; Localized Resectable Neuroblastoma; Localized Unresectable Neuroblastoma; Recurrent Neuroblastoma; Regional Neuroblastoma; Stage 4S Neuroblastoma

 

Last Updated: 16 Nov 2015

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Expanded Access Study of Fenretinide Lym-X-Sorb Plus Ketoconazole in Neuroblastoma
 

Status: Available

Condition Summary: Recurrent Neuroblastoma; Neuroblastoma

 

Last Updated: 12 Apr 2016

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