Neuroblastoma

Common Name(s)

Neuroblastoma

Neuroblastoma is a tumor that develops from a nerve in a child, usually before the age of 5.  It occurs in the abdomen near the adrenal glands, but it can also occur in other parts of the body.  It is considered an aggressive tumor because it often spreads to other parts of the body (metastasizes).   The symptoms of a neuroblastoma may include a lump in the abdomen, pain, diarrhea, or generally feeling unwell.  It affects one out of 100,000 children.   The exact cause of this tumor is not yet known.  Neuroblastoma may be diagnosed by physical examination; specific blood tests; imaging tests such as x-rays, magnetic resonance imaging (MRI), or computed tomography (CT) scans; and a biopsy.   Treatment depends on the size and location of the tumor within the body, as well as the childÕs age. Surgery is often the first step of treatment, and may be followed by chemotherapy, radiation therapy, or a stem cell transplant in more severe cases.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Neuroblastoma" for support, advocacy or research.

National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

Last Updated: 20 Feb 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Neuroblastoma" for support, advocacy or research.

National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

http://www.nbmtlink.org

Last Updated: 20 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Neuroblastoma" returned 2636 free, full-text research articles on human participants. First 3 results:

The development of cisplatin resistance in neuroblastoma is accompanied by epithelial to mesenchymal transition in vitro.
 

Author(s): Olga Piskareva, Harry Harvey, John Nolan, Ross Conlon, Leah Alcock, Patrick Buckley, Paul Dowling, Finbarr O'Sullivan, Isabella Bray, Raymond L Stallings

Journal: Cancer Lett.. 2015 Aug;364(2):142-55.

 

Neuroblastoma is a challenging childhood malignancy, with a very high percentage of patients relapsing following acquisition of drug resistance, thereby necessitating the identification of mechanisms of drug resistance as well as new biological targets contributing to the aggressive ...

Last Updated: 4 Jun 2015

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Differential regulation of HIF-1α and HIF-2α in neuroblastoma: Estrogen-related receptor alpha (ERRα) regulates HIF2A transcription and correlates to poor outcome.
 

Author(s): Arash Hamidian, Kristoffer von Stedingk, Matilda Munksgaard Thorén, Sofie Mohlin, Sven Påhlman

Journal: Biochem. Biophys. Res. Commun.. 2015 Jun;461(3):560-7.

 

Hypoxia-inducible factors (HIFs) are differentially regulated in tumor cells. While the current paradigm supports post-translational regulation of the HIF-α subunits, we recently showed that hypoxic HIF-2α is also transcriptionally regulated via insulin-like growth factor (IGF)-II ...

Last Updated: 18 May 2015

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NCYM promotes calpain-mediated Myc-nick production in human MYCN-amplified neuroblastoma cells.
 

Author(s): Wataru Shoji, Yusuke Suenaga, Yoshiki Kaneko, S M Rafiqul Islam, Jennifer Alagu, Sana Yokoi, Masaki Nio, Akira Nakagawara

Journal: Biochem. Biophys. Res. Commun.. 2015 Jun;461(3):501-6.

 

NCYM is a cis-antisense gene of MYCN and is amplified in human neuroblastomas. High NCYM expression is associated with poor prognoses, and the NCYM protein stabilizes MYCN to promote proliferation of neuroblastoma cells. However, the molecular mechanisms of NCYM in the regulation ...

Last Updated: 18 May 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Neuroblastoma" returned 84 free, full-text review articles on human participants. First 3 results:

Mechanisms of neuroblastoma regression.
 

Author(s): Garrett M Brodeur, Rochelle Bagatell

Journal: Nat Rev Clin Oncol. 2014 Dec;11(12):704-13.

 

Recent genomic and biological studies of neuroblastoma have shed light on the dramatic heterogeneity in the clinical behaviour of this disease, which spans from spontaneous regression or differentiation in some patients, to relentless disease progression in others, despite intensive ...

Last Updated: 24 Nov 2014

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[A review on treatment of high-risk neuroblastoma].
 

Author(s): Suo-Qin Tang

Journal: Zhongguo Dang Dai Er Ke Za Zhi. 2014 Feb;16(2):103-7.

 

So far treatment of advanced neuroblastoma is still difficult, due to its high malignancy. Currently comprehensive therapies, including high-dose multi-drug chemotherapy, surgery, stem cell transplantation, radiation, biological therapy and immune therapy as well as target therapy ...

Last Updated: 26 Feb 2014

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Multidrug resistance and cancer stem cells in neuroblastoma and hepatoblastoma.
 

Author(s): Anna Alisi, William C Cho, Franco Locatelli, Doriana Fruci

Journal:

 

Chemotherapy is one of the major modalities in treating cancers. However, its effectiveness is limited by the acquisition of multidrug resistance (MDR). Several mechanisms could explain the up-regulation of MDR genes/proteins in cancer after chemotherapy. It is known that cancer stem ...

Last Updated: 19 Dec 2013

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Biomarkers in Tumor Tissue Samples From Patients With Newly Diagnosed Neuroblastoma or Ganglioneuroblastoma
 

Status: Recruiting

Condition Summary: Disseminated Neuroblastoma; Ganglioneuroblastoma; Localized Resectable Neuroblastoma; Localized Unresectable Neuroblastoma; Regional Neuroblastoma; Stage 4S Neuroblastoma

 

Last Updated: 12 May 2015

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Study of DNA in Blood Samples From Patients With Neuroblastoma
 

Status: Recruiting

Condition Summary: Disseminated Neuroblastoma; Localized Resectable Neuroblastoma; Localized Unresectable Neuroblastoma; Recurrent Neuroblastoma; Regional Neuroblastoma; Stage 4S Neuroblastoma

 

Last Updated: 11 May 2015

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Expanded Access Study of Fenretinide Lym-X-Sorb Plus Ketoconazole in Neuroblastoma
 

Status: Available

Condition Summary: Recurrent Neuroblastoma; Neuroblastoma

 

Last Updated: 9 Dec 2014

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