Neuroblastoma

Common Name(s)

Neuroblastoma

Neuroblastoma is a tumor that develops from a nerve in a child, usually before the age of 5.  It occurs in the abdomen near the adrenal glands, but it can also occur in other parts of the body.  It is considered an aggressive tumor because it often spreads to other parts of the body (metastasizes).   The symptoms of a neuroblastoma may include a lump in the abdomen, pain, diarrhea, or generally feeling unwell.  It affects one out of 100,000 children.   The exact cause of this tumor is not yet known.  Neuroblastoma may be diagnosed by physical examination; specific blood tests; imaging tests such as x-rays, magnetic resonance imaging (MRI), or computed tomography (CT) scans; and a biopsy.   Treatment depends on the size and location of the tumor within the body, as well as the childÕs age. Surgery is often the first step of treatment, and may be followed by chemotherapy, radiation therapy, or a stem cell transplant in more severe cases.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Neuroblastoma" for support, advocacy or research.

National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

Last Updated: 20 Feb 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Neuroblastoma" for support, advocacy or research.

National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

http://www.nbmtlink.org

Last Updated: 20 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Neuroblastoma" returned 2622 free, full-text research articles on human participants. First 3 results:

Oxovanadium-based inhibitors can drive redox-sensitive cytotoxicity in neuroblastoma cells and synergise strongly with buthionine sulfoximine.
 

Author(s): Owen Clark, Inhye Park, Alessia Di Florio, Ann-Christin Cichon, Sarah Rustin, Roman Jugov, Ruhina Maeshima, Andrew W Stoker

Journal: Cancer Lett.. 2015 Feb;357(1):316-27.

 

In a wide range of neuroblastoma-derived lines oxovanadium compounds such as bis(maltolato)oxovanadium(IV) (BMOV) are cytotoxic. This is not explained by oxidative stress or inhibition of ion channels. Genotoxicity is unlikely given that a p53 response is absent and p53-mutant lines ...

Last Updated: 27 Dec 2014

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Expression quantitative trait loci and receptor pharmacology implicate Arg1 and the GABA-A receptor as therapeutic targets in neuroblastoma.
 

Author(s): Christopher S Hackett, David A Quigley, Robyn A Wong, Justin Chen, Christine Cheng, Young K Song, Jun S Wei, Ludmila Pawlikowska, Yun Bao, David D Goldenberg, Kim Nguyen, W Clay Gustafson, Sundari K Rallapalli, Yoon-Jae Cho, James M Cook, Serguei Kozlov, Jian-Hua Mao, Terry Van Dyke, Pui-Yan Kwok, Javed Khan, Allan Balmain, QiWen Fan, William A Weiss

Journal: Cell Rep. 2014 Nov;9(3):1034-46.

 

The development of targeted therapeutics for neuroblastoma, the third most common tumor in children, has been limited by a poor understanding of growth signaling mechanisms unique to the peripheral nerve precursors from which tumors arise. In this study, we combined genetics with ...

Last Updated: 2 Dec 2014

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Se-methylselenocysteine inhibits apoptosis induced by clusterin knockdown in neuroblastoma N2a and SH-SY5Y cell lines.
 

Author(s): Chao Wang, Zhenyu Zeng, Qiong Liu, Renli Zhang, Jiazuan Ni

Journal:

 

Apoptosis, as a programmed cell death process, is essential for the maintenance of tissue function in organisms. Alteration of this process is linked to many diseases. Over-expression of clusterin (Clu) can antagonize apoptosis in various cells. Selenium (Se) is an essential trace ...

Last Updated: 21 Nov 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Neuroblastoma" returned 85 free, full-text review articles on human participants. First 3 results:

Mechanisms of neuroblastoma regression.
 

Author(s): Garrett M Brodeur, Rochelle Bagatell

Journal: Nat Rev Clin Oncol. 2014 Dec;11(12):704-13.

 

Recent genomic and biological studies of neuroblastoma have shed light on the dramatic heterogeneity in the clinical behaviour of this disease, which spans from spontaneous regression or differentiation in some patients, to relentless disease progression in others, despite intensive ...

Last Updated: 24 Nov 2014

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[A review on treatment of high-risk neuroblastoma].
 

Author(s): Suo-Qin Tang

Journal: Zhongguo Dang Dai Er Ke Za Zhi. 2014 Feb;16(2):103-7.

 

So far treatment of advanced neuroblastoma is still difficult, due to its high malignancy. Currently comprehensive therapies, including high-dose multi-drug chemotherapy, surgery, stem cell transplantation, radiation, biological therapy and immune therapy as well as target therapy ...

Last Updated: 26 Feb 2014

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Multidrug resistance and cancer stem cells in neuroblastoma and hepatoblastoma.
 

Author(s): Anna Alisi, William C Cho, Franco Locatelli, Doriana Fruci

Journal:

 

Chemotherapy is one of the major modalities in treating cancers. However, its effectiveness is limited by the acquisition of multidrug resistance (MDR). Several mechanisms could explain the up-regulation of MDR genes/proteins in cancer after chemotherapy. It is known that cancer stem ...

Last Updated: 19 Dec 2013

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Biomarkers in Tumor Tissue Samples From Patients With Newly Diagnosed Neuroblastoma or Ganglioneuroblastoma
 

Status: Recruiting

Condition Summary: Disseminated Neuroblastoma; Ganglioneuroblastoma; Localized Resectable Neuroblastoma; Localized Unresectable Neuroblastoma; Regional Neuroblastoma; Stage 4S Neuroblastoma

 

Last Updated: 12 May 2015

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Study of DNA in Blood Samples From Patients With Neuroblastoma
 

Status: Recruiting

Condition Summary: Disseminated Neuroblastoma; Localized Resectable Neuroblastoma; Localized Unresectable Neuroblastoma; Recurrent Neuroblastoma; Regional Neuroblastoma; Stage 4S Neuroblastoma

 

Last Updated: 11 May 2015

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Expanded Access Study of Fenretinide Lym-X-Sorb Plus Ketoconazole in Neuroblastoma
 

Status: Available

Condition Summary: Recurrent Neuroblastoma; Neuroblastoma

 

Last Updated: 9 Dec 2014

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