Neuroblastoma

Common Name(s)

Neuroblastoma

Neuroblastoma is a tumor that develops from a nerve in a child, usually before the age of 5.  It occurs in the abdomen near the adrenal glands, but it can also occur in other parts of the body.  It is considered an aggressive tumor because it often spreads to other parts of the body (metastasizes).   The symptoms of a neuroblastoma may include a lump in the abdomen, pain, diarrhea, or generally feeling unwell.  It affects one out of 100,000 children.   The exact cause of this tumor is not yet known.  Neuroblastoma may be diagnosed by physical examination; specific blood tests; imaging tests such as x-rays, magnetic resonance imaging (MRI), or computed tomography (CT) scans; and a biopsy.   Treatment depends on the size and location of the tumor within the body, as well as the childÕs age. Surgery is often the first step of treatment, and may be followed by chemotherapy, radiation therapy, or a stem cell transplant in more severe cases.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Neuroblastoma" for support, advocacy or research.

National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

Last Updated: 20 Feb 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Neuroblastoma" for support, advocacy or research.

National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

http://www.nbmtlink.org

Last Updated: 20 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Neuroblastoma" returned 2614 free, full-text research articles on human participants. First 3 results:

Use of Attribute Driven Incremental Discretization and Logic Learning Machine to build a prognostic classifier for neuroblastoma patients.
 

Author(s): Davide Cangelosi, Marco Muselli, Stefano Parodi, Fabiola Blengio, Pamela Becherini, Rogier Versteeg, Massimo Conte, Luigi Varesio

Journal: BMC Bioinformatics. 2014 ;15 Suppl 5():S4.

 

Cancer patient's outcome is written, in part, in the gene expression profile of the tumor. We previously identified a 62-probe sets signature (NB-hypo) to identify tissue hypoxia in neuroblastoma tumors and showed that NB-hypo stratified neuroblastoma patients in good and poor outcome ...

Last Updated: 1 Aug 2014

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Type-1 interferons contribute to oxygen glucose deprivation induced neuro-inflammation in BE(2)M17 human neuroblastoma cells.
 

Author(s): Myles Robert Minter, Moses Zhang, Robert Charles Ates, Juliet Marie Taylor, Peter John Crack

Journal:

 

Hypoxic-ischaemic injuries such as stroke and traumatic brain injury exhibit features of a distinct neuro-inflammatory response in the hours and days post-injury. Microglial activation, elevated pro-inflammatory cytokines and macrophage infiltration contribute to core tissue damage ...

Last Updated: 31 Mar 2014

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[Management of refractory neuroblastoma with high-dose topotecan plus cyclophosphamide and vincristine].
 

Author(s): Jian Chang, Yu-Tong Zhang, Li-Zhe Wang, Xiao-Dan Zhong

Journal: Zhongguo Dang Dai Er Ke Za Zhi. 2014 Feb;16(2):120-3.

 

Last Updated: 26 Feb 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Neuroblastoma" returned 85 free, full-text review articles on human participants. First 3 results:

[A review on treatment of high-risk neuroblastoma].
 

Author(s): Suo-Qin Tang

Journal: Zhongguo Dang Dai Er Ke Za Zhi. 2014 Feb;16(2):103-7.

 

So far treatment of advanced neuroblastoma is still difficult, due to its high malignancy. Currently comprehensive therapies, including high-dose multi-drug chemotherapy, surgery, stem cell transplantation, radiation, biological therapy and immune therapy as well as target therapy ...

Last Updated: 26 Feb 2014

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Multidrug resistance and cancer stem cells in neuroblastoma and hepatoblastoma.
 

Author(s): Anna Alisi, William C Cho, Franco Locatelli, Doriana Fruci

Journal:

 

Chemotherapy is one of the major modalities in treating cancers. However, its effectiveness is limited by the acquisition of multidrug resistance (MDR). Several mechanisms could explain the up-regulation of MDR genes/proteins in cancer after chemotherapy. It is known that cancer stem ...

Last Updated: 19 Dec 2013

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Advances in chimeric antigen receptor immunotherapy for neuroblastoma.
 

Author(s): Andras Heczey, Chrystal U Louis

Journal: Discov Med. 2013 Dec;16(90):287-94.

 

Neuroblastoma (NBL) is the most common extracranial pediatric solid tumor and has heterogeneous biology and behavior. Patients with high-risk disease have poor prognosis despite complex multimodal therapy; therefore, novel curative approaches are needed. Immunotherapy is a novel therapeutic ...

Last Updated: 16 Dec 2013

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Biomarkers in Tumor Tissue Samples From Patients With Newly Diagnosed Neuroblastoma or Ganglioneuroblastoma
 

Status: Recruiting

Condition Summary: Disseminated Neuroblastoma; Ganglioneuroblastoma; Localized Resectable Neuroblastoma; Localized Unresectable Neuroblastoma; Regional Neuroblastoma; Stage 4S Neuroblastoma

 

Last Updated: 23 Jul 2014

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Study of DNA in Blood Samples From Patients With Neuroblastoma
 

Status: Recruiting

Condition Summary: Disseminated Neuroblastoma; Localized Resectable Neuroblastoma; Localized Unresectable Neuroblastoma; Recurrent Neuroblastoma; Regional Neuroblastoma; Stage 4S Neuroblastoma

 

Last Updated: 18 Feb 2014

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Expanded Access Study of Fenretinide Lym-X-Sorb Plus Ketoconazole in Neuroblastoma
 

Status: Available

Condition Summary: Recurrent Neuroblastoma; Neuroblastoma

 

Last Updated: 22 Apr 2014

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