Neuroblastoma

Common Name(s)

Neuroblastoma

Neuroblastoma is a tumor that develops from a nerve in a child, usually before the age of 5.  It occurs in the abdomen near the adrenal glands, but it can also occur in other parts of the body.  It is considered an aggressive tumor because it often spreads to other parts of the body (metastasizes).   The symptoms of a neuroblastoma may include a lump in the abdomen, pain, diarrhea, or generally feeling unwell.  It affects one out of 100,000 children.   The exact cause of this tumor is not yet known.  Neuroblastoma may be diagnosed by physical examination; specific blood tests; imaging tests such as x-rays, magnetic resonance imaging (MRI), or computed tomography (CT) scans; and a biopsy.   Treatment depends on the size and location of the tumor within the body, as well as the childÕs age. Surgery is often the first step of treatment, and may be followed by chemotherapy, radiation therapy, or a stem cell transplant in more severe cases.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Neuroblastoma" for support, advocacy or research.

National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

Last Updated: 20 Feb 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Neuroblastoma" for support, advocacy or research.

National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

http://www.nbmtlink.org

Last Updated: 20 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Neuroblastoma" returned 3307 free, full-text research articles on human participants. First 3 results:

Proteomic Profiling of Neuroblastoma Cells Adhesion on Hyaluronic Acid-Based Surface for Neural Tissue Engineering.
 

Author(s): Ming-Hui Yang, Ko-Chin Chen, Pei-Wen Chiang, Tze-Wen Chung, Wan-Jou Chen, Pei-Yu Chu, Sharon Chia-Ju Chen, Yi-Shan Lu, Cheng-Hui Yuan, Ming-Chen Wang, Chia-Yang Lin, Ying-Fong Huang, Shiang-Bin Jong, Po-Chiao Lin, Yu-Chang Tyan

Journal: Biomed Res Int. 2016 ;2016():1917394.

 

The microenvironment of neuron cells plays a crucial role in regulating neural development and regeneration. Hyaluronic acid (HA) biomaterial has been applied in a wide range of medical and biological fields and plays important roles in neural regeneration. PC12 cells have been reported ...

Last Updated: 5 Jan 2017

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Lack of Associations between XPC Gene Polymorphisms and Neuroblastoma Susceptibility in a Chinese Population.
 

Author(s): Jintao Zheng, Ruizhong Zhang, Jinhong Zhu, Fenghua Wang, Tianyou Yang, Jing He, Huimin Xia

Journal: Biomed Res Int. 2016 ;2016():2932049.

 

Neuroblastoma is one of the most malignant solid tumors in infants and young children. No more than 40% of neuroblastoma patients can survive for longer than five years after it has been diagnosed. XPC protein is a pivotal factor that recognizes DNA damage and starts up the nucleotide ...

Last Updated: 16 Nov 2016

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In vivo expansion and activation of γδ T cells as immunotherapy for refractory neuroblastoma: A phase 1 study.
 

Author(s): Joseph G Pressey, Julia Adams, Lualhati Harkins, David Kelly, Zhiying You, Lawrence S Lamb

Journal: Medicine (Baltimore). 2016 Sep;95(39):e4909.

 

CD3+ γδ+ T cells comprise 2% to 5% of circulating T cells with Vγ9Vδ2+ cells the dominant circulating subtype. Vγ9Vδ2+ cells recognize non-peptide phosphoantigens and stress-associated NKG2D ligands expressed on malignant cells. Strategies that incorporate the tumoricidal properties ...

Last Updated: 30 Sep 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Neuroblastoma" returned 105 free, full-text review articles on human participants. First 3 results:

Neuroblastoma: A Tough Nut to Crack.
 

Author(s): Frank Speleman, Julie R Park, Tara O Henderson

Journal: Am Soc Clin Oncol Educ Book. 2016 ;35():e548-57.

 

Neuroblastoma, an embryonal tumor arising from neural crest-derived progenitor cells, is the most common solid tumor in childhood, with more than 700 cases diagnosed per year in the United States. In the past several decades, significant advances have been made in the treatment of ...

Last Updated: 2 Jun 2016

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Neuroendocrine Neoplasms of the Sinonasal Tract: Neuroendocrine Carcinomas and Olfactory Neuroblastoma.
 

Author(s): Ketan Shah, Bayardo Perez-Ordóñez

Journal: Head Neck Pathol. 2016 Mar;10(1):85-94.

 

Neuroendocrine neoplasms (NENs) can occur in organs or tissues that do not contain neuroendocrine cells normally and do not necessarily imply embryologic derivation from the neuroectoderm; but rather reflect a shared phenotype characterized by the expression of multiple genes encoding ...

Last Updated: 9 Feb 2016

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Neuroblastoma: oncogenic mechanisms and therapeutic exploitation of necroptosis.
 

Author(s): S Nicolai, M Pieraccioli, A Peschiaroli, G Melino, G Raschellà

Journal:

 

Neuroblastoma (NB) is the most common extracranial childhood tumor classified in five stages (1, 2, 3, 4 and 4S), two of which (3 and 4) identify chemotherapy-resistant, highly aggressive disease. High-risk NB frequently displays MYCN amplification, mutations in ALK and ATRX, and ...

Last Updated: 4 Dec 2015

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Neuroblastoma Precision Trial
 

Status: Recruiting

Condition Summary: Neuroblastoma

 

Last Updated: 15 Nov 2016

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Immunotherapy of Relapsed Refractory Neuroblastoma With Expanded NK Cells
 

Status: Not yet recruiting

Condition Summary: Neuroblastoma

 

Last Updated: 11 Dec 2015

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