Neural tube defects

Common Name(s)

Neural tube defects

Neural tube defects (NTDs) refers to a group of abnormalities resulting from abnormal development of the brain, spine and/or spinal column. During the development of an affected embryo, a structure called the neural tube does not close completely as it should, resulting in a hole somewhere along the spinal column. Specific examples of types of NTDs include spina bifida, anencephaly, and encephalocele. Symptoms vary depending on the type of NTD present but often include various forms of physical and/or mental disabilities. Many affected individuals do not survive. The exact cause of NTDs is not known but is thought to involve both genetic and nongenetic factors. Getting enough folic acid before and during pregnancy can reduce the risk of some NTDs. Treatment depends on the severity and type of defect and may include surgery.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Neural tube defects" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Neural tube defects" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Neural tube defects" returned 450 free, full-text research articles on human participants. First 3 results:

Folic acid fortified milk increases blood folate to concentrations associated with a very low risk of neural tube defects in Singaporean women of childbearing age.
 

Author(s): Magdalin Cheong, Huang Ying Xiao, Vicky Tay, Crystal D Karakochuk, Yazheng Amy Liu, Sarah Harvey, Yvonne Lamers, Lisa A Houghton, David D Kitts, Tim J Green

Journal: Asia Pac J Clin Nutr. 2016 ;25(1):62-70.

 

Folic acid (400 μg/d) taken during the periconceptional period reduces neural tube defect (NTD) risk by >75%. Achieving red cell folate (RCF) or plasma folate (PF) >905 nmol/L and >35 nmol/L, respectively, has been associated with a low risk of NTDs. We determined whether daily consumption ...

Last Updated: 11 Mar 2016

Go To URL
Inositol for the prevention of neural tube defects: a pilot randomised controlled trial.
 

Author(s): Nicholas D E Greene, Kit-Yi Leung, Victoria Gay, Katie Burren, Kevin Mills, Lyn S Chitty, Andrew J Copp

Journal: Br. J. Nutr.. 2016 Mar;115(6):974-83.

 

Although peri-conceptional folic acid (FA) supplementation can prevent a proportion of neural tube defects (NTD), there is increasing evidence that many NTD are FA non-responsive. The vitamin-like molecule inositol may offer a novel approach to preventing FA-non-responsive NTD. Inositol ...

Last Updated: 25 Feb 2016

Go To URL
[Epidemiology and risk factors of the closing neural tube defects: Moroccan data].
 

Author(s): Mohammed Amine Radouani, Naima Chahid, Loubna Benmiloud, Laila Elammari, Khalid Lahlou, Amina Barkat

Journal:

 

Last Updated: 15 Dec 2015

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Neural tube defects" returned 71 free, full-text review articles on human participants. First 3 results:

Describing the Prevalence of Neural Tube Defects Worldwide: A Systematic Literature Review.
 

Author(s): Ibrahim Zaganjor, Ahlia Sekkarie, Becky L Tsang, Jennifer Williams, Hilda Razzaghi, Joseph Mulinare, Joseph E Sniezek, Michael J Cannon, Jorge Rosenthal

Journal:

 

Folate-sensitive neural tube defects (NTDs) are an important, preventable cause of morbidity and mortality worldwide. There is a need to describe the current global burden of NTDs and identify gaps in available NTD data.

Last Updated: 12 Apr 2016

Go To URL
Birth prevalence of neural tube defects and orofacial clefts in India: a systematic review and meta-analysis.
 

Author(s): Komal Preet Allagh, B R Shamanna, Gudlavalleti V S Murthy, Andy R Ness, Pat Doyle, Sutapa B Neogi, Hira B Pant,

Journal:

 

In the last two decades, India has witnessed a substantial decrease in infant mortality attributed to infectious disease and malnutrition. However, the mortality attributed to birth defects remains constant. Studies on the prevalence of birth defects such as neural tube defects and ...

Last Updated: 15 Mar 2015

Go To URL
Uronephrological outcomes of patients with neural tube defects. Does a spina bifida clinic make a difference?
 

Author(s): Hamdan H Al-Hazmi, Mahmoud S Trbay, Abdulmonem B Gomha, Ahmad A Elderwy, Amenah J Khatab, Khalid F Neel

Journal: Saudi Med J. 2014 Dec;35 Suppl 1():S64-7.

 

To review the uronephrological outcomes of myelomeningocele (MMC) patients attending a Spina Bifida Clinic.

Last Updated: 31 Dec 2014

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Genetics of Neural Tube Defects
 

Status: Recruiting

Condition Summary: Neural Tube Defects

 

Last Updated: 2 Dec 2010

Go to URL
Fetoscopic Meningomyelocele Repair Study
 

Status: Recruiting

Condition Summary: Neural Tube Defect

 

Last Updated: 24 May 2016

Go to URL
Mobile Health Self-Management and Support System for Chronic and Complex Health Conditions
 

Status: Recruiting

Condition Summary: Spinal Cord Injuries; Cerebral Palsy; Spinal Dysraphism; Brain Injuries; Spina Bifida; Traumatic Brain Injury

 

Last Updated: 28 Oct 2015

Go to URL