Neural tube defects

Common Name(s)

Neural tube defects

Neural tube defects (NTDs) refers to a group of abnormalities resulting from abnormal development of the brain, spine and/or spinal column. During the development of an affected embryo, a structure called the neural tube does not close completely as it should, resulting in a hole somewhere along the spinal column. Specific examples of types of NTDs include spina bifida, anencephaly, and encephalocele. Symptoms vary depending on the type of NTD present but often include various forms of physical and/or mental disabilities. Many affected individuals do not survive. The exact cause of NTDs is not known but is thought to involve both genetic and nongenetic factors. Getting enough folic acid before and during pregnancy can reduce the risk of some NTDs. Treatment depends on the severity and type of defect and may include surgery.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Neural tube defects" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Neural tube defects" returned 421 free, full-text research articles on human participants. First 3 results:

Research: Prevalence of neural tube defects Khartoum, Sudan August 2014-July 2015.
 

Author(s): Ilham M Omer, Osman M Abdullah, Inaam N Mohammed, Lina A Abbasher

Journal:

 

Neural tube defects (NTDs) are birth defects that results from failure of the neural tube to develop properly during early pregnancy.

Last Updated: 24 Nov 2016

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Lack of association between the methylenetetrahydropholate reductase gene A1298C polymorphism and neural tube defects in a Turkish study group.
 

Author(s): S H Yildiz, M Ozdemir Erdogan, M Solak, O Eser, E S Arıkan Terzi, B Eser, V Kocabaş, A Aslan

Journal:

 

The etiology underlying neural tube defects (NTDs) is not fully understood and is believed to involve a complex milieu of genetic and environmental factors. The A1298C polymorphism in the methylenetetrahydropholate reductase gene (MTHFR) has been associated with mild risk for NTDs. ...

Last Updated: 21 Jun 2016

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Temporal and Spatial Analysis of Neural Tube Defects and Detection of Geographical Factors in Shanxi Province, China.
 

Author(s): Yilan Liao, Yan Zhang, Lei He, Jinfeng Wang, Xin Liu, Ningxu Zhang, Bing Xu

Journal:

 

Neural tube defects (NTDs) are congenital birth defects that occur in the central nervous system, and they have the highest incidence among all birth defects. Shanxi Province in China has the world's highest rate of NTDs. Since the 1990s, China's government has worked on many birth ...

Last Updated: 22 Apr 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Neural tube defects" returned 68 free, full-text review articles on human participants. First 3 results:

Describing the Prevalence of Neural Tube Defects Worldwide: A Systematic Literature Review.
 

Author(s): Ibrahim Zaganjor, Ahlia Sekkarie, Becky L Tsang, Jennifer Williams, Hilda Razzaghi, Joseph Mulinare, Joseph E Sniezek, Michael J Cannon, Jorge Rosenthal

Journal:

 

Folate-sensitive neural tube defects (NTDs) are an important, preventable cause of morbidity and mortality worldwide. There is a need to describe the current global burden of NTDs and identify gaps in available NTD data.

Last Updated: 12 Apr 2016

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Birth prevalence of neural tube defects and orofacial clefts in India: a systematic review and meta-analysis.
 

Author(s): Komal Preet Allagh, B R Shamanna, Gudlavalleti V S Murthy, Andy R Ness, Pat Doyle, Sutapa B Neogi, Hira B Pant,

Journal:

 

In the last two decades, India has witnessed a substantial decrease in infant mortality attributed to infectious disease and malnutrition. However, the mortality attributed to birth defects remains constant. Studies on the prevalence of birth defects such as neural tube defects and ...

Last Updated: 15 Mar 2015

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Uronephrological outcomes of patients with neural tube defects. Does a spina bifida clinic make a difference?
 

Author(s): Hamdan H Al-Hazmi, Mahmoud S Trbay, Abdulmonem B Gomha, Ahmad A Elderwy, Amenah J Khatab, Khalid F Neel

Journal: Saudi Med J. 2014 Dec;35 Suppl 1():S64-7.

 

To review the uronephrological outcomes of myelomeningocele (MMC) patients attending a Spina Bifida Clinic.

Last Updated: 31 Dec 2014

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Fetoscopic Meningomyelocele Repair Study
 

Status: Recruiting

Condition Summary: Neural Tube Defect

 

Last Updated: 26 Sep 2016

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Open Myelomeningocele Repair With High Maternal BMI
 

Status: Recruiting

Condition Summary: Neural Tube Defect

 

Last Updated: 3 Feb 2017

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Genetics of Spina Bifida and Anencephaly
 

Status: Recruiting

Condition Summary: Anencephaly; Acrania

 

Last Updated: 22 Jun 2016

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