Neural tube defects

Common Name(s)

Neural tube defects

Neural tube defects are the second most common type of birth defect after congenital heart defects. The 2 most common NTDs are open spina bifida, also known as spina bifida cystica (SBC) or myelomeningocele, and anencephaly ({206500}) ({10:Detrait et al., 2005}). Spina bifida occulta (SBO) is a bony defect of the spine covered by normal skin. It is mild form of spina bifida and is often asymptomatic. The term 'spinal dysraphia' refers to both SBC and SBO ({5:Botto et al., 1999}; {14:Fineman et al., 1982}). The most severe neural tube defect, craniorachischisis (CRN), leaves the neural tube open from the midbrain or rostral hindbrain to the base of the spine (summary by {31:Robinson et al., 2012}). An X-linked form of spina bifida has been suggested; see {301410}. See also folate-sensitive neural tube defects ({601634}).
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Neural tube defects" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Neural tube defects" returned 381 free, full-text research articles on human participants. First 3 results:

Notes from the field: investigation of a cluster of neural tube defects - central Washington, 2010-2013.
 

Author(s):

Journal: MMWR Morb. Mortal. Wkly. Rep.. 2013 Sep;62(35):728.

 

During August 2012, a health-care provider in central Washington alerted the Washington State Department of Health (DOH) about an excessive number of anencephaly births at a local hospital. After examining referral patterns for high-risk pregnancies in central Washington, DOH identified ...

Last Updated: 5 Sep 2013

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Maternal hyperglycemia activates an ASK1-FoxO3a-caspase 8 pathway that leads to embryonic neural tube defects.
 

Author(s): Peixin Yang, Xuezheng Li, Cheng Xu, Richard L Eckert, E Albert Reece, Horst Ronald Zielke, Fang Wang

Journal:

 

Neural tube defects result from failure to completely close neural tubes during development. Maternal diabetes is a substantial risk factor for neural tube defects, and available evidence suggests that the mechanism that links hyperglycemia to neural tube defects involves oxidative ...

Last Updated: 28 Aug 2013

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Genetic diversity of stem cells and their functional impact on the development of neural tube defects in Eastern population of India.
 

Author(s): A K Saxena, S Pandey, L K Pandey

Journal:

 

Anencephaly and myelomeningocele are the 2 most common forms of neural tube defects (NTDs). During embryogenesis large numbers of extrinsic and intrinsic factors are responsible for the closing of the neural tube. "Stem cells" maintain the pluripotency during differentiation of 3 ...

Last Updated: 27 Aug 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Neural tube defects" returned 44 free, full-text review articles on human participants. First 3 results:

Neural tube defects, folic acid and methylation.
 

Author(s): Apolline Imbard, Jean-Fran├žois Benoist, Henk J Blom

Journal:

 

Neural tube defects (NTDs) are common complex congenital malformations resulting from failure of the neural tube closure during embryogenesis. It is established that folic acid supplementation decreases the prevalence of NTDs, which has led to national public health policies regarding ...

Last Updated: 19 Sep 2013

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Knowledge and periconceptional use of folic acid for the prevention of neural tube defects in ethnic communities in the United Kingdom: systematic review and meta-analysis.
 

Author(s): Jordana N Peake, Andrew J Copp, Jill Shawe

Journal: Birth Defects Res. Part A Clin. Mol. Teratol.. 2013 Jul;97(7):444-51.

 

It is widely accepted that periconceptional supplementation with folic acid can prevent a significant proportion of neural tube defects (NTDs). The present study evaluated how folic acid knowledge and periconceptional use for NTD prevention varies by ethnicity in the United Kingdom (U.K.).

Last Updated: 22 Jul 2013

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The continuing challenge of understanding, preventing, and treating neural tube defects.
 

Author(s): John B Wallingford, Lee A Niswander, Gary M Shaw, Richard H Finnell

Journal: Science. 2013 Mar;339(6123):1222002.

 

Human birth defects are a major public health burden: The Center for Disease Control estimates that 1 of every 33 United States newborns presents with a birth defect, and worldwide the estimate approaches 6% of all births. Among the most common and debilitating of human birth defects ...

Last Updated: 1 Mar 2013

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Genetics of Neural Tube Defects
 

Status: Recruiting

Condition Summary: Neural Tube Defects

 

Last Updated: 2 Dec 2010

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Prevention of Neural Tube Defects by Inositol in Conjunction With Folic Acid (PONTI Study)
 

Status: Recruiting

Condition Summary: Recurrent Neural Tube Defects

 

Last Updated: 27 Mar 2007

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Post T-plant Infusion of Allogeneic Cytokine Induced Killer Cells as Consolidative Therapy in Myelodysplastic Syndromes/Myeloproliferative Disorders
 

Status: Recruiting

Condition Summary: Neural Tube Defects; Anemia; Leukemia, Myeloid; Bone Marrow Transplant Failure; Myelodysplastic Syndromes (MDS); Myeloproliferative Disorders

 

Last Updated: 7 Mar 2014

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