Neural tube defects

Common Name(s)

Neural tube defects

Neural tube defects (NTDs) refers to a group of abnormalities resulting from abnormal development of the brain, spine and/or spinal column. During the development of an affected embryo, a structure called the neural tube does not close completely as it should, resulting in a hole somewhere along the spinal column. Specific examples of types of NTDs include spina bifida, anencephaly, and encephalocele. Symptoms vary depending on the type of NTD present but often include various forms of physical and/or mental disabilities. Many affected individuals do not survive. The exact cause of NTDs is not known but is thought to involve both genetic and nongenetic factors. Getting enough folic acid before and during pregnancy can reduce the risk of some NTDs. Treatment depends on the severity and type of defect and may include surgery.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Neural tube defects" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Neural tube defects" returned 433 free, full-text research articles on human participants. First 3 results:

Folic Acid Intake and Neural Tube Defects: Two Egyptian Centers Experience.
 

Author(s): Mortada H El-Shabrawi, Naglaa Mohamed Kamal, Mona Abbas Elhusseini, Laila Hussein, Enas Abdallah Ali Abdallah, Yahia Zakaria Abdelalim Ali, Ahmed Abelfattah Azab, Mostafa Abdelazim Salama, Muna Kassab, Michael Krawinkel

Journal: Medicine (Baltimore). 2015 Sep;94(37):e1395.

 

Neural tube defects (NTDs) are a group of congenital malformations with worldwide distribution and complex etiopathogenesis. Folic acid plays a pivotal role in their prevention. We aimed to identify the protective effect of folic acid intake against NTDs and its dependence on different ...

Last Updated: 17 Sep 2015

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Maternal consumption of non-staple food in the first trimester and risk of neural tube defects in offspring.
 

Author(s): Meng Wang, Zhi-Ping Wang, Li-Jie Gao, Hui Yang, Zhong-Tang Zhao

Journal:

 

To study the associations between maternal consumption of non-staple food in the first trimester and risk of neural tube defects (NTDs) in offspring. Data collected from a hospital-based case-control study conducted between 2006 and 2008 in Shandong/Shanxi provinces including 459 ...

Last Updated: 29 Apr 2015

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Optimal serum and red blood cell folate concentrations in women of reproductive age for prevention of neural tube defects: World Health Organization guidelines.
 

Author(s): Amy M Cordero, Krista S Crider, Lisa M Rogers, Michael J Cannon, R J Berry

Journal: MMWR Morb. Mortal. Wkly. Rep.. 2015 Apr;64(15):421-3.

 

Neural tube defects (NTDs) such as spina bifida, anencephaly, and encephalocele are serious birth defects of the brain and spine that occur during the first month of pregnancy when the neural tube fails to close completely. Randomized controlled trials and observational studies have ...

Last Updated: 24 Apr 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Neural tube defects" returned 70 free, full-text review articles on human participants. First 3 results:

Birth prevalence of neural tube defects and orofacial clefts in India: a systematic review and meta-analysis.
 

Author(s): Komal Preet Allagh, B R Shamanna, Gudlavalleti V S Murthy, Andy R Ness, Pat Doyle, Sutapa B Neogi, Hira B Pant,

Journal:

 

In the last two decades, India has witnessed a substantial decrease in infant mortality attributed to infectious disease and malnutrition. However, the mortality attributed to birth defects remains constant. Studies on the prevalence of birth defects such as neural tube defects and ...

Last Updated: 15 Mar 2015

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Uronephrological outcomes of patients with neural tube defects. Does a spina bifida clinic make a difference?
 

Author(s): Hamdan H Al-Hazmi, Mahmoud S Trbay, Abdulmonem B Gomha, Ahmad A Elderwy, Amenah J Khatab, Khalid F Neel

Journal: Saudi Med J. 2014 Dec;35 Suppl 1():S64-7.

 

To review the uronephrological outcomes of myelomeningocele (MMC) patients attending a Spina Bifida Clinic.

Last Updated: 31 Dec 2014

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Classification, clinical features, and genetics of neural tube defects.
 

Author(s): Mustafa A Salih, Waleed R Murshid, Mohammed Z Seidahmed

Journal: Saudi Med J. 2014 Dec;35 Suppl 1():S5-S14.

 

Neural tube defects (NTDs) constitute a major health burden (0.5-2/1000 pregnancies worldwide), and remain a preventable cause of still birth, neonatal, and infant death, or significant lifelong handicaps. The malformations result from failure of the neural folds to fuse in the midline, ...

Last Updated: 31 Dec 2014

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Genetics of Neural Tube Defects
 

Status: Recruiting

Condition Summary: Neural Tube Defects

 

Last Updated: 2 Dec 2010

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Fetoscopic Meningomyelocele Repair Study
 

Status: Recruiting

Condition Summary: Neural Tube Defect

 

Last Updated: 29 Jan 2016

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Post T-plant Infusion of Allogeneic Cytokine Induced Killer Cells as Consolidative Therapy in Myelodysplastic Syndromes/Myeloproliferative Disorders
 

Status: Recruiting

Condition Summary: Neural Tube Defects; Anemia; Leukemia, Myeloid; Bone Marrow Transplant Failure; Myelodysplastic Syndromes (MDS); Myeloproliferative Disorders

 

Last Updated: 3 Feb 2015

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