Neural tube defects, folate-sensitive

Common Name(s)

Neural tube defects, folate-sensitive

Neural tube defects have a birth incidence of approximately 1 in 1,000 in American Caucasians and are the second most common type of birth defect after congenital heart defects. The most common NTDs are open spina bifida (myelomeningocele) and anencephaly ({206500}) ({9:Detrait et al., 2005}). Women with elevated plasma homocysteine, low folate, or low vitamin B12 (cobalamin) are at increased risk of having a child with a neural tube defect ({16:O'Leary et al., 2005}). {15:Motulsky (1996)} cited evidence from the Centers for Disease Control ({1: Anonymous, 1992}) that folic acid given before and during the first 4 weeks of pregnancy can prevent 50% or more of neural tube defects. {2:Botto et al. (1999)} and {9:Detrait et al. (2005)} provided reviews of neural tube defects. {8:De Marco et al. (2006)} provided a detailed review of neurulation and the possible etiologies of neural tube defects.
 

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Scientific Literature

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