Nephrogenic diabetes insipidus

Common Name(s)

Nephrogenic diabetes insipidus, Nephrogenic diabetes insipidus, x-linked

Nephrogenic diabetes insipidus is a disorder in which a defect in the small tubes (tubules) in the kidneys causes a person to pass a large amount of urine. Nephrogenic diabetes insipidus occurs when the kidney tubules, which allow water to be removed from the body or reabsorbed, do not respond to a chemical in the body called antidiuretic hormone (ADH) or vasopressin. ADH normally tells the kidneys to make the urine more concentrated. As a result of the defect, the kidneys release an excessive amount of water into the urine, producing a large quantity of very dilute urine.

Nephrogenic diabetes insipidus can be either acquired or hereditary. The acquired form is brought on by certain drugs and chronic diseases and can occur at any time during life. The hereditary form is caused by genetic mutations, and its signs and symptoms usually become apparent within the first few months of life.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Nephrogenic diabetes insipidus" for support, advocacy or research.

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Nephrogenic Diabetes Insipidus Network

The NDI Foundation was formed to support education, research, treatment and cure for Nephrogenic Diabetes Insipidus. Our goal is to create a communication channel to serve the entire NDI community: patients and their families, researchers, physicians and other health care providers. The NDI foundation has helped to stimulate clinical trials and ongoing research to improve the therapy and treatment options for this kidney disorder. While we focus on research, we enthusisaticly provide information to help educate patients and famalies on treatment options, support groups and the lastest research news.

Last Updated: 9 Nov 2012

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Nephrogenic diabetes insipidus" for support, advocacy or research.

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Nephrogenic Diabetes Insipidus Network

The NDI Foundation was formed to support education, research, treatment and cure for Nephrogenic Diabetes Insipidus. Our goal is to create a communication channel to serve the entire NDI community: patients and their families, researchers, physicians and other health care providers. The NDI foundation has helped to stimulate clinical trials and ongoing research to improve the therapy and treatment options for this kidney disorder. While we focus on research, we enthusisaticly provide information to help educate patients and famalies on treatment options, support groups and the lastest research news.

http://www.ndif.org

Last Updated: 9 Nov 2012

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Nephrogenic diabetes insipidus" returned 137 free, full-text research articles on human participants. First 3 results:

A novel mutation affecting the arginine-137 residue of AVPR2 in dizygous twins leads to nephrogenic diabetes insipidus and attenuated urine exosome aquaporin-2.
 

Author(s): Gitte R Hinrichs, Louise H Hansen, Maria R Nielsen, Christina Fagerberg, Hans Dieperink, Søren Rittig, Boye L Jensen

Journal: Physiol Rep. 2016 Apr;4(8):.

 

Mutations in the vasopressin V2 receptor gene AVPR2 may cause X-linked nephrogenic diabetes insipidus by defective apical insertion of aquaporin-2 in the renal collecting duct principal cell. Substitution mutations with exchange of arginine at codon 137 can cause nephrogenic syndrome ...

Last Updated: 27 Apr 2016

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Partial nephrogenic diabetes insipidus caused by a novel AQP2 variation impairing trafficking of the aquaporin-2 water channel.
 

Author(s): Pia Dollerup, Troels Møller Thomsen, Lene N Nejsum, Mia Færch, Martin Österbrand, Niels Gregersen, Søren Rittig, Jane H Christensen, Thomas J Corydon

Journal:

 

Autosomal dominant inheritance of congenital nephrogenic diabetes insipidus (CNDI) is rare and usually caused by variations in the AQP2 gene. We have investigated the genetic and molecular background underlying symptoms of diabetes insipidus (DI) in a Swedish family with autosomal ...

Last Updated: 30 Dec 2015

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Evolutionary Influenced Interaction Pattern as Indicator for the Investigation of Natural Variants Causing Nephrogenic Diabetes Insipidus.
 

Author(s): Steffen Grunert, Dirk Labudde

Journal: Comput Math Methods Med. 2015 ;2015():641393.

 

The importance of short membrane sequence motifs has been shown in many works and emphasizes the related sequence motif analysis. Together with specific transmembrane helix-helix interactions, the analysis of interacting sequence parts is helpful for understanding the process during ...

Last Updated: 16 Jul 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Nephrogenic diabetes insipidus" returned 15 free, full-text review articles on human participants. First 3 results:

Targeting renal purinergic signalling for the treatment of lithium-induced nephrogenic diabetes insipidus.
 

Author(s): B K Kishore, N G Carlson, C M Ecelbarger, D E Kohan, C E Müller, R D Nelson, J Peti-Peterdi, Y Zhang

Journal: Acta Physiol (Oxf). 2015 Jun;214(2):176-88.

 

Lithium still retains its critical position in the treatment of bipolar disorder by virtue of its ability to prevent suicidal tendencies. However, chronic use of lithium is often limited by the development of nephrogenic diabetes insipidus (NDI), a debilitating condition. Lithium-induced ...

Last Updated: 12 May 2015

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Congenital nephrogenic diabetes insipidus with end-stage renal disease.
 

Author(s): Hyun Ho Ryu, Jong Hoon Chung, Byung Chul Shin, Hyun Lee Kim

Journal: Korean J. Intern. Med.. 2015 Mar;30(2):259-61.

 

Last Updated: 9 Mar 2015

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A novel therapeutic effect of statins on nephrogenic diabetes insipidus.
 

Author(s): Leonilde Bonfrate, Giuseppe Procino, David Q-H Wang, Maria Svelto, Piero Portincasa

Journal: J. Cell. Mol. Med.. 2015 Feb;19(2):265-82.

 

Statins competitively inhibit hepatic 3-hydroxy-3-methylglutaryl-coenzyme A reductase, resulting in reduced plasma total and low-density lipoprotein cholesterol levels. Recently, it has been shown that statins exert additional 'pleiotropic' effects by increasing expression levels ...

Last Updated: 29 Jan 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Metformin and Congenital Nephrogenic Diabetes Insipidus
 

Status: Recruiting

Condition Summary: Diabetes Insipidus

 

Last Updated: 20 Apr 2016

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