Narcolepsy

Common Name(s)

Narcolepsy

Narcolepsy is a sleep disorder that causes episodes of extreme daytime sleepiness. Three other major symptoms frequently characterize narcolepsy: cataplexy, or the sudden loss of voluntary muscle tone; vivid hallucinations during sleep onset or upon awakening; and brief episodes of sleep paralysis. The disorder is estimated to affect about one in every 2,000 Americans. Most cases of narcolepsy are sporadic, which means that the condition occurs in one person in a family and is not inherited. However, up to 10 percent of individuals with narcolepsy have a close relative with the same symptoms. Other factors may be involved in causing narcolepsy, such as infection, immune-system dysfunction, trauma, hormonal changes, stress.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Narcolepsy" for support, advocacy or research.

Narcolepsy Network, Inc.

Narcolepsy Network, Inc.'s mission is to: educate the public about narcolepsy and other related sleep disorders, support individuals with narcolepsy, their families and friends, promote the efficient diagnosis of narcolepsy, and encourage and promote research for narcolepsy.

http://www.narcolepsynetwork.org

Last Updated: 26 Mar 2013

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Wake Up Narcolepsy, Inc.

Wake Up Narcolepsy is a 501(c)(3) not-for-profit organization dedicated to supporting narcolepsy awareness and research to find a cure. WUN carries out its mission by: Providing funding to accelerate a cure for narcolepsy; increasing awareness of narcolepsy; decreasing time-lapse from symptom onset to proper diagnosis; and providing supportive resources for people with narcolepsy and their families.

http://www.wakeupnarcolepsy.org/

Last Updated: 7 Jan 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Narcolepsy" for support, advocacy or research.

Narcolepsy Network, Inc.

Narcolepsy Network, Inc.'s mission is to: educate the public about narcolepsy and other related sleep disorders, support individuals with narcolepsy, their families and friends, promote the efficient diagnosis of narcolepsy, and encourage and promote research for narcolepsy.

http://www.narcolepsynetwork.org

Last Updated: 26 Mar 2013

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Wake Up Narcolepsy, Inc.

Wake Up Narcolepsy is a 501(c)(3) not-for-profit organization dedicated to supporting narcolepsy awareness and research to find a cure. WUN carries out its mission by: Providing funding to accelerate a cure for narcolepsy; increasing awareness of narcolepsy; decreasing time-lapse from symptom onset to proper diagnosis; and providing supportive resources for people with narcolepsy and their families.

http://www.wakeupnarcolepsy.org/

Last Updated: 7 Jan 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Narcolepsy" returned 223 free, full-text research articles on human participants. First 3 results:

Clinical and polysomnographic course of childhood narcolepsy with cataplexy.
 

Author(s): Fabio Pizza, Christian Franceschini, Hanna Peltola, Stefano Vandi, Elena Finotti, Francesca Ingravallo, Lino Nobili, Oliviero Bruni, Ling Lin, Mark J Edwards, Markku Partinen, Yves Dauvilliers, Emmanuel Mignot, Kailash P Bhatia, Giuseppe Plazzi

Journal: Brain. 2013 Dec;136(Pt 12):3787-95.

 

Our aim was to investigate the natural evolution of cataplexy and polysomnographic features in untreated children with narcolepsy with cataplexy. To this end, clinical, polysomnographic, and cataplexy-video assessments were performed at diagnosis (mean age of 10 ± 3 and disease duration ...

Last Updated: 16 Dec 2013

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Delayed diagnosis, range of severity, and multiple sleep comorbidities: a clinical and polysomnographic analysis of 100 patients of the innsbruck narcolepsy cohort.
 

Author(s): Birgit Frauscher, Laura Ehrmann, Thomas Mitterling, David Gabelia, Viola Gschliesser, Elisabeth Brandauer, Werner Poewe, Birgit Högl

Journal:

 

Narcolepsy is reported to affect 26-56/100,000 in the general population. We aimed to describe clinical and polysomnographic features of a large narcolepsy cohort in order to comprehensively characterize the narcoleptic spectrum.

Last Updated: 15 Aug 2013

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Plasma total ghrelin and leptin levels in human narcolepsy and matched healthy controls: basal concentrations and response to sodium oxybate.
 

Author(s): Claire E H M Donjacour, Daniel Pardi, N Ahmad Aziz, Marijke Frölich, Ferdinand Roelfsema, Sebastiaan Overeem, Hanno Pijl, Gert Jan Lammers

Journal:

 

Narcolepsy is caused by a selective loss of hypocretin neurons and is associated with obesity. Ghrelin and leptin interact with hypocretin neurons to influence energy homeostasis. Here, we evaluated whether human hypocretin deficiency, or the narcolepsy therapeutic agent sodium oxybate, ...

Last Updated: 15 Aug 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Narcolepsy" returned 30 free, full-text review articles on human participants. First 3 results:

Disrupted nighttime sleep in narcolepsy.
 

Author(s): Thomas Roth, Yves Dauvilliers, Emmanuel Mignot, Jacques Montplaisir, Josh Paul, Todd Swick, Phyllis Zee

Journal: J Clin Sleep Med. 2013 Sep;9(9):955-65.

 

Characterize disrupted nighttime sleep (DNS) in narcolepsy, an important symptom of narcolepsy.

Last Updated: 2 Sep 2013

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[Narcolepsy: etiology, clinical features, diagnosis and treatment].
 

Author(s): Jolanta B Zawilska, Agata Woldan-Tambor, Anna Płocka, Katarzyna Kużajska, Jakub Wojcieszak

Journal:

 

 Narcolepsy is a chronic hypersomnia characterized by excessive daytime sleepiness (EDS) and manifestations of disrupted rapid eye movement sleep stage (cataplexy, sleep paralysis, and hypnagogic/hypnopompic hallucinations). Mechanisms underlying narcolepsy are not fully understood. ...

Last Updated: 23 Nov 2012

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A practical guide to the therapy of narcolepsy and hypersomnia syndromes.
 

Author(s): Emmanuel J M Mignot

Journal: Neurotherapeutics. 2012 Oct;9(4):739-52.

 

Narcolepsy and other syndromes associated with excessive daytime sleepiness can be challenging to treat. New classifications now distinguish narcolepsy/hypocretin deficiency (also called type 1 narcolepsy), a lifelong disorder with well-established diagnostic procedures and etiology, ...

Last Updated: 25 Oct 2012

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Risk of Narcolepsy Associated With Administration of H1N1 Vaccine
 

Status: Recruiting

Condition Summary: Narcolepsy

 

Last Updated: 13 Jul 2011

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Narcolepsy - New Potential Treatment
 

Status: Recruiting

Condition Summary: Narcolepsy

 

Last Updated: 28 Feb 2014

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