Narcolepsy

Common Name(s)

Narcolepsy

Narcolepsy is a sleep disorder that causes episodes of extreme daytime sleepiness. Three other major symptoms frequently characterize narcolepsy: cataplexy, or the sudden loss of voluntary muscle tone; vivid hallucinations during sleep onset or upon awakening; and brief episodes of sleep paralysis. The disorder is estimated to affect about one in every 2,000 Americans. Most cases of narcolepsy are sporadic, which means that the condition occurs in one person in a family and is not inherited. However, up to 10 percent of individuals with narcolepsy have a close relative with the same symptoms. Other factors may be involved in causing narcolepsy, such as infection, immune-system dysfunction, trauma, hormonal changes, stress.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Narcolepsy" for support, advocacy or research.

Caring Voice Coalition,Inc,

Caring Voice Coalition empowers patients who live with a life threatening chronic disease through comprehensive outreach programs and services aimed at financial, emotional and educational support. With a steadfast dedication to the organization’s set of core values, our knowledgeable, caring staff maintains our solid reputation as a dependable, responsive organization with a unique, holistic approach to improving the lives of our patients.

Last Updated: 29 Apr 2014

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Narcolepsy Network, Inc.

Narcolepsy Network, Inc.'s mission is to: educate the public about narcolepsy and other related sleep disorders, support individuals with narcolepsy, their families and friends, promote the efficient diagnosis of narcolepsy, and encourage and promote research for narcolepsy.

Last Updated: 26 Mar 2013

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Wake Up Narcolepsy, Inc.

Wake Up Narcolepsy is a 501(c)(3) not-for-profit organization dedicated to supporting narcolepsy awareness and research to find a cure. WUN carries out its mission by: Providing funding to accelerate a cure for narcolepsy; increasing awareness of narcolepsy; decreasing time-lapse from symptom onset to proper diagnosis; and providing supportive resources for people with narcolepsy and their families.

Last Updated: 29 Apr 2014

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Narcolepsy" for support, advocacy or research.

Caring Voice Coalition,Inc,

Caring Voice Coalition empowers patients who live with a life threatening chronic disease through comprehensive outreach programs and services aimed at financial, emotional and educational support. With a steadfast dedication to the organization’s set of core values, our knowledgeable, caring staff maintains our solid reputation as a dependable, responsive organization with a unique, holistic approach to improving the lives of our patients.

http://www.caringvoice.org

Last Updated: 29 Apr 2014

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Narcolepsy Network, Inc.

Narcolepsy Network, Inc.'s mission is to: educate the public about narcolepsy and other related sleep disorders, support individuals with narcolepsy, their families and friends, promote the efficient diagnosis of narcolepsy, and encourage and promote research for narcolepsy.

http://www.narcolepsynetwork.org

Last Updated: 26 Mar 2013

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Wake Up Narcolepsy, Inc.

Wake Up Narcolepsy is a 501(c)(3) not-for-profit organization dedicated to supporting narcolepsy awareness and research to find a cure. WUN carries out its mission by: Providing funding to accelerate a cure for narcolepsy; increasing awareness of narcolepsy; decreasing time-lapse from symptom onset to proper diagnosis; and providing supportive resources for people with narcolepsy and their families.

http://www.wakeupnarcolepsy.org/

Last Updated: 29 Apr 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Narcolepsy" returned 232 free, full-text research articles on human participants. First 3 results:

Investigation of an association between onset of narcolepsy and vaccination with pandemic influenza vaccine, Ireland April 2009-December 2010.
 

Author(s): D O'Flanagan, A S Barret, M Foley, S Cotter, C Bonner, C Crowe, B Lynch, B Sweeney, H Johnson, B McCoy, E Purcell

Journal:

 

In 2011, the Irish Medicines Board received reports of onset of narcolepsy following vaccination against influenza A(H1N1)pdm09 with Pandemrix. A national steering committee was convened to examine the association between narcolepsy and pandemic vaccination. We conducted a retrospective ...

Last Updated: 13 May 2014

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Clinical and polysomnographic course of childhood narcolepsy with cataplexy.
 

Author(s): Fabio Pizza, Christian Franceschini, Hanna Peltola, Stefano Vandi, Elena Finotti, Francesca Ingravallo, Lino Nobili, Oliviero Bruni, Ling Lin, Mark J Edwards, Markku Partinen, Yves Dauvilliers, Emmanuel Mignot, Kailash P Bhatia, Giuseppe Plazzi

Journal: Brain. 2013 Dec;136(Pt 12):3787-95.

 

Our aim was to investigate the natural evolution of cataplexy and polysomnographic features in untreated children with narcolepsy with cataplexy. To this end, clinical, polysomnographic, and cataplexy-video assessments were performed at diagnosis (mean age of 10 ± 3 and disease duration ...

Last Updated: 16 Dec 2013

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Loss of rapid eye movement sleep atonia in patients with REM sleep behavioral disorder, narcolepsy, and isolated loss of REM atonia.
 

Author(s): Aytakin Khalil, Mary-Anne Wright, Matthew C Walker, Sofia H Eriksson

Journal:

 

To compare the amounts of REM sleep without atonia (RSWA) between patients with REM sleep behavior disorder (RBD), "isolated loss of REM atonia," narcolepsy, and control subjects and determine if there were threshold values for the amount of RSWA that differentiate each group from controls.

Last Updated: 15 Oct 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Narcolepsy" returned 33 free, full-text review articles on human participants. First 3 results:

Disrupted nighttime sleep in narcolepsy.
 

Author(s): Thomas Roth, Yves Dauvilliers, Emmanuel Mignot, Jacques Montplaisir, Josh Paul, Todd Swick, Phyllis Zee

Journal: J Clin Sleep Med. 2013 Sep;9(9):955-65.

 

Characterize disrupted nighttime sleep (DNS) in narcolepsy, an important symptom of narcolepsy.

Last Updated: 2 Sep 2013

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The autoimmune basis of narcolepsy.
 

Author(s): Josh Mahlios, Alberto K De la Herrán-Arita, Emmanuel Mignot

Journal: Curr. Opin. Neurobiol.. 2013 Oct;23(5):767-73.

 

Narcolepsy is a neurological disorder characterized by excessive daytime sleepiness, cataplexy, hypnagonic hallucinations, sleep paralysis, and disturbed nocturnal sleep patterns. Narcolepsy is caused by the loss of hypocretin (orexin)-producing neurons in the lateral hypothalamus. ...

Last Updated: 23 Sep 2013

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Genetic association, seasonal infections and autoimmune basis of narcolepsy.
 

Author(s): Abinav Kumar Singh, Josh Mahlios, Emmanuel Mignot

Journal: J. Autoimmun.. 2013 Jun;43():26-31.

 

In recent years, a growing number of potential autoimmune disorders affecting neurons in the central nervous system have been identified, including narcolepsy. Narcolepsy is a lifelong sleep disorder characterized by excessive daytime sleepiness with irresistible sleep attacks, cataplexy ...

Last Updated: 3 Jun 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Risk of Narcolepsy Associated With Administration of H1N1 Vaccine
 

Status: Recruiting

Condition Summary: Narcolepsy

 

Last Updated: 13 Jul 2011

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Narcolepsy - New Potential Treatment
 

Status: Recruiting

Condition Summary: Narcolepsy

 

Last Updated: 28 Feb 2014

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