Narcolepsy

Common Name(s)

Narcolepsy

Narcolepsy is a sleep disorder that causes episodes of extreme daytime sleepiness. Three other major symptoms frequently characterize narcolepsy: cataplexy, or the sudden loss of voluntary muscle tone; vivid hallucinations during sleep onset or upon awakening; and brief episodes of sleep paralysis. The disorder is estimated to affect about one in every 2,000 Americans. Most cases of narcolepsy are sporadic, which means that the condition occurs in one person in a family and is not inherited. However, up to 10 percent of individuals with narcolepsy have a close relative with the same symptoms. Other factors may be involved in causing narcolepsy, such as infection, immune-system dysfunction, trauma, hormonal changes, stress.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Narcolepsy" for support, advocacy or research.

Caring Voice Coalition,Inc,

Caring Voice Coalition empowers patients who live with a life threatening chronic disease through comprehensive outreach programs and services aimed at financial, emotional and educational support. With a steadfast dedication to the organization’s set of core values, our knowledgeable, caring staff maintains our solid reputation as a dependable, responsive organization with a unique, holistic approach to improving the lives of our patients.

Last Updated: 29 Apr 2014

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Narcolepsy Network, Inc.

Narcolepsy Network, Inc.'s mission is to: educate the public about narcolepsy and other related sleep disorders, support individuals with narcolepsy, their families and friends, promote the efficient diagnosis of narcolepsy, and encourage and promote research for narcolepsy.

Last Updated: 26 Mar 2013

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Wake Up Narcolepsy, Inc.

Wake Up Narcolepsy is a 501(c)(3) not-for-profit organization dedicated to supporting narcolepsy awareness and research to find a cure. WUN carries out its mission by: Providing funding to accelerate a cure for narcolepsy; increasing awareness of narcolepsy; decreasing time-lapse from symptom onset to proper diagnosis; and providing supportive resources for people with narcolepsy and their families.

Last Updated: 29 Apr 2014

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Narcolepsy" for support, advocacy or research.

Caring Voice Coalition,Inc,

Caring Voice Coalition empowers patients who live with a life threatening chronic disease through comprehensive outreach programs and services aimed at financial, emotional and educational support. With a steadfast dedication to the organization’s set of core values, our knowledgeable, caring staff maintains our solid reputation as a dependable, responsive organization with a unique, holistic approach to improving the lives of our patients.

http://www.caringvoice.org

Last Updated: 29 Apr 2014

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Narcolepsy Network, Inc.

Narcolepsy Network, Inc.'s mission is to: educate the public about narcolepsy and other related sleep disorders, support individuals with narcolepsy, their families and friends, promote the efficient diagnosis of narcolepsy, and encourage and promote research for narcolepsy.

http://www.narcolepsynetwork.org

Last Updated: 26 Mar 2013

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Wake Up Narcolepsy, Inc.

Wake Up Narcolepsy is a 501(c)(3) not-for-profit organization dedicated to supporting narcolepsy awareness and research to find a cure. WUN carries out its mission by: Providing funding to accelerate a cure for narcolepsy; increasing awareness of narcolepsy; decreasing time-lapse from symptom onset to proper diagnosis; and providing supportive resources for people with narcolepsy and their families.

http://www.wakeupnarcolepsy.org/

Last Updated: 29 Apr 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Narcolepsy" returned 257 free, full-text research articles on human participants. First 3 results:

Narcolepsy--genes, infections and vaccines: the clues for a new autoimmune disease.
 

Author(s): Maria-Teresa Arango, Shaye Kivity, Joab Chapman, Yehuda Shoenfeld

Journal: Isr. Med. Assoc. J.. 2014 Oct;16(10):636-7.

 

Last Updated: 2 Dec 2014

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HLA DQB1*06:02 negative narcolepsy with hypocretin/orexin deficiency.
 

Author(s): Fang Han, Ling Lin, Barbara Schormair, Fabio Pizza, Giuseppe Plazzi, Hanna M Ollila, Sona Nevsimalova, Poul Jennum, Stine Knudsen, Juliane Winkelmann, Cristin Coquillard, Farbod Babrzadeh, Tim M Strom, Chunlin Wang, Michael Mindrinos, Marcelo Fernandez Vina, Emmanuel Mignot

Journal:

 

To identify rare allelic variants and HLA alleles in narcolepsy patients with hypocretin (orexin, HCRT) deficiency but lacking DQB1*06:02.

Last Updated: 9 Oct 2014

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miRNA profiles in plasma from patients with sleep disorders reveal dysregulation of miRNAs in narcolepsy and other central hypersomnias.
 

Author(s): Anja Holm, Claus Heiner Bang-Berthelsen, Stine Knudsen, Birgitte R Kornum, Signe Modvig, Poul Jennum, Steen Gammeltoft

Journal:

 

MicroRNAs (miRNAs) have been implicated in the pathogenesis of human diseases including neurological disorders. The aim is to address the involvement of miRNAs in the pathophysiology of central hypersomnias including autoimmune narcolepsy with cataplexy and hypocretin deficiency (type ...

Last Updated: 13 Sep 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Narcolepsy" returned 35 free, full-text review articles on human participants. First 3 results:

History of narcolepsy at Stanford University.
 

Author(s): Emmanuel J M Mignot

Journal: Immunol. Res.. 2014 May;58(2-3):315-39.

 

Although narcolepsy was first described in the late nineteenth century in Germany and France, much of the research on this disorder has been conducted at Stanford University, starting with Drs. William C. Dement and Christian Guilleminault in the 1970s. The prevalence of narcolepsy ...

Last Updated: 21 May 2014

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Narcolepsy, 2009 A(H1N1) pandemic influenza, and pandemic influenza vaccinations: what is known and unknown about the neurological disorder, the role for autoimmunity, and vaccine adjuvants.
 

Author(s): S Sohail Ahmed, Peter H Schur, Noni E MacDonald, Lawrence Steinman

Journal: J. Autoimmun.. 2014 May;50():1-11.

 

The vaccine safety surveillance system effectively detected a very rare adverse event, narcolepsy, in subjects receiving AS03-adjuvanted A(H1N1) pandemic vaccine made using the European inactivation/purification protocol. The reports of increased cases of narcolepsy in non-vaccinated ...

Last Updated: 21 Apr 2014

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Usefulness of genetic characterization of narcolepsy and hypersomnia on phenotype definition: a study in Portuguese patients.
 

Author(s): António Martins-da-Silva, João Lopes, João Ramalheira, Cláudia Carvalho, Daniela Cunha, Paulo P Costa, M Berta Silva

Journal: Rev Neurol. 2014 Jan;58(2):49-54.

 

The determination of human leukocyte antigen (HLA) class II genotype is widely used to confirm the diagnosis of narcolepsy with or without cataplexy. The HLA genotyping is reliable, easy to perform and reassures the clinician. It is also less invasive than other methodologies and ...

Last Updated: 8 Jan 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Narcolepsy - New Potential Treatment
 

Status: Recruiting

Condition Summary: Narcolepsy

 

Last Updated: 28 Feb 2014

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