Myelofibrosis

Common Name(s)

Myelofibrosis

Myelofibrosis is a disorder of the bone marrow, in which the marrow is replaced by fibrous (scar) tissue.  Scarring of the bone marrow causes anemia, which can lead to fatigue and weakness, as well as pooling of the blood in abnormal sites like the liver and spleen, causing these organs to swell. Although myelofibrosis can occur at any age, it typically develops after the age of 50.  In most cases, myelofibrosis gets progressively worse. Treatment is aimed at relieving signs and symptoms and may include medications, blood transfusions, chemotherapy, radiation therapy and surgery.    
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Myelofibrosis" for support, advocacy or research.

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MPDSUPPORT.ORG

Since 1994, our MPD-SUPPORT web site and free support email list offers interesting information on chronic myelogenous leukemia, polycythemia vera, essential thrombocythemia, agnogenic myeloid metaplasia, myelodysplasia, and myelofibrosis. Anyone - patient, family member, or health professional, is welcome to join our growing list of subscribers. Our archives are available for you to research information.

Last Updated: 14 Jan 2013

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MPN Research Foundation

The primary mission of the MPN Research Foundation is to stimulate original research in pursuit of new treatments -- and eventually a cure -- for polycythemia vera, essential thrombocythemia and myelofibrosis, known collectively as myeloproliferative neoplasms (MPN).In addition, the MPN Research Foundation promotes collaboration in the scientific community to accelerate research, and serves as a powerful advocacy group for patients and their families

Last Updated: 20 Feb 2013

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National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

Last Updated: 20 Feb 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Myelofibrosis" for support, advocacy or research.

Logo
MPDSUPPORT.ORG

Since 1994, our MPD-SUPPORT web site and free support email list offers interesting information on chronic myelogenous leukemia, polycythemia vera, essential thrombocythemia, agnogenic myeloid metaplasia, myelodysplasia, and myelofibrosis. Anyone - patient, family member, or health professional, is welcome to join our growing list of subscribers. Our archives are available for you to research information.

http://www.mpdsupport.org

Last Updated: 14 Jan 2013

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MPN Research Foundation

The primary mission of the MPN Research Foundation is to stimulate original research in pursuit of new treatments -- and eventually a cure -- for polycythemia vera, essential thrombocythemia and myelofibrosis, known collectively as myeloproliferative neoplasms (MPN).In addition, the MPN Research Foundation promotes collaboration in the scientific community to accelerate research, and serves as a powerful advocacy group for patients and their families

http://www.mpnresearchfoundation.org

Last Updated: 20 Feb 2013

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National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

http://www.nbmtlink.org

Last Updated: 20 Feb 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Myelofibrosis" returned 566 free, full-text research articles on human participants. First 3 results:

Improvement of Anaemia in Patients with Primary Myelofibrosis by Low-Dose Thalidomide and Prednisone.
 

Author(s): Petra Bělohlávková, Vladimír Maisnar, Jaroslava Voglová, Tomáš Buchler, Pavel Žák

Journal: Acta Medica (Hradec Kralove). ;59(2):50-3.

 

A combination of low-dose thalidomide and corticosteroids is a treatment option for anaemic patients with primary myelofibrosis (PMF) who are not eligible for allogeneic hematopoietic stem cell transplantation.

Last Updated: 16 Aug 2016

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Myelofibrosis and acquired hemophilia A: a case report.
 

Author(s): Marie Wrobel, Emilie Comio, Valerie Gay, Noureddine Baroudi, Pascal Meyer, Christine Chuniaud-Louche, Maya Hacini, Gian Matteo Pica

Journal:

 

Myelofibrosis and acquired hemophilia A is a rare association. To the best of our knowledge only one case of myelofibrosis and acquired hemophilia A has been previously described.

Last Updated: 7 May 2016

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Molecular correlates of anemia in primary myelofibrosis: a significant and independent association with U2AF1 mutations.
 

Author(s): D Barraco, Y C Elala, T L Lasho, K H Begna, N Gangat, C Finke, C A Hanson, R P Ketterling, A Pardanani, A Tefferi

Journal:

 

Last Updated: 9 Apr 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Myelofibrosis" returned 58 free, full-text review articles on human participants. First 3 results:

Overcoming treatment challenges in myelofibrosis and polycythemia vera: the role of ruxolitinib.
 

Author(s): Jeffrey C Bryan, Srdan Verstovsek

Journal: Cancer Chemother. Pharmacol.. 2016 06;77(6):1125-42.

 

Myelofibrosis (MF) and polycythemia vera (PV) are BCR-ABL1-negative myeloproliferative neoplasms associated with somatic hematopoietic stem cell mutations leading to over activation of JAK-STAT signaling. MF and PV are pathogenically related and share specific clinical features such ...

Last Updated: 27 May 2016

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Rationale for revision and proposed changes of the WHO diagnostic criteria for polycythemia vera, essential thrombocythemia and primary myelofibrosis.
 

Author(s): T Barbui, J Thiele, A M Vannucchi, A Tefferi

Journal:

 

The 2001/2008 World Health Organization (WHO)-based diagnostic criteria for polycythemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (PMF) were recently revised to accomodate new information on disease-specific mutations and underscore distinguishing morphologic ...

Last Updated: 2 Feb 2016

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Inflammation as a Keystone of Bone Marrow Stroma Alterations in Primary Myelofibrosis.
 

Author(s): Christophe Desterke, Christophe Martinaud, Nadira Ruzehaji, Marie-Caroline Le Bousse-Kerdilès

Journal: Mediators Inflamm.. 2015 ;2015():415024.

 

Primary myelofibrosis (PMF) is a clonal myeloproliferative neoplasm where severity as well as treatment complexity is mainly attributed to a long lasting disease and presence of bone marrow stroma alterations as evidenced by myelofibrosis, neoangiogenesis, and osteosclerosis. While ...

Last Updated: 7 Dec 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Interferon-pegyle α2a Efficiency and Tolerance in Myelofibrosis
 

Status: Recruiting

Condition Summary: Myelofibrosis

 

Last Updated: 19 Sep 2016

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JAK2 Inhibitors RUXOLITINIB in Patients With Myelofibrosis
 

Status: Recruiting

Condition Summary: Myelofibrosis

 

Last Updated: 16 Jan 2017

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Assessment of Allogeneic Hematopoietic Cell Transplantation in Patients With Myelofibrosis
 

Status: Recruiting

Condition Summary: Myelofibrosis

 

Last Updated: 13 Feb 2017

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