Mycosis fungoides

Common Name(s)

Mycosis fungoides

Mycosis fungoides is a disease in which T-cell lymphocytes (a type of white blood cell) become malignant (cancerous) and affect the skin. This condition is one of the most common types of T-cell lymphoma. Mycosis fungoides is characterized by a scaly, red rash that develops on the skin, particularly on areas that are not usually exposed to the sun. The rash may last for months or years without causing any symptoms. Over time, a thin, reddened, eczema-like rash may develop, followed by thickened, red patches of skin. Finally, tumors form which may develop into ulcers and become infected. Mycosis fungoides is difficult to cure. Treatment is usually palliative, with the intention of relieving symptoms and improving the quality of life.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Mycosis fungoides" for support, advocacy or research.

Cutaneous Lymphoma Foundation

The Cutaneous Lymphoma Foundation is an independent, nonprofit patient advocacy organization whose mission is supporting every person with cutaneous lymphoma by promoting awareness and education, advancing patient care and facilitating research.

Last Updated: 6 Jan 2013

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Mycosis fungoides" for support, advocacy or research.

Cutaneous Lymphoma Foundation

The Cutaneous Lymphoma Foundation is an independent, nonprofit patient advocacy organization whose mission is supporting every person with cutaneous lymphoma by promoting awareness and education, advancing patient care and facilitating research.

http://www.clfoundation.org

Last Updated: 6 Jan 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Mycosis fungoides" returned 239 free, full-text research articles on human participants. First 3 results:

Allogeneic hematopoietic stem cell transplantation in mycosis fungoides.
 

Author(s): Angelo Atalla, Abrahão Elias Hallack Neto, Denise Bittencourt Siqueira, Gabriela Cumani Toledo

Journal: An Bras Dermatol. ;88(6 Suppl 1):216-9.

 

Mycosis Fungoides is typically an indolent disease in early stages. However, approximately 30% of patients have advanced staged disease at presentation and 20% will develop it at some time. These patients have a poorer prognosis with a median survival of 2-4 years. The only curative ...

Last Updated: 18 Dec 2013

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miR-223 regulates cell growth and targets proto-oncogenes in mycosis fungoides/cutaneous T-cell lymphoma.
 

Author(s): Laura Y McGirt, Clare M Adams, Devin A Baerenwald, Jeffrey P Zwerner, John A Zic, Christine M Eischen

Journal: J. Invest. Dermatol.. 2014 Apr;134(4):1101-7.

 

The pathogenesis of the cutaneous T-cell lymphoma (CTCL), mycosis fungoides (MF), is unclear. MicroRNA (miRNA) are small noncoding RNAs that target mRNA leading to reduced mRNA translation. Recently, specific miRNA were shown to be altered in CTCL. We detected significantly reduced ...

Last Updated: 20 Mar 2014

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Neurolymphomatosis associated with erythrodermic mycosis fungoides.
 

Author(s): Satoshi Ogawa, Atsushi Fukunaga, Mami Kanata, Ayuko Kikuzawa, Toshinori Bito, Yoshihisa Otsuka, Kenji Sekiguchi, Nobuyuki Oka, Chikako Nishigori

Journal: Acta Derm. Venereol.. 2014 Mar;94(2):227-8.

 

Last Updated: 26 Feb 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Mycosis fungoides" returned 24 free, full-text review articles on human participants. First 3 results:

Hypopigmented mycosis fungoides: a review of its clinical features and pathophysiology.
 

Author(s): Fabricio Cecanho Furlan, José Antonio Sanches

Journal: An Bras Dermatol. ;88(6):954-60.

 

Several distinct clinical forms of mycosis fungoides have been described. Hypopigmented mycosis fungoides should be regarded as a subtype of mycosis fungoides, insofar as it presents some peculiar characteristics that contrast with the clinical features of the classical form. Most ...

Last Updated: 29 Jan 2014

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Mycosis fungoides in plaque stage with pronounced eosinophilic infiltration, folliculotropism, and concomitant invasive squamous cell carcinoma.
 

Author(s): Tadashi Terada

Journal: Int J Clin Exp Pathol. 2013 ;6(4):749-56.

 

Mycosis fungoides (MF) is a relatively rare cutaneous T-cell malignancy. Only two cases of MF with marked eosinophilia have been reported. In addition, MF with concomitant squamous cell carcinoma (SCC) occurring in the site of MF has not been reported. The author reports herein a ...

Last Updated: 10 Apr 2013

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Non-mycosis fungoides cutaneous T-cell lymphomas: report of the 2011 Society for Hematopathology/European Association for Haematopathology workshop.
 

Author(s): Leticia Quintanilla-Martinez, Patty M Jansen, Marsha C Kinney, Steven H Swerdlow, Rein Willemze

Journal: Am. J. Clin. Pathol.. 2013 Apr;139(4):491-514.

 

Primary cutaneous T-cell lymphomas (CTCL) excluding mycosis fungoides (MF) were discussed in 2 sessions of the 2011 Society for Hematopathology/ European Association of Haematopathology Workshop, Los Angeles, CA. Session 2 focused on primary cutaneous CD30+ T-cell lymphoproliferative ...

Last Updated: 25 Mar 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Pembrolizumab in Treating Patients With Relapsed or Refractory Stage IIB-IVB Mycosis Fungoides or Sezary Syndrome
 

Status: Recruiting

Condition Summary: Recurrent Mycosis Fungoides and Sezary Syndrome; Stage IIB Mycosis Fungoides and Sezary Syndrome; Stage IIIA Mycosis Fungoides and Sezary Syndrome; Stage IIIB Mycosis Fungoides and Sezary Syndrome; Stage IVA Mycosis Fungoides and Sezary Syndrome; Stage IVB Mycosis Fungoides and Sezary Syndrome

 

Last Updated: 3 Dec 2014

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Study of Alemtuzumab to Treat Advanced Mycosis Fungoides/Sezary Syndrome
 

Status: Recruiting

Condition Summary: Mycosis Fungoides; Sezary Syndrome

 

Last Updated: 2 Apr 2007

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Stem Cell Transplant Therapy With Campath-1H for Treating Advanced Mycosis Fungoides and Sezary Syndrome
 

Status: Recruiting

Condition Summary: Mycosis Fungoides; Sezary Syndrome

 

Last Updated: 15 May 2014

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