Myasthenia gravis

Common Name(s)

Myasthenia gravis

Myasthenia gravis (MG) is an autoimmune disease that impacts an affected individual’s control of the skeletal muscles. The condition is typically seen in women below the age of 40, and in men above the age of 60. However, there are cases where MG has developed in individuals of all ages.

Symptoms of this condition may include muscle weakness, drooping eyelids, double vision, difficulty swallowing or eating, trouble talking, being unable to fully control facial expressions, fatigue, and difficulty breathing. The muscle weakness appears to increase after the individual is active, but then improves after rest.

Acetylcholine is a chemical that is normally present in the nervous system and is important for passing messages from the brain to the skeletal muscles. In individuals with MG, the body produces antibodies (proteins that are used to detect harmful agents in the body) which mistakenly attack certain sites that are responsible for receiving the acetylcholine messages. As a result, the symptoms of MG occur since the nervous system cannot communicate properly with the muscles. This response is an example of an autoimmune disease, where the body mistakenly begins attacking itself.

Removal of the thymus gland (an organ that is part of the immune system), blood plasma exchanges (where harmful antibodies are removed), and the use of certain types of medications are all current forms of treatment for MG. Other ways to manage the symptoms may include avoiding stressful situations and getting plenty of rest.

Although there is no cure for MG at this time, there are many treatment options available. Doctors seek help from various therapists and community services to provide support and care for families. Talk with a doctor or specialist if you or someone in your family has been diagnosed with Myasthenia gravis to discuss the most current treatment options.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Myasthenia gravis" for support, advocacy or research.

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Muscular Dystrophy Association

MDA is the nonprofit health agency dedicated to curing muscular dystrophy, ALS and related diseases by funding worldwide research. The Association also provides comprehensive health care and support services, advocacy and education.

Last Updated: 15 Jul 2015

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Myasthenia Gravis Foundation of America, Inc.

MGFA is committed to finding a cure for myasthenia gravis and closely related disorders, improving treatment options, and providing information and support to people with myasthenia gravis through research, education, community programs, and advocacy.

Last Updated: 29 Apr 2014

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Myasthenia gravis" for support, advocacy or research.

Logo
Muscular Dystrophy Association

MDA is the nonprofit health agency dedicated to curing muscular dystrophy, ALS and related diseases by funding worldwide research. The Association also provides comprehensive health care and support services, advocacy and education.

http://www.mdausa.org

Last Updated: 15 Jul 2015

View Details
Myasthenia Gravis Foundation of America, Inc.

MGFA is committed to finding a cure for myasthenia gravis and closely related disorders, improving treatment options, and providing information and support to people with myasthenia gravis through research, education, community programs, and advocacy.

http://www.myasthenia.org

Last Updated: 29 Apr 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Myasthenia gravis" returned 964 free, full-text research articles on human participants. First 3 results:

RetroSternal--Looking Back at Thymectomy for Myasthenia Gravis.
 

Author(s): Allan H Ropper

Journal: N. Engl. J. Med.. 2016 Aug;375(6):576-7.

 

Last Updated: 11 Aug 2016

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Randomized Trial of Thymectomy in Myasthenia Gravis.
 

Author(s): Gil I Wolfe, Henry J Kaminski, Inmaculada B Aban, Greg Minisman, Hui-Chien Kuo, Alexander Marx, Philipp Ströbel, Claudio Mazia, Joel Oger, J Gabriel Cea, Jeannine M Heckmann, Amelia Evoli, Wilfred Nix, Emma Ciafaloni, Giovanni Antonini, Rawiphan Witoonpanich, John O King, Said R Beydoun, Colin H Chalk, Alexandru C Barboi, Anthony A Amato, Aziz I Shaibani, Bashar Katirji, Bryan R F Lecky, Camilla Buckley, Angela Vincent, Elza Dias-Tosta, Hiroaki Yoshikawa, Márcia Waddington-Cruz, Michael T Pulley, Michael H Rivner, Anna Kostera-Pruszczyk, Robert M Pascuzzi, Carlayne E Jackson, Guillermo S Garcia Ramos, Jan J G M Verschuuren, Janice M Massey, John T Kissel, Lineu C Werneck, Michael Benatar, Richard J Barohn, Rup Tandan, Tahseen Mozaffar, Robin Conwit, Joanne Odenkirchen, Joshua R Sonett, Alfred Jaretzki, John Newsom-Davis, Gary R Cutter,

Journal: N. Engl. J. Med.. 2016 Aug;375(6):511-22.

 

Thymectomy has been a mainstay in the treatment of myasthenia gravis, but there is no conclusive evidence of its benefit. We conducted a multicenter, randomized trial comparing thymectomy plus prednisone with prednisone alone.

Last Updated: 11 Aug 2016

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Ocular myasthenia gravis accompanied by anosmia.
 

Author(s): Ying Chen, Li Wang, Li Zhou, Ying Gao

Journal: J Tradit Chin Med. 2016 Feb;36(1):125-30.

 

We report a case of ocular myasthenia gravis (MG) accompanied by anosmia. A 76-year-old man had idiopathic anosmia of 2-year duration. Four months before consultation, he began to have drooping in the right upper eyelid along with muscle soreness, distension, and pain in the nape. ...

Last Updated: 7 Mar 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Myasthenia gravis" returned 69 free, full-text review articles on human participants. First 3 results:

Acute Respiratory Failure Induced by Magnesium Replacement in a 62-Year-Old Woman with Myasthenia Gravis.
 

Author(s): Paramveer Singh, Olakunle Idowu, Imrana Malik, Joseph L Nates

Journal:

 

Magnesium is known to act at the neuromuscular junction by inhibiting the presynaptic release of acetylcholine and desensitizing the postsynaptic membrane. Because of these effects, magnesium has been postulated to potentiate neuromuscular weakness. We describe the case of a 62-year-old ...

Last Updated: 27 Oct 2015

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PTPN22 R620W Polymorphism is Associated with Myasthenia Gravis Risk: A Systematic Review and Meta-Analysis.
 

Author(s): Xunbo Xiong, Mingqing Xiang, Xianglin Cheng, Yi Huang

Journal:

 

The association between PTPN22 R620W polymorphism and risk of myasthenia gravis (MG) remains controversial. Therefore, we did this meta-analysis to investigate this association.

Last Updated: 31 Aug 2015

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Clinical profile of patients with myasthenia gravis followed at the University Hospital, Federal University of Minas Gerais.
 

Author(s): Aline Mansueto Mourão, Luiz Sérgio Mageste Barbosa, Elizabeth Regina Comini-Frota, Denise da Silva Freitas, Rodrigo Santiago Gomez, Ted M Burns, Stela Maris Aguiar Lemos, Antonio Lúcio Teixeira

Journal: Rev Assoc Med Bras (1992). ;61(2):156-60.

 

to determine the clinical profile of patients with myasthenia gravis (MG); followed at the Neuromuscular Diseases Clinic of the University Hospital, Federal University of Minas Gerais, Brazil, and to compare it with other Brazilian case series.

Last Updated: 25 Jun 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Tissue Repository for Studies of Myasthenia Gravis
 

Status: Recruiting

Condition Summary: Myasthenia Gravis

 

Last Updated: 14 Sep 2016

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Safety,Tolerability,Pharmacokinetics and Efficacy of CFZ533 in Moderate to Severe Myasthenia Gravis
 

Status: Recruiting

Condition Summary: Myasthenia Gravis, Generalized

 

Last Updated: 27 Oct 2016

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Exercise for Stable Myasthenia Gravis
 

Status: Recruiting

Condition Summary: Myasthenia Gravis

 

Last Updated: 28 Oct 2016

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