Myasthenia gravis

Common Name(s)

Myasthenia gravis

Myasthenia gravis is a chronic autoimmune neuromuscular disease. It is characterized by varying degrees of weakness of the skeletal muscles of the body. Common symptoms include weakness of the muscles that control the eye and eyelid, facial expression, chewing, talking, and swallowing. Weakness tends to increase during periods of activity and improves after periods of rest.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Myasthenia gravis" for support, advocacy or research.

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Muscular Dystrophy Association

MDA is the nonprofit health agency dedicated to curing muscular dystrophy, ALS and related diseases by funding worldwide research. The Association also provides comprehensive health care and support services, advocacy and education.

Last Updated: 8 Mar 2010

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Myasthenia Gravis Foundation of America, Inc.

MGFA is committed to finding a cure for myasthenia gravis and closely related disorders, improving treatment options, and providing information and support to people with myasthenia gravis through research, education, community programs, and advocacy.

Last Updated: 29 Apr 2014

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General Support Organizations

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How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Myasthenia gravis" for support, advocacy or research.

Logo
Muscular Dystrophy Association

MDA is the nonprofit health agency dedicated to curing muscular dystrophy, ALS and related diseases by funding worldwide research. The Association also provides comprehensive health care and support services, advocacy and education.

http://www.mdausa.org

Last Updated: 8 Mar 2010

View Details
Myasthenia Gravis Foundation of America, Inc.

MGFA is committed to finding a cure for myasthenia gravis and closely related disorders, improving treatment options, and providing information and support to people with myasthenia gravis through research, education, community programs, and advocacy.

http://www.myasthenia.org

Last Updated: 29 Apr 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Myasthenia gravis" returned 740 free, full-text research articles on human participants. First 3 results:

Protective effect of Sijunzi decoction on neuromuscular junction ultrastructure in autoimmune myasthenia gravis rats.
 

Author(s): Haibin Wu, Shifeng She, Youzhang Liu, Wensheng Xiong, Yalei Guo, Huansong Fang, Hong Chen, Jia Li

Journal: J Tradit Chin Med. 2013 Oct;33(5):669-73.

 

To investigate the protective role of Sijunzi decoction in neuromuscular junction (NMJ) and muscle cell mitochondria ultrastructure; as well as its effects on the amount of adenosine triphosphate (ATP) and the activities of mitochondrial respiratory chain complexes I, II, III, and ...

Last Updated: 25 Mar 2014

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Dysphonia as the primary complaint in a case of myasthenia gravis: diagnosis and speech therapy.
 

Author(s): Nair Kátia Nemr, Marcia Simões-Zenari, Tainá Soares Ferreira, Heloisa Regina Fernandes, Letícia Lessa Mansur

Journal: Codas. 2013 ;25(3):297-300.

 

Myasthenia gravis is an autoimmune disease, manifested by progressive muscular weakness and fatigue. There are frequent ocular and bulbar symptoms, among them, dysphonia. This article reports a case of dysphonia that contributed to the diagnosis of myasthenia gravis through a speech ...

Last Updated: 10 Jan 2014

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Brazilian cross-cultural translation and adaptation of the "Questionnaire of Life Quality Specific for Myasthenia Gravis - 15 items".
 

Author(s): Aline Mansueto Mourão, Caroline Martins Araújo, Luiz Sérgio Mageste Barbosa, Rodrigo Santiago Gomez, Ted M Burns, Stela Maris Aguiar Lemos, Antonio Lucio Teixeira

Journal: Arq Neuropsiquiatr. 2013 Dec;71(12):955-8.

 

To translate and to perform the cross-cultural adaptation of the "Questionnaire of Life Quality Specific for Myasthenia Gravis - 15 items" (MG-QOL15).

Last Updated: 18 Dec 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Myasthenia gravis" returned 47 free, full-text review articles on human participants. First 3 results:

Recent advances in genetic predisposition of myasthenia gravis.
 

Author(s): Zoi Zagoriti, Manousos E Kambouris, George P Patrinos, Socrates J Tzartos, Konstantinos Poulas

Journal: Biomed Res Int. 2013 ;2013():404053.

 

Myasthenia gravis (MG) is an autoimmune disease mediated by the presence of autoantibodies that bind to components of the neuromuscular junction, causing the symptoms of muscular weakness and fatigability. Like most autoimmune disorders, MG is a multifactorial, noninherited disease, ...

Last Updated: 2 Dec 2013

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Myasthenia gravis: newer therapies offer sustained improvement.
 

Author(s): Yuebing Li, Yeeshu Arora, Kerry Levin

Journal: Cleve Clin J Med. 2013 Nov;80(11):711-21.

 

Myasthenia gravis is a prototypical antibody-mediated autoimmune neuromuscular disorder. Treatments have improved over the past 30 years, leading to significantly fewer deaths and better quality of life. Future research should further elucidate its pathogenesis, reveal better ways ...

Last Updated: 4 Nov 2013

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Neuromuscular transmission failure in myasthenia gravis: decrement of safety factor and susceptibility of extraocular muscles.
 

Author(s): Alessandro Serra, Robert L Ruff, Richard John Leigh

Journal: Ann. N. Y. Acad. Sci.. 2012 Dec;1275():129-35.

 

An appropriate density of acetylcholine receptors (AChRs) and Na(+) channels (NaChs) in the normal neuromuscular junction (NMJ) determines the magnitude of safety factor (SF) that guarantees fidelity of neuromuscular transmission. In myasthenia gravis (MG), an overall simplification ...

Last Updated: 2 Jan 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Exercise for Stable Myasthenia Gravis
 

Status: Recruiting

Condition Summary: Myasthenia Gravis

 

Last Updated: 19 Aug 2013

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Phase II Trial of Rituximab In Myasthenia Gravis
 

Status: Recruiting

Condition Summary: Myasthenia Gravis

 

Last Updated: 29 Jul 2014

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Benefits and Tolerance of Exercise in Patients With Generalized and Stabilized Myasthenia Gravis
 

Status: Not yet recruiting

Condition Summary: Myasthenia Gravis

 

Last Updated: 17 Jul 2014

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