Myasthenia gravis

Common Name(s)

Myasthenia gravis

Myasthenia gravis is a chronic autoimmune neuromuscular disease. It is characterized by varying degrees of weakness of the skeletal muscles of the body. Common symptoms include weakness of the muscles that control the eye and eyelid, facial expression, chewing, talking, and swallowing. Weakness tends to increase during periods of activity and improves after periods of rest.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Myasthenia gravis" for support, advocacy or research.

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Muscular Dystrophy Association

MDA is the nonprofit health agency dedicated to curing muscular dystrophy, ALS and related diseases by funding worldwide research. The Association also provides comprehensive health care and support services, advocacy and education.

Last Updated: 8 Mar 2010

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Myasthenia Gravis Foundation of America, Inc.

MGFA is committed to finding a cure for myasthenia gravis and closely related disorders, improving treatment options, and providing information and support to people with myasthenia gravis through research, education, community programs, and advocacy.

Last Updated: 29 Apr 2014

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Myasthenia gravis" for support, advocacy or research.

Logo
Muscular Dystrophy Association

MDA is the nonprofit health agency dedicated to curing muscular dystrophy, ALS and related diseases by funding worldwide research. The Association also provides comprehensive health care and support services, advocacy and education.

http://www.mdausa.org

Last Updated: 8 Mar 2010

View Details
Myasthenia Gravis Foundation of America, Inc.

MGFA is committed to finding a cure for myasthenia gravis and closely related disorders, improving treatment options, and providing information and support to people with myasthenia gravis through research, education, community programs, and advocacy.

http://www.myasthenia.org

Last Updated: 29 Apr 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Myasthenia gravis" returned 734 free, full-text research articles on human participants. First 3 results:

Once myasthenic, always myasthenic? observations on the behavior and prognosis of myasthenia gravis in a cohort of 100 patients.
 

Author(s): Satish V Khadilkar, Chetan R Chaudhari, Tukaram R Patil, Ninad D Desai, Kamlesh A Jagiasi, Ashish G Bhutada

Journal: Neurol India. ;62(5):492-7.

 

The natural history of myasthenia gravis [MG] is unpredictable: In the first few years the disease course is worst with subsequent gradual disease stabilization. However, some patients tend to have continued disease activity or resurgence of the disease many years into the illness. ...

Last Updated: 12 Nov 2014

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Proteasome inhibition with bortezomib depletes plasma cells and specific autoantibody production in primary thymic cell cultures from early-onset myasthenia gravis patients.
 

Author(s): Alejandro M Gomez, Nick Willcox, Kathleen Vrolix, Jonas Hummel, Gisela Nogales-Gadea, Abhishek Saxena, Hans Duimel, Fons Verheyen, Peter C Molenaar, Wim A Buurman, Marc H De Baets, Pilar Martinez-Martinez, Mario Losen

Journal: J. Immunol.. 2014 Aug;193(3):1055-63.

 

Bortezomib is a potent inhibitor of proteasomes currently used to eliminate malignant plasma cells in multiple myeloma patients. It is also effective in depleting both alloreactive plasma cells in acute Ab-mediated transplant rejection and their autoreactive counterparts in animal ...

Last Updated: 22 Jul 2014

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A conceptual framework for evaluating impairments in myasthenia gravis.
 

Author(s): Carolina Barnett, Vera Bril, Moira Kapral, Abhaya Kulkarni, Aileen M Davis

Journal:

 

Myasthenia gravis is characterized by weakness and fatigability of different muscle groups, including ocular, bulbar and the limbs. Therefore, a measure of disease severity at the impairment level in myasthenia needs to reflect all the relevant impairments, as well as their variations ...

Last Updated: 21 May 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Myasthenia gravis" returned 48 free, full-text review articles on human participants. First 3 results:

Does repeat thymectomy improve symptoms in patients with refractory myasthenia gravis?
 

Author(s): Jonathan K Y Ng, Calvin S H Ng, Malcolm J Underwood, Kelvin K W Lau

Journal: Interact Cardiovasc Thorac Surg. 2014 Mar;18(3):376-80.

 

A best evidence topic in thoracic surgery was written according to a structured protocol. The question addressed was: Does repeat thymectomy improve symptoms in patients with refractory myasthenia gravis after thymectomy? A total of 189 papers were found using the reported search, ...

Last Updated: 17 Feb 2014

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Is thymectomy in non-thymomatous myasthenia gravis of any benefit?
 

Author(s): Andres Diaz, Edward Black, Joel Dunning

Journal: Interact Cardiovasc Thorac Surg. 2014 Mar;18(3):381-9.

 

A best evidence topic in thoracic surgery was written according to a structured protocol. The question addressed was if thymectomy in non-thymomatous myasthenia gravis was of any benefit? Overall, 137 papers were found using the reported search, of which 16 represented the best evidence ...

Last Updated: 17 Feb 2014

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Recent advances in genetic predisposition of myasthenia gravis.
 

Author(s): Zoi Zagoriti, Manousos E Kambouris, George P Patrinos, Socrates J Tzartos, Konstantinos Poulas

Journal: Biomed Res Int. 2013 ;2013():404053.

 

Myasthenia gravis (MG) is an autoimmune disease mediated by the presence of autoantibodies that bind to components of the neuromuscular junction, causing the symptoms of muscular weakness and fatigability. Like most autoimmune disorders, MG is a multifactorial, noninherited disease, ...

Last Updated: 2 Dec 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Exercise for Stable Myasthenia Gravis
 

Status: Recruiting

Condition Summary: Myasthenia Gravis

 

Last Updated: 19 Aug 2013

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Phase II Trial of Rituximab In Myasthenia Gravis
 

Status: Recruiting

Condition Summary: Myasthenia Gravis

 

Last Updated: 10 Feb 2015

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Benefits and Tolerance of Exercise in Patients With Generalized and Stabilized Myasthenia Gravis
 

Status: Recruiting

Condition Summary: Myasthenia Gravis

 

Last Updated: 6 Nov 2014

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