Multiple endocrine neoplasia type 2A

Common Name(s)

Multiple endocrine neoplasia type 2A

Multiple endocrine neoplasia type 2A (MEN 2A) is is an inherited disorder caused by mutations in the RET gene. Individuals with MEN 2A are at high risk of developing medullary carcinoma of the thyroid. About 50% will develop pheochromocytoma, a tumor of the adrenal glands which may increase blood pressure. Individuals with MEN 2A are also at increased risk for parathyroid adenoma or hyperplasia (overgrowth of the parathyroid gland). Occasionally an itchy skin condition called cutaneous lichen amyloidosis also occurs in people with type 2A disease. The condition is inherited in an autosomal dominant manner.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Multiple endocrine neoplasia type 2A" for support, advocacy or research.

AMEND

AMEND exists to inform and support anyone affected by multiple endocrine neoplasia disorders and associated endocrine tumors and syndromes, and to encourage and fund research into the conditions through our Annual Research Grant program and Young Investigator Awards. We provide free patient-aimed information resources, including the MEN Passport and AMEND-sponsored children's comics. We also run a variety of free educational events in the UK and USA as well as social and fundraising events. The AMEND website is HONCode certified and the charity runs several social media pages and groups (private and public).

Last Updated: 29 Apr 2014

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American Multiple Endocrine Neoplasia

The Hageman Foundation supports patient advocacy for a rare disease called Multiple Endocrine Neoplasia. This disease is so elusive that we are the only non-profit in this country which supports the thousands of patients who have this genetic disease. The Hageman Foundation’s mission is to provide education, support and research, using accurate, up-to-date, medical information on Multiple Endocrine Neoplasia (MEN), otherwise referred to as MEN1, MEN2A, MEN2B, and the Whipple Procedure, which is detailed on our website: HagemanFoundation.org. The Hageman Foundation’s current initiative is to provide educational seminars and an educational website, AMENsupport.org, which is designed for the patients, their families, and their advisors who would otherwise not have the means or wherewithal to obtain the information and guidance.

Last Updated: 15 Feb 2013

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Canadian Multiple Endocrine Neoplasia Society, Inc.

We help people with MEN by referring them to Drs and genetist. We also offer emotional support and literature We can be contacted anytime via email. We do try to find a member close to the newly diagnosed MEN Patient to let them know that "They Are Not Alone"

Last Updated: 31 Jan 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Multiple endocrine neoplasia type 2A" for support, advocacy or research.

AMEND

AMEND exists to inform and support anyone affected by multiple endocrine neoplasia disorders and associated endocrine tumors and syndromes, and to encourage and fund research into the conditions through our Annual Research Grant program and Young Investigator Awards. We provide free patient-aimed information resources, including the MEN Passport and AMEND-sponsored children's comics. We also run a variety of free educational events in the UK and USA as well as social and fundraising events. The AMEND website is HONCode certified and the charity runs several social media pages and groups (private and public).

http://www.amend.org.uk

Last Updated: 29 Apr 2014

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American Multiple Endocrine Neoplasia

The Hageman Foundation supports patient advocacy for a rare disease called Multiple Endocrine Neoplasia. This disease is so elusive that we are the only non-profit in this country which supports the thousands of patients who have this genetic disease. The Hageman Foundation’s mission is to provide education, support and research, using accurate, up-to-date, medical information on Multiple Endocrine Neoplasia (MEN), otherwise referred to as MEN1, MEN2A, MEN2B, and the Whipple Procedure, which is detailed on our website: HagemanFoundation.org. The Hageman Foundation’s current initiative is to provide educational seminars and an educational website, AMENsupport.org, which is designed for the patients, their families, and their advisors who would otherwise not have the means or wherewithal to obtain the information and guidance.

http://www.amensupport.org/

Last Updated: 15 Feb 2013

View Details
Logo
Canadian Multiple Endocrine Neoplasia Society, Inc.

We help people with MEN by referring them to Drs and genetist. We also offer emotional support and literature We can be contacted anytime via email. We do try to find a member close to the newly diagnosed MEN Patient to let them know that "They Are Not Alone"

http://mensociety.ca/

Last Updated: 31 Jan 2013

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General Support Organizations

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General Resources

MEN2a Patient Information Booklet - UK

Detailed but easy to read information on MEN2a for patients in the UK

Uploaded By: AMEND

Updated 29 Apr 2014

Open Doc
MEN2a Patient Information Booklet - USA

Detailed but easy to read information for patients with MEN2a in the USA

Uploaded By: AMEND

Updated 29 Apr 2014

Open Doc
 
 
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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Multiple endocrine neoplasia type 2A" returned 41 free, full-text research articles on human participants. First 3 results:

Diagnosis and surgical treatment of multiple endocrine neoplasia type 2A.
 

Author(s): Kun-Long Tang, Yi Lin, Li-Ming Li

Journal:

 

This study aims to introduce the diagnosis and surgical treatment of the rare disease multiple endocrine neoplasia type 2A (MEN 2A).

Last Updated: 15 Jan 2014

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Multiple endocrine neoplasia type 2A: case report.
 

Author(s): D L Păun, C Poiană, R Petriş, S Radian, R Dănciulescu Miulescu, G Constantinescu, C Orban

Journal: Chirurgia (Bucur). ;108(6):900-3.

 

Multiple endocrine neoplasia type 2A (MEN 2A) is a complex autosomal dominant inherited syndrome characterized by medullary thyroid carcinoma (MTC), pheochromocytoma and primary parathyroid hyperplasia. In patients with only one or two clinical features, identification of a germline ...

Last Updated: 16 Dec 2013

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Pheochromocytoma in an 8-year-old patient with multiple endocrine neoplasia type 2A: implications for screening.
 

Author(s): Kathryn J Rowland, Rebecca D Chernock, Jeffrey F Moley

Journal: J Surg Oncol. 2013 Sep;108(4):203-6.

 

Childhood pheochromocytoma in the setting of multiple endocrine neoplasia type 2 (MEN2) remains rare and has not been reported under the age of 12. We present an 8-year-old female with known MEN 2A, C634Y RET mutation, diagnosed with a 6 cm pheochromocytoma requiring laparoscopic ...

Last Updated: 19 Aug 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Multiple endocrine neoplasia type 2A" returned 2 free, full-text review articles on human participants. First 3 results:

Multiple endocrine neoplasia type 2A in two families with the familial medullary thyroid carcinoma associated G533C mutation of the RET proto-oncogene.
 

Author(s): Melpomeni Peppa, Eleni Boutati, Smaragda Kamakari, Vasilios Pikounis, George Peros, Ioannis G Panayiotides, Theofanis Economopoulos, Sotirios A Raptis, Dimitrios Hadjidakis

Journal: Eur. J. Endocrinol.. 2008 Dec;159(6):767-71.

 

Multiple endocrine neoplasia type 2A (MEN2A) is an autosomal dominant hereditary disorder, associated with a cluster of germline gain-of-function mutations of the RET proto-oncogene (RET), mainly in exons 10-15. The G533C mutation in exon 8 of the RET is rare and has been mainly related ...

Last Updated: 5 Dec 2008

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Sporadic multiple endocrine neoplasia type 2A.
 

Author(s): S Yamashita

Journal: Intern. Med.. 1999 Feb;38(2):80.

 

Last Updated: 18 Jun 1999

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Pancreatic Cancer Early Detection Program
 

Status: Recruiting

Condition Summary: Pancreatic Cancer; Pancreas Cancer; Pancreatic Adenocarcinoma; Familial Pancreatic Cancer; BRCA 1/2; HNPCC; Lynch Syndrome; Hereditary Pancreatitis; FAMMM; Familial Atypical Multiple Mole Melanoma; Peutz Jeghers Syndrome

 

Last Updated: 30 Jul 2014

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Presence of Donor-Derived DNA in Semen Samples From Cancer Survivors Who Underwent Donor Stem Cell Transplant
 

Status: Recruiting

Condition Summary: Cancer Survivor; Chronic Myeloproliferative Disorders; Leukemia; Lymphoma; Multiple Myeloma and Plasma Cell Neoplasm; Myelodysplastic Syndromes; Myelodysplastic/Myeloproliferative Neoplasms; Neuroblastoma; Testicular Germ Cell Tumor

 

Last Updated: 19 Jul 2013

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CC-486 (Oral Azacitidine) Bioequivalence Study in Patients With Solid Tumor or Hematologic Malignancies
 

Status: Not yet recruiting

Condition Summary: Hematological Neoplasms; Non-Hodgkin's Lymphoma; Hodgkin's Lymphoma; Lymphoma; Multiple Myeloma; Acute Myeloid Leukemia; Leukemia; Myelodysplastic Syndromes; Neoplasms; Melanoma; Breast Cancer; Metastatic Breast Cancer; Non-Small Cell Lung Cancer; Small Cell Lung Cancer; Renal Cell Carcinoma; Glioblastoma Multiforme; Osteosarcoma; Sarcoma; Thyroid Cancer; Genitourinary

 

Last Updated: 20 Aug 2014

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