Morquio Syndrome

Common Name(s)

Morquio Syndrome

Description for this condition is not yet available.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Morquio Syndrome" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Morquio Syndrome" returned 25 free, full-text research articles on human participants. First 3 results:

Burden of disease in patients with Morquio A syndrome: results from an international patient-reported outcomes survey.
 

Author(s): Christian J Hendriksz, Christine Lavery, Mahmut Coker, Sema Kalkan Ucar, Mohit Jain, Lisa Bell, Christina Lampe

Journal:

 

Morquio A syndrome (or mucopolysaccharidosis IVa) is an ultra-rare multi-organ disease, resulting in significantly impaired functional capacity, mobility and quality of life (QoL).

Last Updated: 12 Mar 2014

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Mucopolysaccharidosis IVA (Morquio A syndrome) and VI (Maroteaux-Lamy syndrome): under-recognized and challenging to diagnose.
 

Author(s): Ralph S Lachman, Barbara K Burton, Lorne A Clarke, Scott Hoffinger, Shiro Ikegawa, Dong-Kyu Jin, Hiroki Kano, Ok-Hwa Kim, Christina Lampe, Nancy J Mendelsohn, Renée Shediac, Pranoot Tanpaiboon, Klane K White

Journal: Skeletal Radiol.. 2014 Mar;43(3):359-69.

 

Mucopolysaccharidosis IVA (MPS IVA, or Morquio A syndrome) and VI (MPS VI, or Maroteaux-Lamy syndrome) are autosomal recessive lysosomal storage disorders. Skeletal abnormalities are common initial presenting symptoms and, when recognized early, may facilitate timely diagnosis and ...

Last Updated: 27 Jan 2014

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MRI morphometric characterisation of the paediatric cervical spine and spinal cord in children with MPS IVA (Morquio-Brailsford syndrome).
 

Author(s): Guirish A Solanki, William B Lo, Christian J Hendriksz

Journal: J. Inherit. Metab. Dis.. 2013 Mar;36(2):329-37.

 

Nearly all children with MPS IVA develop skeletal deformities affecting the spine. At the atlanto-axial spine, odontoid hypoplasia occurs. GAG deposition around the dens, leads to peri-odontoid infiltration. Transverse/alar ligament incompetence causes instability. Atlanto-axial instability ...

Last Updated: 7 Mar 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Morquio Syndrome" returned 2 free, full-text review articles on human participants. First 3 results:

Morquio A syndrome: diagnosis and current and future therapies.
 

Author(s): Shunji Tomatsu, Eriko Yasuda, Pravin Patel, Kristen Ruhnke, Tsutomu Shimada, William G Mackenzie, Robert Mason, Mihir M Thacker, Mary Theroux, Adriana M Montaño, Carlos J Alméciga-Díaz, Luis A Barrera, Yasutsugu Chinen, William S Sly, Daniel Rowan, Yasuyuki Suzuki, Tado Orii

Journal: Pediatr Endocrinol Rev. 2014 Sep;12 Suppl 1():141-51.

 

Morquio A syndrome is an autosomal recessive disorder, one of 50 lysosomal storage diseases (LSDs), and is caused by the deficiency of N-acetylgalactosamine-6-sulfate sulfatase (GALNS). Deficiency of this enzyme causes specific glycosaminoglycan (GAG) accumulation: keratan sulfate ...

Last Updated: 27 Oct 2014

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Spinal involvement in mucopolysaccharidosis IVA (Morquio-Brailsford or Morquio A syndrome): presentation, diagnosis and management.
 

Author(s): Guirish A Solanki, Kenneth W Martin, Mary C Theroux, Christina Lampe, Klane K White, Renée Shediac, Christian G Lampe, Michael Beck, William G Mackenzie, Christian J Hendriksz, Paul R Harmatz

Journal: J. Inherit. Metab. Dis.. 2013 Mar;36(2):339-55.

 

Mucopolysaccharidosis IVA (MPS IVA), also known as Morquio-Brailsford or Morquio A syndrome, is a lysosomal storage disorder caused by a deficiency of the enzyme N-acetyl-galactosamine-6-sulphate sulphatase (GALNS). MPS IVA is multisystemic but manifests primarily as a progressive ...

Last Updated: 7 Mar 2013

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Biomarker for Morquio Disease
 

Status: Recruiting

Condition Summary: Lysosomal Storage Diseases; Morquio Disease

 

Last Updated: 7 Oct 2014

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Dynamic Gait Analysis in Children With Mucopolysaccharidosis Type IVa
 

Status: Not yet recruiting

Condition Summary: Mucopolysaccharidosis IV; Morquio A Disease

 

Last Updated: 29 May 2014

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Psychological Concomitants of Morquio A Syndrome - Longitudinal Effects of Enzyme Replacement Therapy (The MAPLE Study)
 

Status: Recruiting

Condition Summary: Morquio A Syndrome; Mucopolysaccharidosis IV A

 

Last Updated: 5 Aug 2014

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