Microvillus inclusion disease

Common Name(s)

Microvillus inclusion disease, Congenital microvillous atrophy

Microvillus inclusion disease is an intestinal disorder characterized by severe, watery diarrhea and an inability of the intestines to absorb nutrients. Symptoms typically develop in the first days (early-onset) or first months (late-onset) of life. Without adequate water and nutrients, children with this condition can become dehydrated, suffer from malnutrition, and fail to grow and develop normally. Management is difficult and relies on total parenteral nutrition. The advent of intestinal transplantation has improved the outlook for these patients. Microvillus inclusion disease is inherited in an autosomal recessive manner.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Microvillus inclusion disease" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Microvillus inclusion disease" returned 5 free, full-text research articles on human participants. First 3 results:

Myosin Vb uncoupling from RAB8A and RAB11A elicits microvillus inclusion disease.
 

Author(s): Byron C Knowles, Joseph T Roland, Moorthy Krishnan, Matthew J Tyska, Lynne A Lapierre, Paul S Dickman, James R Goldenring, Mitchell D Shub

Journal: J. Clin. Invest.. 2014 Jul;124(7):2947-62.

 

Microvillus inclusion disease (MVID) is a severe form of congenital diarrhea that arises from inactivating mutations in the gene encoding myosin Vb (MYO5B). We have examined the association of mutations in MYO5B and disruption of microvillar assembly and polarity in enterocytes. Stable ...

Last Updated: 3 Jul 2014

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Functional characterization of mutations in the myosin Vb gene associated with microvillus inclusion disease.
 

Author(s): Agata M Szperl, Magdalena R Golachowska, Marcel Bruinenberg, Rytis Prekeris, Andy-Mark W H Thunnissen, Arend Karrenbeld, Gerard Dijkstra, Dick Hoekstra, David Mercer, Janusz Ksiazyk, Cisca Wijmenga, Martin C Wapenaar, Edmond H H M Rings, Sven C D van IJzendoorn

Journal: J. Pediatr. Gastroenterol. Nutr.. 2011 Mar;52(3):307-13.

 

Microvillus inclusion disease (MVID) is a rare autosomal recessive enteropathy characterized by intractable diarrhea and malabsorption. Recently, various MYO5B gene mutations have been identified in patients with MVID. Interestingly, several patients with MVID showed only a MYO5B ...

Last Updated: 21 Feb 2011

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Autophagocytosis of the apical membrane in microvillus inclusion disease.
 

Author(s): K Reinshagen, H Y Naim, K-P Zimmer

Journal: Gut. 2002 Oct;51(4):514-21.

 

Microvillus inclusion disease (MID) is a disorder with the clinical signs of intractable diarrhoea in the newborn and infancy. The typical pathological features of the disease are well known whereas the pathophysiology is still unclear.

Last Updated: 17 Sep 2002

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Reviews from the PubMed Database

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The terms "Microvillus inclusion disease" returned 0 free, full-text review articles on human participants.

 
 
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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

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