Microvillus inclusion disease

Common Name(s)

Microvillus inclusion disease, Congenital microvillous atrophy

Microvillus inclusion disease is an intestinal disorder characterized by severe, watery diarrhea and an inability of the intestines to absorb nutrients. Symptoms typically develop in the first days (early-onset) or first months (late-onset) of life. Without adequate water and nutrients, children with this condition can become dehydrated, suffer from malnutrition, and fail to grow and develop normally. Management is difficult and relies on total parenteral nutrition. The advent of intestinal transplantation has improved the outlook for these patients. Microvillus inclusion disease is inherited in an autosomal recessive manner.
 

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Condition Specific Organizations

Following organizations serve the condition "Microvillus inclusion disease" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Microvillus inclusion disease" returned 14 free, full-text research articles on human participants. First 3 results:

Identification of intestinal ion transport defects in microvillus inclusion disease.
 

Author(s): Dmitri V Kravtsov, Md Kaimul Ahsan, Vandana Kumari, Sven C D van Ijzendoorn, Miguel Reyes-Mugica, Anoop Kumar, Tarunmeet Gujral, Pradeep K Dudeja, Nadia A Ameen

Journal: Am. J. Physiol. Gastrointest. Liver Physiol.. 2016 Jul;311(1):G142-55.

 

Loss of function mutations in the actin motor myosin Vb (Myo5b) lead to microvillus inclusion disease (MVID) and death in newborns and children. MVID results in secretory diarrhea, brush border (BB) defects, villus atrophy, and microvillus inclusions (MVIs) in enterocytes. How loss ...

Last Updated: 31 Dec 1969

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The localisation of the apical Par/Cdc42 polarity module is specifically affected in microvillus inclusion disease.
 

Author(s): Grégoire Michaux, Dominique Massey-Harroche, Ophélie Nicolle, Marion Rabant, Nicole Brousse, Olivier Goulet, André Le Bivic, Frank M Ruemmele

Journal: Biol. Cell. 2016 Jan;108(1):19-28.

 

Microvillus inclusion disease (MVID) is a genetic disorder affecting intestinal absorption. It is caused by mutations in MYO5B or syntaxin 3 (STX3) affecting apical membrane trafficking. Morphologically, MVID is characterised by a depletion of apical microvilli and the formation of ...

Last Updated: 31 Dec 1969

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An inducible mouse model for microvillus inclusion disease reveals a role for myosin Vb in apical and basolateral trafficking.
 

Author(s): Kerstin Schneeberger, Georg F Vogel, Hans Teunissen, Domenique D van Ommen, Harry Begthel, Layla El Bouazzaoui, Anke H M van Vugt, Jeffrey M Beekman, Judith Klumperman, Thomas Müller, Andreas Janecke, Patrick Gerner, Lukas A Huber, Michael W Hess, Hans Clevers, Johan H van Es, Edward E S Nieuwenhuis, Sabine Middendorp

Journal: Proc. Natl. Acad. Sci. U.S.A.. 2015 Oct;112(40):12408-13.

 

Microvillus inclusion disease (MVID) is a rare intestinal enteropathy with an onset within a few days to months after birth, resulting in persistent watery diarrhea. Mutations in the myosin Vb gene (MYO5B) have been identified in the majority of MVID patients. However, the exact pathophysiology ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

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The terms "Microvillus inclusion disease" returned 0 free, full-text review articles on human participants.

 
 
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