Microvillus inclusion disease

Common Name(s)

Microvillus inclusion disease, Congenital microvillous atrophy

Microvillus inclusion disease is an intestinal disorder characterized by severe, watery diarrhea and an inability of the intestines to absorb nutrients. Symptoms typically develop in the first days (early-onset) or first months (late-onset) of life. Without adequate water and nutrients, children with this condition can become dehydrated, suffer from malnutrition, and fail to grow and develop normally. Management is difficult and relies on total parenteral nutrition. The advent of intestinal transplantation has improved the outlook for these patients. Microvillus inclusion disease is inherited in an autosomal recessive manner.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Microvillus inclusion disease" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Microvillus inclusion disease" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Microvillus inclusion disease" returned 12 free, full-text research articles on human participants. First 3 results:

An inducible mouse model for microvillus inclusion disease reveals a role for myosin Vb in apical and basolateral trafficking.
 

Author(s): Kerstin Schneeberger, Georg F Vogel, Hans Teunissen, Domenique D van Ommen, Harry Begthel, Layla El Bouazzaoui, Anke H M van Vugt, Jeffrey M Beekman, Judith Klumperman, Thomas Müller, Andreas Janecke, Patrick Gerner, Lukas A Huber, Michael W Hess, Hans Clevers, Johan H van Es, Edward E S Nieuwenhuis, Sabine Middendorp

Journal: Proc. Natl. Acad. Sci. U.S.A.. 2015 Oct;112(40):12408-13.

 

Microvillus inclusion disease (MVID) is a rare intestinal enteropathy with an onset within a few days to months after birth, resulting in persistent watery diarrhea. Mutations in the myosin Vb gene (MYO5B) have been identified in the majority of MVID patients. However, the exact pathophysiology ...

Last Updated: 7 Oct 2015

Go To URL
Myosin 5b loss of function leads to defects in polarized signaling: implication for microvillus inclusion disease pathogenesis and treatment.
 

Author(s): Dmitri Kravtsov, Anastasia Mashukova, Radia Forteza, Maria M Rodriguez, Nadia A Ameen, Pedro J Salas

Journal: Am. J. Physiol. Gastrointest. Liver Physiol.. 2014 Nov;307(10):G992-G1001.

 

Microvillus inclusion disease (MVID) is an autosomal recessive condition resulting in intractable secretory diarrhea in newborns due to loss-of-function mutations in myosin Vb (Myo5b). Previous work suggested that the apical recycling endosomal (ARE) compartment is the primary location ...

Last Updated: 17 Nov 2014

Go To URL
Myosin Vb uncoupling from RAB8A and RAB11A elicits microvillus inclusion disease.
 

Author(s): Byron C Knowles, Joseph T Roland, Moorthy Krishnan, Matthew J Tyska, Lynne A Lapierre, Paul S Dickman, James R Goldenring, Mitchell D Shub

Journal: J. Clin. Invest.. 2014 Jul;124(7):2947-62.

 

Microvillus inclusion disease (MVID) is a severe form of congenital diarrhea that arises from inactivating mutations in the gene encoding myosin Vb (MYO5B). We have examined the association of mutations in MYO5B and disruption of microvillar assembly and polarity in enterocytes. Stable ...

Last Updated: 3 Jul 2014

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Microvillus inclusion disease" returned 1 free, full-text review articles on human participants. First 3 results:

Gastrointestinal microvillus inclusion disease.
 

Author(s): D E Schofield, R M Agostini, E J Yunis

Journal: Am. J. Clin. Pathol.. 1992 Jul;98(1):119-24.

 

A 3-year-old girl of Navajo heritage had intractable diarrhea beginning at 4 days of age and resulting in long-term hyperalimentation. Investigation before multivisceral transplantation included biopsies of the rectum, stomach, duodenum, and liver. The diagnosis of microvillus inclusion ...

Last Updated: 30 Jul 1992

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.