Meesmann corneal dystrophy

Common Name(s)

Meesmann corneal dystrophy

Meesmann corneal dystrophy is a rare genetic condition affecting the epithelial membrane of the cornea. A slit-lamp examination of the cornea shows diffuse clusters of tiny round cysts in the epithelial membrane.  Overtime these cysts can rupture and cause erosions. The erosions may result in light sensitivity, redness, and pain. Vision remains good in most cases. Meesmann corneal dystrophy can be caused by mutations in the KRT3 or KRT12 gene. It is inherited in an autosomal dominant fashion. 

Click here to view an image of the eye which includes an illustration of the epithelial membrane of the cornea.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Meesmann corneal dystrophy" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Meesmann corneal dystrophy" returned 4 free, full-text research articles on human participants. First 3 results:

Allele-specific siRNA silencing for the common keratin 12 founder mutation in Meesmann epithelial corneal dystrophy.
 

Author(s): Edwin H A Allen, Sarah D Atkinson, Haihui Liao, Jonathan E Moore, Deena M Leslie Pedrioli, Frances J D Smith, William H Irwin McLean, C B Tara Moore

Journal:

 

To identify an allele-specific short interfering RNA (siRNA), against the common KRT12 mutation Arg135Thr in Meesmann epithelial corneal dystrophy (MECD) as a personalized approach to treatment.

Last Updated: 18 Jan 2013

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Development of allele-specific therapeutic siRNA in Meesmann epithelial corneal dystrophy.
 

Author(s): Haihui Liao, Alan D Irvine, Caroline J Macewen, Kathryn H Weed, Louise Porter, Laura D Corden, A Bethany Gibson, Jonathan E Moore, Frances J D Smith, W H Irwin McLean, C B Tara Moore

Journal: PLoS ONE. 2011 ;6(12):e28582.

 

Meesmann epithelial corneal dystrophy (MECD) is an inherited eye disorder caused by dominant-negative mutations in either keratins K3 or K12, leading to mechanical fragility of the anterior corneal epithelium, the outermost covering of the eye. Typically, patients suffer from lifelong ...

Last Updated: 16 Dec 2011

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Genetics of Meesmann corneal dystrophy: a novel mutation in the keratin 3 gene in an asymptomatic family suggests genotype-phenotype correlation.
 

Author(s): Jacek P Szaflik, Monika Ołdak, Radosław B Maksym, Anna Kamińska, Agnieszka Pollak, Monika Udziela, Rafał Płoski, Jerzy Szaflik

Journal:

 

Juvenile epithelial corneal dystrophy of Meesmann (MCD, OMIM 122100) is a dominantly inherited disorder characterized by fragility of the anterior corneal epithelium and intraepithelial microcyst formation. Although the disease is generally mild and affected individuals are often ...

Last Updated: 22 Sep 2008

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Meesmann corneal dystrophy" returned 0 free, full-text review articles on human participants.

 
 
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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

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