Malignant hyperthermia

Common Name(s)

Malignant hyperthermia

Malignant hyperthermia is a severe reaction to particular drugs used during surgery and other invasive procedures. People at increased risk for this disorder are said to have malignant hyperthermia susceptibility. If given these drugs, these people may experience muscle rigidity, breakdown of muscle fibers, a high fever, increased acid levels in the blood and other tissues, and a rapid heart rate. Without prompt treatment, the complications of malignant hyperthermia can be life-threatening. There are at least six forms of malignant hyperthermia susceptibility, which are associated with mutations in different genes (e.g.,  CACNA1S, RYR1). The susceptibility is inherited in an autosomal dominant fashion. People with certain inherited muscle diseases (e.g., central core disease and multiminicore disease) also have malignant hyperthermia susceptibility.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Malignant hyperthermia" for support, advocacy or research.

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Malignant Hyperthermia Association of the United States

The mission of MHAUS is to promote optimum care and scientific understanding of MH and related disorders.

http://www.mhaus.org

Last Updated: 21 Dec 2012

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Malignant hyperthermia" for support, advocacy or research.

Logo
Malignant Hyperthermia Association of the United States

The mission of MHAUS is to promote optimum care and scientific understanding of MH and related disorders.

http://www.mhaus.org

Last Updated: 21 Dec 2012

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General Support Organizations

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General Resources

North American Malignant Hyperthermia Registry

The Registry's goal is to acquire, analyze, and disseminate case-specific clinical and laboratory information related to malignant hyperthermia susceptibility.

Updated 21 Dec 2012

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Malignant hyperthermia" returned 297 free, full-text research articles on human participants. First 3 results:

Malignant hyperthermia during laparoscopic adjustable gastric banding.
 

Author(s): Josue Chery, Chiba Shintaro, Ambibola Pratt, Ronell Kirkley, Barbara Hearne, Andrew Beyzman, Piotr Gorecki

Journal: JSLS. ;17(2):346-9.

 

We report a rare case of malignant hyperthermia during laparoscopic adjustable gastric banding. Case Description: A 32-y-old female with no previous history of adverse reaction to general anesthesia underwent laparoscopic adjustable gastric banding. Intraoperative monitoring revealed ...

Last Updated: 8 Aug 2013

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Continuous veno-venous hemofiltration for massive rhabdomyolysis after malignant hyperthermia: report of 2 cases.
 

Author(s): Shudong Fang, Hui Xu, Yesen Zhu, Hong Jiang

Journal: Anesth Prog. 2013 ;60(1):21-4.

 

We present 2 cases of fulminant malignant hyperthermia (MH), complicated with massive rhabdomyolysis. The patients were successfully treated in the intensive care unit of our university teaching hospital, despite the lack of availability of dantrolene in our country, by early application ...

Last Updated: 19 Mar 2013

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CASQ1 gene is an unlikely candidate for malignant hyperthermia susceptibility in the North American population.
 

Author(s): Natalia Kraeva, Elena Zvaritch, Wanda Frodis, Olga Sizova, Alexander Kraev, David H MacLennan, Sheila Riazi

Journal: Anesthesiology. 2013 Feb;118(2):344-9.

 

Malignant hyperthermia (MH, MIM# 145600) is a complex pharmacogenetic disorder that is manifested in predisposed individuals as a potentially lethal reaction to volatile anesthetics and depolarizing muscle relaxants. Studies of CASQ1-null mice have shown that CASQ1, encoding calsequestrin ...

Last Updated: 4 Mar 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Malignant hyperthermia" returned 26 free, full-text review articles on human participants. First 3 results:

Exercise-induced rhabdomyolysis and stress-induced malignant hyperthermia events, association with malignant hyperthermia susceptibility, and RYR1 gene sequence variations.
 

Author(s): Antonella Carsana

Journal: ScientificWorldJournal. 2013 ;2013():531465.

 

Exertional rhabdomyolysis (ER) and stress-induced malignant hyperthermia (MH) events are syndromes that primarily afflict military recruits in basic training and athletes. Events similar to those occurring in ER and in stress-induced MH events are triggered after exposure to anesthetic ...

Last Updated: 11 Mar 2013

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Malignant hyperthermia.
 

Author(s): Oliver Bandschapp, Thierry Girard

Journal:

 

Malignant hyperthermia (MH) is a subclinical myopathy, usually triggered by volatile anaesthetics and depolarising muscle relaxants. Clinical symptoms are variable, and the condition is sometimes difficult to identify. Nevertheless, rapid recognition and specific as well as symptomatic ...

Last Updated: 1 Aug 2012

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Special article: Future directions in malignant hyperthermia research and patient care.
 

Author(s): Sharon J Hirshey Dirksen, Marilyn Green Larach, Henry Rosenberg, Barbara W Brandom, Jerome Parness, Robert Scott Lang, Meera Gangadharan, Tyler Pezalski

Journal: Anesth. Analg.. 2011 Nov;113(5):1108-19.

 

Malignant hyperthermia (MH) is a complex pharmacogenetic disorder of muscle metabolism. To more closely examine the complexities of MH and other related muscle disorders, the Malignant Hyperthermia Association of the United States (MHAUS) recently sponsored a scientific conference ...

Last Updated: 24 Oct 2011

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Muscle Force Assessment in the Intensive Care Unit Environment
 

Status: Recruiting

Condition Summary: Sepsis; Malignant Hyperthermia

 

Last Updated: 19 Mar 2012

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Effectiveness of Carbon Filters to Reduce the Anesthetic Gas Concentration in an Anesthetized Patient
 

Status: Not yet recruiting

Condition Summary: Malignant Hyperthermia

 

Last Updated: 19 Jun 2012

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Video-assisted Hyperthermic Pleural Chemoperfusion vs Talc Pleurodesis for Refractory Malignant Pleural Effusions.
 

Status: Recruiting

Condition Summary: Safety of Intervention; Efficacy of Intervention; Cost Effectiveness

 

Last Updated: 26 Mar 2014

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