Malignant hyperthermia

Common Name(s)

Malignant hyperthermia

Malignant hyperthermia is a severe reaction to particular drugs used during surgery and other invasive procedures. People at increased risk for this disorder are said to have malignant hyperthermia susceptibility. If given these drugs, these people may experience muscle rigidity, breakdown of muscle fibers, a high fever, increased acid levels in the blood and other tissues, and a rapid heart rate. Without prompt treatment, the complications of malignant hyperthermia can be life-threatening. There are at least six forms of malignant hyperthermia susceptibility, which are associated with mutations in different genes (e.g.,  CACNA1S, RYR1). The susceptibility is inherited in an autosomal dominant fashion. People with certain inherited muscle diseases (e.g., central core disease and multiminicore disease) also have malignant hyperthermia susceptibility.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Malignant hyperthermia" for support, advocacy or research.

Malignant Hyperthermia Association of the United States

The mission of MHAUS is to promote optimum care and scientific understanding of MH and related disorders.

Last Updated: 6 May 2014

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The RYR-1 Foundation

The primary goal of the Foundation is to find a cure for RYR-1 related muscle diseases. To achieve this goal, the Foundation has several missions: 1) Support Research 2) Physician Education 3) Patient/family support and advocacy

Last Updated: 16 Mar 2015

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Malignant hyperthermia" for support, advocacy or research.

Malignant Hyperthermia Association of the United States

The mission of MHAUS is to promote optimum care and scientific understanding of MH and related disorders.

http://www.mhaus.org

Last Updated: 6 May 2014

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The RYR-1 Foundation

The primary goal of the Foundation is to find a cure for RYR-1 related muscle diseases. To achieve this goal, the Foundation has several missions: 1) Support Research 2) Physician Education 3) Patient/family support and advocacy

http://www.ryr1.org

Last Updated: 16 Mar 2015

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General Resources

North American Malignant Hyperthermia Registry

The Registry's goal is to acquire, analyze, and disseminate case-specific clinical and laboratory information related to malignant hyperthermia susceptibility.

Updated 21 Dec 2012

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Malignant hyperthermia" returned 140 free, full-text research articles on human participants. First 3 results:

Contraction versus contracture and centronuclear myopathy versus central part myopathy in malignant hyperthermia.
 

Author(s): Helga Cristina Almeida Da Silva, Pamela Vieira De Andrade, José Luiz Gomes Do Amaral

Journal: Braz J Anesthesiol. ;64(2):142-4.

 

Last Updated: 5 May 2014

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Malignant hyperthermia in the intensive care setting.
 

Author(s): Frank Schuster, Susanne Moegele, Stephan Johannsen, Norbert Roewer

Journal:

 

Last Updated: 7 Mar 2014

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Malignant hyperthermia crisis: optimizing patient outcomes through simulation and interdisciplinary collaboration.
 

Author(s): Cindy L Cain, Matthias L Riess, Lynn Gettrust, Jutta Novalija

Journal: AORN J. 2014 Feb;99(2):301-8; quiz 309-11.

 

Malignant hyperthermia (MH) is a rare, life-threatening event. Many clinicians are unprepared to manage an MH crisis in the perioperative setting because it requires the use of low-frequency, high-risk skills and procedures. Simulation is a recognized educational method for cumulative ...

Last Updated: 29 Jan 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Malignant hyperthermia" returned 22 free, full-text review articles on human participants. First 3 results:

[Malignant hyperthermia - problem in dental surgery. An introductory report].
 

Author(s): Ewa Kamińska, Anna Janas, Piotr Osica

Journal: Dev Period Med. ;18(4):483-8.

 

Malignant hyperthermia is a genetic defect of uncontrolled hypermetabolic skeletal muscle response to anesthetic triggering drugs. Some congenital myopathies are regarded as risk increasing factors. The use of volatile anaesthetics or suxamethonium (succinylcholine) in patients who ...

Last Updated: 16 Apr 2015

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Exercise-induced rhabdomyolysis and stress-induced malignant hyperthermia events, association with malignant hyperthermia susceptibility, and RYR1 gene sequence variations.
 

Author(s): Antonella Carsana

Journal: ScientificWorldJournal. 2013 ;2013():531465.

 

Exertional rhabdomyolysis (ER) and stress-induced malignant hyperthermia (MH) events are syndromes that primarily afflict military recruits in basic training and athletes. Events similar to those occurring in ER and in stress-induced MH events are triggered after exposure to anesthetic ...

Last Updated: 11 Mar 2013

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Malignant hyperthermia: clinical and molecular aspects.
 

Author(s): Ana Carolina de Carvalho Correia, Polyana Cristina Barros Silva, Bagnólia Araújo da Silva

Journal: Rev Bras Anestesiol. ;62(6):820-37.

 

Malignant hyperthermia (MH) is a potentially lethal pharmacogenetic disorder that affects genetically predisposed individuals. It manifests in susceptible individuals in response to exposure to Inhalant anesthetics, depolarizing muscle relaxants or extreme physical activity in hot ...

Last Updated: 26 Nov 2012

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Muscle Force Assessment in the Intensive Care Unit and in Primary Myopathies
 

Status: Recruiting

Condition Summary: Sepsis; Primary Myopathies

 

Last Updated: 15 May 2015

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Registry of Febrile Neutropenia and Invasive Fungal Infections
 

Status: Recruiting

Condition Summary: Hematological Disease; Febrile Neutropenia; Fungal Infections

 

Last Updated: 11 Sep 2012

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Trial Evaluating Surgery With Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Treating Patients With a High Risk of Developing Colorectal Peritoneal Carcinomatosis
 

Status: Not yet recruiting

Condition Summary: Malignant Neoplasm of Large Intestine TNM Staging Primary Tumor (T) T4; Metastases to Ovary; Peritoneal Carcinomatosis

 

Last Updated: 30 Jun 2014

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