Lymphedema distichiasis syndrome

Common Name(s)

Lymphedema distichiasis syndrome

Lymphedema distichiasis syndrome is a condition that affects the normal function of the lymphatic system (part of the immune system that produces and transports fluids and immune cells throughout the body). People with this condition are born with extra eyelashes (distichiasis) and develop puffiness or swelling (lymphedema) of the limbs by the time they are in their forties. The abnormal eyelashes, which grow along the inner lining of the eyelid, often touch the eyeball and can cause damage to the clear covering of the eye (cornea). Other eye problems such as an irregular curvature of the cornea causing blurred vision (astigmatism) or scarring of the cornea may also occur. Other health problems, varicose veins, droopy eyelids (ptosis), heart abnormalities, and an opening in the roof of the mouth (a cleft palate), may also be present. Lymphedema-distichiasis syndrome is caused by mutations in the FOXC2 gene. This condition is inherited in an autosomal dominant pattern.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Lymphedema distichiasis syndrome" for support, advocacy or research.

Lymphatic Education & Research Network

Our Mission is to fight lymphatic disease and lymphedema through education, research and advocacy. We seek to accelerate the prevention, treatment and cure of the disease while bringing patients and medical professionals together to address the unmet needs surrounding lymphatic disorders.

Last Updated: 14 May 2014

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Lymphedema distichiasis syndrome" for support, advocacy or research.

Lymphatic Education & Research Network

Our Mission is to fight lymphatic disease and lymphedema through education, research and advocacy. We seek to accelerate the prevention, treatment and cure of the disease while bringing patients and medical professionals together to address the unmet needs surrounding lymphatic disorders.

http://www.lymphaticnetwork.org

Last Updated: 14 May 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Lymphedema distichiasis syndrome" returned 5 free, full-text research articles on human participants. First 3 results:

Distichiasis-lymphedema syndrome with optic disc pit.
 

Author(s): K Kaarthigeyan, M Ramprakash, G Kalpana

Journal: Indian J Ophthalmol. ;59(1):71-2.

 

Last Updated: 15 Dec 2010

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[Distichiasis-lymphedema syndrome].
 

Author(s): C Guerrero Laleona, S Gimeno Aguilar, D Portilla Córdova, A Honrrubia Grijalbo

Journal: An Pediatr (Barc). 2005 Dec;63(6):567-8.

 

Last Updated: 5 Dec 2005

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FOXC2 haploinsufficient mice are a model for human autosomal dominant lymphedema-distichiasis syndrome.
 

Author(s): Benjamin M Kriederman, Teressa L Myloyde, Marlys H Witte, Susan L Dagenais, Charles L Witte, Margaret Rennels, Michael J Bernas, Michelle T Lynch, Robert P Erickson, Mark S Caulder, Naoyuki Miura, David Jackson, Brian P Brooks, Thomas W Glover

Journal: Hum. Mol. Genet.. 2003 May;12(10):1179-85.

 

Lymphedema-distichiasis (LD) (OMIM 153400) is a rare autosomal-dominant condition characterized by pubertal onset of lower limb lymphedema and an aberrant second row of eyelashes arising from the meibomian glands. In some patients cardiac, skeletal and other defects coexist. We previously ...

Last Updated: 29 Apr 2003

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Lymphedema distichiasis syndrome" returned 0 free, full-text review articles on human participants.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.