Long QT syndrome 5

Common Name(s)

Long QT syndrome 5

Congenital long QT syndrome is electrocardiographically characterized by a prolonged QT interval and polymorphic ventricular arrhythmias (torsade de pointes). These cardiac arrhythmias may result in recurrent syncope, seizure, or sudden death ({1:Jongbloed et al., 1999}). For a discussion of genetic heterogeneity of long QT syndrome, see LQT1 ({192500}).
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Long QT syndrome 5" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Long QT syndrome 5" returned 5 free, full-text research articles on human participants. First 3 results:

Enhanced Classification of Brugada Syndrome-Associated and Long-QT Syndrome-Associated Genetic Variants in the SCN5A-Encoded Na(v)1.5 Cardiac Sodium Channel.
 

Author(s): Jamie D Kapplinger, John R Giudicessi, Dan Ye, David J Tester, Thomas E Callis, Carmen R Valdivia, Jonathan C Makielski, Arthur A Wilde, Michael J Ackerman

Journal: Circ Cardiovasc Genet. 2015 Aug;8(4):582-95.

 

A 2% to 5% background rate of rare SCN5A nonsynonymous single nucleotide variants (nsSNVs) among healthy individuals confounds clinical genetic testing. Therefore, the purpose of this study was to enhance interpretation of SCN5A nsSNVs for clinical genetic testing using estimated ...

Last Updated: 19 Aug 2015

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The human Nav1.5 F1486 deletion associated with long QT syndrome leads to impaired sodium channel inactivation and reduced lidocaine sensitivity.
 

Author(s): Weihua Song, Yucheng Xiao, Hanying Chen, Nicole M Ashpole, Andrew D Piekarz, Peilin Ma, Andy Hudmon, Theodore R Cummins, Weinian Shou

Journal: J. Physiol. (Lond.). 2012 Oct;590(20):5123-39.

 

The deletion of phenylalanine 1486 (F1486del) in the human cardiac voltage-gated sodium channel (hNav1.5) is associated with fatal long QT (LQT) syndrome. In this study we determined how F1486del impairs the functional properties of hNav1.5 and alters action potential firing in heterologous ...

Last Updated: 19 Oct 2012

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Nadolol block of Nav1.5 does not explain its efficacy in the long QT syndrome.
 

Author(s): Alessandra Besana, Dao W Wang, Alfred L George, Peter J Schwartz

Journal: J. Cardiovasc. Pharmacol.. 2012 Mar;59(3):249-53.

 

Beta-adrenergic receptor antagonists (β-blockers) are the therapy of choice for the long QT syndrome but their efficacy is not homogeneous: propranolol and nadolol are the most effective, whereas metoprolol is associated with more treatment failures. Propranolol has a blocking effect ...

Last Updated: 7 Mar 2012

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Reviews from the PubMed Database

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The terms "Long QT syndrome 5" returned 0 free, full-text review articles on human participants.

 
 
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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

5-HT3 Antagonists (Antiemetics) and Cardiac Safety
 

Status: Recruiting

Condition Summary: Adverse Reaction to Other Drugs and Medicines

 

Last Updated: 30 Nov 2015

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