Long QT syndrome 1

Common Name(s)

Long QT syndrome 1

Romano-Ward syndrome is the most common form of inherited long QT syndrome. Symptoms include arrhythmia, fainting, cardiac arrest, and sudden death. There are six different types of this syndrome, long QT 1 through 6. Each type is caused by a change in a different gene. The most prevalent form of long QT syndrome is long QT type 1. Long QT type 1 is caused by changes in the KCNQ1 gene. Romano-Ward syndrome is inherited in an autosomal dominant fashion.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Long QT syndrome 1" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Long QT syndrome 1" returned 23 free, full-text research articles on human participants. First 3 results:

High-risk long QT syndrome mutations in the Kv7.1 (KCNQ1) pore disrupt the molecular basis for rapid K(+) permeation.
 

Author(s): Don E Burgess, Daniel C Bartos, Allison R Reloj, Kenneth S Campbell, Jonathan N Johnson, David J Tester, Michael J Ackerman, Véronique Fressart, Isabelle Denjoy, Pascale Guicheney, Arthur J Moss, Seiko Ohno, Minoru Horie, Brian P Delisle

Journal: Biochemistry. 2012 Nov;51(45):9076-85.

 

Type 1 long QT syndrome (LQT1) is caused by loss-of-function mutations in the KCNQ1 gene, which encodes the K(+) channel (Kv7.1) that underlies the slowly activating delayed rectifier K(+) current in the heart. Intragenic risk stratification suggests LQT1 mutations that disrupt conserved ...

Last Updated: 7 Feb 2013

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Not all beta-blockers are equal in the management of long QT syndrome types 1 and 2: higher recurrence of events under metoprolol.
 

Author(s): Priya Chockalingam, Lia Crotti, Giulia Girardengo, Jonathan N Johnson, Katy M Harris, Jeroen F van der Heijden, Richard N W Hauer, Britt M Beckmann, Carla Spazzolini, Roberto Rordorf, Annika Rydberg, Sally-Ann B Clur, Markus Fischer, Freek van den Heuvel, Stefan Kääb, Nico A Blom, Michael J Ackerman, Peter J Schwartz, Arthur A M Wilde

Journal: J. Am. Coll. Cardiol.. 2012 Nov;60(20):2092-9.

 

The purpose of this study was to compare the efficacy of beta-blockers in congenital long QT syndrome (LQTS).

Last Updated: 9 Nov 2012

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Phylogenetic and physicochemical analyses enhance the classification of rare nonsynonymous single nucleotide variants in type 1 and 2 long-QT syndrome.
 

Author(s): John R Giudicessi, Jamie D Kapplinger, David J Tester, Marielle Alders, Benjamin A Salisbury, Arthur A M Wilde, Michael J Ackerman

Journal: Circ Cardiovasc Genet. 2012 Oct;5(5):519-28.

 

Hundreds of nonsynonymous single nucleotide variants (nsSNVs) have been identified in the 2 most common long-QT syndrome-susceptibility genes (KCNQ1 and KCNH2). Unfortunately, an ≈3%

Last Updated: 17 Oct 2012

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Long QT syndrome 1" returned 0 free, full-text review articles on human participants.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Comparison Between Epinephrine and Exercise Test in QT Long Syndrome Patients
 

Status: Recruiting

Condition Summary: Long QT Syndrome Type 1 or 2

 

Last Updated: 7 Dec 2012

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