Long QT syndrome 1

Common Name(s)

Long QT syndrome 1

Romano-Ward syndrome is the most common form of inherited long QT syndrome. Symptoms include arrhythmia, fainting, cardiac arrest, and sudden death. There are six different types of this syndrome, long QT 1 through 6. Each type is caused by a change in a different gene. The most prevalent form of long QT syndrome is long QT type 1. Long QT type 1 is caused by changes in the KCNQ1 gene. Romano-Ward syndrome is inherited in an autosomal dominant fashion.
 

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Condition Specific Organizations

Following organizations serve the condition "Long QT syndrome 1" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Long QT syndrome 1" returned 39 free, full-text research articles on human participants. First 3 results:

A Common Mutation of Long QT Syndrome Type 1 in Japan.
 

Author(s): Hideki Itoh, Kenichi Dochi, Wataru Shimizu, Isabelle Denjoy, Seiko Ohno, Takeshi Aiba, Hiromi Kimura, Koichi Kato, Megumi Fukuyama, Kanae Hasagawa, Eric Schulze-Bahr, Pascale Guicheney, Minoru Horie

Journal: Circ. J.. 2015 ;79(9):2026-30.

 

Previous studies of long QT syndrome (LQTS) have revealed the presence of country-specific hot spots in KCNQ1 mutations, and the purpose of this study was to evaluate the influence of a common mutation on clinical phenotypes in Japanese LQT1 patients.

Last Updated: 28 Aug 2015

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Third trimester fetal heart rate predicts phenotype and mutation burden in the type 1 long QT syndrome.
 

Author(s): Annika Winbo, Inger Fosdal, Maria Lindh, Ulla-Britt Diamant, Johan Persson, Göran Wettrell, Annika Rydberg

Journal: Circ Arrhythm Electrophysiol. 2015 Aug;8(4):806-14.

 

Early diagnosis and risk stratification is of clinical importance in the long QT syndrome (LQTS), however, little genotype-specific data are available regarding fetal LQTS. We investigate third trimester fetal heart rate, routinely recorded within public maternal health care, as a ...

Last Updated: 19 Aug 2015

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Enhanced Classification of Brugada Syndrome-Associated and Long-QT Syndrome-Associated Genetic Variants in the SCN5A-Encoded Na(v)1.5 Cardiac Sodium Channel.
 

Author(s): Jamie D Kapplinger, John R Giudicessi, Dan Ye, David J Tester, Thomas E Callis, Carmen R Valdivia, Jonathan C Makielski, Arthur A Wilde, Michael J Ackerman

Journal: Circ Cardiovasc Genet. 2015 Aug;8(4):582-95.

 

A 2% to 5% background rate of rare SCN5A nonsynonymous single nucleotide variants (nsSNVs) among healthy individuals confounds clinical genetic testing. Therefore, the purpose of this study was to enhance interpretation of SCN5A nsSNVs for clinical genetic testing using estimated ...

Last Updated: 19 Aug 2015

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Reviews from the PubMed Database

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The terms "Long QT syndrome 1" returned 0 free, full-text review articles on human participants.

 
 
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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Comparison Between Epinephrine and Exercise Test in QT Long Syndrome Patients
 

Status: Recruiting

Condition Summary: Long QT Syndrome Type 1 or 2

 

Last Updated: 4 Oct 2016

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