Long QT syndrome 1

Common Name(s)

Long QT syndrome 1

Romano-Ward syndrome is the most common form of inherited long QT syndrome. Symptoms include arrhythmia, fainting, cardiac arrest, and sudden death. There are six different types of this syndrome, long QT 1 through 6. Each type is caused by a change in a different gene. The most prevalent form of long QT syndrome is long QT type 1. Long QT type 1 is caused by changes in the KCNQ1 gene. Romano-Ward syndrome is inherited in an autosomal dominant fashion.
 

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Condition Specific Organizations

Following organizations serve the condition "Long QT syndrome 1" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Long QT syndrome 1" returned 32 free, full-text research articles on human participants. First 3 results:

MicroRNAs in cardiac arrhythmia: DNA sequence variation of MiR-1 and MiR-133A in long QT syndrome.
 

Author(s): Paula L Hedley, Anting L Carlsen, Kasper M Christiansen, Jørgen K Kanters, Elijah R Behr, Valerie A Corfield, Michael Christiansen

Journal: Scand. J. Clin. Lab. Invest.. 2014 Sep;74(6):485-91.

 

Long QT syndrome (LQTS) is a genetic cardiac condition associated with prolonged ventricular repolarization, primarily a result of perturbations in cardiac ion channels, which predisposes individuals to life-threatening arrhythmias. Using DNA screening and sequencing methods, over ...

Last Updated: 11 Sep 2014

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Multiscale complexity analysis of the cardiac control identifies asymptomatic and symptomatic patients in long QT syndrome type 1.
 

Author(s): Vlasta Bari, José F Valencia, Montserrat Vallverdú, Giulia Girardengo, Andrea Marchi, Tito Bassani, Pere Caminal, Sergio Cerutti, Alfred L George, Paul A Brink, Lia Crotti, Peter J Schwartz, Alberto Porta

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The study assesses complexity of the cardiac control directed to the sinus node and to ventricles in long QT syndrome type 1 (LQT1) patients with KCNQ1-A341V mutation. Complexity was assessed via refined multiscale entropy (RMSE) computed over the beat-to-beat variability series of ...

Last Updated: 7 Apr 2014

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The role of CAV3 in long-QT syndrome: clinical and functional assessment of a caveolin-3/Kv11.1 double heterozygote versus caveolin-3 single heterozygote.
 

Author(s): Paula L Hedley, Jørgen K Kanters, Maja Dembic, Thomas Jespersen, Lasse Skibsbye, Frederik H Aidt, Ole Eschen, Claus Graff, Elijah R Behr, Sarah Schlamowitz, Valerie Corfield, William J McKenna, Michael Christiansen

Journal: Circ Cardiovasc Genet. 2013 Oct;6(5):452-61.

 

Mutations in CAV3, coding for caveolin-3, the major constituent scaffolding protein of cardiac caveolae, have been associated with skeletal muscle disease, cardiomyopathy, and most recently long-QT syndrome (LQTS) and sudden infant death syndrome. We examined the occurrence of CAV3 ...

Last Updated: 16 Oct 2013

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Reviews from the PubMed Database

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The terms "Long QT syndrome 1" returned 0 free, full-text review articles on human participants.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Comparison Between Epinephrine and Exercise Test in QT Long Syndrome Patients
 

Status: Recruiting

Condition Summary: Long QT Syndrome Type 1 or 2

 

Last Updated: 23 May 2014

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Pharmacokinetics of GS-6615 in Adults With Normal and Impaired Renal Function
 

Status: Recruiting

Condition Summary: Long QT Syndrome

 

Last Updated: 11 Jun 2015

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Pharmacokinetics of GS-6615 in Adults With Normal and Impaired Hepatic Function
 

Status: Recruiting

Condition Summary: Long QT Syndrome

 

Last Updated: 9 Jun 2015

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