Li-Fraumeni syndrome 2

Common Name(s)

Li-Fraumeni syndrome 2

Description for this condition is not yet available.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Li-Fraumeni syndrome 2" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Li-Fraumeni syndrome 2" returned 1 free, full-text research articles on human participants. First 3 results:

Leukemic and non-leukemic lymphocytes from patients with Li Fraumeni syndrome demonstrate loss of p53 function, Bcl-2 family dysregulation and intrinsic resistance to conventional chemotherapeutic drugs but not flavopiridol.
 

Author(s): Chris Pepper, Alun Thomas, Terry Hoy, Jane Tighe, Dominic Culligan, Chris Fegan, Paul Bentley

Journal: Cell Cycle. ;2(1):53-8.

 

Li Fraumeni syndrome (LFS) is characterised by a predisposition to the early onset of certain tumors and is associated with germline mutation of the anti-oncogene p53. In this study we analysed the in vitro responses of lymphocytes from two LFS patients to chemotherapeutic drugs in ...

Last Updated: 15 Apr 2003

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Li-Fraumeni syndrome 2" returned 0 free, full-text review articles on human participants.

 
 
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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

p53 and Response to Preoperative Radiotherapy for T2 and T3
 

Status: Recruiting

Condition Summary: Rectal Cancer

 

Last Updated: 14 May 2014

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Clinical, Genetic, Behavioral, Laboratory and Epidemiologic Characterization of Individuals and Families at High Risk of Breast/Ovarian Cancer
 

Status: Recruiting

Condition Summary: Familial Ovarian Cancer; Familial Breast Cancer; BRCA1-associate Malignancies; BRCA2-associated Malignancies

 

Last Updated: 11 Nov 2014

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Study to Determine and Evaluate a Safe and Tolerated Dose of HDM201 in Patients With Selected Advanced Tumors That Are TP53wt
 

Status: Recruiting

Condition Summary: Advanced Solid and Hematological TP53wt Tumors

 

Last Updated: 16 Dec 2014

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