Lewy body dementia

Common Name(s)

Lewy body dementia

Lewy bodies dementia is one of the most common types of dementia. The central feature of this condition is progressive cognitive decline, combined with three additional defining features: (1) fluctuations in alertness and attention, such as frequent drowsiness, lethargy, lengthy periods of time spent staring into space, or disorganized speech; (2) recurrent visual hallucinations, and (3) parkinsonian motor symptoms, such as rigidity and the loss of spontaneous movement. Although the exact cause of this condition is unknown, symptoms result from the build-up of abnormal structures, called Lewy bodies, inside the brain. This condition usually occurs sporadically, in people with no known family history of the disease. However, rare familial cases have been reported.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Lewy body dementia" for support, advocacy or research.

Lewy Body Dementia Association

LBDA's Mission Through outreach, education and research, we support those affected by Lewy body dementias.

Last Updated: 20 Feb 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Lewy body dementia" for support, advocacy or research.

Lewy Body Dementia Association

LBDA's Mission Through outreach, education and research, we support those affected by Lewy body dementias.

http://www.lbda.org

Last Updated: 20 Feb 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Lewy body dementia" returned 45 free, full-text research articles on human participants. First 3 results:

Gene expression profiling of brain samples from patients with Lewy body dementia.
 

Author(s): Maciej Pietrzak, Audrey Papp, Amanda Curtis, Samuel K Handelman, Maria Kataki, Douglas W Scharre, Grzegorz Rempala, Wolfgang Sadee

Journal: Biochem. Biophys. Res. Commun.. 2016 Oct;479(4):875-880.

 

Dementia with Lewy Bodies (DLB) is the second most common neurodegenerative disorder in the elderly. The development and progression of DLB remain unclear. In this study we used next generation sequencing to assess RNA expression profiles and cellular processes associated with DLB ...

Last Updated: 31 Dec 1969

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Prevalence of Dementia With Lewy Body Symptoms: A Cross-Sectional Study in 40 Swedish Nursing Homes.
 

Author(s): Iris Zahirovic, Carina Wattmo, Gustav Torisson, Lennart Minthon, Elisabet Londos

Journal: J Am Med Dir Assoc. 2016 Aug;17(8):706-11.

 

To investigate and establish the prevalence of dementia with Lewy body (DLB) symptoms in all nursing home (NH) residents in Malmö, the third largest city in Sweden. DLB is a neurocognitive disorder with core features, such as parkinsonism, visual hallucinations, and fluctuating cognition/excessive ...

Last Updated: 31 Dec 1969

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GDF15/MIC1 and MMP9 Cerebrospinal Fluid Levels in Parkinson's Disease and Lewy Body Dementia.
 

Author(s): Walter Maetzler, Willy Deleersnijder, Valérie Hanssens, Alice Bernard, Kathrin Brockmann, Justus Marquetand, Isabel Wurster, Tim W Rattay, Lorenzo Roncoroni, Eva Schaeffer, Stefanie Lerche, Anja Apel, Christian Deuschle, Daniela Berg

Journal:

 

Based on animal and ex-vivo experiments, Growth/Differentiation Factor-15 (GDF15, also called Macrophage Inhibitory Cytokine-1, MIC1), a member of the transforming growth factor-beta family, and Matrix Metalloproteinase-9 (MMP9), a member of the matrix metalloprotease family may be ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Lewy body dementia" returned 9 free, full-text review articles on human participants. First 3 results:

Exercise for Individuals with Lewy Body Dementia: A Systematic Review.
 

Author(s): Michael Inskip, Yorgi Mavros, Perminder S Sachdev, Maria A Fiatarone Singh

Journal:

 

Individuals with Lewy body Dementia (LBD), which encompasses both Parkinson disease dementia (PDD) and Dementia with Lewy Bodies (DLB) experience functional decline through Parkinsonism and sedentariness exacerbated by motor, psychiatric and cognitive symptoms. Exercise may improve ...

Last Updated: 31 Dec 1969

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Lewy Body Dementias: Dementia With Lewy Bodies and Parkinson Disease Dementia.
 

Author(s): Stephen N Gomperts

Journal: Continuum (Minneap Minn). 2016 Apr;22(2 Dementia):435-63.

 

This article provides an overview of the clinical features, neuropathologic findings, diagnostic criteria, and management of dementia with Lewy bodies (DLB) and Parkinson disease dementia (PDD), together known as the Lewy body dementias.

Last Updated: 31 Dec 1969

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The possible involvement of mitochondrial dysfunctions in Lewy body dementia: a systematic review.
 

Author(s): Mariangela Spano, Maria Signorelli, Roberta Vitaliani, Eugenio Aguglia, Bruno Giometto

Journal: Funct. Neurol.. ;30(3):151-8.

 

The hallmark of dementia with Lewy bodies (DLB) is the “Lewy body”, an abnormal aggregation of alpha-synuclein found in some areas of the brain. The brain is the organ/system that is most vulnerable to this oxidative damage, and reactive oxygen species can cause neurodegenerative ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Effects of Nucleus Basalis of Meynert Stimulation on Cognitive Disorders in Dementia With Lewy Bodies
 

Status: Recruiting

Condition Summary: Dementia With Lewy Bodies

 

Last Updated: 6 Dec 2016

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Distinguishing Between Alzheimer's Disease, Lewy Body Dementia, and Parkinson's Disease
 

Status: Not yet recruiting

Condition Summary: Alzheimer's Disease; Lewy Body Dementia; Parkinson's Disease

 

Last Updated: 18 Sep 2017

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A Post-Marketing Clinical Study of Aricept in Patients With Dementia With Lewy Bodies (DLB)
 

Status: Recruiting

Condition Summary: Dementia, Lewy Body; Lewy Body Disease

 

Last Updated: 1 Dec 2016

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