Lewy body dementia

Common Name(s)

Lewy body dementia

Lewy bodies dementia is one of the most common types of dementia. The central feature of this condition is progressive cognitive decline, combined with three additional defining features: (1) fluctuations in alertness and attention, such as frequent drowsiness, lethargy, lengthy periods of time spent staring into space, or disorganized speech; (2) recurrent visual hallucinations, and (3) parkinsonian motor symptoms, such as rigidity and the loss of spontaneous movement. Although the exact cause of this condition is unknown, symptoms result from the build-up of abnormal structures, called Lewy bodies, inside the brain. This condition usually occurs sporadically, in people with no known family history of the disease. However, rare familial cases have been reported.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Lewy body dementia" for support, advocacy or research.

Lewy Body Dementia Association

LBDA's Mission Through outreach, education and research, we support those affected by Lewy body dementias.

Last Updated: 20 Feb 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Lewy body dementia" for support, advocacy or research.

Lewy Body Dementia Association

LBDA's Mission Through outreach, education and research, we support those affected by Lewy body dementias.

http://www.lbda.org

Last Updated: 20 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Lewy body dementia" returned 45 free, full-text research articles on human participants. First 3 results:

GDF15/MIC1 and MMP9 Cerebrospinal Fluid Levels in Parkinson's Disease and Lewy Body Dementia.
 

Author(s): Walter Maetzler, Willy Deleersnijder, Valérie Hanssens, Alice Bernard, Kathrin Brockmann, Justus Marquetand, Isabel Wurster, Tim W Rattay, Lorenzo Roncoroni, Eva Schaeffer, Stefanie Lerche, Anja Apel, Christian Deuschle, Daniela Berg

Journal:

 

Based on animal and ex-vivo experiments, Growth/Differentiation Factor-15 (GDF15, also called Macrophage Inhibitory Cytokine-1, MIC1), a member of the transforming growth factor-beta family, and Matrix Metalloproteinase-9 (MMP9), a member of the matrix metalloprotease family may be ...

Last Updated: 4 Mar 2016

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Neural correlates of attention-executive dysfunction in lewy body dementia and Alzheimer's disease.
 

Author(s): Michael Firbank, Xenia Kobeleva, George Cherry, Alison Killen, Peter Gallagher, David J Burn, Alan J Thomas, John T O'Brien, John-Paul Taylor

Journal: Hum Brain Mapp. 2016 Mar;37(3):1254-70.

 

Attentional and executive dysfunction contribute to cognitive impairment in both Lewy body dementia and Alzheimer's disease. Using functional MRI, we examined the neural correlates of three components of attention (alerting, orienting, and executive/conflict function) in 23 patients ...

Last Updated: 10 Feb 2016

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Effects of transcranial direct current stimulation upon attention and visuoperceptual function in Lewy body dementia: a preliminary study.
 

Author(s): Greg J Elder, Michael J Firbank, Hrishikesh Kumar, Payel Chatterjee, Titas Chakraborty, Alakananda Dutt, John-Paul Taylor

Journal: Int Psychogeriatr. 2016 Feb;28(2):341-7.

 

Individuals with Lewy body dementia (LBD) typically exhibit impairments in attentional and executive function. Current pharmacological treatments have limited efficacy, with associated side effects. Transcranial direct current stimulation (tDCS) may represent an alternative treatment, ...

Last Updated: 19 Jan 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Lewy body dementia" returned 7 free, full-text review articles on human participants. First 3 results:

The possible involvement of mitochondrial dysfunctions in Lewy body dementia: a systematic review.
 

Author(s): Mariangela Spano, Maria Signorelli, Roberta Vitaliani, Eugenio Aguglia, Bruno Giometto

Journal: Funct. Neurol.. ;30(3):151-8.

 

The hallmark of dementia with Lewy bodies (DLB) is the “Lewy body”, an abnormal aggregation of alpha-synuclein found in some areas of the brain. The brain is the organ/system that is most vulnerable to this oxidative damage, and reactive oxygen species can cause neurodegenerative ...

Last Updated: 4 Mar 2016

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Lewy body disease and dementia with Lewy bodies.
 

Author(s): Kenji Kosaka

Journal: Proc. Jpn. Acad., Ser. B, Phys. Biol. Sci.. 2014 ;90(8):301-6.

 

In 1976 we reported our first autopsied case with diffuse Lewy body disease (DLBD), the term of which we proposed in 1984. We also proposed the term "Lewy body disease" (LBD) in 1980. Subsequently, we classified LBD into three types according to the distribution pattern of Lewy bodies: ...

Last Updated: 14 Oct 2014

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Lewy body and parkinsonian dementia: common, but often misdiagnosed conditions.
 

Author(s): Brit Mollenhauer, Hans Förstl, Günther Deuschl, Alexander Storch, Wolfgang Oertel, Claudia Trenkwalder

Journal: Dtsch Arztebl Int. 2010 Oct;107(39):684-91.

 

Dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD) are the two most common types of dementing neurodegenerative disease after Alzheimer's disease (AD). Both of these conditions are often diagnosed late or not at all.

Last Updated: 21 Oct 2010

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Study Evaluating Nelotanserin for Treatment of Visual Hallucinations in Subjects With Lewy Body Dementia
 

Status: Recruiting

Condition Summary: Lewy Body Dementia; Visual Hallucinations

 

Last Updated: 7 Dec 2016

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Effects of Nucleus Basalis of Meynert Stimulation on Cognitive Disorders in Dementia With Lewy Bodies
 

Status: Recruiting

Condition Summary: Dementia With Lewy Bodies

 

Last Updated: 6 Dec 2016

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Study Evaluating Intepirdine (RVT-101) in Subjects With Dementia With Lewy Bodies: The HEADWAY-DLB Study
 

Status: Recruiting

Condition Summary: Dementia With Lewy Bodies

 

Last Updated: 1 Dec 2016

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