Leukocyte adhesion deficiency type 1

Common Name(s)

Leukocyte adhesion deficiency type 1

Leukocyte adhesion deficiency (LAD) is an autosomal recessive disorder of neutrophil function resulting from a deficiency of the beta-2 integrin subunit of the leukocyte cell adhesion molecule. The leukocyte cell adhesion molecule is present on the surface of peripheral blood mononuclear leukocytes and granulocytes and mediates cell-cell and cell-extracellular matrix adhesion. LAD is characterized by recurrent bacterial infections; impaired pus formation and wound healing; abnormalities of a wide variety of adhesion-dependent functions of granulocytes, monocytes, and lymphocytes; and a lack of beta-2/alpha-L, beta-2/alpha-M, and beta-2/alpha-X expression.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Leukocyte adhesion deficiency type 1" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Leukocyte adhesion deficiency type 1" returned 8 free, full-text research articles on human participants. First 3 results:

Successful treatment of Fusarium solani ecthyma gangrenosum in a patient affected by leukocyte adhesion deficiency type 1 with granulocytes transfusions.
 

Author(s): Fethi Mellouli, Habib Ksouri, Ridha Barbouche, Mongi Maamer, Leila Ben Hamed, Slama Hmida, Assia Ben Hassen, Mohamed BĂ©jaoui

Journal:

 

Ecthyma gangrenosum (EG) manifests as a skin lesion affecting patients suffering extreme neutropenia and is commonly associated with Pseudomonas aeruginosa in immunocompromised patients. Leukocyte adhesion deficiency I (LAD I) which count among primary immunodeficiency syndromes of ...

Last Updated: 19 Oct 2010

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Pyoderma gangrenosum after bone marrow transplantation for leukocyte adhesion deficiency type 1.
 

Author(s): Yigal Elenberg, Ayelet Shani-Adir, Yehuda Hecht, Moshe Ephros, Haim Bibi

Journal: Isr. Med. Assoc. J.. 2010 Feb;12(2):119-20.

 

Last Updated: 16 Jun 2010

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Osteomyelitis in leukocyte adhesion deficiency type 1 syndrome.
 

Author(s): Farahzad Jabbari Azad, Maryam Ardalan, Ali Hoseinpoor Rafati, Soheila Sotoudeh, Zahra Pourpak

Journal:

 

Leukocyte adhesion deficiency type 1 (LAD-1) is a rare, inherited immunodeficiency that affects one per million people yearly and usually presents with recurrent, indolent bacterial infections of the skin, mouth, and respiratory tract and impaired pus formation and wound healing. ...

Last Updated: 30 Mar 2010

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Reviews from the PubMed Database

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The terms "Leukocyte adhesion deficiency type 1" returned 0 free, full-text review articles on human participants.

 
 
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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Apheresis of Patients With Immunodeficiency
 

Status: Recruiting

Condition Summary: LAD-1; DOCK8; MonoMAC

 

Last Updated: 11 Nov 2014

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Unrelated Hematopoietic Stem Cell Transplantation(HSCT) for Genetic Diseases of Blood Cells
 

Status: Recruiting

Condition Summary: Sickle Cell Disease; Thalassemia; Anemia; Granuloma; Wiskott-Aldrich Syndrome; Chediak Higashi Syndrome; Osteopetrosis; Neutropenia; Thrombocytopenia; Hurler Disease; Niemann-Pick Disease; Fucosidosis

 

Last Updated: 22 Jun 2011

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