Kuru

Common Name(s)

Kuru, Kuru, susceptibility to

Kuru, a fatal neurodegenerative condition, is a human prion disease that primarily affected the Fore linguistic group of the Eastern Highlands of Papua New Guinea. Kuru was transmitted by the practice of consuming dead relatives as a mark of respect and mourning ('transumption'). The incidence has fallen dramatically since the cessation of cannibalism in the 1950s (summary by {16:Wadsworth et al., 2008}).
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Kuru" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Kuru" returned 60 free, full-text research articles on human participants. First 3 results:

Epidemiological mechanisms of genetic resistance to kuru.
 

Author(s): Katherine E Atkins, Jeffrey P Townsend, Jan Medlock, Alison P Galvani

Journal:

 

Transmissible spongiform encephalopathies (TSEs), such as kuru, are invariably fatal neurodegenerative conditions caused by a malformation of the prion protein. Heterozygosity of codon 129 of the prion protein gene has been associated with increased host resistance to TSEs, although ...

Last Updated: 6 Jun 2013

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Replication and spread of CJD, kuru and scrapie agents in vivo and in cell culture.
 

Author(s): Kohtaro Miyazawa, Kaitlin Emmerling, Laura Manuelidis

Journal: Virulence. ;2(3):188-99.

 

Transmissible Spongiform Encephalopathy (TSE) agents are defined by their virulence for particular species, their spread in the population, their incubation time to cause disease, and their neuropathological sequelae. Murine adapted human agents, including sporadic CJD (sCJD), New ...

Last Updated: 30 Jun 2011

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Kuru" returned 12 free, full-text review articles on human participants. First 3 results:

Kuru: genes, cannibals and neuropathology.
 

Author(s): Pawel P Liberski, Beata Sikorska, Shirley Lindenbaum, Lev G Goldfarb, Catriona McLean, Johannes A Hainfellner, Paul Brown

Journal: J. Neuropathol. Exp. Neurol.. 2012 Feb;71(2):92-103.

 

Kuru was the first human transmissible spongiform encephalopathy (TSE) or prion disease identified, occurring in the Fore linguistic group of Papua New Guinea. Kuru was a uniformly fatal cerebellar ataxic syndrome, usually followed by choreiform and athetoid movements. Kuru imposed ...

Last Updated: 19 Jan 2012

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Cannibalism, kuru and anthropology.
 

Author(s): Shirley Lindenbaum

Journal: Folia Neuropathol. 2009 ;47(2):138-44.

 

This essay discusses the image and practice of cannibalism in a wide range of studies. It also presents the anthropological research on kuru which led to the proposal that cannibalism had enabled transmission of the infectious agent, as well as doubts about the hypothesis, and the ...

Last Updated: 20 Jul 2009

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Kuru and D. Carleton Gajdusek: a close encounter.
 

Author(s): PaweĊ‚ P Liberski

Journal: Folia Neuropathol. 2009 ;47(2):114-37.

 

Kuru, the first human transmissible spongiform encephalopathy, was transmitted to chimpanzees by D. Carleton Gajdusek (1923-2008). In this review, I briefly summarize the history of this seminal discovery alongside its epidemiology, clinical picture, neuropathology and molecular genetics. ...

Last Updated: 20 Jul 2009

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

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