Kawasaki Disease

Common Name(s)

Kawasaki Disease, Acute febrile mucocutaneous lymph node syndrome, Kawasaki syndrome

Kawasaki disease, also known as mucocutaneous lymph node syndrome, is a serious condition that is characterized by the inflammation of the blood vessels in the body. The condition typically affects children under the age of five, primarily those of Asian and Pacific Island descent. However, the disease can also develop in individuals of different ages and ethnicities.

Symptoms of this condition generally come in stages. The early symptoms may include a high fever lasting more than five days, blood shot eyes, red cracked lips, swollen strawberry red colored tongue, and rashes on the chest and genital area. Later symptoms may include peeling of the skin on the hands and feet, joint pain, abdominal pain, diarrhea, and vomiting.

At this time, there is not an exact test to determine if someone is experiencing Kawasaki disease. After taking a health history, in addition to other tests to exclude other conditions, a doctor can make a formal diagnosis. Unfortunately, the official cause for this condition is unknown. The disease itself is usually manageable, but without treatment can cause very serious heart conditions for the affected individual. Therefore, if you or someone you know is experiencing the symptoms of Kawasaki disease, speak to your doctor immediately to discuss the most current treatment options.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Kawasaki Disease" for support, advocacy or research.

Kids with Heart National Association for Children's Heart Disorders

Our organization was formed in 1985 with the main mission of providing support, information, resources, and education for the families of the children living with congenital heart defects and to promote public awareness of the issues that these families live with on a day to day basis.

Last Updated: 4 May 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Kawasaki Disease" for support, advocacy or research.

Kids with Heart National Association for Children's Heart Disorders

Our organization was formed in 1985 with the main mission of providing support, information, resources, and education for the families of the children living with congenital heart defects and to promote public awareness of the issues that these families live with on a day to day basis.

http://www.kidswithheart.org

Last Updated: 4 May 2015

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Kawasaki Disease" returned 615 free, full-text research articles on human participants. First 3 results:

Descriptive epidemiology of Kawasaki disease in Japan, 2011-2012: from the results of the 22nd nationwide survey.
 

Author(s): Nobuko Makino, Yosikazu Nakamura, Mayumi Yashiro, Ryusuke Ae, Satoshi Tsuboi, Yasuko Aoyama, Takao Kojo, Ritei Uehara, Kazuhiko Kotani, Hiroshi Yanagawa

Journal: J Epidemiol. 2015 ;25(3):239-45.

 

The number of patients and incidence rate of Kawasaki disease (KD) are increasing in Japan. We have therefore characterized the latest epidemiological information on KD.

Last Updated: 11 Mar 2015

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Cardiac lesions and initial laboratory data in Kawasaki disease: a nationwide survey in Japan.
 

Author(s): Masanari Kuwabara, Mayumi Yashiro, Kazuhiko Kotani, Satoshi Tsuboi, Ryusuke Ae, Yosikazu Nakamura, Hiroshi Yanagawa, Tomisaku Kawasaki

Journal: J Epidemiol. 2015 ;25(3):189-93.

 

Cardiac lesions, such as coronary dilatation, aneurysms, narrowing, myocardial infarction, and valvular lesions, sometimes occur in Kawasaki disease, but most studies have only evaluated cardiac lesions in the later phase of the disease. This study was undertaken to clarify the related ...

Last Updated: 11 Mar 2015

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Hemophagocytic lymphohistiocytosis prior to the diagnosis of Kawasaki disease.
 

Author(s): Masato Ogawa, Takayuki Hoshina

Journal: Indian Pediatr. 2015 Jan;52(1):78.

 

Last Updated: 2 Feb 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Kawasaki Disease" returned 40 free, full-text review articles on human participants. First 3 results:

Management of Kawasaki disease.
 

Author(s): D Eleftheriou, M Levin, D Shingadia, R Tulloh, N J Klein, P A Brogan

Journal: Arch. Dis. Child.. 2014 Jan;99(1):74-83.

 

Kawasaki disease (KD) is an acute self-limiting inflammatory disorder, associated with vasculitis, affecting predominantly medium-sized arteries, particularly the coronary arteries. In developed countries KD is the commonest cause of acquired heart disease in childhood. The aetiology ...

Last Updated: 16 Dec 2013

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Kawasaki disease--the importance of prompt recognition and early referral.
 

Author(s): Daniel Golshevsky, Michael Cheung, David Burgner

Journal: Aust Fam Physician. 2013 Jul;42(7):473-6.

 

Kawasaki disease is an acute, febrile vasculitis of childhood that affects medium sized arteries, particularly the coronary arteries. Consequently, it is the leading cause of paediatric-acquired heart disease in developed countries. It is important to have a high index of suspicion ...

Last Updated: 4 Jul 2013

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Coronary artery sequel of Kawasaki disease in adulthood, a concern for internists and cardiologists.
 

Author(s): Anggoro B Hartopo, Budi Y Setianto

Journal: Acta Med Indones. 2013 Jan;45(1):69-75.

 

Young adults suffered from acute cardiac event, such as acute coronary syndrome, ischemic-associated arrhythmia and sudden death, are frequently encountered without known etiology and significant risk factors. Coronary vasculitis due to Kawasaki disease contributes to be a risk factor ...

Last Updated: 15 Apr 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Etanercept in Kawasaki Disease
 

Status: Recruiting

Condition Summary: Mucocutaneous Lymph Node Syndrome; Kawasaki Disease

 

Last Updated: 8 Apr 2015

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Anakinra and Kawasaki Disease
 

Status: Not yet recruiting

Condition Summary: Kawasaki Disease; Children

 

Last Updated: 11 Mar 2015

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Epidemiologic Features of Kawasaki Disease in Shanghai From 2008 Through 2012
 

Status: Recruiting

Condition Summary: Kawasaki Disease

 

Last Updated: 10 Mar 2015

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