Kawasaki Disease

Common Name(s)

Kawasaki Disease, Acute febrile mucocutaneous lymph node syndrome, Kawasaki syndrome

Kawasaki disease, also known as mucocutaneous lymph node syndrome, is a serious condition that is characterized by the inflammation of the blood vessels in the body. The condition typically affects children under the age of five, primarily those of Asian and Pacific Island descent. However, the disease can also develop in individuals of different ages and ethnicities.

Symptoms of this condition generally come in stages. The early symptoms may include a high fever lasting more than five days, blood shot eyes, red cracked lips, swollen strawberry red colored tongue, and rashes on the chest and genital area. Later symptoms may include peeling of the skin on the hands and feet, joint pain, abdominal pain, diarrhea, and vomiting.

At this time, there is not an exact test to determine if someone is experiencing Kawasaki disease. After taking a health history, in addition to other tests to exclude other conditions, a doctor can make a formal diagnosis. Unfortunately, the official cause for this condition is unknown. The disease itself is usually manageable, but without treatment can cause very serious heart conditions for the affected individual. Therefore, if you or someone you know is experiencing the symptoms of Kawasaki disease, speak to your doctor immediately to discuss the most current treatment options.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Kawasaki Disease" for support, advocacy or research.

Kids with Heart National Association for Children's Heart Disorders

Our organization was formed in 1985 with the main mission of providing support, information, resources, and education for the families of the children living with congenital heart defects and to promote public awareness of the issues that these families live with on a day to day basis.

Last Updated: 4 May 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Kawasaki Disease" for support, advocacy or research.

Kids with Heart National Association for Children's Heart Disorders

Our organization was formed in 1985 with the main mission of providing support, information, resources, and education for the families of the children living with congenital heart defects and to promote public awareness of the issues that these families live with on a day to day basis.

http://www.kidswithheart.org

Last Updated: 4 May 2015

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Kawasaki Disease" returned 687 free, full-text research articles on human participants. First 3 results:

[Association of FGF23 gene polymorphism with Kawasaki disease and coronary artery lesions].
 

Author(s): Ya-Nan Geng, Hong-Yan Zhang

Journal: Zhongguo Dang Dai Er Ke Za Zhi. 2015 Oct;17(10):1107-11.

 

To study the distribution of polymorphism of c.212-37insC (rs3832879) in intron 1 of fibroblast growth factor 23 (FGF23) gene and its association with Kawasaki disease (KD) and coronary artery lesions (CAL).

Last Updated: 20 Oct 2015

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Early Immunoglobulin Therapy and Outcomes in Kawasaki Disease: A Nationwide Cohort Study.
 

Author(s): Chi-Lin Ho, Yun-Ching Fu, Ming-Chih Lin, Sheng-Ling Jan

Journal: Medicine (Baltimore). 2015 Sep;94(39):e1544.

 

Kawasaki disease is the leading cause of acquired heart disease among children in most industrialized countries; however, only few descriptive studies have discussed the pros and cons of early immunoglobulin therapy. This study aimed to see the effect of early immunoglobulin therapy ...

Last Updated: 2 Oct 2015

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[Risk factors for coronary artery lesions secondary to Kawasaki disease in children].
 

Author(s): Yong-Chao Deng, Xun Wang, Xi-Chun Tang, Cai-Zhi Huang, Juan Yang, Li-Ya Mo

Journal: Zhongguo Dang Dai Er Ke Za Zhi. 2015 Sep;17(9):927-31.

 

To explore the risk factors for coronary artery lesions (CAL) secondary to Kawasaki disease (KD) in children.

Last Updated: 28 Sep 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Kawasaki Disease" returned 45 free, full-text review articles on human participants. First 3 results:

Usefulness of natriuretic peptide for the diagnosis of Kawasaki disease: a systematic review and meta-analysis.
 

Author(s): Kuan-Ho Lin, Shy-Shin Chang, Chin-Wei Yu, Shen-Che Lin, Shu-Chun Liu, Hsiao-Yun Chao, Meng-Tse Gabriel Lee, Jiunn-Yih Wu, Chien-Chang Lee

Journal:

 

To examine the diagnostic value of serum B-type natriuretic peptide (BNP) in acute Kawasaki disease (KD).

Last Updated: 15 Apr 2015

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Recurrent Kawasaki disease in a child with retropharyngeal involvement: a case report and literature review.
 

Author(s): Bilge Aldemir-Kocabaş, Mücahit Murat Kıcalı, Mehmet G Ramoğlu, Ercan Tutar, Suat Fitöz, Ergin Çiftçi, Erdal İnce

Journal: Medicine (Baltimore). 2014 Dec;93(29):e139.

 

Kawasaki disease (KD) is a multisystemic vasculitic disease. Recurrent KD is rare and generally presents in a similar clinical picture as the first episode, and early diagnosis with prompt treatment is the key point in preventing associated cardiovascular morbidities. A 9-year-old ...

Last Updated: 30 Dec 2014

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Management of Kawasaki disease.
 

Author(s): D Eleftheriou, M Levin, D Shingadia, R Tulloh, N J Klein, P A Brogan

Journal: Arch. Dis. Child.. 2014 Jan;99(1):74-83.

 

Kawasaki disease (KD) is an acute self-limiting inflammatory disorder, associated with vasculitis, affecting predominantly medium-sized arteries, particularly the coronary arteries. In developed countries KD is the commonest cause of acquired heart disease in childhood. The aetiology ...

Last Updated: 16 Dec 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Etanercept in Kawasaki Disease
 

Status: Recruiting

Condition Summary: Mucocutaneous Lymph Node Syndrome; Kawasaki Disease

 

Last Updated: 10 Dec 2015

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Anakinra and Kawasaki Disease
 

Status: Recruiting

Condition Summary: Kawasaki Disease; Children

 

Last Updated: 8 Dec 2015

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Different Doses of IVIG for Kawasaki Disease
 

Status: Recruiting

Condition Summary: Kawasaki Disease

 

Last Updated: 31 Jan 2016

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