Kawasaki Disease

Common Name(s)

Kawasaki Disease, Acute febrile mucocutaneous lymph node syndrome, Kawasaki syndrome

Kawasaki disease, also known as mucocutaneous lymph node syndrome, is a serious condition that is characterized by the inflammation of the blood vessels in the body. The condition typically affects children under the age of five, primarily those of Asian and Pacific Island descent. However, the disease can also develop in individuals of different ages and ethnicities.

Symptoms of this condition generally come in stages. The early symptoms may include a high fever lasting more than five days, blood shot eyes, red cracked lips, swollen strawberry red colored tongue, and rashes on the chest and genital area. Later symptoms may include peeling of the skin on the hands and feet, joint pain, abdominal pain, diarrhea, and vomiting.

At this time, there is not an exact test to determine if someone is experiencing Kawasaki disease. After taking a health history, in addition to other tests to exclude other conditions, a doctor can make a formal diagnosis. Unfortunately, the official cause for this condition is unknown. The disease itself is usually manageable, but without treatment can cause very serious heart conditions for the affected individual. Therefore, if you or someone you know is experiencing the symptoms of Kawasaki disease, speak to your doctor immediately to discuss the most current treatment options.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Kawasaki Disease" for support, advocacy or research.

Kids with Heart National Association for Children's Heart Disorders

Our organization was formed in 1985 with the main mission of providing support, information, resources, and education for the families of the children living with congenital heart defects and to promote public awareness of the issues that these families live with on a day to day basis.

Last Updated: 30 Oct 2012

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Kawasaki Disease" for support, advocacy or research.

Kids with Heart National Association for Children's Heart Disorders

Our organization was formed in 1985 with the main mission of providing support, information, resources, and education for the families of the children living with congenital heart defects and to promote public awareness of the issues that these families live with on a day to day basis.

http://www.kidswithheart.org

Last Updated: 30 Oct 2012

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Kawasaki Disease" returned 611 free, full-text research articles on human participants. First 3 results:

[Giant coronary artery aneurysm following Kawasaki disease in a child manifesting night waking as a main clinical symptom: a case report].
 

Author(s): Yun-Xia Liu, Yan-Yan Han, Shu Nie

Journal: Zhongguo Dang Dai Er Ke Za Zhi. 2014 Nov;16(11):1170-1.

 

Last Updated: 21 Nov 2014

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[Association between gene polymorphism of CD40 gene and coronary artery lesion in Kawasaki disease].
 

Author(s): Shou-Chao Cheng, Yan-Yang Cheng, Jin-Long Wu

Journal: Zhongguo Dang Dai Er Ke Za Zhi. 2014 Oct;16(10):1025-8.

 

To study the association between two single nucleotide polymorphisms (rs4810485 and rs1535045 in CD40 gene) and Kawasaki disease (KD) in Han Chinese children.

Last Updated: 25 Oct 2014

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Assessment of coronary artery intimal thickening in patients with a previous diagnosis of Kawasaki disease by using high resolution transthoracic echocardiography: our experience.
 

Author(s): Valentina Giacchi, Pietro Sciacca, Ileana Stella, Martina Filippelli, Patrizia Barone, Mario La Rosa, Salvatore Leonardi

Journal:

 

Kawasaki disease (KD) is a generalized systemic vasculitis of unknown etiology involving medium and small size blood vessels, particularly the coronary arteries. In these vessels a progressive stenosis may result from active remodeling with an intimal proliferation and neoangiogenesis. ...

Last Updated: 2 Sep 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Kawasaki Disease" returned 40 free, full-text review articles on human participants. First 3 results:

Management of Kawasaki disease.
 

Author(s): D Eleftheriou, M Levin, D Shingadia, R Tulloh, N J Klein, P A Brogan

Journal: Arch. Dis. Child.. 2014 Jan;99(1):74-83.

 

Kawasaki disease (KD) is an acute self-limiting inflammatory disorder, associated with vasculitis, affecting predominantly medium-sized arteries, particularly the coronary arteries. In developed countries KD is the commonest cause of acquired heart disease in childhood. The aetiology ...

Last Updated: 16 Dec 2013

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Kawasaki disease--the importance of prompt recognition and early referral.
 

Author(s): Daniel Golshevsky, Michael Cheung, David Burgner

Journal: Aust Fam Physician. 2013 Jul;42(7):473-6.

 

Kawasaki disease is an acute, febrile vasculitis of childhood that affects medium sized arteries, particularly the coronary arteries. Consequently, it is the leading cause of paediatric-acquired heart disease in developed countries. It is important to have a high index of suspicion ...

Last Updated: 4 Jul 2013

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Coronary artery sequel of Kawasaki disease in adulthood, a concern for internists and cardiologists.
 

Author(s): Anggoro B Hartopo, Budi Y Setianto

Journal: Acta Med Indones. 2013 Jan;45(1):69-75.

 

Young adults suffered from acute cardiac event, such as acute coronary syndrome, ischemic-associated arrhythmia and sudden death, are frequently encountered without known etiology and significant risk factors. Coronary vasculitis due to Kawasaki disease contributes to be a risk factor ...

Last Updated: 15 Apr 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Etanercept in Kawasaki Disease
 

Status: Recruiting

Condition Summary: Mucocutaneous Lymph Node Syndrome; Kawasaki Disease

 

Last Updated: 8 Apr 2015

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Anakinra and Kawasaki Disease
 

Status: Not yet recruiting

Condition Summary: Kawasaki Disease; Children

 

Last Updated: 11 Mar 2015

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Epidemiologic Features of Kawasaki Disease in Shanghai From 2008 Through 2012
 

Status: Recruiting

Condition Summary: Kawasaki Disease

 

Last Updated: 10 Mar 2015

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