Kawasaki Disease

Common Name(s)

Kawasaki Disease, Acute febrile mucocutaneous lymph node syndrome, Kawasaki syndrome

Kawasaki disease, also known as mucocutaneous lymph node syndrome, is a serious condition that is characterized by the inflammation of the blood vessels in the body. The condition typically affects children under the age of five, primarily those of Asian and Pacific Island descent. However, the disease can also develop in individuals of different ages and ethnicities.

Symptoms of this condition generally come in stages. The early symptoms may include a high fever lasting more than five days, blood shot eyes, red cracked lips, swollen strawberry red colored tongue, and rashes on the chest and genital area. Later symptoms may include peeling of the skin on the hands and feet, joint pain, abdominal pain, diarrhea, and vomiting.

At this time, there is not an exact test to determine if someone is experiencing Kawasaki disease. After taking a health history, in addition to other tests to exclude other conditions, a doctor can make a formal diagnosis. Unfortunately, the official cause for this condition is unknown. The disease itself is usually manageable, but without treatment can cause very serious heart conditions for the affected individual. Therefore, if you or someone you know is experiencing the symptoms of Kawasaki disease, speak to your doctor immediately to discuss the most current treatment options.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Kawasaki Disease" for support, advocacy or research.

Kids with Heart National Association for Children's Heart Disorders

Our organization was formed in 1985 with the main mission of providing support, information, resources, and education for the families of the children living with congenital heart defects and to promote public awareness of the issues that these families live with on a day to day basis.

Last Updated: 4 May 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Kawasaki Disease" for support, advocacy or research.

Kids with Heart National Association for Children's Heart Disorders

Our organization was formed in 1985 with the main mission of providing support, information, resources, and education for the families of the children living with congenital heart defects and to promote public awareness of the issues that these families live with on a day to day basis.

http://www.kidswithheart.org

Last Updated: 4 May 2015

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Kawasaki Disease" returned 723 free, full-text research articles on human participants. First 3 results:

[Association of TIAM1 gene polymorphisms with Kawasaki disease and its clinical characteristics].
 

Author(s): Xian Wang, Tian-Jiao Zhu, Xiong-Fei Zhou, Zhi-Ting Wan

Journal: Zhongguo Dang Dai Er Ke Za Zhi. 2015 Nov;17(11):1217-20.

 

To investigate the association of single nucleotide polymorphisms (SNP) rs22833188 and rs2833195 in TIAM1 gene with the susceptibility to Kawasaki disease (KD) and its clinical characteristic in children.

Last Updated: 20 Nov 2015

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Coronary ostial dilatation after Kawasaki disease.
 

Author(s): Milad El-Segaier, M O Galal

Journal: Acta Cardiol. 2015 Oct;70(5):605-6.

 

Last Updated: 16 Nov 2015

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[Association of FGF23 gene polymorphism with Kawasaki disease and coronary artery lesions].
 

Author(s): Ya-Nan Geng, Hong-Yan Zhang

Journal: Zhongguo Dang Dai Er Ke Za Zhi. 2015 Oct;17(10):1107-11.

 

To study the distribution of polymorphism of c.212-37insC (rs3832879) in intron 1 of fibroblast growth factor 23 (FGF23) gene and its association with Kawasaki disease (KD) and coronary artery lesions (CAL).

Last Updated: 20 Oct 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Kawasaki Disease" returned 49 free, full-text review articles on human participants. First 3 results:

[Renal artery injury caused by Kawasaki disease].
 

Author(s): Zhi-Jian Wang, Mei-Hua Zhu, Li Zhang, Jun-Chu Chen, Li-Ling Zhu, Min Liang, Yun Peng

Journal: Zhongguo Dang Dai Er Ke Za Zhi. 2016 Jan;18(1):29-33.

 

To investigate renal artery injury caused by Kawasaki disease (KD).

Last Updated: 19 Jan 2016

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Peripheral Endothelial (Dys)Function, Arterial Stiffness and Carotid Intima-Media Thickness in Patients after Kawasaki Disease: A Systematic Review and Meta-Analyses.
 

Author(s): Sanne M Dietz, Carline E A Tacke, Barbara A Hutten, Taco W Kuijpers

Journal:

 

Kawasaki disease (KD) is a systemic pediatric vasculitis. Its main complication is the development of coronary arterial aneurysms (CAA), causing an increased risk for ischemia and myocardial infarction. It is unclear whether KD patients, apart from the presence of CAA, have an increased ...

Last Updated: 11 Jul 2015

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A Case of Complete Adult-Onset Kawasaki Disease: A Review of Pathogenesis and Classification.
 

Author(s): Francesco Drago, Sanja Javor, Giulia Ciccarese, Emanuele Cozzani, Aurora Parodi

Journal: Dermatology (Basel). 2015 ;231(1):5-8.

 

Kawasaki disease (KD) is an acute systemic vasculitis that occurs primarily in children and rarely in adults, possibly after bacterial or viral infections in genetically susceptible hosts. KD may frequently be undiagnosed especially in adult patients without the presence of all the ...

Last Updated: 26 Jun 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Etanercept in Kawasaki Disease
 

Status: Recruiting

Condition Summary: Mucocutaneous Lymph Node Syndrome; Kawasaki Disease

 

Last Updated: 10 Dec 2015

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Anakinra and Kawasaki Disease
 

Status: Recruiting

Condition Summary: Kawasaki Disease; Children

 

Last Updated: 8 Dec 2015

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Different Doses of IVIG for Kawasaki Disease
 

Status: Recruiting

Condition Summary: Kawasaki Disease

 

Last Updated: 31 Jan 2016

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