Kartagener syndrome

Common Name(s)

Kartagener syndrome, Dextrocardia-Bronchiectasis-Sinusitis

Kartagener syndrome is a type of primary ciliary dyskinesia that is also characterized by situs inversus totalis (mirror-image reversal of internal organs). The signs and symptoms vary but may include neonatal respiratory distress; frequent lung, sinus and middle ear infections beginning in early childhood; and infertility. It can be cause by changes (mutations) in many different genes that are inherited in an autosomal recessive manner. Although scientists have identified many of the genes associated with Kartagener syndrome, the genetic cause of some cases is unknown. There is no cure for Kartagener syndrome. Treatment varies based on the signs and symptoms present in each person but may include airway clearance therapy and antibiotics.
 

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Condition Specific Organizations

Following organizations serve the condition "Kartagener syndrome" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Kartagener syndrome" returned 13 free, full-text research articles on human participants. First 3 results:

[Kartagener syndrome: management and prognosis].
 

Author(s): Soumaya Ben Saad, Sonia Maâlej, Samira Aouadi, Asma Zidi, Ali Ben Kheder, Ikram Drira

Journal: Tunis Med. 2014 Apr;92(4):293-5.

 

Last Updated: 16 Sep 2014

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Primary ciliary dyskinesia diagnosed by electron microscopy in one case of Kartagener syndrome.
 

Author(s): Aniela Luminiţa Rugină, Alexandru Grigore Dimitriu, Nicolai Nistor, Doina Mihăilă

Journal: Rom J Morphol Embryol. 2014 ;55(2 Suppl):697-701.

 

Primary ciliary dyskinesia (PCD) is associated with abnormalities in the structure of a function of motile cilia, causing impairment of muco-ciliary clearence, with bacterial overinfection of the upper and lower respiratory tract (chronic oto-sino-pulmonary disease), heterotaxia (situs ...

Last Updated: 2 Sep 2014

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Re: Kartagener syndrome with focal segmental glomerulosclerosis.
 

Author(s): Mohammad-Reza Ardalan, Hamid Nasri

Journal: Iran J Kidney Dis. 2014 Jul;8(4):348-9.

 

Last Updated: 8 Jul 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Kartagener syndrome" returned 2 free, full-text review articles on human participants. First 3 results:

Coronary artery bypass surgery in a patient with Kartagener syndrome: a case report and literature review.
 

Author(s): Ioannis Bougioukas, Dimitrios Mikroulis, Bernhard Danner, Lukman Lawal, Savvas Eleftheriadis, George Bougioukas, Vassilios Didilis

Journal:

 

Kartagener syndrome consists of congenital bronchiectasis, sinusitis, and total situs inversus in half of the patients. A patient diagnosed with Kartagener syndrome was referred to our department due to 3-vessel coronary disease. An off-pump coronary artery bypass operation was performed ...

Last Updated: 17 Sep 2010

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Clinical and genetic aspects of primary ciliary dyskinesia/Kartagener syndrome.
 

Author(s): Margaret W Leigh, Jessica E Pittman, Johnny L Carson, Thomas W Ferkol, Sharon D Dell, Stephanie D Davis, Michael R Knowles, Maimoona A Zariwala

Journal: Genet. Med.. 2009 Jul;11(7):473-87.

 

Primary ciliary dyskinesia is a genetically heterogeneous disorder of motile cilia. Most of the disease-causing mutations identified to date involve the heavy (dynein axonemal heavy chain 5) or intermediate(dynein axonemal intermediate chain 1) chain dynein genes in ciliary outer ...

Last Updated: 15 Jul 2009

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Genetics of Primary Ciliary Dyskinesia
 

Status: Recruiting

Condition Summary: Primary Ciliary Dyskinesia; Kartagener Syndrome

 

Last Updated: 7 Apr 2015

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Pathogenesis of Primary Ciliary Dyskinesia (PCD) Lung Disease
 

Status: Recruiting

Condition Summary: Kartagener Syndrome

 

Last Updated: 17 Dec 2014

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Otolith Function in Patients With Primary Ciliary Dyskinesia
 

Status: Recruiting

Condition Summary: Primary Ciliary Dyskinesia

 

Last Updated: 14 Aug 2013

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