Juvenile myoclonic epilepsy

Common Name(s)

Juvenile myoclonic epilepsy

Juvenile myoclonic epilepsy is an epilepsy syndrome characterized by myoclonic jerks (quick jerks of the arms or legs), generalized tonic-clonic seizures (GTCSs), and sometimes, absence seizures.  The seizures of juvenile myoclonic epilepsy often occur when people first awaken in the morning, especially if they are sleep-deprived. Drinking alcohol and psychological stress may also make these seizures more likely.  Onset typically occurs around adolesence in otherwise healthy children.  The exact cause of juvenile myoclonic epilepsy remains unknown.  Although patients usually require lifelong treatment with anticonvulsants, their overall prognosis is generally good.


 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Juvenile myoclonic epilepsy" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Juvenile myoclonic epilepsy" returned 136 free, full-text research articles on human participants. First 3 results:

Lack of association between the prothrombin rs1799963 polymorphism and juvenile myoclonic epilepsy.
 

Author(s): João Paulo Lopes Born, Bruna Priscila dos Santos, Rodrigo Secolin, Fernando Tenório Gameleira, Tiago Gomes de Andrade, Luciana Cláudia Herculano Machado, Lívia Leite Góes Gitaí, Daniel Leite Góes Gitaí

Journal: Arq Neuropsiquiatr. 2015 Apr;73(4):289-92.

 

Juvenile myoclonic epilepsy (JME) accounts for 26% of generalized idiopathic epileptic syndromes. The highest levels of thrombin activity are closely involved in the development of neurological diseases, including epilepsy. The prothrombin c.20210G>A (rs1799963) variation, which alters ...

Last Updated: 21 May 2015

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Novel carboxypeptidase A6 (CPA6) mutations identified in patients with juvenile myoclonic and generalized epilepsy.
 

Author(s): Matthew R Sapio, Monique Vessaz, Pierre Thomas, Pierre Genton, Lloyd D Fricker, Annick Salzmann

Journal:

 

Carboxypeptidase A6 (CPA6) is a peptidase that removes C-terminal hydrophobic amino acids from peptides and proteins. The CPA6 gene is expressed in the brains of humans and animals, with high levels of expression during development. It is translated with a prodomain (as proCPA6), ...

Last Updated: 16 Apr 2015

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Fronto-insula network activity explains emotional dysfunctions in juvenile myoclonic epilepsy: combined evidence from pupillometry and fMRI.
 

Author(s): Frieder Michel Paulus, Sören Krach, Marius Blanke, Christine Roth, Marcus Belke, Jens Sommer, Laura Müller-Pinzler, Katja Menzler, Andreas Jansen, Felix Rosenow, Frank Bremmer, Wolfgang Einhäuser, Susanne Knake

Journal: Cortex. 2015 Apr;65():219-31.

 

Emotional instability, difficulties in social adjustment, and disinhibited behavior are the most common symptoms of the psychiatric comorbidities in juvenile myoclonic epilepsy (JME). This psychopathology has been associated with dysfunctions of mesial-frontal brain circuits. The ...

Last Updated: 3 Apr 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Juvenile myoclonic epilepsy" returned 8 free, full-text review articles on human participants. First 3 results:

Transition issues for benign epilepsy with centrotemporal spikes, nonlesional focal epilepsy in otherwise normal children, childhood absence epilepsy, and juvenile myoclonic epilepsy.
 

Author(s): Carol S Camfield, Anne Berg, Ulrich Stephani, Elaine C Wirrell

Journal: Epilepsia. 2014 Aug;55 Suppl 3():16-20.

 

This chapter covers the syndromes of benign epilepsy with centrotemporal spikes (BECTS), nonlesional focal epilepsy in otherwise normal children (NLFN), and the genetic generalized epilepsies. BECTS is an epilepsy syndrome that always enters terminal remission before the general age ...

Last Updated: 11 Sep 2014

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Frontal lobe function and structure in juvenile myoclonic epilepsy: a comprehensive review of neuropsychological and imaging data.
 

Author(s): Britta Wandschneider, Pamela J Thompson, Christian Vollmar, Matthias J Koepp

Journal: Epilepsia. 2012 Dec;53(12):2091-8.

 

Juvenile myoclonic epilepsy is the most common idiopathic epilepsy syndrome and is considered a benign seizure disorder that responds well to antiepileptic drug treatment, in particular sodium valproate. By definition, routine brain imaging shows no abnormalities, but advanced imaging ...

Last Updated: 4 Dec 2012

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[Juvenile myoclonic epilepsy].
 

Author(s): Marte Roa Syvertsen, Rune Markhus, Kaja Kristine Selmer, Karl O Nakken

Journal: Tidsskr. Nor. Laegeforen.. 2012 Aug;132(14):1610-3.

 

Juvenile myoclonic epilepsy (JME) is a generalised epilepsy with seizure onset in youth. The aim of this review is to present updated knowledge about the etiology, diagnosis and treatment of JME.

Last Updated: 9 Aug 2012

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Physical Exercise in Subjects With Juvenile Myoclonic Epilepsy
 

Status: Recruiting

Condition Summary: Epilepsy; Epilepsia; Epileptic Seizures; Seizure Disorder

 

Last Updated: 9 Oct 2011

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