Inflammatory bowel disease

Common Name(s)

Inflammatory bowel disease, IBD

Inflammatory bowel disease (IBD) is the chronic redness and swelling (inflammation) of all or part of the digestive tract, which includes the esophagus, stomach, small intestine, and large intestine. The exact cause of the inflammation in IBD is not known, but a person’s immune system and genetic makeup are both thought to play a role. Risk factors for developing IBD includes older age, Caucasian (white) ethnic background, cigarette smoking, and using certain medications.

The two main types of IBD are ulcerative colitis and Crohn’s disease. Ulcerative colitis is a condition that causes inflammation and sores (ulcers) on the inside lining of the large intestine. Crohn’s disease causes inflammation that spreads deep into the affected tissue and usually affects the large intestine, the small intestine, or both. Symptoms of IBD vary and depend on the location and severity of the inflammation. Symptoms may include diarrhea, fever and fatigue, abdominal pain and cramping, blood in the stool, reduced appetite, and unintended weight loss.

To diagnose IBD, a physician will first rule out other possible causes of the symptoms. To confirm a diagnosis of IBD, your doctor may order a blood test to look for low red blood cells (anemia), a procedure that uses a small camera to examines your digestive tract for signs of IBD (endoscopy or colonoscopy), and imaging tests (X-rays, CT, or MRI) to look for evidence of IBD. Treatment includes the use of medications that reduces the immune system’s response and decreases the inflammation in the digestive tract. In severe cases, surgery may be needed. Although this condition is serious, affected individuals can live a normal life with proper treatment and care. If you or your child has been diagnosed with IBD, talk with your doctor about the current treatment options.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Inflammatory bowel disease" for support, advocacy or research.

Crohn's & Colitis Foundation of America, Inc.

CCFA's mission is to cure Crohn's disease and ulcerative colitis and to improve the quality of life of children and adults affected by these diseases.

Last Updated: 8 Apr 2014

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Inflammatory bowel disease" for support, advocacy or research.

Crohn's & Colitis Foundation of America, Inc.

CCFA's mission is to cure Crohn's disease and ulcerative colitis and to improve the quality of life of children and adults affected by these diseases.

http://www.ccfa.org

Last Updated: 8 Apr 2014

View Details

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Inflammatory bowel disease" returned 2018 free, full-text research articles on human participants. First 3 results:

The Specific Carbohydrate Diet for Inflammatory Bowel Disease: A Case Series.
 

Author(s): Samir Kakodkar, Azam J Farooqui, Sue L Mikolaitis, Ece A Mutlu

Journal: J Acad Nutr Diet. 2015 Aug;115(8):1226-32.

 

Last Updated: 27 Jul 2015

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Cancers Complicating Inflammatory Bowel Disease.
 

Author(s): Laurent Beaugerie, Steven H Itzkowitz

Journal: N. Engl. J. Med.. 2015 Jul;373(2):195.

 

Last Updated: 9 Jul 2015

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Diagnosis of Iron Deficiency in Inflammatory Bowel Disease by Transferrin Receptor-Ferritin Index.
 

Author(s): Vered Abitbol, Didier Borderie, Vanessa Polin, Fanny Maksimovic, Gilles Sarfati, Anouk Esch, Tessa Tabouret, Marion Dhooge, Johann Dreanic, Geraldine Perkins, Romain Coriat, Stanislas Chaussade

Journal: Medicine (Baltimore). 2015 Jul;94(26):e1011.

 

Iron deficiency is common in patients with inflammatory bowel disease (IBD), but can be difficult to diagnose in the presence of inflammation because ferritin is an acute phase reactant. The transferrin receptor-ferritin index (TfR-F) has a high sensitivity and specificity for iron ...

Last Updated: 3 Jul 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Inflammatory bowel disease" returned 735 free, full-text review articles on human participants. First 3 results:

Management of Iron-Deficiency Anemia in Inflammatory Bowel Disease: A Systematic Review.
 

Author(s): Ole Haagen Nielsen, Mark Ainsworth, Mehmet Coskun, Günter Weiss

Journal: Medicine (Baltimore). 2015 Jun;94(23):e963.

 

Anemia is the most frequent complication of inflammatory bowel disease (IBD), but anemia, mostly due to iron deficiency, has long been neglected in these patients. The aim was to briefly present the pathophysiology, followed by a balanced overview of the different forms of iron replacement ...

Last Updated: 11 Jun 2015

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Surgical strategies in paediatric inflammatory bowel disease.
 

Author(s): Colin T Baillie, Jennifer A Smith

Journal: World J. Gastroenterol.. 2015 May;21(20):6101-16.

 

Inflammatory bowel disease (IBD) comprises two distinct but related chronic relapsing inflammatory conditions affecting different parts of the gastrointestinal tract. Crohn's disease is characterised by a patchy transmural inflammation affecting both small and large bowel segments ...

Last Updated: 2 Jun 2015

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Relationship Between Cytomegalovirus Infection and Steroid Resistance in Inflammatory Bowel Disease: A Meta-Analysis.
 

Author(s): Xiao-wei Wu, Lin Wu, Hong-zan Ji, Fang-yu Wang

Journal: Dig. Dis. Sci.. 2015 Nov;60(11):3203-8.

 

Steroid resistance presents an administration difficulty in inflammatory bowel disease (IBD). The reason of steroid resistance is still unclear, but cytomegalovirus (CMV) infection may be a potential cause in some IBD patients. We carried out a meta-analysis to investigate the relationship ...

Last Updated: 27 Oct 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Gene Expression in Inflammatory Bowel Disease
 

Status: Recruiting

Condition Summary: Inflammatory Bowel Disease

 

Last Updated: 6 Jul 2011

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Multi-Center African-American Inflammatory Bowel Disease Study (MAAIS): The Search for New Genes
 

Status: Recruiting

Condition Summary: Inflammatory Bowel Disease

 

Last Updated: 6 Jul 2011

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Standardized Fecal Microbiota Transplantation for Inflammatory Bowel Disease
 

Status: Recruiting

Condition Summary: Inflammatory Bowel Disease; Ulcerative Colitis; Crohn's Disease

 

Last Updated: 8 Jan 2015

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