Inflammatory bowel disease

Common Name(s)

Inflammatory bowel disease, IBD

Inflammatory bowel disease (IBD) is the chronic redness and swelling (inflammation) of all or part of the digestive tract, which includes the esophagus, stomach, small intestine, and large intestine. The exact cause of the inflammation in IBD is not known, but a person’s immune system and genetic makeup are both thought to play a role. Risk factors for developing IBD includes older age, Caucasian (white) ethnic background, cigarette smoking, and using certain medications.

The two main types of IBD are ulcerative colitis and Crohn’s disease. Ulcerative colitis is a condition that causes inflammation and sores (ulcers) on the inside lining of the large intestine. Crohn’s disease causes inflammation that spreads deep into the affected tissue and usually affects the large intestine, the small intestine, or both. Symptoms of IBD vary and depend on the location and severity of the inflammation. Symptoms may include diarrhea, fever and fatigue, abdominal pain and cramping, blood in the stool, reduced appetite, and unintended weight loss.

To diagnose IBD, a physician will first rule out other possible causes of the symptoms. To confirm a diagnosis of IBD, your doctor may order a blood test to look for low red blood cells (anemia), a procedure that uses a small camera to examines your digestive tract for signs of IBD (endoscopy or colonoscopy), and imaging tests (X-rays, CT, or MRI) to look for evidence of IBD. Treatment includes the use of medications that reduces the immune system’s response and decreases the inflammation in the digestive tract. In severe cases, surgery may be needed. Although this condition is serious, affected individuals can live a normal life with proper treatment and care. If you or your child has been diagnosed with IBD, talk with your doctor about the current treatment options.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Inflammatory bowel disease" for support, advocacy or research.

Crohn's & Colitis Foundation of America, Inc.

CCFA's mission is to cure Crohn's disease and ulcerative colitis and to improve the quality of life of children and adults affected by these diseases.

Last Updated: 8 Apr 2014

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Inflammatory bowel disease" for support, advocacy or research.

Crohn's & Colitis Foundation of America, Inc.

CCFA's mission is to cure Crohn's disease and ulcerative colitis and to improve the quality of life of children and adults affected by these diseases.

http://www.ccfa.org

Last Updated: 8 Apr 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Inflammatory bowel disease" returned 2228 free, full-text research articles on human participants. First 3 results:

Public versus Private Drug Insurance and Outcomes of Patients Requiring Biologic Therapies for Inflammatory Bowel Disease.
 

Author(s): Amir Rumman, Roberto Candia, Justina J Sam, Kenneth Croitoru, Mark S Silverberg, A Hillary Steinhart, Geoffrey C Nguyen

Journal: Can J Gastroenterol Hepatol. 2017 ;2017():7365937.

 

Background. Antitumor necrosis factor (anti-TNF) therapy is a highly effective but costly treatment for inflammatory bowel disease (IBD). Methods. We conducted a retrospective cohort study of IBD patients who were prescribed anti-TNF therapy (2007-2014) in Ontario. We assessed if ...

Last Updated: 27 Feb 2017

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Cytomegalovirus colitis in hospitalized inflammatory bowel disease patients in Taiwan: a referral center study.
 

Author(s): Meng-Tzu Weng, Chien-Chih Tung, Yi-Shuan Lee, Yew-Loong Leong, Ming-Jium Shieh, Chia-Tung Shun, Cheng-Yi Wang, Jau-Min Wong, Shu-Chen Wei

Journal:

 

Colitis is exacerbated in patients with concurrent cytomegalovirus (CMV) infection and inflammatory bowel disease (IBD). We assessed the prevalence and clinical features of CMV colitis in hospitalized IBD patients.

Last Updated: 14 Feb 2017

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Anti-TNF-Mediated Modulation of Prohepcidin Improves Iron Availability in Inflammatory Bowel Disease, in an IL-6-Mediated Fashion.
 

Author(s): Flaminia Cavallaro, Lorena Duca, Laura Francesca Pisani, Roberta Rigolini, Luisa Spina, Gian Eugenio Tontini, Nadia Munizio, Elena Costa, Maria Domenica Cappellini, Maurizio Vecchi, Luca Pastorelli

Journal: Can J Gastroenterol Hepatol. 2017 ;2017():6843976.

 

Background. Anaemia is common in inflammatory bowel disease (IBD), frequently resulting from a combination of iron deficiency and of anaemia of chronic disease (ACD). ACD is characterized by macrophage iron retention induced by proinflammatory cytokines. Hepcidin is the master inducer ...

Last Updated: 13 Feb 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Inflammatory bowel disease" returned 860 free, full-text review articles on human participants. First 3 results:

Aseptic Abscesses and Inflammatory Bowel Disease: Two Cases and Review of Literature.
 

Author(s): Natasha Bollegala, Rishad Khan, Michael A Scaffidi, Ahmed Al-Mazroui, Jenna Tessolini, Adrienne Showler, Errol Colak, Samir C Grover

Journal: Can J Gastroenterol Hepatol. 2017 ;2017():5124354.

 

Background. Aseptic abscesses (AA) are sterile lesions that represent an extraintestinal manifestation (EIM) of inflammatory bowel disease (IBD). Though Canada has the highest prevalence of IBD in the world, reports of IBD-associated AA are absent in Canada. This may represent a different ...

Last Updated: 7 Mar 2017

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Functional relevance of intestinal epithelial cells in inflammatory bowel disease.
 

Author(s): Ryuichi Okamoto, Mamoru Watanabe

Journal: Nihon Rinsho Meneki Gakkai Kaishi. 2016 ;39(6):522-527.

 

  The intestinal epithelium constitutes a physical barrier between inner and outer side of our body. It also functions as a "hub" which connects factors that determine the development of inflammatory bowel disease, such as microbiota, susceptibility genes, and host immune response. ...

Last Updated: 4 Jan 2017

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Smoking influences the need for surgery in patients with the inflammatory bowel diseases: a systematic review and meta-analysis incorporating disease duration.
 

Author(s): M Ellen Kuenzig, Sang Min Lee, Bertus Eksteen, Cynthia H Seow, Cheryl Barnabe, Remo Panaccione, Gilaad G Kaplan

Journal:

 

Studies examining the association between smoking and the need for surgery in patients with Crohn's disease and ulcerative colitis have reached inconsistent conclusions. These studies often do not differentiate between patients undergoing early surgery and patients having surgery ...

Last Updated: 22 Dec 2016

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Inflammatory Bowel Disease Registry in Daegu-Gyeongbuk
 

Status: Recruiting

Condition Summary: Idiopathic Chronic Inflammatory Bowel Disease

 

Last Updated: 23 Jul 2016

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A Study on the Effectiveness of a Nutritional Supplement With Natural Mastiha in Inflammatory Bowel Diseases.
 

Status: Recruiting

Condition Summary: Inflammatory Bowel Diseases

 

Last Updated: 24 Mar 2017

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Safety and Tolerability Of Allogeneic Mesenchymal Stromal Cells in Pediatric Inflammatory Bowel Disease
 

Status: Recruiting

Condition Summary: Inflammatory Bowel Diseases

 

Last Updated: 19 Oct 2016

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