Inflammatory bowel disease

Common Name(s)

Inflammatory bowel disease, IBD

Inflammatory bowel disease (IBD) is the chronic redness and swelling (inflammation) of all or part of the digestive tract, which includes the esophagus, stomach, small intestine, and large intestine. The exact cause of the inflammation in IBD is not known, but a person’s immune system and genetic makeup are both thought to play a role. Risk factors for developing IBD includes older age, Caucasian (white) ethnic background, cigarette smoking, and using certain medications.

The two main types of IBD are ulcerative colitis and Crohn’s disease. Ulcerative colitis is a condition that causes inflammation and sores (ulcers) on the inside lining of the large intestine. Crohn’s disease causes inflammation that spreads deep into the affected tissue and usually affects the large intestine, the small intestine, or both. Symptoms of IBD vary and depend on the location and severity of the inflammation. Symptoms may include diarrhea, fever and fatigue, abdominal pain and cramping, blood in the stool, reduced appetite, and unintended weight loss.

To diagnose IBD, a physician will first rule out other possible causes of the symptoms. To confirm a diagnosis of IBD, your doctor may order a blood test to look for low red blood cells (anemia), a procedure that uses a small camera to examines your digestive tract for signs of IBD (endoscopy or colonoscopy), and imaging tests (X-rays, CT, or MRI) to look for evidence of IBD. Treatment includes the use of medications that reduces the immune system’s response and decreases the inflammation in the digestive tract. In severe cases, surgery may be needed. Although this condition is serious, affected individuals can live a normal life with proper treatment and care. If you or your child has been diagnosed with IBD, talk with your doctor about the current treatment options.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Inflammatory bowel disease" for support, advocacy or research.

Crohn's & Colitis Foundation of America, Inc.

CCFA's mission is to cure Crohn's disease and ulcerative colitis and to improve the quality of life of children and adults affected by these diseases.

Last Updated: 8 Apr 2014

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Inflammatory bowel disease" for support, advocacy or research.

Crohn's & Colitis Foundation of America, Inc.

CCFA's mission is to cure Crohn's disease and ulcerative colitis and to improve the quality of life of children and adults affected by these diseases.

http://www.ccfa.org

Last Updated: 8 Apr 2014

View Details

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Inflammatory bowel disease" returned 2435 free, full-text research articles on human participants. First 3 results:

Comparative risk of incident venous thromboembolism in patients with inflammatory bowel disease initiating tumour necrosis factor-α inhibitors or nonbiologic agents: a cohort study.
 

Author(s): Rishi J Desai, Joshua J Gagne, Joyce Lii, Jun Liu, Sonia Friedman, Seoyoung C Kim

Journal: CMAJ. 2017 Nov;189(47):E1438-E1447.

 

Inflammatory bowel disease (IBD) increases the risk of venous thromboembolism (VTE) by 2 to 3 times. We compared the reduction in risk of incident VTE associated with use of tumour necrosis factor-α (TNF-α) inhibitors versus nonbiologic immunomodulatory agents in patients with IBD.

Last Updated: 31 Dec 1969

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Results of home parenteral nutrition in patients with severe inflammatory bowel disease - an alternative for surgery of malnourished patients.
 

Author(s): Maryla Turkot, Jacek Sobocki

Journal: Pol Przegl Chir. 2017 Oct;89(5):23-28.

 

In the world, the inflammatory bowel disease affects an increasing number of younger and younger patients, and in some of them parenteral nutrition is an alternative to high-risk surgical intervention due to advancement of the disease and malnutrition.

Last Updated: 31 Dec 1969

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Body mass index influences infliximab post-infusion levels and correlates with prospective loss of response to the drug in a cohort of inflammatory bowel disease patients under maintenance therapy with Infliximab.
 

Author(s): Franco Scaldaferri, Daria D'Ambrosio, Grainne Holleran, Andrea Poscia, Valentina Petito, Loris Lopetuso, Cristina Graziani, Lucrezia Laterza, Maria Teresa Pistone, Silvia Pecere, Diego Currò, Eleonora Gaetani, Alessandro Armuzzi, Alfredo Papa, Giovanni Cammarota, Antonio Gasbarrini

Journal:

 

Infliximab is an effective treatment for inflammatory bowel disease (IBD). Studies differ regarding the influence of body mass index (BMI) on the response to infliximab, with the majority of studies indicating that increased BMI may be associated with a poorer response to Infliximab. ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Inflammatory bowel disease" returned 936 free, full-text review articles on human participants. First 3 results:

A systematic review of cost-effectiveness studies comparing conventional, biological and surgical interventions for inflammatory bowel disease.
 

Author(s): Nadia Pillai, Mark Dusheiko, Bernard Burnand, Valérie Pittet

Journal:

 

Inflammatory bowel disease (IBD) is a chronic disease placing a large health and economic burden on health systems worldwide. The treatment landscape is complex with multiple strategies to induce and maintain remission while avoiding long-term complications. The extent to which rising ...

Last Updated: 31 Dec 1969

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Host gene-microbiome interactions: molecular mechanisms in inflammatory bowel disease.
 

Author(s): Hiutung Chu

Journal:

 

Recent studies have identified links between host genetic variants and microbial recognition of the microbiome. Defects in host-microbiome interactions in individuals harboring inflammatory bowel disease risk alleles may result in imbalances of the microbial community, impaired pathogen ...

Last Updated: 31 Dec 1969

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Inflammatory Bowel Disease (IBD) pharmacotherapy and the risk of serious infection: a systematic review and network meta-analysis.
 

Author(s): Chelle L Wheat, Cynthia W Ko, Kindra Clark-Snustad, David Grembowski, Timothy A Thornton, Beth Devine

Journal:

 

The magnitude of risk of serious infections due to available medical therapies of inflammatory bowel disease (IBD) remains controversial. We conducted a systematic review and network meta-analysis of the existing IBD literature to estimate the risk of serious infection in adult IBD ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Inflammatory Bowel Disease Registry in Daegu-Gyeongbuk
 

Status: Recruiting

Condition Summary: Idiopathic Chronic Inflammatory Bowel Disease

 

Last Updated: 23 Jul 2016

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Safety and Tolerability Of Allogeneic Mesenchymal Stromal Cells in Pediatric Inflammatory Bowel Disease
 

Status: Recruiting

Condition Summary: Inflammatory Bowel Diseases

 

Last Updated: 17 Aug 2017

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MyChart in Patients With Inflammatory Bowel Disease.
 

Status: Not yet recruiting

Condition Summary: Inflammatory Bowel Diseases

 

Last Updated: 13 Nov 2017

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