Inflammatory bowel disease

Common Name(s)

Inflammatory bowel disease, IBD

Inflammatory bowel disease (IBD) is the chronic redness and swelling (inflammation) of all or part of the digestive tract, which includes the esophagus, stomach, small intestine, and large intestine. The exact cause of the inflammation in IBD is not known, but a person’s immune system and genetic makeup are both thought to play a role. Risk factors for developing IBD includes older age, Caucasian (white) ethnic background, cigarette smoking, and using certain medications.

The two main types of IBD are ulcerative colitis and Crohn’s disease. Ulcerative colitis is a condition that causes inflammation and sores (ulcers) on the inside lining of the large intestine. Crohn’s disease causes inflammation that spreads deep into the affected tissue and usually affects the large intestine, the small intestine, or both. Symptoms of IBD vary and depend on the location and severity of the inflammation. Symptoms may include diarrhea, fever and fatigue, abdominal pain and cramping, blood in the stool, reduced appetite, and unintended weight loss.

To diagnose IBD, a physician will first rule out other possible causes of the symptoms. To confirm a diagnosis of IBD, your doctor may order a blood test to look for low red blood cells (anemia), a procedure that uses a small camera to examines your digestive tract for signs of IBD (endoscopy or colonoscopy), and imaging tests (X-rays, CT, or MRI) to look for evidence of IBD. Treatment includes the use of medications that reduces the immune system’s response and decreases the inflammation in the digestive tract. In severe cases, surgery may be needed. Although this condition is serious, affected individuals can live a normal life with proper treatment and care. If you or your child has been diagnosed with IBD, talk with your doctor about the current treatment options.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Inflammatory bowel disease" for support, advocacy or research.

Crohn's & Colitis Foundation of America, Inc.

CCFA's mission is to cure Crohn's disease and ulcerative colitis and to improve the quality of life of children and adults affected by these diseases.

Last Updated: 8 Apr 2014

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Inflammatory bowel disease" for support, advocacy or research.

Crohn's & Colitis Foundation of America, Inc.

CCFA's mission is to cure Crohn's disease and ulcerative colitis and to improve the quality of life of children and adults affected by these diseases.

http://www.ccfa.org

Last Updated: 8 Apr 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Inflammatory bowel disease" returned 2086 free, full-text research articles on human participants. First 3 results:

Fecal Calprotectin as an Activity Marker of Inflammatory Bowel Disease in Children.
 

Author(s): Elżbieta Krzesiek

Journal: Adv Clin Exp Med. ;24(5):815-22.

 

Children constitute 20% of patients with inflammatory bowel diseases (IBD). Still there is a search for a perfect marker for this group of patients which would help in the diagnosis of the disease, in determinating its activity and in monitoring the treatment.

Last Updated: 15 Jan 2016

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Genetics and phenotypes in inflammatory bowel disease.
 

Author(s): Joana Torres, Jean-Frédéric Colombel

Journal: Lancet. 2016 Jan;387(10014):98-100.

 

Last Updated: 4 Feb 2016

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Measurement and clinical implications of choroidal thickness in patients with inflammatory bowel disease.
 

Author(s): Ibrahim Koral Onal, Erdem Yuksel, Kemal Bayrakceken, Muhammed Mustafa Demir, Emine Esra Karaca, Mehmet Ibis, Nasser Alizadeh, Zeynep Gok Sargin, Ahmet Murat Hondur, Mehmet Arhan

Journal: Arq Bras Oftalmol. ;78(5):278-82.

 

Ocular inflammation is a frequent extraintestinal manifestation of inflammatory bowel disease (IBD) and may parallel disease activity. In this study, we evaluated the utility of a choroidal thickness measurement in assessing IBD activity.

Last Updated: 15 Oct 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Inflammatory bowel disease" returned 763 free, full-text review articles on human participants. First 3 results:

Enterohepatic Helicobacter Species as a Potential Causative Factor in Inflammatory Bowel Disease: A Meta-Analysis.
 

Author(s): Qiao Yu, Shenghong Zhang, Li Li, Lishou Xiong, Kang Chao, Bihui Zhong, Yuwen Li, Huiling Wang, Minhu Chen

Journal: Medicine (Baltimore). 2015 Nov;94(45):e1773.

 

The Helicobacter species in the gut microbiota comprise Helicobacter pylori (H pylori) and enterohepatic Helicobacter species (EHS), which can colonize the intestinal mucosa. However, it is unclear whether EHS are associated with inflammatory bowel disease (IBD). Therefore, we conducted ...

Last Updated: 12 Nov 2015

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Genetically engineered mouse models for studying inflammatory bowel disease.
 

Author(s): Atsushi Mizoguchi, Takahito Takeuchi, Hidetomo Himuro, Toshiyuki Okada, Emiko Mizoguchi

Journal: J. Pathol.. 2016 Jan;238(2):205-19.

 

Inflammatory bowel disease (IBD) is a chronic intestinal inflammatory condition that is mediated by very complex mechanisms controlled by genetic, immune, and environmental factors. More than 74 kinds of genetically engineered mouse strains have been established since 1993 for studying ...

Last Updated: 23 Dec 2015

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Inflammatory Bowel Disease: An Overview of Immune Mechanisms and Biological Treatments.
 

Author(s): Bruno Rafael Ramos de Mattos, Maellin Pereira Gracindo Garcia, Julia Bier Nogueira, Lisiery Negrini Paiatto, Cassia Galdino Albuquerque, Caique Lopes Souza, Luís Gustavo Romani Fernandes, Wirla Maria da Silva Cunha Tamashiro, Patricia Ucelli Simioni

Journal: Mediators Inflamm.. 2015 ;2015():493012.

 

Inflammatory bowel diseases (IBD) are characterized by chronic inflammation of the intestinal tract associated with an imbalance of the intestinal microbiota. Crohn's disease (CD) and ulcerative colitis (UC) are the most widely known types of IBD and have been the focus of attention ...

Last Updated: 4 Sep 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Gene Expression in Inflammatory Bowel Disease
 

Status: Recruiting

Condition Summary: Inflammatory Bowel Disease

 

Last Updated: 6 Jul 2011

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Multi-Center African-American Inflammatory Bowel Disease Study (MAAIS): The Search for New Genes
 

Status: Recruiting

Condition Summary: Inflammatory Bowel Disease

 

Last Updated: 6 Jul 2011

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Standardized Fecal Microbiota Transplantation for Inflammatory Bowel Disease
 

Status: Recruiting

Condition Summary: Inflammatory Bowel Disease; Ulcerative Colitis; Crohn's Disease

 

Last Updated: 8 Jan 2015

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