Inflammatory bowel disease

Common Name(s)

Inflammatory bowel disease, IBD

Inflammatory bowel disease (IBD) is the chronic redness and swelling (inflammation) of all or part of the digestive tract, which includes the esophagus, stomach, small intestine, and large intestine. The exact cause of the inflammation in IBD is not known, but a person’s immune system and genetic makeup are both thought to play a role. Risk factors for developing IBD includes older age, Caucasian (white) ethnic background, cigarette smoking, and using certain medications.

The two main types of IBD are ulcerative colitis and Crohn’s disease. Ulcerative colitis is a condition that causes inflammation and sores (ulcers) on the inside lining of the large intestine. Crohn’s disease causes inflammation that spreads deep into the affected tissue and usually affects the large intestine, the small intestine, or both. Symptoms of IBD vary and depend on the location and severity of the inflammation. Symptoms may include diarrhea, fever and fatigue, abdominal pain and cramping, blood in the stool, reduced appetite, and unintended weight loss.

To diagnose IBD, a physician will first rule out other possible causes of the symptoms. To confirm a diagnosis of IBD, your doctor may order a blood test to look for low red blood cells (anemia), a procedure that uses a small camera to examines your digestive tract for signs of IBD (endoscopy or colonoscopy), and imaging tests (X-rays, CT, or MRI) to look for evidence of IBD. Treatment includes the use of medications that reduces the immune system’s response and decreases the inflammation in the digestive tract. In severe cases, surgery may be needed. Although this condition is serious, affected individuals can live a normal life with proper treatment and care. If you or your child has been diagnosed with IBD, talk with your doctor about the current treatment options.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Inflammatory bowel disease" for support, advocacy or research.

Crohn's & Colitis Foundation of America, Inc.

CCFA's mission is to cure Crohn's disease and ulcerative colitis and to improve the quality of life of children and adults affected by these diseases.

Last Updated: 8 Apr 2014

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Inflammatory bowel disease" for support, advocacy or research.

Crohn's & Colitis Foundation of America, Inc.

CCFA's mission is to cure Crohn's disease and ulcerative colitis and to improve the quality of life of children and adults affected by these diseases.

http://www.ccfa.org

Last Updated: 8 Apr 2014

View Details

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Inflammatory bowel disease" returned 2160 free, full-text research articles on human participants. First 3 results:

Serotype-Specific Pneumococcal Status prior to PCV 13 Administration in Children and Adolescents with Inflammatory Bowel Disease.
 

Author(s): Aleksandra Banaszkiewicz, Brygida Targońska, Kinga Kowalska-Duplaga, Katarzyna Karolewska-Bochenek, Agnieszka Sieczkowska, Agnieszka Gawrońska, Urszula Grzybowska-Chlebowczyk, Elzbieta Krzesiek, Izabella Łazowska-Przeorek, Maria Kotowska, Edyta Sienkiewicz, Jarosław Walkowiak, Hanna Gregorek, Andrzej Radzikowski, Piotr Albrecht

Journal: Pol. J. Microbiol.. 2016 ;65(1):89-91.

 

The aim of this study was to evaluate the serotype-specific pneumococcal status of children and adolescents with inflammatory bowel disease (IBD) who were naïve to pneumococcal vaccination before administering the 13-valent pneumococcal conjugate vaccine (PCV 13). This was an open, ...

Last Updated: 10 Jun 2016

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Inflammatory Bowel Disease: Epidemiology, Evaluation, Treatment, and Health Maintenance.
 

Author(s): William R Harlan, Angela Meyer, Jessica Fisher

Journal: N C Med J. ;77(3):198-201.

 

The incidence and prevalence of inflammatory bowel disease are rising. Crohn's disease and ulcerative colitis each have distinct features. Treatments are changing rapidly, and there are many new drugs in the pipeline. Health maintenance also plays a key role in the care of this patient population.

Last Updated: 7 May 2016

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DNA damage and apoptosis in blood neutrophils of inflammatory bowel disease patients and in Caco-2 cells in vitro exposed to betanin.
 

Author(s): Małgorzata Zielińska-Przyjemska, Anna Olejnik, Agnieszka Dobrowolska-Zachwieja, Michał Łuczak, Wanda Baer-Dubowska

Journal:

 

Inflammatory bowel diseases (IBD) are chronic, relapsing, inflammatory disorders of the gastrointestinal tract, and continuing colonic inflammation is considered an important risk factor in the development of colorectal cancer. Our previous studies showed that beetroot (Beta vulgaris ...

Last Updated: 27 Apr 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Inflammatory bowel disease" returned 784 free, full-text review articles on human participants. First 3 results:

Intravenous Versus Oral Iron for the Treatment of Anemia in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
 

Author(s): Stefanos Bonovas, Gionata Fiorino, Mariangela Allocca, Theodore Lytras, Argirios Tsantes, Laurent Peyrin-Biroulet, Silvio Danese

Journal: Medicine (Baltimore). 2016 Jan;95(2):e2308.

 

Anemia is the most prevalent extraintestinal complication of inflammatory bowel disease (IBD). Our aim was to evaluate the comparative efficacy and harm of intravenous (IV) versus oral iron supplementation for correcting anemia in adult IBD patients.We conducted a systematic review ...

Last Updated: 15 Jan 2016

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Emerging Epidemic of Inflammatory Bowel Disease in a Middle Income Country: A Nation-wide Study from Iran.
 

Author(s): Masoud M Malekzadeh, Homayoon Vahedi, Kimiya Gohari, Parinaz Mehdipour, Sadaf G Sepanlou, Nasser Ebrahimi Daryani, Mohammad-Reza Zali, Fariborz Mansour-Ghanaei, Alireza Safaripour, Rahim Aghazadeh, Hassan Vossoughinia, Hafez Fakheri, Mohammad H Somi, Iradj Maleki, Vahid Hoseini, Mohammad-Reza Ghadir, Hamed Daghaghzadeh, Payman Adibi, Hamid Tavakoli, Alireza Taghavi, Mohammad-Javad Zahedi, Taghi Amiriani, Masoud Tabib, Zainab Alipour, Hossein Nobakht, Abbas Yazdanbod, Masoud Sadreddini, Alireza Bakhshipour, Ahmad Khosravi, Pejman Khosravi, Siavosh Nasseri-Moghaddam, Shahin Merat, Rasoul Sotoudehmanesh, Farhad Barazandeh, Peyman Arab, Nadieh Baniasadi, Seyyed-Javad Pournaghi, Mahboubeh Parsaeian, Farshad Farzadfar, Reza Malekzadeh

Journal: Arch Iran Med. 2016 Jan;19(1):2-15.

 

The burden of inflammatory bowel disease (IBD) hasn't been reported in Iran. We aimed to estimate the prevalence and incidence of IBD and its trend in Iran at national and subnational level from 1990 to 2012.

Last Updated: 25 Dec 2015

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Body Mass Index Is Associated with Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis.
 

Author(s): Jie Dong, Yi Chen, Yuchen Tang, Fei Xu, Chaohui Yu, Youming Li, Prasoon Pankaj, Ning Dai

Journal:

 

Prior work suggested that patients with inflammatory bowel diseases (IBD) have lower body mass index (BMI) than controls and patients with lower BMI have more serious complications.

Last Updated: 15 Dec 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Gene Expression in Inflammatory Bowel Disease
 

Status: Recruiting

Condition Summary: Inflammatory Bowel Disease

 

Last Updated: 6 Jul 2011

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Multi-Center African-American Inflammatory Bowel Disease Study (MAAIS): The Search for New Genes
 

Status: Recruiting

Condition Summary: Inflammatory Bowel Disease

 

Last Updated: 6 Jul 2011

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Standardized Fecal Microbiota Transplantation for Inflammatory Bowel Disease
 

Status: Recruiting

Condition Summary: Inflammatory Bowel Disease; Ulcerative Colitis; Crohn's Disease

 

Last Updated: 8 Jan 2015

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