Immunodysregulation, polyendocrinopathy and enteropathy X-linked

Common Name(s)

Immunodysregulation, polyendocrinopathy and enteropathy X-linked

Immunodysregulation polyendocrinopathy enteropathy x-linked (IPEX) syndrome is a condition that affects the immune system of a male baby in the first six months of life.  The symptoms of IPEX syndrome include severe diarrhea, diabetes, skin conditions (such as eczema, erythroderma, or psoriasis), and thyroid disease (thyroiditis).  Some cases of IPEX syndrome have been shown to be caused by a change (mutation) of the FOXP3 gene, which is located on the X chromosome.  Treatment of IPEX syndrome consists of medications that limit immune system functioning; a bone marrow transplantation can cure some cases of this condition.   In a separate condition known as IPEX-like syndrome, affected individuals may have symptoms similar to those of IPEX syndrome but no mutation can be found in the FOXP3 gene; both males and females have been diagnosed with IPEX-like syndrome.  The cause of IPEX-like syndrome has not yet been identified.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Immunodysregulation, polyendocrinopathy and enteropathy X-linked" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

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Research articles describe the outcome of a single study. They are the published results of original research.
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The terms "Immunodysregulation, polyendocrinopathy and enteropathy X-linked" returned 0 free, full-text review articles on human participants.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Reduced Intensity Conditioning for Non-Malignant Disorders Undergoing UCBT, BMT or PBSCT
 

Status: Recruiting

Condition Summary: Primary Immunodeficiency (PID); Congenital Bone Marrow Failure Syndromes; Inherited Metabolic Disorders (IMD); Hereditary Anemias; Inflammatory Conditions

 

Last Updated: 23 May 2018

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Treosulfan and Fludarabine Phosphate Before Donor Stem Cell Transplant in Treating Patients With Nonmalignant Inherited Disorders
 

Status: Recruiting

Condition Summary: Hematopoietic Cell Transplantation Recipient; Non-Malignant

 

Last Updated: 23 Apr 2018

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