Idiopathic thrombocytopenic purpura

Common Name(s)

Idiopathic thrombocytopenic purpura

Idiopathic thrombocytopenic purpura (ITP) is a bleeding disorder characterized by too few platelets in the blood. This is because platelets are being destroyed by the immune system. Symptoms may include bruising, nosebleed or bleeding in the mouth, bleeding into the skin, and abnormally heavy menstruation. With treatment, the chance of remission (a symptom-free period) is good. Rarely, ITP may become a chronic ailment in adults and reappear, even after remission.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Idiopathic thrombocytopenic purpura" for support, advocacy or research.

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The Haemophilia Society

To ensure that people affected by bleeding disorders have the freedom to make choices and seize opportunities To enable people affected by bleeding disorders to better understand and manage their condition or situation. To enable people affected by bleeding disorders to participate in decision making and service delivery. To influence policy and improve services to people with bleeding disorders.

Last Updated: 3 Apr 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Idiopathic thrombocytopenic purpura" for support, advocacy or research.

Logo
The Haemophilia Society

To ensure that people affected by bleeding disorders have the freedom to make choices and seize opportunities To enable people affected by bleeding disorders to better understand and manage their condition or situation. To enable people affected by bleeding disorders to participate in decision making and service delivery. To influence policy and improve services to people with bleeding disorders.

http://www.haemophilia.org.uk/

Last Updated: 3 Apr 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Idiopathic thrombocytopenic purpura" returned 249 free, full-text research articles on human participants. First 3 results:

Safety and efficacy of Gammaplex® in idiopathic thrombocytopenic purpura (ClinicalTrials.gov--NCT00504075).
 

Author(s): Clive H Dash, Kate R Gillanders, Margaret E Stratford Bobbitt, Ernie W Gascoigne, Samantha J Leach

Journal:

 

This multicentre, open-label study investigated the safety and efficacy of Gammaplex, a 5% Intravenous Immunoglobulin (IVIg), in patients with idiopathic (immune) thrombocytopenic purpura (ITP).

Last Updated: 4 Jun 2014

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Successful treatment of an elderly frail patient with acquired idiopathic thrombotic thrombocytopenic purpura under close monitoring of ADAMTS13 activity and anti-ADAMTS13 antibody titers.
 

Author(s): Keigo Sano, Hideo Yagi, Hitoshi Hanamoto, Mariko Fujita, Takashi Iizuka, Keiko Yamazaki, Kazuo Tsubaki

Journal: Transfus. Apher. Sci.. 2014 Apr;50(2):235-8.

 

A 68-year-old woman was admitted to the regional hospital because of hemolytic anemia, thrombocytopenia, and neurological abnormalities including unconsciousness. One week before admission, she suffered from diarrhea and subsequently passed out and hit her face on the ground. She ...

Last Updated: 20 May 2014

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Alterations in immune cell subsets and their cytokine secretion profile in childhood idiopathic thrombocytopenic purpura (ITP).
 

Author(s): R M Talaat, A M Elmaghraby, S S Barakat, M El-Shahat

Journal: Clin. Exp. Immunol.. 2014 May;176(2):291-300.

 

Immune thrombocytopenic purpura (ITP) is acquired autoimmune disease in children characterized by the breakdown of immune tolerance. This work is designed to explore the contribution of different lymphocyte subsets in acute and chronic ITP children. Imbalance in the T helper type ...

Last Updated: 9 Apr 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Idiopathic thrombocytopenic purpura" returned 23 free, full-text review articles on human participants. First 3 results:

Eltrombopag for the treatment of chronic idiopathic (immune) thrombocytopenic purpura (ITP).
 

Author(s): D Boyers, X Jia, M Crowther, D Jenkinson, C Fraser, G Mowatt

Journal: Health Technol Assess. 2011 May;15 Suppl 1():23-32.

 

This paper presents a summary of the evidence review group (ERG) report into the clinical effectiveness and cost-effectiveness of eltrombopag for the treatment of adults with chronic idiopathic (immune) thrombocytopenic purpura (ITP), based on a review of the manufacturer's submission ...

Last Updated: 25 May 2011

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The European Medicines Agency review of eltrombopag (Revolade) for the treatment of adult chronic immune (idiopathic) thrombocytopenic purpura: summary of the scientific assessment of the Committee for Medicinal Products for Human Use.
 

Author(s): Maria Nieto, Gonzalo Calvo, Ian Hudson, Peter Feldschreiber, David Brown, Ching Cheng Lee, Geoffrey Lay, Anna Valeri, Eric Abadie, Angela Thomas, Francesco Pignatti

Journal: Haematologica. 2011 Sep;96(9):e33-40.

 

On 11(th) March 2010, the European Commission issued a marketing authorization valid throughout the European Union for Revolade for the treatment of adult chronic immune (idiopathic) thrombocytopenic purpura. Revolade is an orphan medicinal product indicated for splenectomized patients ...

Last Updated: 1 Sep 2011

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Idiopathic thrombocytopenic purpura and coronary artery disease: comparison between coronary artery bypass grafting and percutaneous coronary intervention.
 

Author(s): Antonio Russo, Marina Cannizzo, Gabriele Ghetti, Elena Barbaresi, Elisa Filippini, Salvatore Specchia, Angelo Branzi

Journal: Interact Cardiovasc Thorac Surg. 2011 Aug;13(2):153-7.

 

Idiopathic thrombocytopenic purpura (ITP) is an autoimmune disorder characterized by a low platelet count and an increased risk of bleeding. At the same time, ITP patients present an increased risk of thrombosis and atherosclerosis related to the high presence of haemostatic factors ...

Last Updated: 21 Jul 2011

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Cohort of Children With Acute Immune or Idiopathic Thrombocytopenic Purpura (ITP) : a Prospective Study in Pays De La Loire
 

Status: Not yet recruiting

Condition Summary: Acute Idiopathic Thrombocytopenic Purpura

 

Last Updated: 29 May 2006

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Recombinant Human Thrombopoietin in Combination With Rituximab in Immune Thrombocytopenia (ITP)
 

Status: Recruiting

Condition Summary: Purpura; Idiopathic Thrombocytopenic Purpura

 

Last Updated: 20 Jan 2012

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Last Updated: 17 Jun 2013

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