Hypotrichosis 6

Common Name(s)

Hypotrichosis 6

Localized autosomal recessive hypotrichosis is characterized by fragile hairs that break easily, leaving short, sparse scalp hairs. The disorder affects the trunk and extremities as well as the scalp, and the eyebrows and eyelashes may also be involved, whereas beard, pubic, and axillary hairs are largely spared. In addition, patients can develop hyperkeratotic follicular papules, erythema, and pruritus in affected areas. In some patients with congenital hypotrichosis, monilethrix-like hairs showing elliptical nodes have been observed (summary by {5:Schaffer et al., 2006}). Genetic Heterogeneity of Autosomal Recessive Localized Hypotrichosis LAH2 (HYPT7; {604379}) is caused by mutation in the LIPH gene ({607365}) on chromosome 3q27, and LAH3 (HYPT8; {278150}) is caused by mutation in the LPAR6 (P2RY5) gene ({609239}) on chromosome 13q14.12-q14.2. See also hypotrichosis and recurrent skin vesicles ({613102}), which is caused by mutation in the DSC3 gene ({600271}).
 

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Condition Specific Organizations

Following organizations serve the condition "Hypotrichosis 6" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hypotrichosis 6" returned 1 free, full-text research articles on human participants. First 3 results:

A novel mutation in lysophosphatidic acid receptor 6 gene in autosomal recessive hypotrichosis and evidence for a founder effect.
 

Author(s): Aysha Azhar, Muhammad Tariq, Shahid Mahmood Baig, Niklas Dahl, Joakim Klar

Journal: Eur J Dermatol. ;22(4):464-6.

 

Mutations in the lysophosphatidic acid receptor 6 (LPAR6) gene cause localized autosomal recessive hypotrichosis. We report six consanguineous families from Pakistan with segregating hypotrichosis localized to the scalp. Genetic investigation using polymorphic microsatellite markers ...

Last Updated: 21 Aug 2012

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The terms "Hypotrichosis 6" returned 0 free, full-text review articles on human participants.

 
 
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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Plasma Rich in Growth Factors (PRGF-Endoret)in the Treatment of Androgenetic Alopecia
 

Status: Not yet recruiting

Condition Summary: Androgenetic Alopecia

 

Last Updated: 24 Jun 2013

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