Hypoplastic left heart syndrome

Common Name(s)

Hypoplastic left heart syndrome

Hypoplastic left heart syndrome (HLHS) is a problem with the heartÕs structure that is present at birth (congenital). It occurs when parts of the left side of the heart (mitral valve, left ventricle, aortic valve, and aorta) do not develop completely. The underdeveloped left side of the heart is unable to provide enough blood flow to the body, which decreases the oxygen-rich blood supply. Babies with HLHS might look normal at birth, but will develop symptoms of HLHS within a few days. These symptoms might include: poor feeding, problems breathing, pounding heart, weak pulse, and ashen or bluish skin color. The cause of HLHs is presently unknown.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hypoplastic left heart syndrome" for support, advocacy or research.

Saving Little Hearts

Saving Little Hearts is dedicated to helping children with congenital heart defects and their families by providing emotional assistance and educational information primarily through the distribution of Care Packages.

http://www.savinglittlehearts.com

Last Updated: 15 Mar 2013

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hypoplastic left heart syndrome" for support, advocacy or research.

Saving Little Hearts

Saving Little Hearts is dedicated to helping children with congenital heart defects and their families by providing emotional assistance and educational information primarily through the distribution of Care Packages.

http://www.savinglittlehearts.com

Last Updated: 15 Mar 2013

View Details

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hypoplastic left heart syndrome" returned 100 free, full-text research articles on human participants. First 3 results:

Head and neck vessel size by angiography predicts neo-aortic arch obstruction after Norwood/Sano operation for hypoplastic left heart syndrome.
 

Author(s): Michael D Seckeler, Frank J Raucci, Christine Saunders, James J Gangemi, Benjamin B Peeler, K Anitha Jayakumar

Journal: J Invasive Cardiol. 2013 Feb;25(2):73-5.

 

To identify and predict neo-aortic arch obstruction (NAAO) in children after Norwood/Sano operation (NO) for hypoplastic left heart syndrome (HLHS).

Last Updated: 7 Feb 2013

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Serial magnetic resonance imaging in hypoplastic left heart syndrome gives valuable insight into ventricular and vascular adaptation.
 

Author(s): Hannah R Bellsham-Revell, Shane M Tibby, Aaron J Bell, Thomas Witter, John Simpson, Philipp Beerbaum, David Anderson, Conal B Austin, Gerald F Greil, Reza Razavi

Journal: J. Am. Coll. Cardiol.. 2013 Feb;61(5):561-70.

 

This study sought to investigate changes in magnetic resonance imaging (MRI) ventricular volumes and vascular dimensions before hemi-Fontan (HF) and before total cavopulmonary connection (TCPC) in children with hypoplastic left heart syndrome (HLHS).

Last Updated: 1 Feb 2013

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Subjective evaluation of right ventricular systolic function in hypoplastic left heart syndrome: how accurate is it?
 

Author(s): Hannah R Bellsham-Revell, John M Simpson, Owen I Miller, Aaron J Bell

Journal: J Am Soc Echocardiogr. 2013 Jan;26(1):52-6.

 

The geometry and heterogeneity of the right ventricle in hypoplastic left heart syndrome makes objective echocardiographic assessment of systolic function challenging. Consequently, subjective echocardiographic assessment of right ventricular (RV) function is still routinely undertaken. ...

Last Updated: 24 Dec 2012

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hypoplastic left heart syndrome" returned 10 free, full-text review articles on human participants. First 3 results:

Nutrition algorithms for infants with hypoplastic left heart syndrome; birth through the first interstage period.
 

Author(s): Julie Slicker, David A Hehir, Megan Horsley, Jessica Monczka, Kenan W Stern, Brandis Roman, Elena C Ocampo, Liz Flanagan, Erin Keenan, Linda M Lambert, Denise Davis, Marcy Lamonica, Nancy Rollison, Haleh Heydarian, Jeffrey B Anderson,

Journal: Congenit Heart Dis. ;8(2):89-102.

 

Failure to thrive is common in infants with hypoplastic left heart syndrome and its variants and those with poor growth may be at risk for worse surgical and neurodevelopmental outcomes. The etiology of growth failure in this population is multifactorial and complex, but may be impacted ...

Last Updated: 4 Apr 2013

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Neurodevelopment and quality of life for children with hypoplastic left heart syndrome: current knowns and unknowns.
 

Author(s): Caren S Goldberg, Kathleen Mussatto, Daniel Licht, Gil Wernovsky

Journal: Cardiol Young. 2011 Dec;21 Suppl 2():88-92.

 

The aim of this review is to describe the current state of knowledge related to neurodevelopmental outcomes and quality of life for children with hypoplastic left heart syndrome and to explore future questions to be answered for this group of children.

Last Updated: 13 Dec 2011

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[Contemporary strategies of the hypoplastic left heart syndrome treatment].
 

Author(s): Jacek Kołcz, Janusz Skalski

Journal: Kardiol Pol. 2011 ;69(3):275-80.

 

Last Updated: 24 Mar 2011

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Fetal Intervention for Aortic Stenosis and Evolving Hypoplastic Left Heart Syndrome
 

Status: Recruiting

Condition Summary: Aortic Stenosis; Hypoplastic Left Heart Syndrome

 

Last Updated: 9 Apr 2014

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Safety Study of Autologous Umbilical Cord Blood Cells for Treatment of Hypoplastic Left Heart Syndrome
 

Status: Recruiting

Condition Summary: Hypoplastic Left Heart Syndrome

 

Last Updated: 4 Feb 2014

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A Prospective Study of Patients With Hypoplastic Left Heart Syndrome (HLHS) Following Stage II Surgical Palliation
 

Status: Recruiting

Condition Summary: Hypoplastic Left Heart Syndrome

 

Last Updated: 4 Feb 2014

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