Hyperlipoproteinemia type 1

Common Name(s)

Hyperlipoproteinemia type 1

Hyperlipoproteinemia type 1 is an inherited condition that disrupts the normal breakdown of fats in the body. This condition is characterized by inflammation of the pancreas (pancreatitis), abdominal pain, enlargement of the liver and spleen (hepatosplenomegaly), and small yellow skin lesions called eruptive xanthomas. Mutations in the LPL gene cause hyperlipoproteinemia type 1, and this condition is inherited in an autosomal recessive pattern. The treatment for hyperlipoproteinemia type 1 is a low-fat diet.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hyperlipoproteinemia type 1" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hyperlipoproteinemia type 1" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hyperlipoproteinemia type 1" returned 2 free, full-text research articles on human participants. First 3 results:

Type 1 hyperlipoproteinemia and recurrent acute pancreatitis due to lipoprotein lipase antibody in a young girl with Sjogren's syndrome.
 

Author(s): Ambika P Ashraf, Timothy Beukelman, Valerie Pruneta-Deloche, David R Kelly, Abhimanyu Garg

Journal: J. Clin. Endocrinol. Metab.. 2011 Nov;96(11):3302-7.

 

Type 1 hyperlipoproteinemia (T1HLP) in childhood is most often due to genetic deficiency of lipoprotein lipase (LPL) or other related proteins.

Last Updated: 7 Nov 2011

Go To URL
Dominant expression of type III hyperlipoproteinemia. Pathophysiological insights derived from the structural and kinetic characteristics of ApoE-1 (Lys146-->Glu).
 

Author(s): W A Mann, P Lohse, R E Gregg, R Ronan, J M Hoeg, L A Zech, H B Brewer

Journal: J. Clin. Invest.. 1995 Aug;96(2):1100-7.

 

Type III hyperlipoproteinemia is characterized by delayed chylomicron and VLDL remnant catabolism and is associated with homozygosity for the apoE-2 allele. We have identified a kindred in which heterozygosity for an apoE mutant, apoE-1 (Lys146-->Glu), is dominantly associated with ...

Last Updated: 11 Sep 1995

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hyperlipoproteinemia type 1" returned 0 free, full-text review articles on human participants.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Pilot Study To Assess CAT-2003 in Patients With Chylomicronemia
 

Status: Recruiting

Condition Summary: Lipoprotein Lipase Deficiency, Familial; Hyperlipoproteinemia Type I; Chylomicronemia, Familial; Hypertriglyceridemia

 

Last Updated: 7 Apr 2014

Go to URL
Extension to a Randomized, Double-blind, Placebo Controlled Study of LCQ908 in Subjects With Familial Chylomicronemia Syndrome.
 

Status: Recruiting

Condition Summary: Familial Chylomicronemia Syndrome (FCS) (HLP Type I)

 

Last Updated: 25 Jun 2014

Go to URL
The APPROACH Study: A Study of ISIS-APOCIIIRx in Patients With Familial Chylomicronemia Syndrome
 

Status: Not yet recruiting

Condition Summary: Familial Chylomicronemia Syndrome

 

Last Updated: 12 Aug 2014

Go to URL