Hyperkalemic periodic paralysis

Common Name(s)

Hyperkalemic periodic paralysis

Hyperkalemic periodic paralysis is a genetic condition that causes episodes of extreme muscle weakness, usually beginning in infancy or early childhood. Most often, these episodes involve a temporary inability to move muscles in the arms and legs. Episodes tend to increase in frequency until about age 25, after which they may occur less frequently. Factors that can trigger attacks include rest after exercise, potassium-rich foods, stress, fatigue, and long periods without food. Muscle strength improves between attacks, although many affected people continue to experience mild stiffness, particularly in muscles of the face and hands. This condition is caused by mutations in the SCN4A gene and is inherited in an autosomal dominant fashion.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hyperkalemic periodic paralysis" for support, advocacy or research.

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Periodic Paralysis International

Our Mission statement is to disseminate timely, medically accurate and useful information, to provide supportive services, and to encourage research which enhances the quality of life for people with the skeletal muscle ion channelopathies classified as the periodic paralyses.

Last Updated: 12 Feb 2013

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hyperkalemic periodic paralysis" for support, advocacy or research.

Logo
Periodic Paralysis International

Our Mission statement is to disseminate timely, medically accurate and useful information, to provide supportive services, and to encourage research which enhances the quality of life for people with the skeletal muscle ion channelopathies classified as the periodic paralyses.

http://hkpp.org

Last Updated: 12 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hyperkalemic periodic paralysis" returned 9 free, full-text research articles on human participants. First 3 results:

Characterization of hyperkalemic periodic paralysis: a survey of genetically diagnosed individuals.
 

Author(s): G Charles, C Zheng, F Lehmann-Horn, K Jurkat-Rott, J Levitt

Journal: J. Neurol.. 2013 Oct;260(10):2606-13.

 

This exploratory study aims to create an evidence-based comprehensive characterization of hyperkalemic periodic paralysis (hyperPP). HyperPP is a rare genetic disorder that causes episodes of flaccid paralysis. Disease descriptions in the literature are based upon isolated clinical ...

Last Updated: 11 Oct 2013

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Management of a patient with hyperkalemic periodic paralysis requiring coronary artery bypass grafts.
 

Author(s): Sanjay Orathi Patangi, Mathew Garner, Hazel Powell

Journal: Ann Card Anaesth. ;15(4):302-4.

 

Hyperkalemic periodic paralysis (HPP) is an autosomal-dominant inherited muscle disease characterized by episodes of flaccid weakness and intermittent myotonia. There are no previous reports in the literature about anesthesia for cardiac surgery with cardiopulmonary bypass in this ...

Last Updated: 8 Oct 2012

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Hyperkalemic periodic paralysis M1592V mutation modifies activation in human skeletal muscle Na+ channel.
 

Author(s): C V Rojas, A Neely, G Velasco-Loyden, V Palma, M Kukuljan

Journal: Am. J. Physiol.. 1999 Jan;276(1 Pt 1):C259-66.

 

Mutations in the human skeletal muscle Na+ channel underlie the autosomal dominant disease hyperkalemic periodic paralysis (HPP). Muscle fibers from affected individuals exhibit sustained Na+ currents thought to depolarize the sarcolemma and thus inactivate normal Na+ channels. We ...

Last Updated: 9 Mar 1999

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hyperkalemic periodic paralysis" returned 0 free, full-text review articles on human participants.

 
 
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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Lamotrigine as Treatment of Myotonia
 

Status: Recruiting

Condition Summary: Dystrophia Myotonica Type 1; Myotonia Congenita; Paramyotonia Congenita; Hyperkalemic Periodic Paralysis; Potassium-Aggravated Myotonia

 

Last Updated: 4 Jun 2014

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