Hyperimmunoglobulin E syndrome

Common Name(s)

Hyperimmunoglobulin E syndrome

Hyper-IgE recurrent infection syndrome is a primary immunodeficiency disorder characterized by chronic eczema, recurrent Staphylococcal infections, increased serum IgE, and eosinophilia. Patients have a distinctive coarse facial appearance, abnormal dentition, hyperextensibility of the joints, and bone fractures ({7:Buckley et al., 1972}; {16:Grimbacher et al., 1999}).
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hyperimmunoglobulin E syndrome" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hyperimmunoglobulin E syndrome" returned 22 free, full-text research articles on human participants. First 3 results:

Inhaled alpha1-antitrypsin administered to treat pneumatocele in autosomal dominant hyperimmunoglobulin E syndrome.
 

Author(s): E Karakoc-Aydiner, S Baris, S Keles, C Ozdemir, T Chatila, I Barlan

Journal: J Investig Allergol Clin Immunol. 2013 ;23(5):359-61.

 

Last Updated: 22 Nov 2013

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Hyperimmunoglobulin E syndrome-like symptoms in a hemodialysis patient who developed multiple subcutaneous Staphylococcus aureus abscesses.
 

Author(s): Kazuki Yokota, Toshikazu Kanemitsu, Naoya Igaki

Journal: Intern. Med.. 2013 ;52(20):2367-70.

 

Hyperimmunoglobulin E syndrome (HIES) is sporadically triggered by de novo genetic mutations of the signal transducer and activator of transcription 3 (STAT3). Dialysis patients frequently exhibit HIES-like symptoms including elevated IgE levels and recurrent bacterial infections. ...

Last Updated: 15 Oct 2013

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Diagnosis of autosomal-dominant hyperimmunoglobulin E syndrome.
 

Author(s): P Garc├ęs, F Garcia-Martin, D Detkova, T Espanol

Journal: J Investig Allergol Clin Immunol. 2012 ;22(2):149-52.

 

Last Updated: 26 Apr 2012

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hyperimmunoglobulin E syndrome" returned 2 free, full-text review articles on human participants. First 3 results:

The hyperimmunoglobulin E syndrome--clinical manifestation diversity in primary immune deficiency.
 

Author(s): Aleksandra Szczawinska-Poplonyk, Zdzislawa Kycler, Barbara Pietrucha, Edyta Heropolitanska-Pliszka, Anna Breborowicz, Karolina Gerreth

Journal:

 

The hyper-IgE syndromes are rare, complex primary immunodeficiencies characterized by clinical manifestation diversity, by particular susceptibility to staphylococcal and mycotic infections as well as by a heterogeneous genetic origin. Two distinct entities--the classical hyper-IgE ...

Last Updated: 30 Nov 2011

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A review on the vascular features of the hyperimmunoglobulin E syndrome.
 

Author(s): H Yavuz, R Chee

Journal: Clin. Exp. Immunol.. 2010 Mar;159(3):238-44.

 

Autosomal recessive, autosomal dominant and the sporadic forms of hyperimmunoglobulin E syndrome (HIES) are multi-system disorders. Although HIES patients may present with cold abscesses, the vascular features of HIES are not well recognized. The objective of this review is to characterize ...

Last Updated: 22 Jan 2010

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Study of Clinical Features and Genetics of Hyperimmunoglobulin E Recurrent Infection
 

Status: Recruiting

Condition Summary: Job's Syndrome

 

Last Updated: 15 Aug 2014

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Study of Mycobacterial Infections
 

Status: Recruiting

Condition Summary: Atypical Mycobacterium Infections; Cystic Fibrosis; Job's Syndrome

 

Last Updated: 19 Jul 2014

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Detection and Characterization of Infections and Infection Susceptibility
 

Status: Recruiting

Condition Summary: Immune Disorders; Chronic Granulomatous Disease; Genetic Immunological Deficiencies; Hyperimmunoglobulin-E Recurrent Infection Syndrome; Recurrent Infections

 

Last Updated: 14 May 2014

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