Gilbert syndrome

Common Name(s)

Gilbert syndrome, Hyperbilirubinemia type 1

Gilbert syndrome is an inherited condition in which the liver does not correctly process bilirubin, a yellow-ish substance produced during the normal breakdown of old red blood cells. Bilirubin travels through the bloodstream to the liver where it is processed and removed from the blood. The symptom of cholemia or hyperbilirubinemia (high bilirubin levels) is jaundice or yellowing of the skin and whites of the eyes. It is generally a mild condition and does not usually require treatment. Times of jaundice are sometimes induced in children and adults during infections and illness, lack of sleep, fasting (stretches of not eating), menstruation cycles, and stress and may be accompanied by mild abdominal pain or nausea. The jaundice during these times goes away on its own after the person recovers. In the newborn period, jaundice can be longer-lasting and more severe. Diagnosis often occurs by accident when blood is drawn for another reason unless a person or newborn has a severe bout of jaundice and the yellow in the skin or eyes is noted. Treatment is only necessary if bilirubin levels are very high.

More males than females have been diagnosed with Gilbert syndrome. This condition is caused by mutations in the UGT1A1 gene. Gilbert syndrome is inherited or passed through families in an autosomal recessive manner. This means that to be affected, an individual must have two copies of the changed gene that causes the condition. An affected person has then inherited one changed gene from each of his or her parents. Each child of two carrier parents has a 25% chance of inheriting both changed genes and therefore the condition. A genetic counselor can provide an understanding of the underlying cause as well as recurrence risks.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Gilbert syndrome" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Gilbert syndrome" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Gilbert syndrome" returned 28 free, full-text research articles on human participants. First 3 results:

Evaluation of aortic stiffness in Gilbert syndrome patients: a protective effect of elevated bilirubin levels.
 

Author(s): Süleyman Yüce, Erkan Cüre, Yüksel Çiçek, Medine Cumhur Cüre, Arif Yılmaz, Bayram Kızılkaya

Journal: Turk Kardiyol Dern Ars. 2015 Oct;43(7):599-606.

 

Gilbert's syndrome (GS) is an autosomal recessive disease that is characterized by an increase in indirect bilirubin (IB). The incidence of atherosclerotic heart disease is decreased in GS. This study aimed to investigate the relation between pulse wave velocity (PWV) and the presence of GS.

Last Updated: 5 Nov 2015

Go To URL
Protective effect of elevated bilirubin levels on cardiovascular disease in patients with Gilbert syndrome.
 

Author(s): Emre Gürel, Mustafa Kürşat Tigen

Journal: Turk Kardiyol Dern Ars. 2015 Oct;43(7):591-3.

 

Last Updated: 5 Nov 2015

Go To URL
Gilbert syndrome acts as a risk factor of developing gallstone among β hemoglobinopathy Tunisian patients.
 

Author(s): Leila Chaouch, Miniar Kalai, Dorra Chaouachi, Fethi Mallouli, Raouf Hafsia, Slim Ben Ammar, Salem Abbes

Journal: Tunis Med. 2015 Apr;93(4):237-41.

 

As a result of chronic hemolysis, hyperbilirubinemia is often observed, leading to the formation of pigment cholelithiasis which could be busted by the presence of uridine diphosphoglucuronosyltransferase 1A1 defects.

Last Updated: 17 Sep 2015

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Gilbert syndrome" returned 0 free, full-text review articles on human participants.

 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.