Huntington disease

Common Name(s)

Huntington disease, Huntington's chorea

Huntington disease is a progressive disorder that causes brain cell (neuron) degeneration in certain areas of the brain.  This results in uncontrolled movements, loss of intellectual abilities, and emotional disturbances. Symptoms typically appear between the ages of 35 and 44 years. People with Huntington disease most often live for 15 to 18 years after the condition appears. Huntington disease caused by mutations in the HTT gene and is inherited in an autosomal dominant manner. Each child of a person with Huntington disease has a 50 percent (1 in 2) chance of inheriting the mutation. There is also a less common, early-onset from that begins in childhood or adolescence, called juvenile Huntington disease.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Huntington disease" for support, advocacy or research.

Caring Voice Coalition,Inc,

Caring Voice Coalition is dedicated to building relationships with charitable organizations founded to help individuals and families affected by serious chronic disorders and diseases.

http://www.caringvoice.org

Last Updated: 1 Mar 2013

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Hereditary Disease Foundation

The Hereditary Disease Foundation is a non-profit, basic-science organization dedicated to the cure of genetic disease, with a focus on Huntington disease.

http://www.hdfoundation.org

Last Updated: 1 Mar 2013

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Huntington's Disease Society of America

We are a national non-profit voluntary health agency dedicated to finding a cure for Huntington's Disease. We provide vital support, information and educational services to improve the lives of those affected by HD, offer resources and guidance for HD families through our national network of volunteer-based chapters and affiliates as well as through our HDSA Centers of Excellence for Family Services, and promote and support research to find a cure for HD.

http://www.hdsa.org

Last Updated: 11 Oct 2012

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Movement Disorder Society

The Movement Disorder Society (MDS) is an international professional society of clinicians, scientists, and other healthcare professionals, who are interested in Parkinson's disease, related neurodegenerative and neurodevelopmental disorders, hyperkinetic movement disorders, and abnormalities in muscle tone and motor control.

www.movementdisorders.org

Last Updated: 16 Jan 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Huntington disease" for support, advocacy or research.

Caring Voice Coalition,Inc,

Caring Voice Coalition is dedicated to building relationships with charitable organizations founded to help individuals and families affected by serious chronic disorders and diseases.

http://www.caringvoice.org

Last Updated: 1 Mar 2013

View Details
Hereditary Disease Foundation

The Hereditary Disease Foundation is a non-profit, basic-science organization dedicated to the cure of genetic disease, with a focus on Huntington disease.

http://www.hdfoundation.org

Last Updated: 1 Mar 2013

View Details
Huntington's Disease Society of America

We are a national non-profit voluntary health agency dedicated to finding a cure for Huntington's Disease. We provide vital support, information and educational services to improve the lives of those affected by HD, offer resources and guidance for HD families through our national network of volunteer-based chapters and affiliates as well as through our HDSA Centers of Excellence for Family Services, and promote and support research to find a cure for HD.

http://www.hdsa.org

Last Updated: 11 Oct 2012

View Details
Movement Disorder Society

The Movement Disorder Society (MDS) is an international professional society of clinicians, scientists, and other healthcare professionals, who are interested in Parkinson's disease, related neurodegenerative and neurodevelopmental disorders, hyperkinetic movement disorders, and abnormalities in muscle tone and motor control.

www.movementdisorders.org

Last Updated: 16 Jan 2013

View Details

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Huntington disease" returned 276 free, full-text research articles on human participants. First 3 results:

Clinical and genetic features of Huntington disease in Sri Lanka.
 

Author(s): Dulika S Sumathipala, Rohan W Jayasekara, Vajira H W Dissanayake

Journal:

 

Huntington disease was one of the first neurological hereditary diseases for which genetic testing was made possible as early as 1993. The study describes the clinical and genetic characteristics of patients with Huntington disease in Sri Lanka.

Last Updated: 16 Dec 2013

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Huntington disease arises from a combinatory toxicity of polyglutamine and copper binding.
 

Author(s): Guiran Xiao, Qiangwang Fan, Xiaoxi Wang, Bing Zhou

Journal: Proc. Natl. Acad. Sci. U.S.A.. 2013 Sep;110(37):14995-5000.

 

Huntington disease (HD) is a progressive neurodegenerative disorder caused by dominant polyglutamine (polyQ) expansion within the N terminus of huntingtin (Htt) protein. Abnormal metal accumulation in the striatum of HD patients has been reported for many years, but a causative relationship ...

Last Updated: 11 Sep 2013

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De novo Huntington disease caused by 26-44 CAG repeat expansion on a low-risk haplotype.
 

Author(s): Gunnar Houge, Ove Bruland, Inga Bjørnevoll, Michael R Hayden, Alicia Semaka

Journal: Neurology. 2013 Sep;81(12):1099-100.

 

Last Updated: 17 Sep 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Huntington disease" returned 25 free, full-text review articles on human participants. First 3 results:

Neuronal Ca(2+) dyshomeostasis in Huntington disease.
 

Author(s): Marta Giacomello, Juan C Oliveros, Jose R Naranjo, Ernesto Carafoli

Journal: Prion. ;7(1):76-84.

 

The expansion of the N-terminal poly-glutamine tract of the huntingtin (Htt) protein is responsible for Huntington disease (HD). A large number of studies have explored the neuronal phenotype of HD, but the molecular aethiology of the disease is still very poorly understood. This ...

Last Updated: 18 Feb 2013

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Therapeutic approaches to preventing cell death in Huntington disease.
 

Author(s): Anna Kaplan, Brent R Stockwell

Journal: Prog. Neurobiol.. 2012 Dec;99(3):262-80.

 

Neurodegenerative diseases affect the lives of millions of patients and their families. Due to the complexity of these diseases and our limited understanding of their pathogenesis, the design of therapeutic agents that can effectively treat these diseases has been challenging. Huntington ...

Last Updated: 23 Nov 2012

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Comprehensive treatment of Huntington disease and other choreic disorders.
 

Author(s): Carlos Singer

Journal: Cleve Clin J Med. 2012 Jul;79 Suppl 2():S30-4.

 

The management of choreic disorders presents significant challenges, including identifying the etiology of the disorder, treating and preventing motor symptoms, and managing a range of other neurologic and behavioral complications. Chorea may occur in several neurodegenerative, genetic, ...

Last Updated: 4 Jul 2012

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Clinical Trial Information This information is provided by ClinicalTrials.gov

REGISTRY - an Observational Study of the European Huntington's Disease Network (EHDN)
 

Status: Recruiting

Condition Summary: Huntington Disease; Huntington's Disease

 

Last Updated: 4 Sep 2013

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Bioavailability of Ubiquinol in Huntington Disease
 

Status: Recruiting

Condition Summary: Huntington Disease

 

Last Updated: 18 Sep 2009

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Neuroleptic and Huntington Disease Comparison of : Olanzapine, la Tetrabenazine and Tiapride
 

Status: Recruiting

Condition Summary: Huntington Disease

 

Last Updated: 26 Feb 2014

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