Huntington disease

Common Name(s)

Huntington disease, Huntington's chorea

Huntington disease is a progressive disorder that causes brain cell (neuron) degeneration in certain areas of the brain.  This results in uncontrolled movements, loss of intellectual abilities, and emotional disturbances. Symptoms typically appear between the ages of 35 and 44 years. People with Huntington disease most often live for 15 to 18 years after the condition appears. Huntington disease caused by mutations in the HTT gene and is inherited in an autosomal dominant manner. Each child of a person with Huntington disease has a 50 percent (1 in 2) chance of inheriting the mutation. There is also a less common, early-onset from that begins in childhood or adolescence, called juvenile Huntington disease.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Huntington disease" for support, advocacy or research.

Caring Voice Coalition,Inc,

Caring Voice Coalition empowers patients who live with a life threatening chronic disease through comprehensive outreach programs and services aimed at financial, emotional and educational support. With a steadfast dedication to the organization’s set of core values, our knowledgeable, caring staff maintains our solid reputation as a dependable, responsive organization with a unique, holistic approach to improving the lives of our patients.

Last Updated: 29 Apr 2014

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Hereditary Disease Foundation

The Hereditary Disease Foundation is a non-profit, basic-science organization dedicated to the cure of genetic disease, with a focus on Huntington disease.

Last Updated: 1 Mar 2013

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Huntington's Disease Society of America

We are a national non-profit voluntary health agency dedicated to finding a cure for Huntington's Disease. We provide vital support, information and educational services to improve the lives of those affected by HD, offer resources and guidance for HD families through our national network of volunteer-based chapters and affiliates as well as through our HDSA Centers of Excellence for Family Services, and promote and support research to find a cure for HD.

Last Updated: 11 Oct 2012

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Movement Disorder Society

The Movement Disorder Society (MDS) is an international professional society of clinicians, scientists, and other healthcare professionals, who are interested in Parkinson's disease, related neurodegenerative and neurodevelopmental disorders, hyperkinetic movement disorders, and abnormalities in muscle tone and motor control.

Last Updated: 5 May 2014

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Huntington disease" for support, advocacy or research.

Caring Voice Coalition,Inc,

Caring Voice Coalition empowers patients who live with a life threatening chronic disease through comprehensive outreach programs and services aimed at financial, emotional and educational support. With a steadfast dedication to the organization’s set of core values, our knowledgeable, caring staff maintains our solid reputation as a dependable, responsive organization with a unique, holistic approach to improving the lives of our patients.

http://www.caringvoice.org

Last Updated: 29 Apr 2014

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Hereditary Disease Foundation

The Hereditary Disease Foundation is a non-profit, basic-science organization dedicated to the cure of genetic disease, with a focus on Huntington disease.

http://www.hdfoundation.org

Last Updated: 1 Mar 2013

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Huntington's Disease Society of America

We are a national non-profit voluntary health agency dedicated to finding a cure for Huntington's Disease. We provide vital support, information and educational services to improve the lives of those affected by HD, offer resources and guidance for HD families through our national network of volunteer-based chapters and affiliates as well as through our HDSA Centers of Excellence for Family Services, and promote and support research to find a cure for HD.

http://www.hdsa.org

Last Updated: 11 Oct 2012

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Movement Disorder Society

The Movement Disorder Society (MDS) is an international professional society of clinicians, scientists, and other healthcare professionals, who are interested in Parkinson's disease, related neurodegenerative and neurodevelopmental disorders, hyperkinetic movement disorders, and abnormalities in muscle tone and motor control.

http://www.movementdisorders.org/MDS.htm

Last Updated: 5 May 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Huntington disease" returned 345 free, full-text research articles on human participants. First 3 results:

Sequence-Level Analysis of the Major European Huntington Disease Haplotype.
 

Author(s): Jong-Min Lee, Kyung-Hee Kim, Aram Shin, Michael J Chao, Kawther Abu Elneel, Tammy Gillis, Jayalakshmi Srinidhi Mysore, Julia A Kaye, Hengameh Zahed, Ian H Kratter, Aaron C Daub, Steven Finkbeiner, Hong Li, Jared C Roach, Nathan Goodman, Leroy Hood, Richard H Myers, Marcy E MacDonald, James F Gusella

Journal: Am. J. Hum. Genet.. 2015 Sep;97(3):435-44.

 

Huntington disease (HD) reflects the dominant consequences of a CAG-repeat expansion in HTT. Analysis of common SNP-based haplotypes has revealed that most European HD subjects have distinguishable HTT haplotypes on their normal and disease chromosomes and that ∼50% of the latter ...

Last Updated: 5 Sep 2015

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Exploring Genetic Factors Involved in Huntington Disease Age of Onset: E2F2 as a New Potential Modifier Gene.
 

Author(s): Leire Valcárcel-Ocete, Gorka Alkorta-Aranburu, Mikel Iriondo, Asier Fullaondo, María García-Barcina, José Manuel Fernández-García, Elena Lezcano-García, José María Losada-Domingo, Javier Ruiz-Ojeda, Amaia Álvarez de Arcaya, José María Pérez-Ramos, Raymund A C Roos, Jørgen E Nielsen, Carsten Saft, , Ana M Zubiaga, Ana Aguirre

Journal:

 

Age of onset (AO) of Huntington disease (HD) is mainly determined by the length of the CAG repeat expansion (CAGexp) in exon 1 of the HTT gene. Additional genetic variation has been suggested to contribute to AO, although the mechanism by which it could affect AO is presently unknown. ...

Last Updated: 7 Jul 2015

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HTT/Huntingtin in selective autophagy and Huntington disease: A foe or a friend within?
 

Author(s): Yan-Ning Rui, Zhen Xu, Bindi Patel, Ana Maria Cuervo, Sheng Zhang

Journal: Autophagy. 2015 ;11(5):858-60.

 

Last Updated: 29 May 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Huntington disease" returned 31 free, full-text review articles on human participants. First 3 results:

Huntington Disease in Asia.
 

Author(s): Miao Xu, Zhi-Ying Wu

Journal: Chin. Med. J.. 2015 Jul;128(13):1815-9.

 

The objective was to review the major differences of Huntington disease (HD) in Asian population from those in the Caucasian population.

Last Updated: 26 Jun 2015

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Understanding the Outcomes Measures used in Huntington Disease Pharmacological Trials: A Systematic Review.
 

Author(s): Noelle E Carlozzi, Angela Miciura, Nicholas Migliore, Praveen Dayalu

Journal: J Huntingtons Dis. 2014 ;3(3):233-52.

 

The identification of the gene mutation causing Huntington disease has raised hopes for new treatments to ease symptoms and slow functional decline. As such, there has been a push towards designing efficient pharmacological trials (i.e., drug trials), especially with regard to selecting ...

Last Updated: 10 Oct 2014

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Neuronal Ca(2+) dyshomeostasis in Huntington disease.
 

Author(s): Marta Giacomello, Juan C Oliveros, Jose R Naranjo, Ernesto Carafoli

Journal: Prion. ;7(1):76-84.

 

The expansion of the N-terminal poly-glutamine tract of the huntingtin (Htt) protein is responsible for Huntington disease (HD). A large number of studies have explored the neuronal phenotype of HD, but the molecular aethiology of the disease is still very poorly understood. This ...

Last Updated: 18 Feb 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

REGISTRY - an Observational Study of the European Huntington's Disease Network (EHDN)
 

Status: Recruiting

Condition Summary: Huntington Disease; Huntington's Disease

 

Last Updated: 18 Feb 2015

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Neurobiological Predictors of Huntington's Disease (PREDICT-HD)
 

Status: Recruiting

Condition Summary: Huntington Disease

 

Last Updated: 1 Dec 2015

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Growth and Development of the Striatum in Huntington's Disease
 

Status: Recruiting

Condition Summary: Huntington's Disease

 

Last Updated: 11 May 2016

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