Huntington disease

Common Name(s)

Huntington disease, Huntington's chorea

Huntington disease is a progressive disorder that causes brain cell (neuron) degeneration in certain areas of the brain.  This results in uncontrolled movements, loss of intellectual abilities, and emotional disturbances. Symptoms typically appear between the ages of 35 and 44 years. People with Huntington disease most often live for 15 to 18 years after the condition appears. Huntington disease caused by mutations in the HTT gene and is inherited in an autosomal dominant manner. Each child of a person with Huntington disease has a 50 percent (1 in 2) chance of inheriting the mutation. There is also a less common, early-onset from that begins in childhood or adolescence, called juvenile Huntington disease.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Huntington disease" for support, advocacy or research.

Caring Voice Coalition,Inc,

Caring Voice Coalition empowers patients who live with a life threatening chronic disease through comprehensive outreach programs and services aimed at financial, emotional and educational support. With a steadfast dedication to the organization’s set of core values, our knowledgeable, caring staff maintains our solid reputation as a dependable, responsive organization with a unique, holistic approach to improving the lives of our patients.

Last Updated: 17 Feb 2017

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Hereditary Disease Foundation

The Hereditary Disease Foundation is a non-profit, basic-science organization dedicated to the cure of genetic disease, with a focus on Huntington disease.

Last Updated: 1 Mar 2013

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Huntington's Disease Society of America

We are a national non-profit voluntary health agency dedicated to finding a cure for Huntington's Disease. We provide vital support, information and educational services to improve the lives of those affected by HD, offer resources and guidance for HD families through our national network of volunteer-based chapters and affiliates as well as through our HDSA Centers of Excellence for Family Services, and promote and support research to find a cure for HD.

Last Updated: 11 Oct 2012

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Movement Disorder Society

The Movement Disorder Society (MDS) is an international professional society of clinicians, scientists, and other healthcare professionals, who are interested in Parkinson's disease, related neurodegenerative and neurodevelopmental disorders, hyperkinetic movement disorders, and abnormalities in muscle tone and motor control.

Last Updated: 5 May 2014

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Huntington disease" for support, advocacy or research.

Caring Voice Coalition,Inc,

Caring Voice Coalition empowers patients who live with a life threatening chronic disease through comprehensive outreach programs and services aimed at financial, emotional and educational support. With a steadfast dedication to the organization’s set of core values, our knowledgeable, caring staff maintains our solid reputation as a dependable, responsive organization with a unique, holistic approach to improving the lives of our patients.

http://www.caringvoice.org

Last Updated: 17 Feb 2017

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Hereditary Disease Foundation

The Hereditary Disease Foundation is a non-profit, basic-science organization dedicated to the cure of genetic disease, with a focus on Huntington disease.

http://www.hdfoundation.org

Last Updated: 1 Mar 2013

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Huntington's Disease Society of America

We are a national non-profit voluntary health agency dedicated to finding a cure for Huntington's Disease. We provide vital support, information and educational services to improve the lives of those affected by HD, offer resources and guidance for HD families through our national network of volunteer-based chapters and affiliates as well as through our HDSA Centers of Excellence for Family Services, and promote and support research to find a cure for HD.

http://www.hdsa.org

Last Updated: 11 Oct 2012

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Movement Disorder Society

The Movement Disorder Society (MDS) is an international professional society of clinicians, scientists, and other healthcare professionals, who are interested in Parkinson's disease, related neurodegenerative and neurodevelopmental disorders, hyperkinetic movement disorders, and abnormalities in muscle tone and motor control.

http://www.movementdisorders.org/MDS.htm

Last Updated: 5 May 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Huntington disease" returned 390 free, full-text research articles on human participants. First 3 results:

Huntington Disease: The Complexities of Making and Disclosing a Clinical Diagnosis After Premanifest Genetic Testing.
 

Author(s): Elizabeth A McCusker, Clement T Loy

Journal:

 

The management of patients and families affected by Huntington disease (HD) is complicated by several factors, both practical and ethical. It can be difficult to determine the onset of clinically manifest HD (mHD). In addition, it can be challenging to decide when to disclose the ...

Last Updated: 31 Dec 1969

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The CREST-E study of creatine for Huntington disease: A randomized controlled trial.
 

Author(s): Steven M Hersch, Giovanni Schifitto, David Oakes, Amy-Lee Bredlau, Catherine M Meyers, Richard Nahin, Herminia Diana Rosas,

Journal: Neurology. 2017 Aug;89(6):594-601.

 

To investigate whether creatine administration could slow progressive functional decline in adults with early symptoms of Huntington disease.

Last Updated: 31 Dec 1969

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Analysis of Participant Withdrawal in Huntington Disease Clinical Trials.
 

Author(s): Haruhiko Banno, Kelly L Andrzejewski, Michael P McDermott, Alyssa Murphy, Madhurima Majumder, Elisabeth A de Blieck, Peggy Auinger, Merit E Cudkowicz, Nazem Atassi

Journal: J Huntingtons Dis. 2017 ;6(2):149-156.

 

Excellent retention in Huntington disease (HD) clinical trials is essential for testing new therapies. The stage of disease, cognitive status, and availability of a care partner may influence retention in HD clinical trials.

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Huntington disease" returned 33 free, full-text review articles on human participants. First 3 results:

Evaluating the current state of the art of Huntington disease research: a scientometric analysis.
 

Author(s): L A Barboza, N C Ghisi

Journal:

 

Huntington disease (HD) is an incurable neurodegenerative disorder caused by a dominant mutation on the 4th chromosome. We aim to present a scientometric analysis of the extant scientific undertakings devoted to better understanding HD. Therefore, a quantitative study was performed ...

Last Updated: 31 Dec 1969

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Preimplantation genetics and other reproductive options in Huntington disease.
 

Author(s): Jan K Blancato, Erin M Wolfe, Preston C Sacks

Journal: Handb Clin Neurol. 2017 ;144():107-111.

 

Preimplantation genetic diagnosis (PGD) is a form of prenatal diagnosis applied to potential parents with known carrier status of a genetic disease, such as Huntington disease. It employs the use of polymerase chain reaction to amplify single cells from early embryos obtained with ...

Last Updated: 31 Dec 1969

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Development of Research on Huntington Disease in China.
 

Author(s): Hong-Lei Li, Yan-Bin Zhang, Zhi-Ying Wu

Journal: Neurosci Bull. 2017 Jun;33(3):312-316.

 

Huntington disease (HD) is a progressive autosomal dominantly inherited neurodegenerative disorder, characterized with the typical manifestations of involuntary movements, cognitive dysfunction, and psychiatric or behavioral disturbance. It results from an expansion in the number ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 8 May 2018

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Dose-response Evaluation of the Cellavita HD Product in Patients With Huntington's Disease
 

Status: Recruiting

Condition Summary: Huntington Disease

 

Last Updated: 19 Jun 2018

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Last Updated: 14 Aug 2018

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