Huntington disease

Common Name(s)

Huntington disease, Huntington's chorea

Huntington disease is a progressive disorder that causes brain cell (neuron) degeneration in certain areas of the brain.  This results in uncontrolled movements, loss of intellectual abilities, and emotional disturbances. Symptoms typically appear between the ages of 35 and 44 years. People with Huntington disease most often live for 15 to 18 years after the condition appears. Huntington disease caused by mutations in the HTT gene and is inherited in an autosomal dominant manner. Each child of a person with Huntington disease has a 50 percent (1 in 2) chance of inheriting the mutation. There is also a less common, early-onset from that begins in childhood or adolescence, called juvenile Huntington disease.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Huntington disease" for support, advocacy or research.

Caring Voice Coalition,Inc,

Caring Voice Coalition empowers patients who live with a life threatening chronic disease through comprehensive outreach programs and services aimed at financial, emotional and educational support. With a steadfast dedication to the organization’s set of core values, our knowledgeable, caring staff maintains our solid reputation as a dependable, responsive organization with a unique, holistic approach to improving the lives of our patients.

Last Updated: 29 Apr 2014

View Details
Hereditary Disease Foundation

The Hereditary Disease Foundation is a non-profit, basic-science organization dedicated to the cure of genetic disease, with a focus on Huntington disease.

Last Updated: 1 Mar 2013

View Details
Huntington's Disease Society of America

We are a national non-profit voluntary health agency dedicated to finding a cure for Huntington's Disease. We provide vital support, information and educational services to improve the lives of those affected by HD, offer resources and guidance for HD families through our national network of volunteer-based chapters and affiliates as well as through our HDSA Centers of Excellence for Family Services, and promote and support research to find a cure for HD.

Last Updated: 11 Oct 2012

View Details
Movement Disorder Society

The Movement Disorder Society (MDS) is an international professional society of clinicians, scientists, and other healthcare professionals, who are interested in Parkinson's disease, related neurodegenerative and neurodevelopmental disorders, hyperkinetic movement disorders, and abnormalities in muscle tone and motor control.

Last Updated: 5 May 2014

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Huntington disease" for support, advocacy or research.

Caring Voice Coalition,Inc,

Caring Voice Coalition empowers patients who live with a life threatening chronic disease through comprehensive outreach programs and services aimed at financial, emotional and educational support. With a steadfast dedication to the organization’s set of core values, our knowledgeable, caring staff maintains our solid reputation as a dependable, responsive organization with a unique, holistic approach to improving the lives of our patients.

http://www.caringvoice.org

Last Updated: 29 Apr 2014

View Details
Hereditary Disease Foundation

The Hereditary Disease Foundation is a non-profit, basic-science organization dedicated to the cure of genetic disease, with a focus on Huntington disease.

http://www.hdfoundation.org

Last Updated: 1 Mar 2013

View Details
Huntington's Disease Society of America

We are a national non-profit voluntary health agency dedicated to finding a cure for Huntington's Disease. We provide vital support, information and educational services to improve the lives of those affected by HD, offer resources and guidance for HD families through our national network of volunteer-based chapters and affiliates as well as through our HDSA Centers of Excellence for Family Services, and promote and support research to find a cure for HD.

http://www.hdsa.org

Last Updated: 11 Oct 2012

View Details
Movement Disorder Society

The Movement Disorder Society (MDS) is an international professional society of clinicians, scientists, and other healthcare professionals, who are interested in Parkinson's disease, related neurodegenerative and neurodevelopmental disorders, hyperkinetic movement disorders, and abnormalities in muscle tone and motor control.

http://www.movementdisorders.org/MDS.htm

Last Updated: 5 May 2014

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Huntington disease" returned 353 free, full-text research articles on human participants. First 3 results:

Treatment with the MAO-A inhibitor clorgyline elevates monoamine neurotransmitter levels and improves affective phenotypes in a mouse model of Huntington disease.
 

Author(s): Marta Garcia-Miralles, Jolene Ooi, Costanza Ferrari Bardile, Liang Juin Tan, Maya George, Chester L Drum, Rachel Yanping Lin, Michael R Hayden, Mahmoud A Pouladi

Journal: Exp. Neurol.. 2016 Apr;278():4-10.

 

Abnormal monoamine oxidase A and B (MAO-A/B) activity and an imbalance in monoamine neurotransmitters have been suggested to underlie the pathobiology of depression, a major psychiatric symptom observed in patients with neurodegenerative diseases, such as Huntington disease (HD). ...

Last Updated: 11 Mar 2016

Go To URL
Activating transcription factor 6 derepression mediates neuroprotection in Huntington disease.
 

Author(s): José R Naranjo, Hongyu Zhang, Diego Villar, Paz González, Xose M Dopazo, Javier Morón-Oset, Elena Higueras, Juan C Oliveros, María D Arrabal, Angela Prieto, Pilar Cercós, Teresa González, Alicia De la Cruz, Juan Casado-Vela, Alberto Rábano, Carmen Valenzuela, Marta Gutierrez-Rodriguez, Jia-Yi Li, Britt Mellström

Journal: J. Clin. Invest.. 2016 Feb;126(2):627-38.

 

Deregulated protein and Ca2+ homeostasis underlie synaptic dysfunction and neurodegeneration in Huntington disease (HD); however, the factors that disrupt homeostasis are not fully understood. Here, we determined that expression of downstream regulatory element antagonist modulator ...

Last Updated: 2 Feb 2016

Go To URL
RNA Sequence Analysis of Human Huntington Disease Brain Reveals an Extensive Increase in Inflammatory and Developmental Gene Expression.
 

Author(s): Adam Labadorf, Andrew G Hoss, Valentina Lagomarsino, Jeanne C Latourelle, Tiffany C Hadzi, Joli Bregu, Marcy E MacDonald, James F Gusella, Jiang-Fan Chen, Schahram Akbarian, Zhiping Weng, Richard H Myers

Journal:

 

Huntington's Disease (HD) is a devastating neurodegenerative disorder that is caused by an expanded CAG trinucleotide repeat in the Huntingtin (HTT) gene. Transcriptional dysregulation in the human HD brain has been documented but is incompletely understood. Here we present a genome-wide ...

Last Updated: 5 Dec 2015

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Huntington disease" returned 31 free, full-text review articles on human participants. First 3 results:

Huntington Disease in Asia.
 

Author(s): Miao Xu, Zhi-Ying Wu

Journal: Chin. Med. J.. 2015 Jul;128(13):1815-9.

 

The objective was to review the major differences of Huntington disease (HD) in Asian population from those in the Caucasian population.

Last Updated: 26 Jun 2015

Go To URL
Understanding the Outcomes Measures used in Huntington Disease Pharmacological Trials: A Systematic Review.
 

Author(s): Noelle E Carlozzi, Angela Miciura, Nicholas Migliore, Praveen Dayalu

Journal: J Huntingtons Dis. 2014 ;3(3):233-52.

 

The identification of the gene mutation causing Huntington disease has raised hopes for new treatments to ease symptoms and slow functional decline. As such, there has been a push towards designing efficient pharmacological trials (i.e., drug trials), especially with regard to selecting ...

Last Updated: 10 Oct 2014

Go To URL
Neuronal Ca(2+) dyshomeostasis in Huntington disease.
 

Author(s): Marta Giacomello, Juan C Oliveros, Jose R Naranjo, Ernesto Carafoli

Journal: Prion. ;7(1):76-84.

 

The expansion of the N-terminal poly-glutamine tract of the huntingtin (Htt) protein is responsible for Huntington disease (HD). A large number of studies have explored the neuronal phenotype of HD, but the molecular aethiology of the disease is still very poorly understood. This ...

Last Updated: 18 Feb 2013

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

REGISTRY - an Observational Study of the European Huntington's Disease Network (EHDN)
 

Status: Recruiting

Condition Summary: Huntington Disease; Huntington's Disease

 

Last Updated: 18 Feb 2015

Go to URL
Growth and Development of the Striatum in Huntington's Disease
 

Status: Recruiting

Condition Summary: Huntington's Disease

 

Last Updated: 11 May 2016

Go to URL
Enroll -HD: A Prospective Registry Study in a Global Huntington's Disease Cohort
 

Status: Recruiting

Condition Summary: Huntington's Disease

 

Last Updated: 1 Jun 2015

Go to URL