Huntington disease

Common Name(s)

Huntington disease, Huntington's chorea

Huntington disease is a progressive disorder that causes brain cell (neuron) degeneration in certain areas of the brain.  This results in uncontrolled movements, loss of intellectual abilities, and emotional disturbances. Symptoms typically appear between the ages of 35 and 44 years. People with Huntington disease most often live for 15 to 18 years after the condition appears. Huntington disease caused by mutations in the HTT gene and is inherited in an autosomal dominant manner. Each child of a person with Huntington disease has a 50 percent (1 in 2) chance of inheriting the mutation. There is also a less common, early-onset from that begins in childhood or adolescence, called juvenile Huntington disease.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Huntington disease" for support, advocacy or research.

Caring Voice Coalition,Inc,

Caring Voice Coalition empowers patients who live with a life threatening chronic disease through comprehensive outreach programs and services aimed at financial, emotional and educational support. With a steadfast dedication to the organization’s set of core values, our knowledgeable, caring staff maintains our solid reputation as a dependable, responsive organization with a unique, holistic approach to improving the lives of our patients.

Last Updated: 29 Apr 2014

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Hereditary Disease Foundation

The Hereditary Disease Foundation is a non-profit, basic-science organization dedicated to the cure of genetic disease, with a focus on Huntington disease.

Last Updated: 1 Mar 2013

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Huntington's Disease Society of America

We are a national non-profit voluntary health agency dedicated to finding a cure for Huntington's Disease. We provide vital support, information and educational services to improve the lives of those affected by HD, offer resources and guidance for HD families through our national network of volunteer-based chapters and affiliates as well as through our HDSA Centers of Excellence for Family Services, and promote and support research to find a cure for HD.

Last Updated: 11 Oct 2012

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Movement Disorder Society

The Movement Disorder Society (MDS) is an international professional society of clinicians, scientists, and other healthcare professionals, who are interested in Parkinson's disease, related neurodegenerative and neurodevelopmental disorders, hyperkinetic movement disorders, and abnormalities in muscle tone and motor control.

Last Updated: 5 May 2014

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Huntington disease" for support, advocacy or research.

Caring Voice Coalition,Inc,

Caring Voice Coalition empowers patients who live with a life threatening chronic disease through comprehensive outreach programs and services aimed at financial, emotional and educational support. With a steadfast dedication to the organization’s set of core values, our knowledgeable, caring staff maintains our solid reputation as a dependable, responsive organization with a unique, holistic approach to improving the lives of our patients.

http://www.caringvoice.org

Last Updated: 29 Apr 2014

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Hereditary Disease Foundation

The Hereditary Disease Foundation is a non-profit, basic-science organization dedicated to the cure of genetic disease, with a focus on Huntington disease.

http://www.hdfoundation.org

Last Updated: 1 Mar 2013

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Huntington's Disease Society of America

We are a national non-profit voluntary health agency dedicated to finding a cure for Huntington's Disease. We provide vital support, information and educational services to improve the lives of those affected by HD, offer resources and guidance for HD families through our national network of volunteer-based chapters and affiliates as well as through our HDSA Centers of Excellence for Family Services, and promote and support research to find a cure for HD.

http://www.hdsa.org

Last Updated: 11 Oct 2012

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Movement Disorder Society

The Movement Disorder Society (MDS) is an international professional society of clinicians, scientists, and other healthcare professionals, who are interested in Parkinson's disease, related neurodegenerative and neurodevelopmental disorders, hyperkinetic movement disorders, and abnormalities in muscle tone and motor control.

http://www.movementdisorders.org/MDS.htm

Last Updated: 5 May 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Huntington disease" returned 289 free, full-text research articles on human participants. First 3 results:

Huntington' disease--imbalance of amino acid levels in plasma of patients and mutation carriers.
 

Author(s): Beata Gruber, Gabriela Kłaczkow, Małgorzata Jaworska, Jolanta Krzysztoń-Russjan, Elżbieta L Anuszewska, Daniel Zielonka, Aneta Klimberg, Jerzy T Marcinkowski

Journal: Ann Agric Environ Med. 2013 ;20(4):779-83.

 

Determination of the plasma amino acid (AA) levels in Huntington's disease (HD) can make it possible to find the metabolic markers used in early diagnosis. The aim of the presented study was to determine the AA profile in plasma samples from HD patients and presymptomatic carriers, ...

Last Updated: 24 Dec 2013

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C9orf72 expansions are the most common genetic cause of Huntington disease phenocopies.
 

Author(s): Davina J Hensman Moss, Mark Poulter, Jon Beck, Jason Hehir, James M Polke, Tracy Campbell, Garry Adamson, Ese Mudanohwo, Peter McColgan, Andrea Haworth, Edward J Wild, Mary G Sweeney, Henry Houlden, Simon Mead, Sarah J Tabrizi

Journal: Neurology. 2014 Jan;82(4):292-9.

 

In many cases where Huntington disease (HD) is suspected, the genetic test for HD is negative: these are known as HD phenocopies. A repeat expansion in the C9orf72 gene has recently been identified as a major cause of familial and sporadic frontotemporal lobar degeneration and amyotrophic ...

Last Updated: 28 Jan 2014

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Mitochondrial permeability transition pore induces mitochondria injury in Huntington disease.
 

Author(s): Rodrigo A Quintanilla, Youngnam N Jin, Rommy von Bernhardi, Gail V W Johnson

Journal:

 

Mitochondrial impairment has been implicated in the pathogenesis of Huntington's disease (HD). However, how mutant huntingtin impairs mitochondrial function and thus contributes to HD has not been fully elucidated. In this study, we used striatal cells expressing wild type (STHdhQ7/Q7) ...

Last Updated: 20 Dec 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Huntington disease" returned 25 free, full-text review articles on human participants. First 3 results:

Neuronal Ca(2+) dyshomeostasis in Huntington disease.
 

Author(s): Marta Giacomello, Juan C Oliveros, Jose R Naranjo, Ernesto Carafoli

Journal: Prion. ;7(1):76-84.

 

The expansion of the N-terminal poly-glutamine tract of the huntingtin (Htt) protein is responsible for Huntington disease (HD). A large number of studies have explored the neuronal phenotype of HD, but the molecular aethiology of the disease is still very poorly understood. This ...

Last Updated: 18 Feb 2013

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Therapeutic approaches to preventing cell death in Huntington disease.
 

Author(s): Anna Kaplan, Brent R Stockwell

Journal: Prog. Neurobiol.. 2012 Dec;99(3):262-80.

 

Neurodegenerative diseases affect the lives of millions of patients and their families. Due to the complexity of these diseases and our limited understanding of their pathogenesis, the design of therapeutic agents that can effectively treat these diseases has been challenging. Huntington ...

Last Updated: 23 Nov 2012

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Comprehensive treatment of Huntington disease and other choreic disorders.
 

Author(s): Carlos Singer

Journal: Cleve Clin J Med. 2012 Jul;79 Suppl 2():S30-4.

 

The management of choreic disorders presents significant challenges, including identifying the etiology of the disorder, treating and preventing motor symptoms, and managing a range of other neurologic and behavioral complications. Chorea may occur in several neurodegenerative, genetic, ...

Last Updated: 4 Jul 2012

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Clinical Trial Information This information is provided by ClinicalTrials.gov

REGISTRY - an Observational Study of the European Huntington's Disease Network (EHDN)
 

Status: Recruiting

Condition Summary: Huntington Disease; Huntington's Disease

 

Last Updated: 4 Sep 2013

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Bioavailability of Ubiquinol in Huntington Disease
 

Status: Recruiting

Condition Summary: Huntington Disease

 

Last Updated: 18 Sep 2009

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Neuroleptic and Huntington Disease Comparison of : Olanzapine, la Tetrabenazine and Tiapride
 

Status: Recruiting

Condition Summary: Huntington Disease

 

Last Updated: 26 Feb 2014

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