Hirschsprung's disease

Common Name(s)

Hirschsprung's disease, Hirschsprung disease 1

Hirschsprung disease is a disease of the large intestine or colon. People with this disease do not have the nerve cells in the intestine required to expel stools from the body normally. Symptoms of Hirschsprung disease usually show up in very young children, but sometimes not until adolescence or adulthood. The symptoms may vary with age, but often involve constipation and/or obstruction of the bowel.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hirschsprung's disease" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

Last Updated: 28 Feb 2015

View Details
Mowat Wilson Support

We are a support group and website where families can share information about Mowat-Wilson Syndrome. Our website includes support group information, a forum, photos and profiles of children with MWS and parent survey pages. We want to help inform the public about this rare condition and to help those affected by it not feel so alone by giving them a place to exchange information and experiences with others in the same situation.

Last Updated: 6 Mar 2014

View Details
Pull-thru Network, Inc.

The Pull-thru Network is a volunteer-based organization dedicated to providing education, information, support and advocacy for those individuals, and the families of those individuals, who are affected by any congenital anorectal, colorectal or urogenital disorder and any of the variety of related diagnoses.

Last Updated: 8 Nov 2012

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hirschsprung's disease" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

http://www.agmd-gimotility.org

Last Updated: 28 Feb 2015

View Details
Mowat Wilson Support

We are a support group and website where families can share information about Mowat-Wilson Syndrome. Our website includes support group information, a forum, photos and profiles of children with MWS and parent survey pages. We want to help inform the public about this rare condition and to help those affected by it not feel so alone by giving them a place to exchange information and experiences with others in the same situation.

http://www.mowatwilson.org

Last Updated: 6 Mar 2014

View Details
Pull-thru Network, Inc.

The Pull-thru Network is a volunteer-based organization dedicated to providing education, information, support and advocacy for those individuals, and the families of those individuals, who are affected by any congenital anorectal, colorectal or urogenital disorder and any of the variety of related diagnoses.

http://www.PullthruNetwork.org

Last Updated: 8 Nov 2012

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hirschsprung's disease" returned 173 free, full-text research articles on human participants. First 3 results:

Expression profiles of HA117 and its neighboring gene DPF3 in different colon segments of Hirschsprung's disease.
 

Author(s): Hang Liu, Yuanyuan Luo, Shuangshuang Li, Shiqi Wang, Ning Wang, Xianqing Jin

Journal:

 

Hirschsprung's disease (HSCR) is characterized by the absence of enteric ganglion cells along variable regions of the colon. Established theory demonstrates that HSCR is the consequence caused by the abnormal arrest of the migration and differentiation of neural crest-derived stem ...

Last Updated: 14 Aug 2014

Go To URL
MiR-195 affects cell migration and cell proliferation by down-regulating DIEXF in Hirschsprung's disease.
 

Author(s): Hao Lei, Junwei Tang, Hongxing Li, Hongwei Zhang, Changgui Lu, Huan Chen, Wei Li, Yankai Xia, Weibing Tang

Journal:

 

Hirschsprung's disease (HSCR) is the most common congenital gut motility disorder. We aimed to investigate the roles of miR-195 in the pathogenesis of HSCR.

Last Updated: 16 Jul 2014

Go To URL
Hirschsprung's disease in children: a five year experience at a university teaching hospital in northwestern Tanzania.
 

Author(s): Joseph B Mabula, Neema M Kayange, Mange Manyama, Alphonce B Chandika, Peter F Rambau, Phillipo L Chalya

Journal:

 

Hirschsprung's disease (HD) is the commonest cause of functional intestinal obstruction in children and poses challenges to pediatricians and pediatric surgeons practicing in resource-limited countries. This study describes the clinical characteristics and outcome of management of ...

Last Updated: 7 Jul 2014

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hirschsprung's disease" returned 13 free, full-text review articles on human participants. First 3 results:

Advances in molecular genetics of Hirschsprung's disease.
 

Author(s): Zhi-Wen Pan, Ji-Cheng Li

Journal: Anat Rec (Hoboken). 2012 Oct;295(10):1628-38.

 

Hirschsprung's disease (HSCR) is a developmental disorder of the enteric nervous system, which occurs due to the failure of neural crest cells to fully colonize the gut during embryonic development. It is characterized by the absence of the enteric ganglia in a variable length of ...

Last Updated: 13 Sep 2012

Go To URL
Genetic interactions and modifier genes in Hirschsprung's disease.
 

Author(s): Adam S Wallace, Richard B Anderson

Journal: World J. Gastroenterol.. 2011 Dec;17(45):4937-44.

 

Hirschsprung's disease is a congenital disorder that occurs in 1:5000 live births. It is characterised by an absence of enteric neurons along a variable region of the gastrointestinal tract. Hirschsprung's disease is classified as a multigenic disorder, because the same phenotype ...

Last Updated: 16 Dec 2011

Go To URL
Genetic model system studies of the development of the enteric nervous system, gut motility and Hirschsprung's disease.
 

Author(s): G Burzynski, I T Shepherd, H Enomoto

Journal: Neurogastroenterol. Motil.. 2009 Feb;21(2):113-27.

 

The enteric nervous system (ENS) is the largest and most complicated subdivision of the peripheral nervous system. Its action is necessary to regulate many of the functions of the gastrointestinal tract including its motility. Whilst the ENS has been studied extensively by developmental ...

Last Updated: 13 Feb 2009

Go To URL
 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 2 Feb 2015

Go to URL
Hirschsprung Disease Genetic Study
 

Status: Recruiting

Condition Summary: Hirschsprung Disease

 

Last Updated: 28 Oct 2014

Go to URL
Genetic Mosaicism in Hirschsprung's Disease
 

Status: Recruiting

Condition Summary: Hirschsprung Disease

 

Last Updated: 10 Feb 2015

Go to URL