Herpetic keratitis

Common Name(s)

Herpetic keratitis, Herpes zoster ophthalmicus

Herpetic keratitis is a herpes simplex virus infection of the eye. There are two types of herpes viruses, herpes simplex 1 (HS1) and 2 (HS2). HS2 herpetic keratitis is more rare since HS2 is sexually transmitted. HS1, however can spread to the eye by touching an infected mouth sore and then touching the eye. Symptoms of herpetic keratitis include redness, photophobia (light sensitivity), blurred vision, tearing, and pain. Herpetic keratitis is also the most common form of infectious blindness in the world. Most infections, however, are healed on their own within three weeks. Oral and topical antiviral therapies are also effective treatments for herpetic keratitis.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Herpetic keratitis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Herpetic keratitis" returned 42 free, full-text research articles on human participants. First 3 results:

Common and new acyclovir resistant herpes simplex virus-1 mutants causing bilateral recurrent herpetic keratitis in an immunocompetent patient.
 

Author(s): Dongli Pan, Stephen B Kaye, Mark Hopkins, Ruaidhri Kirwan, Ian J Hart, Donald M Coen

Journal: J. Infect. Dis.. 2014 Feb;209(3):345-9.

 

We investigated thymidine kinase (tk) mutants isolated during multiple episodes of recurrent bilateral acyclovir resistant herpes simplex keratitis in an immunocompetent patient. From one eye, we found a single guanine insertion, previously shown to greatly reduce TK expression, and ...

Last Updated: 8 Jan 2014

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Acyclovir prophylaxis predisposes to antiviral-resistant recurrent herpetic keratitis.
 

Author(s): Monique van Velzen, David A M C van de Vijver, Freek B van Loenen, Albert D M E Osterhaus, Lies Remeijer, Georges M G M Verjans

Journal: J. Infect. Dis.. 2013 Nov;208(9):1359-65.

 

Long-term acyclovir (ACV) prophylaxis, recommended to prevent recurrent herpes simplex virus type 1 (HSV-1) ocular disorders, may pose a risk for ACV-refractory disease due to ACV resistance. We determined the effect of ACV prophylaxis on the prevalence of corneal ACV-resistant (ACV(R)) ...

Last Updated: 4 Oct 2013

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A possible pitfall in acyclovir prophylaxis for recurrent herpetic keratitis?
 

Author(s): Scott H James, Mark N Prichard

Journal: J. Infect. Dis.. 2013 Nov;208(9):1353-5.

 

Last Updated: 4 Oct 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Herpetic keratitis" returned 3 free, full-text review articles on human participants. First 3 results:

Potential function of miRNAs in herpetic stromal keratitis.
 

Author(s): Sachin Mulik, Siddheshvar Bhela, Barry T Rouse

Journal:

 

MicroRNAs (miRNAs), the newly discovered regulators of gene expression, act by promoting degradation of mRNA and/or by inhibiting protein expression. Dysregulation of miRNA expression has been noted in an expanding number of diseases; and in some instances, manipulating miRNA expression ...

Last Updated: 18 Jan 2013

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Recurrent herpetic stromal keratitis in mice: a model for studying human HSK.
 

Author(s): Patrick M Stuart, Tammie L Keadle

Journal: Clin. Dev. Immunol.. 2012 ;2012():728480.

 

Herpes simplex virus 1 (HSV-1) infection of the cornea leads to a potentially blinding disease, termed herpetic stromal keratitis (HSK) that is characterized by lesions of an immunoinflammatory nature. In spite of the fact that HSK typically presents as a recurrent disease due to ...

Last Updated: 17 May 2012

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[Current concepts in the treatment of herpetic keratitis].
 

Author(s): M Labetoulle, J Colin

Journal: J Fr Ophtalmol. 2012 Apr;35(4):292-307.

 

Herpes simplex virus is a frequent cause of keratitis. Clinical forms are usually classified as epithelial, stromal, endothelial, or neurotrophic. Management depends on the respective degrees of these various components, with some patients presenting with compound forms. In the acute ...

Last Updated: 2 Apr 2012

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 11 Sep 2014

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