Hereditary neuralgic amyotrophy

Common Name(s)

Hereditary neuralgic amyotrophy

Hereditary neuralgic amyotrophy is a type of nervous system disease that affects the brachial plexus. Common signs and symptoms include episodes of severe pain and muscle wasting in one or both shoulders and arms.  Attacks may be spontaneous or triggered (e.g., by exercise, childbirth, surgery, infection etc.).  Secondary complications, such as decreased sensation, abnormal sensations (e.g., numbness and tingling), chronic pain, and impaired movement may develop overtime. Affected members in some families may share additional distinct physical and facial characteristics. Hereditary neuralgic amyotrophy can be caused by mutations in the SEPT9 gene.  It is inherited in an autosomal dominant fashion.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hereditary neuralgic amyotrophy" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hereditary neuralgic amyotrophy" returned 6 free, full-text research articles on human participants. First 3 results:

SEPT9 gene sequencing analysis reveals recurrent mutations in hereditary neuralgic amyotrophy.
 

Author(s): M C Hannibal, E K Ruzzo, L R Miller, B Betz, J G Buchan, D M Knutzen, K Barnett, M L Landsverk, A Brice, E LeGuern, H M Bedford, B B Worrall, S Lovitt, S H Appel, E Andermann, T D Bird, P F Chance

Journal: Neurology. 2009 May;72(20):1755-9.

 

Hereditary neuralgic amyotrophy (HNA) is an autosomal dominant disorder that manifests as recurrent, episodic, painful brachial neuropathies. A gene for HNA maps to chromosome 17q25.3 where mutations in SEPT9, encoding the septin-9 protein, have been identified.

Last Updated: 19 May 2009

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Duplication within the SEPT9 gene associated with a founder effect in North American families with hereditary neuralgic amyotrophy.
 

Author(s): Megan L Landsverk, Elizabeth K Ruzzo, Heather C Mefford, Karen Buysse, Jillian G Buchan, Evan E Eichler, Elizabeth M Petty, Esther A Peterson, Dana M Knutzen, Karen Barnett, Martin R Farlow, Judy Caress, Gareth J Parry, Dianna Quan, Kathy L Gardner, Ming Hong, Zachary Simmons, Thomas D Bird, Phillip F Chance, Mark C Hannibal

Journal: Hum. Mol. Genet.. 2009 Apr;18(7):1200-8.

 

Hereditary neuralgic amyotrophy (HNA) is an autosomal dominant disorder associated with recurrent episodes of focal neuropathy primarily affecting the brachial plexus. Point mutations in the SEPT9 gene have been previously identified as the molecular basis of HNA in some pedigrees. ...

Last Updated: 17 Mar 2009

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Histology of hereditary neuralgic amyotrophy.
 

Author(s): N van Alfen, A A W M Gabreëls-Festen, H J Ter Laak, W F M Arts, F J M Gabreëls, B G M van Engelen

Journal: J. Neurol. Neurosurg. Psychiatr.. 2005 Mar;76(3):445-7.

 

We report the findings in five muscle and three sural nerve biopsies, and in one postmortem plexus specimen, from six patients with hereditary neuralgic amyotrophy (HNA). We found that the sensory nerves are definitely involved in HNA despite the mainly motor symptoms, and that lesions ...

Last Updated: 17 Feb 2005

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Reviews from the PubMed Database

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The terms "Hereditary neuralgic amyotrophy" returned 0 free, full-text review articles on human participants.

 
 
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