Hereditary diffuse gastric cancer

Common Name(s)

Hereditary diffuse gastric cancer

Hereditary diffuse gastric cancer is an inherited cancer syndrome that greatly increases the chance of developing cancer of the stomach lining. This syndrome is caused by mutations in the CDH1 gene. In hereditary diffuse gastric cancer, stomach cancer typically develops in a person's late thirties or early forties. Mutations in the CDH1 gene also increase a person's risk for lobular breast cancer. This condition is inherited in an autosomal dominant pattern.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hereditary diffuse gastric cancer" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hereditary diffuse gastric cancer" returned 22 free, full-text research articles on human participants. First 3 results:

Clinical utility gene card for: Hereditary diffuse gastric cancer (HDGC).
 

Author(s): Carla Oliveira, Raquel Seruca, Nicoline Hoogerbrugge, Marjolijn Ligtenberg, Fátima Carneiro

Journal: Eur. J. Hum. Genet.. 2013 Aug;21(8):.

 

Last Updated: 18 Jul 2013

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Catenin family genes are not commonly mutated in hereditary diffuse gastric cancer.
 

Author(s): Johanna M Schuetz, Stephen Leach, Pardeep Kaurah, Jennifer Jeyes, Yaron Butterfield, David Huntsman, Angela R Brooks-Wilson

Journal: Cancer Epidemiol. Biomarkers Prev.. 2012 Dec;21(12):2272-4.

 

Approximately one third of the hereditary diffuse gastric cancer (HDGC) families carry germline mutations in the E-cadherin gene (CDH1). Risk prediction in members of families with this rare but deadly cancer could be improved by the identification of additional HDGC genes in non-CDH1 families.

Last Updated: 10 Dec 2012

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Hereditary diffuse gastric cancer: strategies to reduce tumoral risk.
 

Author(s): Maite Herráiz, Víctor Valentí, Jesús Sola, Pilar Pérez-Rojo, Fernando Rotellar, Javier A Cienfuegos

Journal: Rev Esp Enferm Dig. 2012 Jun;104(6):326-9.

 

The main goal at a High-Risk Gastrointestinal Cancer Clinic is to identify individuals at increased risk of developing tumors for diagnosis them in presymptomatic stages, when they are potentially curable. We report an asymptomatic patient belonging to a family with hereditary diffuse ...

Last Updated: 28 Jun 2012

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hereditary diffuse gastric cancer" returned 4 free, full-text review articles on human participants. First 3 results:

Hereditary diffuse gastric cancer: a family diagnosis and treatment.
 

Author(s): Adedayo A Onitilo, Govinda Aryal, Jessica M Engel

Journal: Clin Med Res. 2013 Feb;11(1):36-41.

 

Hereditary diffuse gastric cancer (HDGC) is a rare cancer representing approximately 2% of all gastric cancers. It is caused by CDHI gene mutations, inherited in an autosomal dominant fashion, that affect the function of E-cadherin. Approximately 38% of HDGC families have a CDHI gene ...

Last Updated: 15 Feb 2013

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Hereditary diffuse gastric cancer: prophylactic surgical oncology implications.
 

Author(s): Henry T Lynch, Edibaldo Silva, Debrah Wirtzfeld, Pamela Hebbard, Jane Lynch, David G Huntsman

Journal: Surg. Clin. North Am.. 2008 Aug;88(4):759-78, vi-vii.

 

Hereditary diffuse gastric cancer (HDGC) is an autosomal dominantly inherited syndrome attributed to mutations of the E-cadherin gene, CDH1. There is no proven effective screening for early HDGC, and symptomatic disease is almost universally fatal. The only available effective option ...

Last Updated: 1 Aug 2008

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Hereditary diffuse gastric cancer: association with lobular breast cancer.
 

Author(s): Kasmintan A Schrader, Serena Masciari, Niki Boyd, Sara Wiyrick, Pardeep Kaurah, Janine Senz, Wylie Burke, Henry T Lynch, Judy E Garber, David G Huntsman

Journal: Fam. Cancer. 2008 ;7(1):73-82.

 

Hereditary diffuse gastric cancer (HDGC) has been shown to be caused by germline mutations in the gene CDH1 located at 16q22.1, which encodes the cell-cell adhesion molecule, E-cadherin. Not only does loss of expression of E-cadherin account for the morphologic differences between ...

Last Updated: 25 Feb 2008

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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.