Hereditary diffuse gastric cancer

Common Name(s)

Hereditary diffuse gastric cancer, HDGC

Hereditary diffuse gastric cancer (HDGC) is a type of stomach (gastric) cancer that runs through families. HDGC is different from other types of stomach cancer because the cancer cells do not form into a solid tumor. Instead, HDGC cancer cells disperse or scatter throughout the stomach tissue. Because of this, this type of cancer spreads (metastasizes) more easily to other parts of the body.

Symptoms of this condition are often not recognized until the cancer is in later stages. These symptoms may include stomach pain, vomiting, and weight loss. Unfortunately, this type of cancer is difficult to catch in early stages. Therefore, if you have a history of HDGC in your family, it is important to get regular and frequent stomach (endoscopy) exams to detect for any cancer cell formation.

HDGC is caused by a genetic mutation in the CDH1 gene which is located on chromosome 16. When a mutation is present in the gene, the gene is unable to pass along the correct instructions to the rest of the cells of the body. As a result, a person with a mutation in the CDH1 gene has a higher risk of developing HDGC, lobular breast cancer, and some forms of colon cancer.

Inheriting a CDH1 mutation does not mean that you will definitely develop these forms of cancer. Rather, the mutation increases your risk of developing HDGC, lobular breast cancer and colon cancer. If you have a family member diagnosed with HDGC or a mutation in the CDH1 gene, talk with a genetic counselor to see if genetic testing is right for you. If you or a family member has been diagnosed with HDGC, talk with your doctor and specialists about the most current treatment options.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hereditary diffuse gastric cancer" for support, advocacy or research.

No Stomach For Cancer

Our mission is to support research and united the caring power of people worldwide affected by stomach cancer. We advance awareness and education about stomach cancer, including Hereditary Diffuse Gastric Cancer (HDGC), provide a support network for affected families, and support research for screening, early detection, treatment, and prevention of stomach cancer.

Last Updated: 7 Jan 2016

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hereditary diffuse gastric cancer" for support, advocacy or research.

No Stomach For Cancer

Our mission is to support research and united the caring power of people worldwide affected by stomach cancer. We advance awareness and education about stomach cancer, including Hereditary Diffuse Gastric Cancer (HDGC), provide a support network for affected families, and support research for screening, early detection, treatment, and prevention of stomach cancer.

http://www.nostomachforcancer.org

Last Updated: 7 Jan 2016

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hereditary diffuse gastric cancer" returned 27 free, full-text research articles on human participants. First 3 results:

Hereditary diffuse gastric cancer: laparoscopic surgical approach associated to rare mutattion of CDH1 gene.
 

Author(s): Eurico Cleto Ribeiro de Campos, Saturnino Ribeiro, Rafaella Higashi, Ricardo Manfredini, Diogo Kfouri, Teresa Cristina Santos Cavalcanti

Journal: Arq Bras Cir Dig. ;28(2):149-51.

 

Last Updated: 16 Jul 2015

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Hereditary diffuse gastric cancer associated with E-cadherin germline mutation: a case report.
 

Author(s): Michael D Black, Raynette Kaneshiro, Jennifer I Lai, David M Shimizu

Journal: Hawaii J Med Public Health. 2014 Jul;73(7):204-7.

 

Hereditary diffuse gastric cancer (HDGC) is an autosomal dominate cancer syndrome that leads to an increased risk of developing invasive diffuse type (signet ring cell) gastric carcinoma. Approximately 30% of HDGC cases are caused by a germline mutation involving the E-cadherin (CDH1) ...

Last Updated: 4 Aug 2014

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Clinical utility gene card for: Hereditary diffuse gastric cancer (HDGC).
 

Author(s): Carla Oliveira, Raquel Seruca, Nicoline Hoogerbrugge, Marjolijn Ligtenberg, Fátima Carneiro

Journal: Eur. J. Hum. Genet.. 2013 Aug;21(8):.

 

Last Updated: 18 Jul 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hereditary diffuse gastric cancer" returned 6 free, full-text review articles on human participants. First 3 results:

Hereditary diffuse gastric cancer: updated clinical guidelines with an emphasis on germline CDH1 mutation carriers.
 

Author(s): Rachel S van der Post, Ingrid P Vogelaar, Fátima Carneiro, Parry Guilford, David Huntsman, Nicoline Hoogerbrugge, Carlos Caldas, Karen E Chelcun Schreiber, Richard H Hardwick, Margreet G E M Ausems, Linda Bardram, Patrick R Benusiglio, Tanya M Bisseling, Vanessa Blair, Eveline Bleiker, Alex Boussioutas, Annemieke Cats, Daniel Coit, Lynn DeGregorio, Joana Figueiredo, James M Ford, Esther Heijkoop, Rosella Hermens, Bostjan Humar, Pardeep Kaurah, Gisella Keller, Jennifer Lai, Marjolijn J L Ligtenberg, Maria O'Donovan, Carla Oliveira, Hugo Pinheiro, Krish Ragunath, Esther Rasenberg, Susan Richardson, Franco Roviello, Hans Schackert, Raquel Seruca, Amy Taylor, Anouk Ter Huurne, Marc Tischkowitz, Sheena Tjon A Joe, Benjamin van Dijck, Nicole C T van Grieken, Richard van Hillegersberg, Johanna W van Sandick, Rianne Vehof, J Han van Krieken, Rebecca C Fitzgerald

Journal: J. Med. Genet.. 2015 Jun;52(6):361-74.

 

Germline CDH1 mutations confer a high lifetime risk of developing diffuse gastric (DGC) and lobular breast cancer (LBC). A multidisciplinary workshop was organised to discuss genetic testing, surgery, surveillance strategies, pathology reporting and the patient's perspective on multiple ...

Last Updated: 24 May 2015

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Hereditary diffuse gastric cancer: a family diagnosis and treatment.
 

Author(s): Adedayo A Onitilo, Govinda Aryal, Jessica M Engel

Journal: Clin Med Res. 2013 Feb;11(1):36-41.

 

Hereditary diffuse gastric cancer (HDGC) is a rare cancer representing approximately 2% of all gastric cancers. It is caused by CDHI gene mutations, inherited in an autosomal dominant fashion, that affect the function of E-cadherin. Approximately 38% of HDGC families have a CDHI gene ...

Last Updated: 15 Feb 2013

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Hereditary diffuse gastric cancer: a manifestation of lost cell polarity.
 

Author(s): Bostjan Humar, Parry Guilford

Journal: Cancer Sci.. 2009 Jul;100(7):1151-7.

 

Hereditary diffuse gastric cancer is a cancer syndrome caused by germline mutations in the gene for the cell adhesion protein E-cadherin (CDH1). E-cadherin plays a central role in the maintenance of cell polarity and its loss during tumorigenesis is associated with poorly differentiated ...

Last Updated: 2 Jul 2009

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Hereditary Colorectal and Associated Tumor Registry Study
 

Status: Recruiting

Condition Summary: Lynch Syndrome; FAP; Hereditary Diffuse Gastric Cancer; Juvenile Polyposis Syndrome; Peutz-Jeghers Syndrome

 

Last Updated: 14 Jan 2016

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