Lynch syndrome

Common Name(s)

Lynch syndrome, Hereditary non-polyposis colorectal cancer (HNPCC)

Lynch syndrome is a genetic condition that causes an increased risk for several different types of cancer. People with Lynch syndrome have a lifetime cancer risk of 52-82% for colorectal (cancer of the colon or rectum), 25-60% for endometrial (cancer of the inner lining of the uterus), 6-13% for gastric (stomach cancer) and 4-12% for ovarian cancer. Lynch syndrome also causes a higher risk for cancer of the upper urinary tract, kidneys, small intestine, skin, and brain.

Lynch syndrome is caused by a mutation (change) in one of several genes important in our cell’s DNA (genetic code) repair. Mistakes happen when a cell makes a copy of its DNA during mitosis. Mitosis is the way our body’s cells make more cells (one cell splits into 2 cells). The MLH1, MSH2, MSH6, PMS2, and EPCAM genes make proteins which find and fix mistakes in the newly copied DNA. If one of these DNA repair proteins is missing, there is a greater chance for DNA copy errors to not be fixed, leading to the increased risk of certain cancers.

Mutations that cause Lynch syndrome can occur by chance for the first time in a family (de novo), but are often inherited from a parent in an autosomal dominant manner (a mutation in one copy of the gene causes the condition). People with Lynch syndrome will have a 50% chance of passing it on to any of their children.

Lynch syndrome is often diagnosed based on an individual’s cancer and family history. Genetic testing is used to confirm the diagnosis. If you or someone in your family has been diagnosed with Lynch syndrome, talk with a genetic counselor to discuss inheritance risks and testing options. Most doctors and specialists recommend you receive routine cancer screenings to catch any developing cancer in the early stages. Talk with your doctor about the most current options to screen for cancer. Support groups are a good source of information and help connect you with others living with Lynch syndrome.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Lynch syndrome" for support, advocacy or research.

Center for Jewish Genetics

The Center is dedicated to gathering and disseminating knowledge about Jewish genetic disorders and hereditary cancers. Its mission is to educate and serve health care professionals, clergy and the Jewish community.

Last Updated: 26 Dec 2012

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Colon Cancer Alliance for Research & Education for Lynch Syndrome

CCARE Lynch Syndrome is the national non-profit devoted to saving lives and leading the fight against Lynch syndrome through education, advocacy and research.

Last Updated: 5 Aug 2013

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Lynch Syndrome International

To provide support for those at high risk to hereditary Lynch syndrome cancers, public awareness of Lynch syndrome, education for medical offices and support for research endeavors.

Last Updated: 16 Jun 2015

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General Support Organizations

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How do you compare to others with this condition?

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Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Lynch syndrome" for support, advocacy or research.

Center for Jewish Genetics

The Center is dedicated to gathering and disseminating knowledge about Jewish genetic disorders and hereditary cancers. Its mission is to educate and serve health care professionals, clergy and the Jewish community.

http://www.jewishgenetics.org

Last Updated: 26 Dec 2012

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Colon Cancer Alliance for Research & Education for Lynch Syndrome

CCARE Lynch Syndrome is the national non-profit devoted to saving lives and leading the fight against Lynch syndrome through education, advocacy and research.

http://fightlynch.org/

Last Updated: 5 Aug 2013

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Lynch Syndrome International

To provide support for those at high risk to hereditary Lynch syndrome cancers, public awareness of Lynch syndrome, education for medical offices and support for research endeavors.

http://www.lynchcancers.com

Last Updated: 16 Jun 2015

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Lynch syndrome" returned free, full-text research articles on human participants.

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Lynch syndrome" returned 48 free, full-text review articles on human participants. First 3 results:

[Clinicopathological screening of Lynch syndrome: a report of 2 cases and literature review].
 

Author(s): Jing-wen Si, Li Wang, Xiao-jun Ba, Xu Zhang, Ying Dong, Ji-xin Zhang, Wen-ting Li, Ting Li

Journal: Beijing Da Xue Xue Bao. 2015 Oct;47(5):858-64.

 

Lynch syndrome is an autosomal dominant genetic disease characterized by the early onset of colon cancer, endometrial cancer and other tumors caused by a genetic mutation within DNA mismatch repair (MMR) genes. A small subgroup (approximately 3%-5%) of endometrial cancer and colorectal ...

Last Updated: 17 Oct 2015

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Advances in the study of Lynch syndrome in China.
 

Author(s): Jun-Yu Lu, Jian-Qiu Sheng

Journal: World J. Gastroenterol.. 2015 Jun;21(22):6861-71.

 

Lynch syndrome, also known as hereditary nonpolyposis colorectal cancer, is an autosomal dominant genetic condition that has a high risk of colon cancer as well as other cancers due to inherited mutations in mismatch repair (MMR) genes. During the last decades, there have been great ...

Last Updated: 16 Jun 2015

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First reported case of a squamous cell carcinoma arising in the duodenum in a patient with Lynch syndrome.
 

Author(s): Ali I Amjad, Aatur D Singhi, Edward P Balaban, Beth Dudley, Randall E Brand, Nathan Bahary

Journal:

 

A 58 y/o male with Lynch syndrome, who was diagnosed with a squamous cell carcinoma (SCC) arising in the duodenum, is described. Previous malignancies included two metachronous colorectal adenocarcinomas, and a known family history of Lynch syndrome associated with deletion of exons ...

Last Updated: 12 Feb 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Registry for Women Who Are At Risk Or May Have Lynch Syndrome
 

Status: Recruiting

Condition Summary: Hereditary Nonpolyposis Colorectal Cancer; Lynch Syndrome

 

Last Updated: 12 May 2016

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Multi-Organ Screening Recommendations in Patients With Lynch Syndrome
 

Status: Recruiting

Condition Summary: Lynch Syndrome

 

Last Updated: 26 Jul 2016

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Universal Screening for Lynch Syndrome in Women With Endometrial and Non-Serous Ovarian Cancer
 

Status: Recruiting

Condition Summary: Lynch Syndrome; Endometrial Neoplasms; Ovarian Neoplasms; Colorectal Neoplasms

 

Last Updated: 15 Apr 2016

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