Lynch syndrome

Common Name(s)

Lynch syndrome, Hereditary Non-Polyposis Colorectal Cancer (HNPCC)

Lynch syndrome is an inherited condition that causes an increased risk of developing cancer. Individuals with Lynch syndrome have a higher risk of developing colon and rectal cancer, as well as cancers of the stomach, small intestine, liver, gallbladder ducts, upper urinary tract, brain, skin, and prostate. Women with Lynch syndrome also have a high risk of developing uterine cancer (also called endometrial cancer) and ovarian cancer. Even though the disorder was originally described as not involving noncancerous (benign) growths (polyps) in the colon, people with Lynch syndrome may occasionally have colon polyps. Lynch syndrome has an autosomal dominant pattern of inheritance and is caused by a mutation in the MLH1, MSH2, MSH6, PMS2 or EPCAM gene.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Lynch syndrome" for support, advocacy or research.

Center for Jewish Genetics

The Center is dedicated to gathering and disseminating knowledge about Jewish genetic disorders and hereditary cancers. Its mission is to educate and serve health care professionals, clergy and the Jewish community.

http://www.jewishgenetics.org

Last Updated: 26 Dec 2012

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Colon Cancer Alliance for Research & Education for Lynch Syndrome

CCARE Lynch Syndrome is the national non-profit devoted to saving lives and leading the fight against Lynch syndrome through education, advocacy and research.

http://fightlynch.org/

Last Updated: 5 Aug 2013

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Lynch Syndrome International

To provide support for those at high risk to hereditary Lynch syndrome cancers, public awareness of Lynch syndrome, education for medical offices and support for research endeavors.

http://www.lynchcancers.com

Last Updated: 13 Feb 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Lynch syndrome" for support, advocacy or research.

Center for Jewish Genetics

The Center is dedicated to gathering and disseminating knowledge about Jewish genetic disorders and hereditary cancers. Its mission is to educate and serve health care professionals, clergy and the Jewish community.

http://www.jewishgenetics.org

Last Updated: 26 Dec 2012

View Details
Colon Cancer Alliance for Research & Education for Lynch Syndrome

CCARE Lynch Syndrome is the national non-profit devoted to saving lives and leading the fight against Lynch syndrome through education, advocacy and research.

http://fightlynch.org/

Last Updated: 5 Aug 2013

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Lynch Syndrome International

To provide support for those at high risk to hereditary Lynch syndrome cancers, public awareness of Lynch syndrome, education for medical offices and support for research endeavors.

http://www.lynchcancers.com

Last Updated: 13 Feb 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Lynch syndrome" returned 167 free, full-text research articles on human participants. First 3 results:

Distinct gene expression signatures in lynch syndrome and familial colorectal cancer type x.
 

Author(s): Mev Dominguez-Valentin, Christina Therkildsen, Srinivas Veerla, Mats Jönsson, Inge Bernstein, Ake Borg, Mef Nilbert

Journal:

 

Heredity is estimated to cause at least 20% of colorectal cancer. The hereditary nonpolyposis colorectal cancer subset is divided into Lynch syndrome and familial colorectal cancer type X (FCCTX) based on presence of mismatch repair (MMR) gene defects.

Last Updated: 16 Aug 2013

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Is prostate cancer a Lynch syndrome cancer?
 

Author(s): Aung Ko Win

Journal: Asian J. Androl.. 2013 Sep;15(5):588-9.

 

Last Updated: 2 Sep 2013

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UMD-MLH1/MSH2/MSH6 databases: description and analysis of genetic variations in French Lynch syndrome families.
 

Author(s): Philippe Grandval, Aurélie J Fabre, Pascaline Gaildrat, Stéphanie Baert-Desurmont, Marie-Pierre Buisine, Anthony Ferrari, Qing Wang, Christophe Béroud, Sylviane Olschwang

Journal:

 

Lynch syndrome is an autosomal dominant disease caused by germ line heterozygous mutations mainly involving the MSH2, MLH1 and MSH6 genes that belong to the DNA MisMatch Repair (MMR) genes family. The French network counting the 16 licensed laboratories involved in Lynch syndrome ...

Last Updated: 4 Jun 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Lynch syndrome" returned 22 free, full-text review articles on human participants. First 3 results:

Genetic modifiers of cancer risk in Lynch syndrome: a review.
 

Author(s): Bente A Talseth-Palmer, Juul T Wijnen, Desma M Grice, Rodney J Scott

Journal: Fam. Cancer. 2013 Jun;12(2):207-16.

 

The report by Aldred Scott Warthin in 1913 of a cancer family history and expanded on by Henry T. Lynch demonstrated one of the most enduring traits observed in patients with Lynch syndrome. The recognition of a variety of malignancies occurring at differing ages within a single family ...

Last Updated: 22 Jul 2013

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Hereditary nonpolyposis colorectal cancer (HNPCC)/Lynch syndrome.
 

Author(s): Verena Steinke, Christoph Engel, Reinhard Büttner, Hans Konrad Schackert, Wolff H Schmiegel, Peter Propping

Journal: Dtsch Arztebl Int. 2013 Jan;110(3):32-8.

 

Hereditary nonpolyposis colorectal cancer HNPCC, Lynch syndrome) is a genetic disease of autosomal dominant inheritance. It is caused by a mutation in one of four genes of the DNA mismatch repair system and confers a markedly increased risk for various types of cancer, particularly ...

Last Updated: 15 Feb 2013

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Epimutation and cancer: a new carcinogenic mechanism of Lynch syndrome (Review).
 

Author(s): Kouji Banno, Iori Kisu, Megumi Yanokura, Kosuke Tsuji, Kenta Masuda, Arisa Ueki, Yusuke Kobayashi, Wataru Yamagami, Hiroyuki Nomura, Eiichiro Tominaga, Nobuyuki Susumu, Daisuke Aoki

Journal: Int. J. Oncol.. 2012 Sep;41(3):793-7.

 

Epimutation is defined as abnormal transcriptional repression of active genes and/or abnormal activation of usually repressed genes caused by errors in epigenetic gene repression. Epimutation arises in somatic cells and the germline, and constitutional epimutation may also occur. ...

Last Updated: 16 Jul 2012

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Women Who Are At Risk Or May Have Lynch Syndrome
 

Status: Recruiting

Condition Summary: Hereditary Nonpolyposis Colorectal Cancer; Lynch Syndrome

 

Last Updated: 11 Nov 2013

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I-Scan For Colon Polyp Detection In HNPCC
 

Status: Recruiting

Condition Summary: Hereditary Non-polyposis Colon Carcinoma; HNPCC; Lynch Syndrome

 

Last Updated: 29 Mar 2013

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Molecular Screening for Lynch Syndrome in Denmark
 

Status: Recruiting

Condition Summary: Colorectal Cancer; Lynch Syndrome; HNPCC

 

Last Updated: 28 Mar 2014

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