Lynch syndrome

Common Name(s)

Lynch syndrome, Hereditary non-polyposis colorectal cancer (HNPCC)

Lynch syndrome is a genetic condition that causes an increased risk for several different types of cancer. People with Lynch syndrome have a lifetime cancer risk of 52-82% for colorectal (cancer of the colon or rectum), 25-60% for endometrial (cancer of the inner lining of the uterus), 6-13% for gastric (stomach cancer) and 4-12% for ovarian cancer. Lynch syndrome also causes a higher risk for cancer of the upper urinary tract, kidneys, small intestine, skin, and brain.

Lynch syndrome is caused by a mutation (change) in one of several genes important in our cell’s DNA (genetic code) repair. Mistakes happen when a cell makes a copy of its DNA during mitosis. Mitosis is the way our body’s cells make more cells (one cell splits into 2 cells). The MLH1, MSH2, MSH6, PMS2, and EPCAM genes make proteins which find and fix mistakes in the newly copied DNA. If one of these DNA repair proteins is missing, there is a greater chance for DNA copy errors to not be fixed, leading to the increased risk of certain cancers.

Mutations that cause Lynch syndrome can occur by chance for the first time in a family (de novo), but are often inherited from a parent in an autosomal dominant manner (a mutation in one copy of the gene causes the condition). People with Lynch syndrome will have a 50% chance of passing it on to any of their children.

Lynch syndrome is often diagnosed based on an individual’s cancer and family history. Genetic testing is used to confirm the diagnosis. If you or someone in your family has been diagnosed with Lynch syndrome, talk with a genetic counselor to discuss inheritance risks and testing options. Most doctors and specialists recommend you receive routine cancer screenings to catch any developing cancer in the early stages. Talk with your doctor about the most current options to screen for cancer. Support groups are a good source of information and help connect you with others living with Lynch syndrome.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Lynch syndrome" for support, advocacy or research.

Center for Jewish Genetics

The Center is dedicated to gathering and disseminating knowledge about Jewish genetic disorders and hereditary cancers. Its mission is to educate and serve health care professionals, clergy and the Jewish community.

Last Updated: 26 Dec 2012

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Colon Cancer Alliance for Research & Education for Lynch Syndrome

CCARE Lynch Syndrome is the national non-profit devoted to saving lives and leading the fight against Lynch syndrome through education, advocacy and research.

Last Updated: 5 Aug 2013

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Lynch Syndrome International

To provide support for those at high risk to hereditary Lynch syndrome cancers, public awareness of Lynch syndrome, education for medical offices and support for research endeavors.

Last Updated: 16 Jun 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Lynch syndrome" for support, advocacy or research.

Center for Jewish Genetics

The Center is dedicated to gathering and disseminating knowledge about Jewish genetic disorders and hereditary cancers. Its mission is to educate and serve health care professionals, clergy and the Jewish community.

http://www.jewishgenetics.org

Last Updated: 26 Dec 2012

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Colon Cancer Alliance for Research & Education for Lynch Syndrome

CCARE Lynch Syndrome is the national non-profit devoted to saving lives and leading the fight against Lynch syndrome through education, advocacy and research.

http://fightlynch.org/

Last Updated: 5 Aug 2013

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Lynch Syndrome International

To provide support for those at high risk to hereditary Lynch syndrome cancers, public awareness of Lynch syndrome, education for medical offices and support for research endeavors.

http://www.lynchcancers.com

Last Updated: 16 Jun 2015

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Lynch syndrome" returned 238 free, full-text research articles on human participants. First 3 results:

[Molecular characterization of Lynch syndrome in Tunisia].
 

Author(s): Aissi Sana, Zérimech Farid, Moussa Amel, Kourda Nadia, Mezlini Amel, Abdelli Nabil, Najjar Taoufik, Ben Ayed Farhat, Ben Jilani Sarah, Manai Mohamed, Buisine Marie-Pierre

Journal: Tunis Med. 2014 Jul;92(7):458-62.

 

High rates of early colorectal cancers (CRC) are observed in Tunisia suggesting genetic susceptibility. Nevertheless, up to now no molecular studies have been performed in the Tunisian population.

Last Updated: 17 Mar 2015

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Comparison of clinical features between suspected familial colorectal cancer type X and Lynch syndrome in Japanese patients with colorectal cancer: a cross-sectional study conducted by the Japanese Society for Cancer of the Colon and Rectum.
 

Author(s): Tatsuro Yamaguchi, Yoichi Furukawa, Yusuke Nakamura, Nagahide Matsubara, Hideki Ishikawa, Masami Arai, Naohiro Tomita, Kazuo Tamura, Kokichi Sugano, Chikashi Ishioka, Teruhiko Yoshida, Yoshihiro Moriya, Hideyuki Ishida, Toshiaki Watanabe, Kenichi Sugihara,

Journal: Jpn. J. Clin. Oncol.. 2015 Feb;45(2):153-9.

 

The characteristics of familial colorectal cancer type X are poorly defined. Here we aimed to clarify the differences in clinical features between suspected familial colorectal cancer type X and Lynch syndrome in Japanese patients.

Last Updated: 2 Feb 2015

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Role of endometrial cancer abnormal MMR protein in screening Lynch-syndrome families.
 

Author(s): Qiongxian Long, Yong Peng, Zhirong Tang, Cailiang Wu

Journal:

 

To identify patients with endometrial cancer with potential Lynch-related DNA mismatch repair (MMR) protein expression defects and to explore the role of these defects in screening for LS.

Last Updated: 17 Nov 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Lynch syndrome" returned 38 free, full-text review articles on human participants. First 3 results:

A systematic review and economic evaluation of diagnostic strategies for Lynch syndrome.
 

Author(s): Tristan Snowsill, Nicola Huxley, Martin Hoyle, Tracey Jones-Hughes, Helen Coelho, Chris Cooper, Ian Frayling, Chris Hyde

Journal: Health Technol Assess. 2014 Sep;18(58):1-406.

 

Lynch syndrome (LS) is an inherited autosomal dominant disorder characterised by an increased risk of colorectal cancer (CRC) and other cancers, and caused by mutations in the deoxyribonucleic acid (DNA) mismatch repair genes.

Last Updated: 23 Sep 2014

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Role of the clinical pathology laboratory in the evaluation of endometrial carcinomas for Lynch syndrome.
 

Author(s): Bojana Djordjevic, Russell R Broaddus

Journal: Semin Diagn Pathol. 2014 May;31(3):195-204.

 

Molecular diagnostic testing of endometrial carcinomas in the pathology laboratory has recently emerged as a key component of the clinical evaluation of Lynch syndrome in many centers. Testing modalities involve immunohistochemical and PCR-based analyses. This article outlines the ...

Last Updated: 21 Jun 2014

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Cervical neuroendocrine tumor in a young female with Lynch Syndrome.
 

Author(s): Ibraheem Yousef, Fadi Siyam, Lester Layfield, Carl Freter, James R Sowers

Journal: Neuro Endocrinol. Lett.. 2014 ;35(2):89-94.

 

Neuroendocrine tumors rarely occur in the cervix or other components of the reproductive system. These tumors have been associated with microsatellite instability, are very aggressive and often associated with poor outcome. Lynch syndrome is an inherited cancer syndrome that has also ...

Last Updated: 7 Jul 2014

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Women Who Are At Risk Or May Have Lynch Syndrome
 

Status: Recruiting

Condition Summary: Hereditary Nonpolyposis Colorectal Cancer; Lynch Syndrome

 

Last Updated: 14 May 2015

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Molecular Screening for Lynch Syndrome in Denmark
 

Status: Recruiting

Condition Summary: Colorectal Cancer; Lynch Syndrome; HNPCC

 

Last Updated: 3 Jun 2015

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I-Scan For Colon Polyp Detection In HNPCC
 

Status: Recruiting

Condition Summary: Hereditary Non-polyposis Colon Carcinoma; HNPCC; Lynch Syndrome

 

Last Updated: 29 Mar 2013

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