Hemophilia B

Common Name(s)

Hemophilia B, Hereditary factor IX deficiency disease

Hemophilia B is a bleeding disorder that slows the blood clotting process. People with this condition experience prolonged bleeding or oozing following an injury or surgery. In severe cases of hemophilia, heavy bleeding occurs after minor trauma or even in the absence of injury. Serious complications can result from bleeding into the joints, muscles, brain, or other internal organs. Milder forms may not become apparent until abnormal bleeding occurs following surgery or a serious injury. People with an unusual form of hemophilia B, known as hemophilia B Leyden, experience episodes of excessive bleeding in childhood but have few bleeding problems after puberty. Hemophilia B is inherited in an X-linked recessive pattern and is caused by mutations in the F9 gene.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hemophilia B" for support, advocacy or research.

Bleeding Disorders Alliance Illinois

The Bleeding Disorders Alliance Illinois exists to improve the quality of life for persons affected by hemophilia and other inherited bleeding disorders.

http://www.bdai.org

Last Updated: 25 Sep 2013

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Hemophilia Federation of America

The Hemophilia Federation of America is a national non-profit organization that assists and advocates for the bleeding disorders community.

http://www.hemophiliafed.org

Last Updated: 26 Nov 2012

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hemophilia B" for support, advocacy or research.

Bleeding Disorders Alliance Illinois

The Bleeding Disorders Alliance Illinois exists to improve the quality of life for persons affected by hemophilia and other inherited bleeding disorders.

http://www.bdai.org

Last Updated: 25 Sep 2013

View Details
Hemophilia Federation of America

The Hemophilia Federation of America is a national non-profit organization that assists and advocates for the bleeding disorders community.

http://www.hemophiliafed.org

Last Updated: 26 Nov 2012

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hemophilia B" returned 138 free, full-text research articles on human participants. First 3 results:

A CpG mutational hotspot in a ONECUT binding site accounts for the prevalent variant of hemophilia B Leyden.
 

Author(s): Alister P W Funnell, Michael D Wilson, Benoit Ballester, Ka Sin Mak, Jon Burdach, Natisha Magan, Richard C M Pearson, Frederic P Lemaigre, Kathryn M Stowell, Duncan T Odom, Paul Flicek, Merlin Crossley

Journal: Am. J. Hum. Genet.. 2013 Mar;92(3):460-7.

 

Hemophilia B, or the "royal disease," arises from mutations in coagulation factor IX (F9). Mutations within the F9 promoter are associated with a remarkable hemophilia B subtype, termed hemophilia B Leyden, in which symptoms ameliorate after puberty. Mutations at the -5/-6 site (nucleotides ...

Last Updated: 11 Mar 2013

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[Carrier diagnosis of F9 gross deletion by multiple ligation-dependent probe amplification in hemophilia B].
 

Author(s): Xing Chen, Yan Liang, Mei Yan, Jing-zhong Liu

Journal: Zhonghua Xue Ye Xue Za Zhi. 2012 Dec;33(12):1038-41.

 

To investigate the application of multiplex ligation-dependent probe amplification (MLPA) in the gene diagnosis of hemophilia B (HB).

Last Updated: 31 Jan 2013

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Genetically modified adipose tissue-derived stem/stromal cells, using simian immunodeficiency virus-based lentiviral vectors, in the treatment of hemophilia B.
 

Author(s): Natsumi Watanabe, Kazuo Ohashi, Kohei Tatsumi, Rie Utoh, In Kyong Shim, Kazuko Kanegae, Yuji Kashiwakura, Tsukasa Ohmori, Yoichi Sakata, Makoto Inoue, Mamoru Hasegawa, Teruo Okano

Journal: Hum. Gene Ther.. 2013 Mar;24(3):283-94.

 

Hemophilia is an X-linked bleeding disorder, and patients with hemophilia are deficient in a biologically active coagulation factor. This study was designed to combine the efficiency of lentiviral vector transduction techniques with murine adipose tissue-derived stem/stromal cells ...

Last Updated: 21 Mar 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hemophilia B" returned 2 free, full-text review articles on human participants. First 3 results:

Self-complementary adeno-associated viral vectors for gene therapy of hemophilia B: progress and challenges.
 

Author(s): Deepak Raj, Andrew M Davidoff, Amit C Nathwani

Journal: Expert Rev Hematol. 2011 Oct;4(5):539-49.

 

Therapies currently used for hemophilia involve injection of protein concentrates that are expensive, invasive and associated with side effects such as development of neutralizing antibodies (inhibitors) that diminish therapeutic efficacy. Gene transfer is an attractive alternative ...

Last Updated: 23 Sep 2011

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[Extracorporeal shock wave lithotripsy in a patient with hemophilia B].
 

Author(s): T Yokoyama, Y Nasu

Journal: Nippon Hinyokika Gakkai Zasshi. 1993 Mar;84(3):566-9.

 

We report a successful treatment of extracorporeal shock wave lithotripsy (ESWL) on a renal stone in a patient with severe hemophilia B. The patient was 44 years old man who had suffered left flank colicky pain with gross hematuria. A radiographic study showed a left renal stone, ...

Last Updated: 21 Jul 1993

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 25 Mar 2014

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Study of Recombinant Factor IX Product, IB1001, in Previously Treated Subjects With Hemophilia B
 

Status: Not yet recruiting

Condition Summary: Hemophilia B

 

Last Updated: 27 Jan 2014

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Hemophilia B Gene Therapy - Spark
 

Status: Recruiting

Condition Summary: Hemophilia B

 

Last Updated: 20 Dec 2013

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