Hemophagocytic lymphohistiocytosis, familial, 3

Common Name(s)

Hemophagocytic lymphohistiocytosis, familial, 3

Secretion of the contents of cytolytic granules at the immunologic synapse is a highly regulated process essential for lymphocyte cytotoxicity. This process requires the rapid transfer of perforin ({170280})-containing lytic granules to the target cell interface, followed by their docking and fusion with the plasma membrane. Familial hemophagocytic lymphohistiocytosis (HPLH) is a genetically heterogeneous condition characterized by defective cytotoxicity. For a more detailed description of HPLH, see {267700}.
 

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Condition Specific Organizations

Following organizations serve the condition "Hemophagocytic lymphohistiocytosis, familial, 3" for support, advocacy or research.

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Scientific Literature

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Clinical Trial Information This information is provided by ClinicalTrials.gov

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