Hailey Hailey Disease

Common Name(s)

Hailey Hailey Disease, Familial benign pemphigus, Hailey-Hailey Disease

Hailey-Hailey disease is an inherited condition characterized by recurrent blisters seen primarily on the neck, groin, and axillae (armpit). Precipitating factors include heat, sweating, skin infection, and ultraviolet radiation. The disorder often becomes apparent after puberty, usually by the third or fourth decade, but symptoms can develop at any age.  Hailey-Hailey disease occurs due to a mutation in a specific gene (ATP2C1) that creates a protein that is essential for skin health. There is no cure for this condition. Treatment is aimed at reducing symptoms and preventing flare-ups. This condition is inherited in an autosomal dominant fashion.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hailey Hailey Disease" for support, advocacy or research.

Hailey-Hailey Disease Society

Our primary mission is the dissemination of free, correct and useful information and support for HHD patients and the health care community. We support an informational website and forum and manage the Yahoo Group, TalkHHD.

Last Updated: 8 Mar 2013

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hailey Hailey Disease" for support, advocacy or research.

Hailey-Hailey Disease Society

Our primary mission is the dissemination of free, correct and useful information and support for HHD patients and the health care community. We support an informational website and forum and manage the Yahoo Group, TalkHHD.

http://haileyhailey.com

Last Updated: 8 Mar 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hailey Hailey Disease" returned 32 free, full-text research articles on human participants. First 3 results:

A novel ATP2C1 early truncation mutation suggests haploinsufficiency as a pathogenic mechanism in a patient with Hailey-Hailey disease.
 

Author(s): Akitaka Shibata, Kazumitsu Sugiura, Utako Kimura, Kenji Takamori, Masashi Akiyama

Journal: Acta Derm. Venereol.. 2013 Nov;93(6):719-20.

 

Last Updated: 23 Oct 2013

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Six novel mutations of ATP2C1 identified in eight Chinese patients with Hailey-Hailey disease.
 

Author(s): Hongqing Tian, Mingfei Chen, Jiabao You, Xi'an Fu, Hong Liu, Zhongxiang Shi, Meiling Yu, Mei Wu, Yongxiang Yu, Gongqi Yu, Furen Zhang

Journal: Indian J Dermatol Venereol Leprol. ;79(2):245-7.

 

Last Updated: 27 Feb 2013

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Successful therapeutic use of targeted narrow-band ultraviolet B therapy for refractory Hailey-Hailey disease.
 

Author(s): Toshihisa Hamada, Hiroshi Umemura, Yumi Aoyama, Keiji Iwatsuki

Journal: Acta Derm. Venereol.. 2013 Jan;93(1):110-1.

 

Last Updated: 10 Jan 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hailey Hailey Disease" returned 2 free, full-text review articles on human participants. First 3 results:

Hailey-Hailey disease as an orthodisease of PMR1 deficiency in Saccharomyces cerevisiae.
 

Author(s): Richard Kellermayer

Journal: FEBS Lett.. 2005 Apr;579(10):2021-5.

 

The term orthodisease has recently been introduced to define human disorders in which the pathogenic gene has orthologs in model organism genomes. Here, we describe Hailey-Hailey disease (HHD), a blistering skin disorder caused by haploinsufficiency of ATP2C1 as an orthodisease from ...

Last Updated: 6 Apr 2005

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Yeast researchers consider Hailey-Hailey disease.
 

Author(s): Theodora Marie Mauro

Journal: J. Invest. Dermatol.. 2004 Dec;123(6):xxii-xxiii.

 

Last Updated: 21 Dec 2004

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.