Graves' Disease

Common Name(s)

Graves' Disease, Graves Disease, Basedow's disease

Graves' disease is an autoimmune disorder that leads to overactivity of the thyroid gland (hyperthyroidism). It is caused by an abnormal immune system response that causes the thyroid gland to produce too much thyroid hormones. Graves disease is the most common cause of hyperthyroidism and occurs most often in women over age 20. However, the disorder may occur at any age and may affect males as well.  Treatment may include radioiodine therapy, antithyroid drugs, and/or thyroid surgery.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Graves' Disease" for support, advocacy or research.

Graves' Disease and Thyroid Foundation

The purpose and mission of the Graves' Disease & Thyroid Foundation is to provide support and educational services for patients and family members impacted by Graves' disease, thyroid eye disease, Hashimoto's thyroiditis, and other thyroid-related disorders. Services are delivered via phone/e-mail/U.S. Mail, social media, online forums, local support groups, and national educational events.

Last Updated: 15 Jun 2015

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Graves' Disease" for support, advocacy or research.

Graves' Disease and Thyroid Foundation

The purpose and mission of the Graves' Disease & Thyroid Foundation is to provide support and educational services for patients and family members impacted by Graves' disease, thyroid eye disease, Hashimoto's thyroiditis, and other thyroid-related disorders. Services are delivered via phone/e-mail/U.S. Mail, social media, online forums, local support groups, and national educational events.

http://www.gdatf.org

Last Updated: 15 Jun 2015

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Graves' Disease" returned 712 free, full-text research articles on human participants. First 3 results:

Establishment of a tear protein biomarker panel differentiating between Graves' disease with or without orbitopathy.
 

Author(s): Cecilie Aass, Ingrid Norheim, Erik Fink Eriksen, Ellen Charlotte Børnick, Per Medbøe Thorsby, Milaim Pepaj

Journal:

 

Graves' orbitopathy (GO) is an autoimmune inflammatory ocular complication and one of the most frequent manifestations of Graves' disease (GD). Clinical judgment of GO is subjective sometimes leading to clinical and therapeutic challenges. Better tools to diagnose this severe complication ...

Last Updated: 18 Apr 2017

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An improved method for the establishment of a model of Graves' disease in BALB/c mice.
 

Author(s): Wei Zheng, Renfei Wang, Jian Tan, Ning Li, Zhaowei Meng

Journal: Mol Med Rep. 2017 Apr;15(4):1471-1478.

 

The present study aimed to develop a stable Graves' disease (GD) model in BALB/c mice by immunization and electroporation (EP). A total of 90 mice were divided into experimental (n=50), control (n=20) and blank (n=20) groups. The recombinant plasmid pcDNA3.1/thyroid‑stimulating ...

Last Updated: 5 Mar 2017

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MST-4 and TRAF-6 expression in the peripheral blood mononuclear cells of patients with Graves' disease and its significance.
 

Author(s): Ai Guo, Yan Tan, Chun Liu, Xiaoya Zheng

Journal:

 

MST-4 and TRAF-6 are involved in the regulation of inflammatory and immune responses. However, whether they participate in the pathogenesis of Graves' disease (GD) has not yet been reported. Therefore, the purpose of this study was to investigate the expression of MST-4 and TRAF-6 ...

Last Updated: 21 Feb 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Graves' Disease" returned 52 free, full-text review articles on human participants. First 3 results:

MANAGEMENT OF ENDOCRINE DISEASE: Arguments for the prolonged use of antithyroid drugs in children with Graves' disease.
 

Author(s): Juliane Léger, Jean-Claude Carel

Journal: Eur. J. Endocrinol.. 2017 Aug;177(2):R59-R67.

 

Graves' disease is an autoimmune disorder. It is the leading cause of hyperthyroidism, but is rare in children. Patients are initially managed with antithyroid drugs (ATDs), such as methimazole/carbimazole. A major disadvantage of treatment with ATD is the high risk of relapse, exceeding ...

Last Updated: 6 Apr 2017

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Management of Fetal and Neonatal Graves' Disease.
 

Author(s): Juliane Léger

Journal: Horm Res Paediatr. 2017 ;87(1):1-6.

 

Fetal and neonatal autoimmune hyperthyroidism is a rare, serious but transient disorder. Early diagnosis and treatment are key objectives for an optimal prognosis and the well-being of the child. This review focuses on the management of these patients during the fetal and neonatal ...

Last Updated: 15 Dec 2016

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Can we predict relapse in Graves' disease? Results from a systematic review and meta-analysis.
 

Author(s): Tristan Struja, Hannah Fehlberg, Alexander Kutz, Larissa Guebelin, Christian Degen, Beat Mueller, Philipp Schuetz

Journal: Eur. J. Endocrinol.. 2017 Jan;176(1):87-97.

 

Identification of pretreatment risk factors predicting relapse in patients with hyperthyroidism of Graves' disease after stopping anti-thyroid drugs (ATD) is decisive to guide therapeutic options.

Last Updated: 26 Oct 2016

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Next-generation Sequencing (NGS) of Peripheral Blood Immune Repertoire in Graves' Disease
 

Status: Not yet recruiting

Condition Summary: Graves Disease

 

Last Updated: 5 Aug 2014

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HIFU vs RAI in the Relapsed Graves' Disease
 

Status: Recruiting

Condition Summary: Graves Disease

 

Last Updated: 12 Jul 2017

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K1-70 - A Study in Subjects With Graves' Disease
 

Status: Recruiting

Condition Summary: Graves' Disease

 

Last Updated: 14 Oct 2016

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