Graves' Disease

Common Name(s)

Graves' Disease, Graves Disease, Basedow's disease

Graves' disease is an autoimmune disorder that leads to overactivity of the thyroid gland (hyperthyroidism). It is caused by an abnormal immune system response that causes the thyroid gland to produce too much thyroid hormones. Graves disease is the most common cause of hyperthyroidism and occurs most often in women over age 20. However, the disorder may occur at any age and may affect males as well.  Treatment may include radioiodine therapy, antithyroid drugs, and/or thyroid surgery.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Graves' Disease" for support, advocacy or research.

Graves' Disease and Thyroid Foundation

The purpose and mission of the Graves' Disease & Thyroid Foundation is to provide support and educational services for patients and family members impacted by Graves' disease, thyroid eye disease, Hashimoto's thyroiditis, and other thyroid-related disorders. Services are delivered via phone/e-mail/U.S. Mail, social media, online forums, local support groups, and national educational events.

Last Updated: 15 Jun 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Graves' Disease" for support, advocacy or research.

Graves' Disease and Thyroid Foundation

The purpose and mission of the Graves' Disease & Thyroid Foundation is to provide support and educational services for patients and family members impacted by Graves' disease, thyroid eye disease, Hashimoto's thyroiditis, and other thyroid-related disorders. Services are delivered via phone/e-mail/U.S. Mail, social media, online forums, local support groups, and national educational events.

http://www.gdatf.org

Last Updated: 15 Jun 2015

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Graves' Disease" returned 640 free, full-text research articles on human participants. First 3 results:

Total thyroidectomy in Basedow-Graves' disease treatment: our experience.
 

Author(s): M Barbuscia, A Querci, A Tonante, D Paparo, F Taranto, A Ilacqua, E Gagliano, A Milone

Journal: G Chir. ;36(3):117-21.

 

In the present study the authors, after a short historical description of the Basedow-Graves' disease, describe their case-study gathered over the last five years. They mention the most widely accepted hypothesis regarding disease's etiology, strongly linked to autoimmune disorders, ...

Last Updated: 20 Jul 2015

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Factors predicting abnormal liver function tests induced by Graves' disease alone: a retrospective cohort study.
 

Author(s): Ruiguo Zhang, Xun Tian, Lan Qin, Xiaoer Wei, Junqi Wang, Jie Shen

Journal: Medicine (Baltimore). 2015 May;94(19):e839.

 

Abnormal liver function tests (LFTs) are often observed in patients with Graves' disease (GD). To date, there are limited data demonstrating the factors or biochemical indexes contributing to LFT abnormalities in this patient population. The aim of this study was to explore factors ...

Last Updated: 19 May 2015

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Prognostic value of (99m)Tc-pertechnetate thyroid scintigraphy in radioiodine therapy in a cohort of Chinese Graves' disease patients: a pilot clinical study.
 

Author(s): Haifeng Hou, Shu Hu, Rong Fan, Wen Sun, Xiaofei Zhang, Mei Tian

Journal: Biomed Res Int. 2015 ;2015():974689.

 

This study is to assess the prognostic value of (99m)Tc-pertechnetate thyroid scintigraphy for predicting the outcomes of fixed low dose of radioiodine therapy (RIT) in a cohort of Chinese Graves' disease (GD) patients.

Last Updated: 16 Apr 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Graves' Disease" returned 40 free, full-text review articles on human participants. First 3 results:

Dendritic cells in Graves' disease.
 

Author(s): Dyah Purnamasari, Pradana Soewondo, Samsuridjal Djauzi

Journal: Acta Med Indones. 2015 Jan;47(1):61-9.

 

Dendritic cells are major antigen-presenting cells (APC) that stimulate naive T cells, which induce adaptive immune responses. Graves' disease (GD) is an autoimmune disease characterized by the presence of autoantibodies against Thyroid Stimulating Hormone Receptor (TSHR). The autoantibodies ...

Last Updated: 7 May 2015

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Graves' disease presenting as bi-ventricular heart failure with severe pulmonary hypertension and pre-eclampsia in pregnancy--a case report and review of the literature.
 

Author(s): Khandker Mohammad Nurus Sabah, Abdul Wadud Chowdhury, Mohammad Shahidul Islam, Fathima Aaysha Cader, Shamima Kawser, Md Imam Hosen, Mohammed Abaye Deen Saleh, Md Shariful Alam, Mohammad Monjurul Kader Chowdhury, Humayara Tabassum

Journal:

 

Graves' disease, a well-known cause of hyperthyroidism, is an autoimmune disease with multi-system involvement. More prevalent among young women, it appears as an uncommon cardiovascular complication during pregnancy, posing a diagnostic challenge, largely owing to difficulty in detecting ...

Last Updated: 1 May 2015

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Simultaneous occurrence of type 1 diabetes mellitus and Graves' disease: a report of two cases and a review of the literature.
 

Author(s): Tetsuya Mizokami, Ayumi Yamauchi, Yuichi Sato, Masae Toyonaga, Hirofumi Imoto, Hiroto Kojima, Hiroh Saji, Kiyohide Nunoi

Journal: Intern. Med.. 2013 ;52(22):2537-43.

 

Two unrelated Japanese women, 41 and 27 years of age, were admitted with histories of thirst, weight loss and palpitations of a few weeks' duration. Both were diagnosed to have diabetic ketosis or ketoacidosis with acute-onset type 1 diabetes (T1D) and Graves' disease (GD) (autoimmune ...

Last Updated: 18 Nov 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Comparative Study of Different I-131 Doses in Graves' Disease
 

Status: Recruiting

Condition Summary: Graves' Disease

 

Last Updated: 14 Apr 2014

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Next-generation Sequencing (NGS) of Peripheral Blood Immune Repertoire in Graves' Disease
 

Status: Not yet recruiting

Condition Summary: Graves Disease

 

Last Updated: 5 Aug 2014

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Radioactive Iodide Therapy for Pediatric Graves' Disease
 

Status: Recruiting

Condition Summary: Graves' Disease

 

Last Updated: 24 Nov 2015

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