Graves' Disease

Common Name(s)

Graves' Disease, Graves Disease, Basedow's disease

Graves' disease is an autoimmune disorder that leads to overactivity of the thyroid gland (hyperthyroidism). It is caused by an abnormal immune system response that causes the thyroid gland to produce too much thyroid hormones. Graves disease is the most common cause of hyperthyroidism and occurs most often in women over age 20. However, the disorder may occur at any age and may affect males as well.  Treatment may include radioiodine therapy, antithyroid drugs, and/or thyroid surgery.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Graves' Disease" for support, advocacy or research.

Graves' Disease and Thyroid Foundation

The purpose and mission of the Graves' Disease & Thyroid Foundation is to provide support and educational services for patients and family members impacted by Graves' disease, thyroid eye disease, Hashimoto's thyroiditis, and other thyroid-related disorders. Services are delivered via phone/e-mail/U.S. Mail, social media, online forums, local support groups, and national educational events.

Last Updated: 15 Jun 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Graves' Disease" for support, advocacy or research.

Graves' Disease and Thyroid Foundation

The purpose and mission of the Graves' Disease & Thyroid Foundation is to provide support and educational services for patients and family members impacted by Graves' disease, thyroid eye disease, Hashimoto's thyroiditis, and other thyroid-related disorders. Services are delivered via phone/e-mail/U.S. Mail, social media, online forums, local support groups, and national educational events.

http://www.gdatf.org

Last Updated: 15 Jun 2015

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Graves' Disease" returned 702 free, full-text research articles on human participants. First 3 results:

MST-4 and TRAF-6 expression in the peripheral blood mononuclear cells of patients with Graves' disease and its significance.
 

Author(s): Ai Guo, Yan Tan, Chun Liu, Xiaoya Zheng

Journal:

 

MST-4 and TRAF-6 are involved in the regulation of inflammatory and immune responses. However, whether they participate in the pathogenesis of Graves' disease (GD) has not yet been reported. Therefore, the purpose of this study was to investigate the expression of MST-4 and TRAF-6 ...

Last Updated: 21 Feb 2017

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A new method of subtotal thyroidectomy for Graves' disease leaving a unilateral remnant based on the upper pole.
 

Author(s): Yu Liu, Bin Liu, Rui-Lei Liu, Hua Jiang, Ze-Nan Huang, Yong Huang

Journal: Medicine (Baltimore). 2017 Feb;96(6):e5919.

 

The aim of this prospective randomized study was to evaluate the feasibility of subtotal thyroidectomy with leaving a unilateral remnant based on the upper pole.

Last Updated: 8 Feb 2017

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Copy number variations exploration of multiple genes in Graves' disease.
 

Author(s): Rong-Hua Song, Xiao-Qing Shao, Ling Li, Wen Wang, Jin-An Zhang

Journal: Medicine (Baltimore). 2017 Jan;96(4):e5866.

 

Few previous published papers reported copy number variations of genes could affect the predisposition of Graves' disease (GD). Herein, the aim of this study was to explore the association between copy number variations (CNV) profile and GD.

Last Updated: 25 Jan 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Graves' Disease" returned 48 free, full-text review articles on human participants. First 3 results:

Can we predict relapse in Graves' disease? Results from a systematic review and meta-analysis.
 

Author(s): Tristan Struja, Hannah Fehlberg, Alexander Kutz, Larissa Guebelin, Christian Degen, Beat Mueller, Philipp Schuetz

Journal: Eur. J. Endocrinol.. 2017 Jan;176(1):87-97.

 

Identification of pretreatment risk factors predicting relapse in patients with hyperthyroidism of Graves' disease after stopping anti-thyroid drugs (ATD) is decisive to guide therapeutic options.

Last Updated: 26 Oct 2016

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MANAGEMENT OF ENDOCRINE DISEASE: Rituximab therapy for Graves' orbitopathy - lessons from randomized control trials.
 

Author(s): Marius N Stan, Mario Salvi

Journal: Eur. J. Endocrinol.. 2017 Feb;176(2):R101-R109.

 

Rituximab (RTX) use in open-label series has been associated with very encouraging responses in patients with active and moderate-to-severe Graves' orbitopathy (GO). Recently, randomized controlled trials of RTX have been performed in such patients to answer the question of clinical ...

Last Updated: 20 Oct 2016

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ENDOCRINOLOGY IN PREGNANCY: Pregnancy and the incidence, diagnosing and therapy of Graves' disease.
 

Author(s): Peter Laurberg, Stine Linding Andersen

Journal: Eur. J. Endocrinol.. 2016 Nov;175(5):R219-30.

 

Thyroid hormones are essential developmental factors, and Graves' disease (GD) may severely complicate a pregnancy. This review describes how pregnancy changes the risk of developing GD, how early pregnancy by several mechanisms leads to considerable changes in the results of the ...

Last Updated: 26 Sep 2016

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Next-generation Sequencing (NGS) of Peripheral Blood Immune Repertoire in Graves' Disease
 

Status: Not yet recruiting

Condition Summary: Graves Disease

 

Last Updated: 5 Aug 2014

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ATX-GD-59 in Patients With Graves Disease Not Treated With Anti-thyroid Therapy
 

Status: Recruiting

Condition Summary: Graves Disease

 

Last Updated: 3 Apr 2017

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HIFU vs RAI in the Relapsed Graves' Disease
 

Status: Not yet recruiting

Condition Summary: Graves Disease

 

Last Updated: 5 Jan 2017

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