Graves' Disease

Common Name(s)

Graves' Disease, Graves Disease, Basedow's disease

Graves' disease is an autoimmune disorder that leads to overactivity of the thyroid gland (hyperthyroidism). It is caused by an abnormal immune system response that causes the thyroid gland to produce too much thyroid hormones. Graves disease is the most common cause of hyperthyroidism and occurs most often in women over age 20. However, the disorder may occur at any age and may affect males as well.  Treatment may include radioiodine therapy, antithyroid drugs, and/or thyroid surgery.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Graves' Disease" for support, advocacy or research.

Graves' Disease and Thyroid Foundation

The purpose and mission of the Graves' Disease & Thyroid Foundation is to provide support and educational services for patients and family members impacted by Graves' disease, thyroid eye disease, Hashimoto's thyroiditis, and other thyroid-related disorders. Services are delivered via phone/e-mail/U.S. Mail, social media, online forums, local support groups, and national educational events.

Last Updated: 15 Jun 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Graves' Disease" for support, advocacy or research.

Graves' Disease and Thyroid Foundation

The purpose and mission of the Graves' Disease & Thyroid Foundation is to provide support and educational services for patients and family members impacted by Graves' disease, thyroid eye disease, Hashimoto's thyroiditis, and other thyroid-related disorders. Services are delivered via phone/e-mail/U.S. Mail, social media, online forums, local support groups, and national educational events.

http://www.gdatf.org

Last Updated: 15 Jun 2015

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Graves' Disease" returned 595 free, full-text research articles on human participants. First 3 results:

Case of graves' disease with remarkable psychiatric symptoms.
 

Author(s): Fumi Kuno, Yosuke Okada, Tadashi Arao, Akira Kurozumi, Yoshiya Tanaka

Journal: J. UOEH. 2015 Mar;37(1):49-53.

 

A 42-year-old woman visited our hospital with palpitations, excessive sweating, and finger tremors in March 2011. She was diagnosed with Graves' disease based on the following test results: thyroid stimulating hormone < 0.01 μU/ml, free thyroxine 6.15 ng/ml, and thyrotropin receptor ...

Last Updated: 19 Mar 2015

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A second course of antithyroid drug therapy for recurrent Graves' disease: an experience in endocrine practice.
 

Author(s): Xiaomei Liu, Wei Qiang, Xingjun Liu, Lianye Liu, Shu Liu, Aibo Gao, Shan Gao, Bingyin Shi

Journal: Eur. J. Endocrinol.. 2015 Mar;172(3):321-6.

 

There are scarce reports regarding the prognosis of a second course of antithyroid drug (ATD) therapy on recurrent Graves' disease (GD). The aim of this study was to assess the long-term remission rate after a second ATD therapy and verify significant clinical predictors of a remission.

Last Updated: 9 Feb 2015

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Radioiodine treatment of Graves' disease - dose/response analysis.
 

Author(s): Jitka Cepková, Jiří Horáček, Jaroslav Vižďa, Jiří Doležal

Journal: Acta Medica (Hradec Kralove). 2014 ;57(2):49-55.

 

The clinical outcome of 153 Graves' disease patients treated with a wide dose range of radioactive iodine-131 (RAI) was analyzed retrospectively. Six to nine months after the first dose of RAI 60 patients (39%) were hypothyroid (or rather thyroxine-substituted) and 26 (17%) were euthyroid, ...

Last Updated: 26 Sep 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Graves' Disease" returned 38 free, full-text review articles on human participants. First 3 results:

Simultaneous occurrence of type 1 diabetes mellitus and Graves' disease: a report of two cases and a review of the literature.
 

Author(s): Tetsuya Mizokami, Ayumi Yamauchi, Yuichi Sato, Masae Toyonaga, Hirofumi Imoto, Hiroto Kojima, Hiroh Saji, Kiyohide Nunoi

Journal: Intern. Med.. 2013 ;52(22):2537-43.

 

Two unrelated Japanese women, 41 and 27 years of age, were admitted with histories of thirst, weight loss and palpitations of a few weeks' duration. Both were diagnosed to have diabetic ketosis or ketoacidosis with acute-onset type 1 diabetes (T1D) and Graves' disease (GD) (autoimmune ...

Last Updated: 18 Nov 2013

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[Selenium in Graves' disease].
 

Author(s): Jadwiga Kryczyk, Paweł Zagrodzki

Journal:

 

The aim of this study was to present the current state of knowledge of the role of selenium in Graves' disease. Recently, in the pathogenesis and course of this autoimmune disease, more attention has been paid to the relationship between oxidative stress and the antioxidant system, ...

Last Updated: 11 Jun 2013

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[Treatment of hyperthyroidism due to Graves' disease: what is the recommended antithyroid drug during pregnancy?].
 

Author(s): P Caron

Journal: J Gynecol Obstet Biol Reprod (Paris). 2013 May;42(3):232-7.

 

Clinical hyperthyroidism during the first trimester of pregnancy due to Graves' disease can be associated with maternal, obstetrical and fetal complications, indicating an active treatment to restore normal thyroid function. Antithyroid drugs are the first line treatment in pregnant ...

Last Updated: 1 May 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Comparative Study of Different I-131 Doses in Graves' Disease
 

Status: Recruiting

Condition Summary: Graves' Disease

 

Last Updated: 14 Apr 2014

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Next-generation Sequencing (NGS) of Peripheral Blood Immune Repertoire in Graves' Disease
 

Status: Not yet recruiting

Condition Summary: Graves Disease

 

Last Updated: 5 Aug 2014

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Radioactive Iodide Therapy for Pediatric Graves' Disease
 

Status: Recruiting

Condition Summary: Graves' Disease

 

Last Updated: 16 Apr 2015

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