Glucose Galactose Malabsorption

Common Name(s)

Glucose Galactose Malabsorption, Congenital glucose-galactose malabsorption

Glucose-galactose malabsorption is an inherited condition in which the cells lining the intestine cannot take in the sugars glucose and galactose, which prevents proper digestion. This condition typically becomes apparent in the first few weeks of a baby's life. When fed breast milk or regular infant formulas, affected infants experience severe diarrhea resulting in life-threatening dehydration, acidosis, and weight loss. Some children are better able to tolerate glucose and galactose as they get older. Affected individuals can also develop kidney stones or more widespread deposits of calcium within the kidneys. This condition is caused by mutations in the SLC5A1 gene and is inherited in an autosomal recessive fashion.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Glucose Galactose Malabsorption" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Glucose Galactose Malabsorption" returned 7 free, full-text research articles on human participants. First 3 results:

A case of neonatal diarrhoea caused by congenital glucose-galactose malabsorption.
 

Author(s): W S Lee, C G Tay, N Nazrul, M Paed, P F Chai

Journal: Med. J. Malaysia. 2009 Mar;64(1):83-5.

 

A five-month-old Indian girl, product of consanguineous marriage, presented with diarrhoea with an onset within two days after birth, severe malnutrition and metabolic acidosis. The diarrhoea persisted even with lactose-free formula, amino acid-based formula and glucose-containing ...

Last Updated: 26 Oct 2009

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D28G mutation in congenital glucose-galactose malabsorption.
 

Author(s): Hamid-Reza Kianifar, Saeed Talebi, Saeed Talebi, Jalil Tavakkol-Afshari, Mohammad Esmaili, Behrouz Davachi, Azam Brook

Journal: Arch Iran Med. 2007 Oct;10(4):514-8.

 

Congenital glucose-galactose malabsorption is a rare autosomal recessive disorder of the intestinal transport of glucose and galactose, leading to watery diarrhea, dehydration, failure to thrive, and early death.

Last Updated: 1 Oct 2007

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Glucose-galactose malabsorption: demonstration of specific jejunal brush border membrane defect.
 

Author(s): I W Booth, P B Patel, D Sule, G A Brown, R Buick, K Beyreiss

Journal: Gut. 1988 Dec;29(12):1661-5.

 

Jejunal brush border glucose transport was studied in a patient with glucose-galactose malabsorption and in controls, using jejunal brush border membrane vesicles (BBMV) prepared from conventional jejunal biopsies. Whereas BBMV from controls showed a seven-fold enhancement of D-glucose ...

Last Updated: 23 Mar 1989

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Reviews from the PubMed Database

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The terms "Glucose Galactose Malabsorption" returned 1 free, full-text review articles on human participants. First 3 results:

I. Glucose galactose malabsorption.
 

Author(s): E M Wright

Journal: Am. J. Physiol.. 1998 Nov;275(5 Pt 1):G879-82.

 

Glucose Galactose Malabsorption is a genetic disorder caused by a defect in glucose and galactose transport across the intestinal brush border. Normally, lactose in milk is broken down into glucose and galactose by lactase, an ectoenzyme on the brush border, and the hexoses are transported ...

Last Updated: 14 Dec 1998

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Symptoms, Diagnosis, and Treatment

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