Glucose 6 Phosphate Dehydrogenase Deficiency

Common Name(s)

Glucose 6 Phosphate Dehydrogenase Deficiency

Glucose 6 phosphate dehydrogenase (G6PD) deficiency is a hereditary condition in which red blood cells break down (hemolysis) when the body is exposed to certain foods, drugs, infections or stress. This condition occurs when a person is missing or doesn't have enough glucose-6-phosphate dehydrogenase, an enzyme which helps red blood cells work properly. G6PD deficiency is more likely to occur in males, particularly African Americans, and those from certain parts of Africa, Asia, and the Mediterranean. This condition is inherited in an X-linked recessive manner and is caused by mutations in the G6PD gene.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Glucose 6 Phosphate Dehydrogenase Deficiency" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Glucose 6 Phosphate Dehydrogenase Deficiency" returned 177 free, full-text research articles on human participants. First 3 results:

Glucose-6-phosphate dehydrogenase deficiency among malaria suspects attending Gambella hospital, southwest Ethiopia.
 

Author(s): Arega Tsegaye, Lemu Golassa, Hassen Mamo, Berhanu Erko

Journal:

 

Glucose-6-phosphate dehydrogenase deficiency (G6PDd) is widespread across malaria endemic regions. G6PD-deficient individuals are at risk of haemolysis when exposed, among other agents, to primaquine and tafenoquine, which are capable of blocking malaria transmission by killing Plasmodium ...

Last Updated: 28 Nov 2014

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Noninferiority of glucose-6-phosphate dehydrogenase deficiency diagnosis by a point-of-care rapid test vs the laboratory fluorescent spot test demonstrated by copper inhibition in normal human red blood cells.
 

Author(s): J Kevin Baird, Mewahyu Dewi, Decy Subekti, Iqbal Elyazar, Ari W Satyagraha

Journal: Transl Res. 2015 Jun;165(6):677-88.

 

Tens of millions of patients diagnosed with vivax malaria cannot safely receive primaquine therapy against repeated attacks caused by activation of dormant liver stages called hypnozoites. Most of these patients lack access to screening for glucose-6-phosphate dehydrogenase (G6PD) ...

Last Updated: 15 May 2015

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Glucose-6-phosphate dehydrogenase deficiency in northern Mexico and description of a novel mutation.
 

Author(s): N García-Magallanes, F Luque-Ortega, E M Aguilar-Medina, R Ramos-Payán, C Galaviz-Hernández, J G Romero-Quintana, L Del Pozo-Yauner, H Rangel-Villalobos, E Arámbula-Meraz

Journal: J. Genet.. 2014 Aug;93(2):325-30.

 

Glucose-6-phosphate dehydrogenase deficiency (G6PD) is the most common enzyme pathology in humans; it is X-linked inherited and causes neonatal hyperbilirubinaemia, chronic nonspherocytic haemolytic anaemia and drug-induced acute haemolytic anaemia. G6PD deficiency has scarcely been ...

Last Updated: 5 Sep 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Glucose 6 Phosphate Dehydrogenase Deficiency" returned 8 free, full-text review articles on human participants. First 3 results:

Glucose-6-phosphate dehydrogenase deficiency in transfusion medicine: the unknown risks.
 

Author(s): R O Francis, J S Jhang, H P Pham, E A Hod, J C Zimring, S L Spitalnik

Journal: Vox Sang.. 2013 Nov;105(4):271-82.

 

The hallmark of glucose-6-phosphate dehydrogenase (G6PD) deficiency is red blood cell (RBC) destruction in response to oxidative stress. Patients requiring RBC transfusions may simultaneously receive oxidative medications or have concurrent infections, both of which can induce haemolysis ...

Last Updated: 14 Oct 2013

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Review of key knowledge gaps in glucose-6-phosphate dehydrogenase deficiency detection with regard to the safe clinical deployment of 8-aminoquinoline treatment regimens: a workshop report.
 

Author(s): Lorenz von Seidlein, Sarah Auburn, Fe Espino, Dennis Shanks, Qin Cheng, James McCarthy, Kevin Baird, Catherine Moyes, Rosalind Howes, Didier Ménard, Germana Bancone, Ari Winasti-Satyahraha, Lasse S Vestergaard, Justin Green, Gonzalo Domingo, Shunmay Yeung, Ric Price

Journal:

 

The diagnosis and management of glucose-6-phosphate dehydrogenase (G6PD) deficiency is a crucial aspect in the current phases of malaria control and elimination, which will require the wider use of 8-aminoquinolines for both reducing Plasmodium falciparum transmission and achieving ...

Last Updated: 5 Apr 2013

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Impact of glucose-6-phosphate dehydrogenase deficiency on the pathophysiology of cardiovascular disease.
 

Author(s): Peter A Hecker, Jane A Leopold, Sachin A Gupte, Fabio A Recchia, William C Stanley

Journal: Am. J. Physiol. Heart Circ. Physiol.. 2013 Feb;304(4):H491-500.

 

Glucose-6-phosphate dehydrogenase (G6PD) catalyzes the rate-determining step in the pentose phosphate pathway and produces NADPH to fuel glutathione recycling. G6PD deficiency is the most common enzyme deficiency in humans and affects over 400 million people worldwide; however, its ...

Last Updated: 18 Feb 2013

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Diet Challenge in G6PD Deficient Egyptian Children: A One- Year Prospective Single Center Study With Genotype - Phenotype Correlation
 

Status: Not yet recruiting

Condition Summary: Glucose-6-Phosphate Dehydrogenase Deficiency

 

Last Updated: 14 Jul 2015

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Safety and Tolerability of Low Dose Primaquine
 

Status: Recruiting

Condition Summary: Malaria, Falciparum; G6PD Deficiency

 

Last Updated: 30 Apr 2015

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