Glucose 6 Phosphate Dehydrogenase Deficiency

Common Name(s)

Glucose 6 Phosphate Dehydrogenase Deficiency

Glucose 6 phosphate dehydrogenase (G6PD) deficiency is a hereditary condition in which red blood cells break down (hemolysis) when the body is exposed to certain foods, drugs, infections or stress. This condition occurs when a person is missing or doesn't have enough glucose-6-phosphate dehydrogenase, an enzyme which helps red blood cells work properly. G6PD deficiency is more likely to occur in males, particularly African Americans, and those from certain parts of Africa, Asia, and the Mediterranean. This condition is inherited in an X-linked recessive manner and is caused by mutations in the G6PD gene.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Glucose 6 Phosphate Dehydrogenase Deficiency" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Glucose 6 Phosphate Dehydrogenase Deficiency" returned 211 free, full-text research articles on human participants. First 3 results:

Tolerability and safety of weekly primaquine against relapse of Plasmodium vivax in Cambodians with glucose-6-phosphate dehydrogenase deficiency.
 

Author(s): Sim Kheng, Sinoun Muth, Walter R J Taylor, Narann Tops, Khem Kosal, Khon Sothea, Phum Souy, Saorin Kim, Chuor Meng Char, Chan Vanna, Po Ly, Pascal Ringwald, Virak Khieu, Alexandra Kerleguer, Pety Tor, John K Baird, Steven Bjorge, Didier Menard, Eva Christophel

Journal:

 

Primaquine is used to prevent Plasmodium vivax relapse; however, it is not implemented in many malaria-endemic countries, including Cambodia, for fear of precipitating primaquine-induced acute haemolytic anaemia in patients with glucose-6-phosphate dehydrogenase deficiency (G6PDd). ...

Last Updated: 25 Aug 2015

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Prevalence of glucose-6-phosphate dehydrogenase (G6PD) deficiency in southeast Iran: implications for malaria elimination.
 

Author(s): Seyed Mehdi Tabatabaei, Alireza Salimi Khorashad, Mohammad Sakeni, Ahmad Raeisi, Zahra Metanat

Journal:

 

Glucose-6-phosphate dehydrogenase deficiency (G6PD) is an X-linked genetic disorder with a relatively high frequency in malaria-endemic regions. It is an obstacle to malaria elimination, as primaquine administered in the treatment of malaria can cause hemolysis in G6PD-deficient individuals. ...

Last Updated: 16 Mar 2015

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Antimalarial NADPH-Consuming Redox-Cyclers As Superior Glucose-6-Phosphate Dehydrogenase Deficiency Copycats.
 

Author(s): Max Bielitza, Didier Belorgey, Katharina Ehrhardt, Laure Johann, Don Antoine Lanfranchi, Valentina Gallo, Evelin Schwarzer, Franziska Mohring, Esther Jortzik, David L Williams, Katja Becker, Paolo Arese, Mourad Elhabiri, Elisabeth Davioud-Charvet

Journal: Antioxid. Redox Signal.. 2015 May;22(15):1337-51.

 

Early phagocytosis of glucose-6-phosphate dehydrogenase (G6PD)-deficient erythrocytes parasitized by Plasmodium falciparum were shown to protect G6PD-deficient populations from severe malaria. Here, we investigated the mechanism of a novel antimalarial series, namely 3-[substituted-benzyl]-menadiones, ...

Last Updated: 30 Apr 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Glucose 6 Phosphate Dehydrogenase Deficiency" returned 9 free, full-text review articles on human participants. First 3 results:

Glucose-6-phosphate dehydrogenase deficiency in transfusion medicine: the unknown risks.
 

Author(s): R O Francis, J S Jhang, H P Pham, E A Hod, J C Zimring, S L Spitalnik

Journal: Vox Sang.. 2013 Nov;105(4):271-82.

 

The hallmark of glucose-6-phosphate dehydrogenase (G6PD) deficiency is red blood cell (RBC) destruction in response to oxidative stress. Patients requiring RBC transfusions may simultaneously receive oxidative medications or have concurrent infections, both of which can induce haemolysis ...

Last Updated: 14 Oct 2013

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Review of key knowledge gaps in glucose-6-phosphate dehydrogenase deficiency detection with regard to the safe clinical deployment of 8-aminoquinoline treatment regimens: a workshop report.
 

Author(s): Lorenz von Seidlein, Sarah Auburn, Fe Espino, Dennis Shanks, Qin Cheng, James McCarthy, Kevin Baird, Catherine Moyes, Rosalind Howes, Didier Ménard, Germana Bancone, Ari Winasti-Satyahraha, Lasse S Vestergaard, Justin Green, Gonzalo Domingo, Shunmay Yeung, Ric Price

Journal:

 

The diagnosis and management of glucose-6-phosphate dehydrogenase (G6PD) deficiency is a crucial aspect in the current phases of malaria control and elimination, which will require the wider use of 8-aminoquinolines for both reducing Plasmodium falciparum transmission and achieving ...

Last Updated: 5 Apr 2013

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Impact of glucose-6-phosphate dehydrogenase deficiency on the pathophysiology of cardiovascular disease.
 

Author(s): Peter A Hecker, Jane A Leopold, Sachin A Gupte, Fabio A Recchia, William C Stanley

Journal: Am. J. Physiol. Heart Circ. Physiol.. 2013 Feb;304(4):H491-500.

 

Glucose-6-phosphate dehydrogenase (G6PD) catalyzes the rate-determining step in the pentose phosphate pathway and produces NADPH to fuel glutathione recycling. G6PD deficiency is the most common enzyme deficiency in humans and affects over 400 million people worldwide; however, its ...

Last Updated: 18 Feb 2013

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Diet Challenge in G6PD Deficient Egyptian Children: A One- Year Prospective Single Center Study With Genotype - Phenotype Correlation
 

Status: Not yet recruiting

Condition Summary: Glucose-6-Phosphate Dehydrogenase Deficiency

 

Last Updated: 14 Jul 2015

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Last Updated: 31 Oct 2015

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Safety and Tolerability of Low Dose Primaquine
 

Status: Recruiting

Condition Summary: Malaria, Falciparum; G6PD Deficiency

 

Last Updated: 30 Apr 2015

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