Glucose 6 Phosphate Dehydrogenase Deficiency

Common Name(s)

Glucose 6 Phosphate Dehydrogenase Deficiency

Glucose 6 phosphate dehydrogenase (G6PD) deficiency is a hereditary condition in which red blood cells break down (hemolysis) when the body is exposed to certain foods, drugs, infections or stress. This condition occurs when a person is missing or doesn't have enough glucose-6-phosphate dehydrogenase, an enzyme which helps red blood cells work properly. G6PD deficiency is more likely to occur in males, particularly African Americans, and those from certain parts of Africa, Asia, and the Mediterranean. This condition is inherited in an X-linked recessive manner and is caused by mutations in the G6PD gene.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Glucose 6 Phosphate Dehydrogenase Deficiency" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Glucose 6 Phosphate Dehydrogenase Deficiency" returned 221 free, full-text research articles on human participants. First 3 results:

Glucose-6-Phosphate Dehydrogenase Deficiency and Haemoglobin Drop after Sulphadoxine-Pyrimethamine Use for Intermittent Preventive Treatment of Malaria during Pregnancy in Ghana - A Cohort Study.
 

Author(s): Ruth Owusu, Kwaku Poku Asante, Emmanuel Mahama, Elizabeth Awini, Thomas Anyorigiya, David Dosoo, Alberta Amu, Gabriel Jakpa, Emmanuel Ofei, Sylvester Segbaya, Abraham Rexford Oduro, Margaret Gyapong, Abraham Hodgson, Constance Bart-Plange, Seth Owusu-Agyei

Journal:

 

Sulphadoxine-Pyrimethamine (SP) is still the only recommended antimalarial for use in intermittent preventive treatment of malaria during pregnancy (IPTp) in some malaria endemic countries including Ghana. SP has the potential to cause acute haemolysis in G6PD deficient people resulting ...

Last Updated: 2 Sep 2015

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Tolerability and safety of weekly primaquine against relapse of Plasmodium vivax in Cambodians with glucose-6-phosphate dehydrogenase deficiency.
 

Author(s): Sim Kheng, Sinoun Muth, Walter R J Taylor, Narann Tops, Khem Kosal, Khon Sothea, Phum Souy, Saorin Kim, Chuor Meng Char, Chan Vanna, Po Ly, Pascal Ringwald, Virak Khieu, Alexandra Kerleguer, Pety Tor, John K Baird, Steven Bjorge, Didier Menard, Eva Christophel

Journal:

 

Primaquine is used to prevent Plasmodium vivax relapse; however, it is not implemented in many malaria-endemic countries, including Cambodia, for fear of precipitating primaquine-induced acute haemolytic anaemia in patients with glucose-6-phosphate dehydrogenase deficiency (G6PDd). ...

Last Updated: 25 Aug 2015

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Glucose-6-phosphate dehydrogenase deficiency among malaria patients of Honduras: a descriptive study of archival blood samples.
 

Author(s): Miguel Á Zúñiga, Rosa E Mejía, Ana L Sánchez, Wilfredo H Sosa-Ochoa, Gustavo A Fontecha

Journal:

 

The frequency of deficient variants of glucose-6-phosphate dehydrogenase (G6PDd) is particularly high in areas where malaria is endemic. The administration of antirelapse drugs, such as primaquine, has the potential to trigger an oxidative event in G6PD-deficient individuals. According ...

Last Updated: 7 Aug 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Glucose 6 Phosphate Dehydrogenase Deficiency" returned 10 free, full-text review articles on human participants. First 3 results:

Dual Antiplatelet Therapy in Patients with Glucose-6-Phosphate Dehydrogenase Deficiency undergoing PCI with Drug-Eluting Stents.
 

Author(s): Simone Biscaglia, Alessandra Ferri, Rita Pavasini, Gianluca Campo, Roberto Ferrari

Journal: J. Atheroscler. Thromb.. 2015 ;22(5):535-41.

 

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common human enzyme defect, affecting more than 400 million people worldwide. In patients with G6PD deficiency, the use of aspirin is controversial, since past studies have reported a potential risk of haemolysis related ...

Last Updated: 21 May 2015

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Glucose-6-phosphate dehydrogenase deficiency in transfusion medicine: the unknown risks.
 

Author(s): R O Francis, J S Jhang, H P Pham, E A Hod, J C Zimring, S L Spitalnik

Journal: Vox Sang.. 2013 Nov;105(4):271-82.

 

The hallmark of glucose-6-phosphate dehydrogenase (G6PD) deficiency is red blood cell (RBC) destruction in response to oxidative stress. Patients requiring RBC transfusions may simultaneously receive oxidative medications or have concurrent infections, both of which can induce haemolysis ...

Last Updated: 14 Oct 2013

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Review of key knowledge gaps in glucose-6-phosphate dehydrogenase deficiency detection with regard to the safe clinical deployment of 8-aminoquinoline treatment regimens: a workshop report.
 

Author(s): Lorenz von Seidlein, Sarah Auburn, Fe Espino, Dennis Shanks, Qin Cheng, James McCarthy, Kevin Baird, Catherine Moyes, Rosalind Howes, Didier Ménard, Germana Bancone, Ari Winasti-Satyahraha, Lasse S Vestergaard, Justin Green, Gonzalo Domingo, Shunmay Yeung, Ric Price

Journal:

 

The diagnosis and management of glucose-6-phosphate dehydrogenase (G6PD) deficiency is a crucial aspect in the current phases of malaria control and elimination, which will require the wider use of 8-aminoquinolines for both reducing Plasmodium falciparum transmission and achieving ...

Last Updated: 5 Apr 2013

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Diet Challenge in G6PD Deficient Egyptian Children: A One- Year Prospective Single Center Study With Genotype - Phenotype Correlation
 

Status: Not yet recruiting

Condition Summary: Glucose-6-Phosphate Dehydrogenase Deficiency

 

Last Updated: 14 Jul 2015

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Last Updated: 31 Oct 2015

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G6PD Assessment Before Primaquine for Radical Treatment of Vivax Malaria
 

Status: Not yet recruiting

Condition Summary: Vivax Malaria

 

Last Updated: 22 Aug 2016

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