Glucocorticoid-remediable aldosteronism

Common Name(s)

Glucocorticoid-remediable aldosteronism

Glucocorticoid-remediable aldosteronism is an autosomal dominant disorder characterized by hypertension, variable hyperaldosteronism, and abnormal adrenal steroid production, including 18-oxocortisol and 18-hydroxycortisol ({10:Lifton et al., 1992}). There is significant phenotypic heterogeneity, and some individuals never develop hypertension ({20:Stowasser et al., 2000}). Genetic Heterogeneity of Familial Hyperaldosteronism Familial hyperaldosteronism type II (HALD2; {605635}) has been mapped to chromosome 7p22. Familial hyperaldosteronism type III (HALD3; {613677}) is caused by mutation in the KCNJ5 gene ({600734}) on chromosome 11q24. Familial hyperaldosteronism type IV (HALD4; {617027}) is caused by mutation in the CACNA1H gene ({607904}) on chromosome 16p13.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Glucocorticoid-remediable aldosteronism" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Glucocorticoid-remediable aldosteronism" returned 7 free, full-text research articles on human participants. First 3 results:

Genetic analyses of the chimeric CYP11B1/CYP11B2 gene in a Korean family with glucocorticoid-remediable aldosteronism.
 

Author(s): Ihn Suk Lee, Seul Young Kim, Hye Won Jang, Min Kyeong Kim, Ju Hee Lee, Yun Hyeong Lee, Young Suk Jo

Journal: J. Korean Med. Sci.. 2010 Sep;25(9):1379-83.

 

Glucocorticoid-remediable aldosteronism (GRA) is an autosomal-dominant inheritable form of hyperaldosteronism with early onset hypertension. GRA is caused by unequal crossing-over of the steroid 11 beta-hydroxylase (CYP11B1) and aldosterone synthase (CYP11B2) genes. As a result of ...

Last Updated: 2 Sep 2010

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Japanese family with glucocorticoid-remediable aldosteronism diagnosed by long-polymerase chain reaction.
 

Author(s): K Yokota, T Ogura, M Kishida, J Suzuki, F Otsuka, Y Mimura, T Oishi, M Hirata, K Tobe, H Makino

Journal: Hypertens. Res.. 2001 Sep;24(5):589-94.

 

We report a Japanese family with glucocorticoid-remediable aldosteronism (GRA) in whom gene abnormality was identified by the long-polymerase chain reaction (PCR) method. The proband was a 21-year-old female incidentally found to have high blood pressure (173/107 mmHg). Laboratory ...

Last Updated: 24 Oct 2001

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Is random screening of value in detecting glucocorticoid-remediable aldosteronism within a hypertensive population?
 

Author(s): L J Gates, N Benjamin, N E Haites, A A MacConnachie, J S McLay

Journal: J Hum Hypertens. 2001 Mar;15(3):173-6.

 

Glucocorticoid-remediable aldosteronism (GRA) is a rare inherited cause for hypertension associated with a significant morbidity and mortality at an early age. Individuals with this abnormality frequently present with severe hypertension which is resistant to standard antihypertensive ...

Last Updated: 24 Apr 2001

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Reviews from the PubMed Database

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The terms "Glucocorticoid-remediable aldosteronism" returned 1 free, full-text review articles on human participants. First 3 results:

Glucocorticoid-remediable aldosteronism.
 

Author(s): Graham T McMahon, Robert G Dluhy

Journal: Arq Bras Endocrinol Metabol. 2004 Oct;48(5):682-6.

 

Glucocorticoid-remediable aldosteronism (GRA) is a monogenic form of human hypertension that predisposes to cerebral hemorrhage. As a result of a chimeric gene duplication, aldosterone is ectopically synthesized in the cortisol-secreting zona fasciculata of the adrenal gland under ...

Last Updated: 11 Mar 2005

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Symptoms, Diagnosis, and Treatment

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