Glucocorticoid-remediable aldosteronism

Common Name(s)

Glucocorticoid-remediable aldosteronism

Glucocorticoid-remediable aldosteronism is an autosomal dominant disorder characterized by hypertension, variable hyperaldosteronism, and abnormal adrenal steroid production, including 18-oxocortisol and 18-hydroxycortisol ({10:Lifton et al., 1992}). There is significant phenotypic heterogeneity, and some individuals never develop hypertension ({20:Stowasser et al., 2000}). Genetic Heterogeneity of Familial Hyperaldosteronism Familial hyperaldosteronism type II ({605635}) has been mapped to chromosome 7p22. Familial hyperaldosteronism type III ({613677}) is caused by mutation in the KCNJ5 gene ({600734}) on chromosome 11q24.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Glucocorticoid-remediable aldosteronism" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Glucocorticoid-remediable aldosteronism" returned 9 free, full-text research articles on human participants. First 3 results:

Genetic analyses of the chimeric CYP11B1/CYP11B2 gene in a Korean family with glucocorticoid-remediable aldosteronism.
 

Author(s): Ihn Suk Lee, Seul Young Kim, Hye Won Jang, Min Kyeong Kim, Ju Hee Lee, Yun Hyeong Lee, Young Suk Jo

Journal: J. Korean Med. Sci.. 2010 Sep;25(9):1379-83.

 

Glucocorticoid-remediable aldosteronism (GRA) is an autosomal-dominant inheritable form of hyperaldosteronism with early onset hypertension. GRA is caused by unequal crossing-over of the steroid 11 beta-hydroxylase (CYP11B1) and aldosterone synthase (CYP11B2) genes. As a result of ...

Last Updated: 2 Sep 2010

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A German family with glucocorticoid-remediable aldosteronism.
 

Author(s): Oliver Vonend, Christian Altenhenne, Nicolaus J Büchner, Gabriele Dekomien, Christiane Maser-Gluth, Stefan M Weiner, Lorenz Sellin, Stefan Hofebauer, Jörg T Epplen, Lars C Rump

Journal: Nephrol. Dial. Transplant.. 2007 Apr;22(4):1123-30.

 

The prevalence of primary hyperaldosteronism (PHA) in the hypertensive population has increased in recent years. Glucocorticoid-remediable aldosteronism (GRA) is a rare monogenic form of PHA. Here we report a German family with GRA. Since the phenotype of GRA varies widely, we asked ...

Last Updated: 26 Mar 2007

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Clinical and gene mutation studies on a Chinese pedigree with glucocorticoid-remediable aldosteronism.
 

Author(s): Wei Ding, Libin Liu, Renming Hu, Manyin Xu, Jialun Chen

Journal: Chin. Med. J.. 2002 Jul;115(7):979-82.

 

To report the clinical characteristics, biochemical profiles, diagnosis and treatment of one Chinese pedigree with glucocorticoid-remediable aldosteronism (GRA) and to study its molecular mechanism.

Last Updated: 1 Aug 2002

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Glucocorticoid-remediable aldosteronism" returned 2 free, full-text review articles on human participants. First 3 results:

Glucocorticoid-remediable aldosteronism.
 

Author(s): Graham T McMahon, Robert G Dluhy

Journal: Arq Bras Endocrinol Metabol. 2004 Oct;48(5):682-6.

 

Glucocorticoid-remediable aldosteronism (GRA) is a monogenic form of human hypertension that predisposes to cerebral hemorrhage. As a result of a chimeric gene duplication, aldosterone is ectopically synthesized in the cortisol-secreting zona fasciculata of the adrenal gland under ...

Last Updated: 11 Mar 2005

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Glucocorticoid-remediable aldosteronism.
 

Author(s): R G Dluhy, G H Williams

Journal: Cardiovasc. Res.. 1996 Jun;31(6):870-2.

 

Last Updated: 11 Oct 1996

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.