Gigantomastia

Common Name(s)

Gigantomastia

Gigantomastia is a rare condition that is characterized by excessive breast growth that may occur spontaneously, during puberty or pregnancy, or while taking certain medications. To date, there is no universally accepted definition for gigantomastia; however, Dancey et al. (2007) state that a review of the medical literature suggests that definitions range from a D-cup bra size to breast enlargement requiring reduction of over 0.8 - 2 kg, which is equivalent to about 1.75 - 4.5 pounds. The exact cause of gigantomastia has not been determined. Nonetheless, the following theories have been proposed to explain gigantomastia: (1) end-organ hypersensitivity (a condition in which the breast tissue is more sensitive to hormones circulating in the body), (2) autoimmune issues, (3) high IGF-1 (insulin growth factor-1, a hormone involved in regulating bone growth) and (4) hyperprolactanemia (high levels of prolactin). Gigantomastia has been noted as a side effect of treatment with certain medications like D-pencillamine and in one case as an apparently hereditary condition. Symptoms of gigantomastic may include mastalgia (breast pain), ulceration/infection, posture problems, back pain and chronic traction injury to 4th/5th/6th intercostal nerves with resultant loss of nipple sensation. It is may also associated with decreased fetal growth, if the gigantomastia is present during pregnancy. Treatment is based on the person's symptoms and may include breast reduction, mastectomy with or without reconstruction, hormonal treatment, or a combination of treatments.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Gigantomastia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Gigantomastia" returned 7 free, full-text research articles on human participants. First 3 results:

A case of gestational gigantomastia in a 37-years-old woman associated with elevated ANA: a casual linkage?
 

Author(s): Nicola Zingaretti, Fabrizio De Biasio, Michele Riccio, Nastassia Nardini, Laura Mariuzzi, Pier Camillo Parodi

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Hypertrophy of the breast (macromastia and gigantomastia) is a rare medical condition of the breast connective tissues. The etiology of this condition is still not clear; rarely, gigantomastia has been reported to develop in the setting of an autoimmune illness. We reported a case ...

Last Updated: 14 Sep 2017

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An exceptional case of bilateral gestational gigantomastia with multiple breast lumps.
 

Author(s): Bangaly Traoré, Bakarou Kamate, Mamoudou Conde, Ahmed Monzomba Keita, Tidiane Kourouma, Ahmadou Dem

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Bilateral gigantomastia is a rare condition, often associated with pregnancy that is characterized by a diffuse enlargement of both breasts. Here we present a case of a late 20s woman in her seven months pregnancy with a bilateral gestational gigantomastia associated with multiple ...

Last Updated: 10 Jul 2015

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[Gestational gigantomastia at the Institute of Cancer Dakar: about 2 cases].
 

Author(s): Sidy Ka, Jaafar Thiam, Maimouna Mane, Rolland Some, Rokhaya Niang, Céline Goudiaby, Ahmadou Dem

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Last Updated: 15 Mar 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Gigantomastia" returned 1 free, full-text review articles on human participants. First 3 results:

[Gigantomastia: report of a case and review of the literature].
 

Author(s): Nisrine Mamouni, Sanaa Erraghay, Aya Oufkir, Hanane Saadi, Chahrazed Bouchikhi, Abdelaziz Banani

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Last Updated: 24 Nov 2014

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Symptoms, Diagnosis, and Treatment

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