Gastrointestinal Stromal Tumors

Common Name(s)

Gastrointestinal Stromal Tumors, GIST

Gastrointestinal stromal tumors are a type of soft tissue sarcoma (tumor) that usually begins in cells in the wall of the stomach, intestines, or rectum. These tumors may be noncancerous or cancerous. They can affect adults, adolescents, or children.  It is estimated that around 5,000 new cases of gastrointestinal stromal tumors are diagnosed in the United States each year.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Gastrointestinal Stromal Tumors" for support, advocacy or research.

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GIST Support International

GIST Support International provides support and education for those interested in GIST. This is achieved through a comprehensive and up to date website as well as on line communication via a listserve and facebook. GSI also hosts a once a year patient educaion meeting presented by top GIST experts.

http://www.gistsupport.org

Last Updated: 19 Feb 2013

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Life Raft Group

The Life Raft Group has a simple focus: to cure a form of cancer — GIST (gastrointestinal stromal tumors) – and to help those living with it until then. The mission of the Life Raft Group is to ensure the survival of GIST patients through a comprehensive approach connecting individual patients’ needs, the worldwide community of GIST advocates and the global health and research environment. To do this, we focus on three key areas: research, advocacy and patient support & education.

http://www.liferaftgroup.org

Last Updated: 28 Mar 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Gastrointestinal Stromal Tumors" for support, advocacy or research.

Logo
GIST Support International

GIST Support International provides support and education for those interested in GIST. This is achieved through a comprehensive and up to date website as well as on line communication via a listserve and facebook. GSI also hosts a once a year patient educaion meeting presented by top GIST experts.

http://www.gistsupport.org

Last Updated: 19 Feb 2013

View Details
Logo
Life Raft Group

The Life Raft Group has a simple focus: to cure a form of cancer — GIST (gastrointestinal stromal tumors) – and to help those living with it until then. The mission of the Life Raft Group is to ensure the survival of GIST patients through a comprehensive approach connecting individual patients’ needs, the worldwide community of GIST advocates and the global health and research environment. To do this, we focus on three key areas: research, advocacy and patient support & education.

http://www.liferaftgroup.org

Last Updated: 28 Mar 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Gastrointestinal Stromal Tumors" returned 329 free, full-text research articles on human participants. First 3 results:

[Stromal gastrointestinal tumors: retrospective study of 24 cases].
 

Author(s): Hanène Boudabous, Youssef Chaker, Ramzi Nouira, Chadli Dziri

Journal: Tunis Med. 2013 Nov;91(11):661-7.

 

Gastrointestinal stromal tumors (GIST) are the most common digestive sarcomas. They develop in most cases in the stomach and small intestine, more rarely rectum, colon, esophagus or mesentery. These tumors typically express the phenotype CD117/KIT + and CD34 +.

Last Updated: 17 Dec 2013

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Gastrointestinal stromal tumors of the duodenum: surgical management and survival results.
 

Author(s): Xiao Liang, Hong Yu, Lin-Hua Zhu, Xian-Fa Wang, Xiu-Jun Cai

Journal: World J. Gastroenterol.. 2013 Sep;19(36):6000-10.

 

To provide long-term survival results of operable duodenal gastrointestinal stromal tumors (DGISTs) in a tertiary center in China.

Last Updated: 9 Oct 2013

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Multiple gastrointestinal and extragastrointestinal stromal tumors in a male infant--an extreme rarity.
 

Author(s): Kamal Nain Rattan, Pradeep Kajal, Vivek Singh Malik, Gargi Soni

Journal: Trop Gastroenterol. ;33(4):285-7.

 

Last Updated: 7 Aug 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Gastrointestinal Stromal Tumors" returned 44 free, full-text review articles on human participants. First 3 results:

A case of neurofibromatosis type 1 coinciding with bilateral pheochromocytomas, multiple gastrointestinal stromal tumors, and malignant peripheral nerve sheath tumor.
 

Author(s): Yuji Hataya, Yasato Komatsu, Keisuke Osaki, Yorihide Fukuda, Teruyuki Sato, Taisuke Morimoto

Journal: Intern. Med.. 2012 ;51(12):1531-6.

 

Neurofibromatosis type 1 (NF1) is associated with benign and malignant neoplasms, but the coincidence of abdominal neoplasms is rare. A 65-year-old woman with NF1 had episodes of nausea, tachycardia, hypertension, and loss of consciousness. Bilateral adrenal tumors were detected by ...

Last Updated: 25 Jun 2012

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Gastrointestinal stromal tumors (GIST): a rare entity, a tumor model for personalized therapy, and yet ten different molecular subtypes.
 

Author(s): Jean-Yves Blay, Axel Le Cesne, Philippe A Cassier, Isabelle L Ray-Coquard

Journal: Discov Med. 2012 May;13(72):357-67.

 

Gastrointestinal stromal tumors (GIST) are the most frequent sarcoma and were recognized as distinct molecular entities in 1998. Following the identification of driving molecular alterations in KIT, imatinib was rapidly introduced for the treatment of GIST, and became the paradigm ...

Last Updated: 30 May 2012

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Imatinib rechallenge in patients with advanced gastrointestinal stromal tumors.
 

Author(s): J-Y Blay, D Pérol, A Le Cesne

Journal: Ann. Oncol.. 2012 Jul;23(7):1659-65.

 

Imatinib is the standard of care for patients with advanced gastrointestinal stromal tumors (GIST).

Last Updated: 3 Jul 2012

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Dose-Escalation Study of TH-302 in Combination With Sunitinib to Treat Patients With Advanced Renal Cell Carcinoma,Gastrointestinal Stromal Tumors and Pancreatic Neuroendocrine Tumors
 

Status: Recruiting

Condition Summary: Advanced Renal Cell Carcinoma; Gastrointestinal Stromal Tumors; Pancreatic Neuroendocrine Tumors

 

Last Updated: 7 Apr 2014

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Efficacy and Safety of PD-0332991 in Patients With Advanced Gastrointestinal Stromal Tumors Refractory to Imatinib and Sunitinib
 

Status: Not yet recruiting

Condition Summary: Advanced Gastrointestinal Stromal Tumors

 

Last Updated: 24 Jul 2013

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