Gastrointestinal Stromal Tumors

Common Name(s)

Gastrointestinal Stromal Tumors, GIST

Gastrointestinal stromal tumors are a type of soft tissue sarcoma (tumor) that usually begins in cells in the wall of the stomach, intestines, or rectum. These tumors may be noncancerous or cancerous. They can affect adults, adolescents, or children.  It is estimated that around 5,000 new cases of gastrointestinal stromal tumors are diagnosed in the United States each year.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Gastrointestinal Stromal Tumors" for support, advocacy or research.

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GIST Support International

GIST Support International provides support and education for those interested in GIST. This is achieved through a comprehensive and up to date website as well as on line communication via a listserve and facebook. GSI also hosts a once a year patient educaion meeting presented by top GIST experts.

Last Updated: 19 Feb 2013

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Life Raft Group

The Life Raft Group has a simple focus: to cure a form of cancer — GIST (gastrointestinal stromal tumors) – and to help those living with it until then. The mission of the Life Raft Group is to ensure the survival of GIST patients through a comprehensive approach connecting individual patients’ needs, the worldwide community of GIST advocates and the global health and research environment. To do this, we focus on three key areas: research, advocacy and patient support & education.

Last Updated: 28 Mar 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Gastrointestinal Stromal Tumors" for support, advocacy or research.

Logo
GIST Support International

GIST Support International provides support and education for those interested in GIST. This is achieved through a comprehensive and up to date website as well as on line communication via a listserve and facebook. GSI also hosts a once a year patient educaion meeting presented by top GIST experts.

http://www.gistsupport.org

Last Updated: 19 Feb 2013

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Life Raft Group

The Life Raft Group has a simple focus: to cure a form of cancer — GIST (gastrointestinal stromal tumors) – and to help those living with it until then. The mission of the Life Raft Group is to ensure the survival of GIST patients through a comprehensive approach connecting individual patients’ needs, the worldwide community of GIST advocates and the global health and research environment. To do this, we focus on three key areas: research, advocacy and patient support & education.

http://www.liferaftgroup.org

Last Updated: 28 Mar 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Gastrointestinal Stromal Tumors" returned 341 free, full-text research articles on human participants. First 3 results:

Thyroid hormone inactivation in gastrointestinal stromal tumors.
 

Author(s): Michelle A Maynard, Stephen A Huang

Journal: N. Engl. J. Med.. 2014 Jul;371(1):86-7.

 

Last Updated: 3 Jul 2014

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[Stromal gastrointestinal tumors: retrospective study of 24 cases].
 

Author(s): Hanène Boudabous, Youssef Chaker, Ramzi Nouira, Chadli Dziri

Journal: Tunis Med. 2013 Nov;91(11):661-7.

 

Gastrointestinal stromal tumors (GIST) are the most common digestive sarcomas. They develop in most cases in the stomach and small intestine, more rarely rectum, colon, esophagus or mesentery. These tumors typically express the phenotype CD117/KIT + and CD34 +.

Last Updated: 17 Dec 2013

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Physical properties of gastrointestinal stromal tumors based on atomic force microscope analysis.
 

Author(s): Y Zhao, T B Zhang, C H Bao, X Y Chen, Y Wang, Q Wang

Journal:

 

This study was designed to detect the stiffness of single living gastrointestinal stromal tumor (GIST) cells in vitro using an atomic force microscope as a probe tool. We determined that the stiffness of living GIST cells was 3913 Pa, the stiffness of the membrane was 642 Pa, and ...

Last Updated: 4 Dec 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Gastrointestinal Stromal Tumors" returned 49 free, full-text review articles on human participants. First 3 results:

Anal canal gastrointestinal stromal tumors: case report and literature review.
 

Author(s): Nuno Carvalho, Diogo Albergaria, Rui Lebre, João Giria, Vitor Fernandes, Helena Vidal, Maria José Brito

Journal: World J. Gastroenterol.. 2014 Jan;20(1):319-22.

 

Gastrointestinal stromal tumors (GIST) are an uncommon group of tumors of mesenchymal origin. GIST of the anal canal is extremely rare. At present, only 10 cases of c-kit positive anal GIST have been reported in the literature. There is no widely accepted treatment approach for this ...

Last Updated: 13 Jan 2014

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Gastrointestinal stromal tumors associated with neurofibromatosis 1: a single centre experience and systematic review of the literature including 252 cases.
 

Author(s): Pier Federico Salvi, Laura Lorenzon, Salvatore Caterino, Laura Antolino, Maria Serena Antonelli, Genoveffa Balducci

Journal: Int J Surg Oncol. 2013 ;2013():398570.

 

The objectives of this study were (a) to report our experience regarding the association between neurofibromatosis type 1 (NF1) and gastrointestinal stromal tumors (GISTs); (b) to provide a systematic review of the literature in this field; and (c) to compare the features of NF1-associated ...

Last Updated: 3 Jan 2014

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Correlation of imatinib resistance with the mutational status of KIT and PDGFRA genes in gastrointestinal stromal tumors: a meta-analysis.
 

Author(s): Ju-Han Lee, Younghye Kim, Jung-Woo Choi, Young-Sik Kim

Journal: J Gastrointestin Liver Dis. 2013 Dec;22(4):413-8.

 

Imatinib resistance is the most important clinical issue in patients with gastrointestinal stromal tumor (GIST). However, the association of imatinib resistance with the genetic characteristics of GIST has not been clearly defined. Our meta-analysis aimed to investigate the association ...

Last Updated: 26 Dec 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Efficacy and Safety of PD-0332991 in Patients With Advanced Gastrointestinal Stromal Tumors Refractory to Imatinib and Sunitinib
 

Status: Not yet recruiting

Condition Summary: Advanced Gastrointestinal Stromal Tumors

 

Last Updated: 24 Jul 2013

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