Gastrointestinal Stromal Tumors

Common Name(s)

Gastrointestinal Stromal Tumors, GIST

Gastrointestinal stromal tumors are a type of soft tissue sarcoma (tumor) that usually begins in cells in the wall of the stomach, intestines, or rectum. These tumors may be noncancerous or cancerous. They can affect adults, adolescents, or children.  It is estimated that around 5,000 new cases of gastrointestinal stromal tumors are diagnosed in the United States each year.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Gastrointestinal Stromal Tumors" for support, advocacy or research.

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GIST Support International

GIST Support International provides support and education for those interested in GIST. This is achieved through a comprehensive and up to date website as well as on line communication via a listserve and facebook. GSI also hosts a once a year patient educaion meeting presented by top GIST experts.

Last Updated: 19 Feb 2013

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Life Raft Group

The Life Raft Group has a simple focus: to cure a form of cancer — GIST (gastrointestinal stromal tumors) – and to help those living with it until then. The mission of the Life Raft Group is to ensure the survival of GIST patients through a comprehensive approach connecting individual patients’ needs, the worldwide community of GIST advocates and the global health and research environment. To do this, we focus on three key areas: research, advocacy and patient support & education.

Last Updated: 28 Mar 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Gastrointestinal Stromal Tumors" for support, advocacy or research.

Logo
GIST Support International

GIST Support International provides support and education for those interested in GIST. This is achieved through a comprehensive and up to date website as well as on line communication via a listserve and facebook. GSI also hosts a once a year patient educaion meeting presented by top GIST experts.

http://www.gistsupport.org

Last Updated: 19 Feb 2013

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Life Raft Group

The Life Raft Group has a simple focus: to cure a form of cancer — GIST (gastrointestinal stromal tumors) – and to help those living with it until then. The mission of the Life Raft Group is to ensure the survival of GIST patients through a comprehensive approach connecting individual patients’ needs, the worldwide community of GIST advocates and the global health and research environment. To do this, we focus on three key areas: research, advocacy and patient support & education.

http://www.liferaftgroup.org

Last Updated: 28 Mar 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Gastrointestinal Stromal Tumors" returned 367 free, full-text research articles on human participants. First 3 results:

Thyroid hormone inactivation in gastrointestinal stromal tumors.
 

Author(s): Michelle A Maynard, Stephen A Huang

Journal: N. Engl. J. Med.. 2014 Jul;371(1):86-7.

 

Last Updated: 3 Jul 2014

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Prognostic impact of gastrointestinal bleeding and expression of PTEN and Ki-67 on primary gastrointestinal stromal tumors.
 

Author(s): Hao Wang, Ping Chen, Xin-Xin Liu, Wei Zhao, Lei Shi, Xue-Wen Gu, Chang-Ren Zhu, Hai-Hang Zhu, Liang Zong

Journal:

 

Prognostic indicators for gastrointestinal stromal tumors (GISTs) are under investigation. The latest risk classification criteria may still have room for improvement. This study aims to investigate prognostic factors for primary GISTs from three aspects, including clinicopathological ...

Last Updated: 17 Apr 2014

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Thyroid hormone inactivation in gastrointestinal stromal tumors.
 

Author(s): Michelle A Maynard, Adrian Marino-Enriquez, Jonathan A Fletcher, David M Dorfman, Chandrajit P Raut, Leila Yassa, Cuicui Guo, Yuexiang Wang, Clara Dorfman, Henry A Feldman, Mary C Frates, Huaidong Song, Rebecca H Jugo, Takahiro Taguchi, Jerome M Hershman, P Reed Larsen, Stephen A Huang

Journal: N. Engl. J. Med.. 2014 Apr;370(14):1327-34.

 

Gastrointestinal stromal tumors (GISTs) are resistant to traditional chemotherapy but are responsive to the tyrosine kinase inhibitors imatinib and sunitinib. The use of these agents has improved the outcome for patients but is associated with adverse effects, including hypothyroidism. ...

Last Updated: 3 Apr 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Gastrointestinal Stromal Tumors" returned 59 free, full-text review articles on human participants. First 3 results:

Anal canal gastrointestinal stromal tumors: case report and literature review.
 

Author(s): Nuno Carvalho, Diogo Albergaria, Rui Lebre, João Giria, Vitor Fernandes, Helena Vidal, Maria José Brito

Journal: World J. Gastroenterol.. 2014 Jan;20(1):319-22.

 

Gastrointestinal stromal tumors (GIST) are an uncommon group of tumors of mesenchymal origin. GIST of the anal canal is extremely rare. At present, only 10 cases of c-kit positive anal GIST have been reported in the literature. There is no widely accepted treatment approach for this ...

Last Updated: 13 Jan 2014

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Gastrointestinal stromal tumors associated with neurofibromatosis 1: a single centre experience and systematic review of the literature including 252 cases.
 

Author(s): Pier Federico Salvi, Laura Lorenzon, Salvatore Caterino, Laura Antolino, Maria Serena Antonelli, Genoveffa Balducci

Journal: Int J Surg Oncol. 2013 ;2013():398570.

 

The objectives of this study were (a) to report our experience regarding the association between neurofibromatosis type 1 (NF1) and gastrointestinal stromal tumors (GISTs); (b) to provide a systematic review of the literature in this field; and (c) to compare the features of NF1-associated ...

Last Updated: 3 Jan 2014

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Correlation of imatinib resistance with the mutational status of KIT and PDGFRA genes in gastrointestinal stromal tumors: a meta-analysis.
 

Author(s): Ju-Han Lee, Younghye Kim, Jung-Woo Choi, Young-Sik Kim

Journal: J Gastrointestin Liver Dis. 2013 Dec;22(4):413-8.

 

Imatinib resistance is the most important clinical issue in patients with gastrointestinal stromal tumor (GIST). However, the association of imatinib resistance with the genetic characteristics of GIST has not been clearly defined. Our meta-analysis aimed to investigate the association ...

Last Updated: 26 Dec 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Efficiency of Imatinib Treatment Maintenance or Interruption After 3 Years of Adjuvant Treatment in Patients With Gastrointestinal Stromal Tumours (GIST)
 

Status: Not yet recruiting

Condition Summary: Gastrointestinal Stromal Tumors; KIT +; Resected Gastrointestinal Stromal Tumors; Non-metastatic; High Risk of Recurrence

 

Last Updated: 6 Oct 2014

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Perioperative Imatinib Mesylate in Treating Patients With Locally Advanced Gastrointestinal Stromal Tumor
 

Status: Recruiting

Condition Summary: Gastrointestinal Stromal Tumor

 

Last Updated: 27 Dec 2010

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