Gastrointestinal Stromal Tumors

Common Name(s)

Gastrointestinal Stromal Tumors, GIST

Gastrointestinal stromal tumors are a type of soft tissue sarcoma (tumor) that usually begins in cells in the wall of the stomach, intestines, or rectum. These tumors may be noncancerous or cancerous. They can affect adults, adolescents, or children.  It is estimated that around 5,000 new cases of gastrointestinal stromal tumors are diagnosed in the United States each year.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Gastrointestinal Stromal Tumors" for support, advocacy or research.

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GIST Support International

GIST Support International provides support and education for those interested in GIST. This is achieved through a comprehensive and up to date website as well as on line communication via a listserve and facebook. GSI also hosts a once a year patient educaion meeting presented by top GIST experts.

Last Updated: 19 Feb 2013

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Life Raft Group

The Life Raft Group has a simple focus: to cure a form of cancer — GIST (gastrointestinal stromal tumors) – and to help those living with it until then. The mission of the Life Raft Group is to ensure the survival of GIST patients through a comprehensive approach connecting individual patients’ needs, the worldwide community of GIST advocates and the global health and research environment. To do this, we focus on three key areas: research, advocacy and patient support & education.

Last Updated: 28 Mar 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Gastrointestinal Stromal Tumors" for support, advocacy or research.

Logo
GIST Support International

GIST Support International provides support and education for those interested in GIST. This is achieved through a comprehensive and up to date website as well as on line communication via a listserve and facebook. GSI also hosts a once a year patient educaion meeting presented by top GIST experts.

http://www.gistsupport.org

Last Updated: 19 Feb 2013

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Life Raft Group

The Life Raft Group has a simple focus: to cure a form of cancer — GIST (gastrointestinal stromal tumors) – and to help those living with it until then. The mission of the Life Raft Group is to ensure the survival of GIST patients through a comprehensive approach connecting individual patients’ needs, the worldwide community of GIST advocates and the global health and research environment. To do this, we focus on three key areas: research, advocacy and patient support & education.

http://www.liferaftgroup.org

Last Updated: 28 Mar 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Gastrointestinal Stromal Tumors" returned 456 free, full-text research articles on human participants. First 3 results:

Treatment and Prognoses in Patients With Primary Gastrointestinal Stromal Tumors ≥10  cm: A Single-Institution Experience in China.
 

Author(s): Chaoyong Shen, Haining Chen, Yuan Yin, Jiaju Chen, Sumin Tang, Bo Zhang, Luyin Han, Zhixin Chen, Jiaping Chen

Journal: Medicine (Baltimore). 2015 Jul;94(28):e1117.

 

Data on treatments and specific outcomes of primary gastrointestinal stromal tumors (GISTs) ≥10  cm are limited. We here report the treatments and survival outcomes concerning a subgroup of primary giant GISTs. Data of 83 consecutive patients with primary GISTs ≥10  cm in ...

Last Updated: 18 Jul 2015

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Feasibility and Timing of Cytoreduction Surgery in Advanced (Metastatic or Recurrent) Gastrointestinal Stromal Tumors During the Era of Imatinib.
 

Author(s): Shih-Chun Chang, Chien-Hung Liao, Shang-Yu Wang, Chun-Yi Tsai, Kun-Chun Chiang, Chi-Tung Cheng, Ta-Sen Yeh, Yen-Yang Chen, Ming-Chun Ma, Chien-Ting Liu, Chun-Nan Yeh

Journal: Medicine (Baltimore). 2015 Jun;94(24):e1014.

 

The prognosis of advanced gastrointestinal stromal tumors (GISTs) was dramatically improved in the era of imatinib. Cytoreduction surgery was advocated as an additional treatment for advanced GISTs, especially when patients having poor response to imatinib or developing resistance ...

Last Updated: 20 Jun 2015

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Expression profile of microRNAs in gastrointestinal stromal tumors revealed by high throughput quantitative RT-PCR microarray.
 

Author(s): Han-Xing Tong, Yu-Hong Zhou, Ying-Yong Hou, Yong Zhang, Yuan Huang, Bin Xie, Jiong-Yuan Wang, Quan Jiang, Jun-Yi He, Ye-Bo Shao, Wu-Mei Han, Ruo-Ying Tan, Jun Zhu, Wei-Qi Lu

Journal: World J. Gastroenterol.. 2015 May;21(19):5843-55.

 

To investigate the microRNA (miRNA) expression profile in gastrointestinal stromal tumor (GIST) tissues that could serve as a novel diagnostic biomarker for GIST detection.

Last Updated: 28 May 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Gastrointestinal Stromal Tumors" returned 73 free, full-text review articles on human participants. First 3 results:

Succinate dehydrogenase-deficient gastrointestinal stromal tumors.
 

Author(s): Ya-Mei Wang, Meng-Li Gu, Feng Ji

Journal: World J. Gastroenterol.. 2015 Feb;21(8):2303-14.

 

Most gastrointestinal stromal tumors (GISTs) are characterized by KIT or platelet-derived growth factor alpha (PDGFRA) activating mutations. However, there are still 10%-15% of GISTs lacking KIT and PDGFRA mutations, called wild-type GISTs (WT GISTs). Among these so-called WT GISTs, ...

Last Updated: 5 Mar 2015

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Gastrointestinal stromal tumors: current translational research and management modalities.
 

Author(s): R-X Huang, P Xiang, C Huang

Journal: Eur Rev Med Pharmacol Sci. 2014 Oct;18(20):3076-85.

 

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract. In recent years, detection of these subepithelial lesions has improved due to advances in endoscopic imaging techniques. Furthermore, developments in immunohistochemical ...

Last Updated: 13 Nov 2014

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Gastrointestinal stromal tumors: who should get imatinib and for how long?
 

Author(s): Vinod P Balachandran, Ronald P DeMatteo

Journal: Adv Surg. 2014 ;48():165-83.

 

The application of imatinib for the treatment of GIST remains a remarkable illustration of the ability and promise of targeted molecular therapy. It is gradually becoming evident that the benefit of imatinib depends on the complex interplay between mutational variations that govern ...

Last Updated: 9 Oct 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Efficiency of Imatinib Treatment Maintenance or Interruption After 3 Years of Adjuvant Treatment in Patients With Gastrointestinal Stromal Tumours (GIST)
 

Status: Recruiting

Condition Summary: Gastrointestinal Stromal Tumors; KIT +; Resected Gastrointestinal Stromal Tumors; Non-metastatic; High Risk of Recurrence

 

Last Updated: 8 Jun 2015

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Last Updated: 23 Jul 2015

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