Gastrointestinal Stromal Tumors

Common Name(s)

Gastrointestinal Stromal Tumors, GIST

Gastrointestinal stromal tumors are a type of soft tissue sarcoma (tumor) that usually begins in cells in the wall of the stomach, intestines, or rectum. These tumors may be noncancerous or cancerous. They can affect adults, adolescents, or children.  It is estimated that around 5,000 new cases of gastrointestinal stromal tumors are diagnosed in the United States each year.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Gastrointestinal Stromal Tumors" for support, advocacy or research.

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GIST Support International

GIST Support International provides support and education for those interested in GIST. This is achieved through a comprehensive and up to date website as well as on line communication via a listserve and facebook. GSI also hosts a once a year patient educaion meeting presented by top GIST experts.

Last Updated: 19 Feb 2013

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Life Raft Group

The Life Raft Group has a simple focus: to cure a form of cancer — GIST (gastrointestinal stromal tumors) – and to help those living with it until then. The mission of the Life Raft Group is to ensure the survival of GIST patients through a comprehensive approach connecting individual patients’ needs, the worldwide community of GIST advocates and the global health and research environment. To do this, we focus on three key areas: research, advocacy and patient support & education.

Last Updated: 28 Mar 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Gastrointestinal Stromal Tumors" for support, advocacy or research.

Logo
GIST Support International

GIST Support International provides support and education for those interested in GIST. This is achieved through a comprehensive and up to date website as well as on line communication via a listserve and facebook. GSI also hosts a once a year patient educaion meeting presented by top GIST experts.

http://www.gistsupport.org

Last Updated: 19 Feb 2013

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Life Raft Group

The Life Raft Group has a simple focus: to cure a form of cancer — GIST (gastrointestinal stromal tumors) – and to help those living with it until then. The mission of the Life Raft Group is to ensure the survival of GIST patients through a comprehensive approach connecting individual patients’ needs, the worldwide community of GIST advocates and the global health and research environment. To do this, we focus on three key areas: research, advocacy and patient support & education.

http://www.liferaftgroup.org

Last Updated: 28 Mar 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Gastrointestinal Stromal Tumors" returned 472 free, full-text research articles on human participants. First 3 results:

The cut-off value of tumor size and appropriate timing of follow-up for management of minimal EUS-suspected gastric gastrointestinal stromal tumors.
 

Author(s): Zhidong Gao, Chao Wang, Qian Xue, Jingtong Wang, Zhanlong Shen, Kewei Jiang, Kai Shen, Bin Liang, Xiaodong Yang, Qiwei Xie, Shan Wang, Yingjiang Ye

Journal:

 

The detectable rate of minimal gastric GISTs has continuously increased. While the surveillance and management of GIST <2 cm have been deemed controversial or lack evidence-based approaches.  The aim of the current study is to propose a cut-off value of tumor size for treatment ...

Last Updated: 12 Jan 2017

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A lower dosage of imatinib in patients with gastrointestinal stromal tumors with toxicity of the treatment.
 

Author(s): Yuan Yin, Jin Xiang, Sumin Tang, Jiaju Chen, Qin Yu, Bo Zhang

Journal: Medicine (Baltimore). 2016 Dec;95(49):e5488.

 

This study investigated the efficiency and safety of imatinib in the lower dose (300 mg/d) in patients with gastrointestinal stromal tumor (GIST) who cannot tolerate imatinib in the standard dose (400 mg/d).Steady-state imatinib trough concentration (Cmin) values in 18 patients ...

Last Updated: 8 Dec 2016

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Gastrointestinal stromal tumors (GISTs) and second malignancies: A novel "sentinel tumor"? A monoinstitutional, STROBE-compliant observational analysis.
 

Author(s): Maria Grazia Rodriquenz, Sabrina Rossi, Riccardo Ricci, Maurizio Martini, Mario Larocca, Angelo Dipasquale, Michela Quirino, Giovanni Schinzari, Michele Basso, Ettore D'Argento, Antonia Strippoli, Carlo Barone, Alessandra Cassano

Journal: Medicine (Baltimore). 2016 Sep;95(38):e4718.

 

Several evidences showed that patients with gastrointestinal stromal tumors (GISTs) develop additional malignancies. However, thorough incidence of second tumors remains uncertain as the possibility of a common molecular pathogenesis.A retrospective series of 128 patients with histologically ...

Last Updated: 24 Sep 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Gastrointestinal Stromal Tumors" returned 79 free, full-text review articles on human participants. First 3 results:

Regorafenib: A novel tyrosine kinase inhibitor: A brief review of its therapeutic potential in the treatment of metastatic colorectal carcinoma and advanced gastrointestinal stromal tumors.
 

Author(s): P Thangaraju, H Singh, A Chakrabarti

Journal: Indian J Cancer. ;52(3):257-60.

 

Regorafenib is a novel oral multitargeted tyrosine kinase inhibitor having both antitumor and anti-angiogenic activities. Regorafenib was recently approved by US Food and Drug Administration in February 25, 2013 in the treatment for patients with advanced gastrointestinal stromal ...

Last Updated: 24 Feb 2016

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Prognostic role of microscopically positive margins for primary gastrointestinal stromal tumors: a systematic review and meta-analysis.
 

Author(s): Xiaofei Zhi, Baofei Jiang, Junbo Yu, Oluf Dimitri Røe, Jun Qin, Qingfeng Ni, Luning Sun, Meirong Xu, Jianwei Zhu, Lilin Ma

Journal:

 

The impact and management of microscopically positive margins in gastrointestinal stromal tumors (GISTs) remain unclear. The aim of this study is to estimate the prognostic value of surgical margins for disease-free survival (DFS) and overall survival (OS) in patients with primary ...

Last Updated: 19 Feb 2016

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Clinicopathological significance of c-KIT mutation in gastrointestinal stromal tumors: a systematic review and meta-analysis.
 

Author(s): Lin Yan, Lei Zou, Wenhua Zhao, Yansen Wang, Bo Liu, Hongliang Yao, Haihua Yu

Journal:

 

Many types of KIT mutations have been observed in gastrointestinal stromal tumors (GISTs), but their prognostic and predictive significance are still unclear. A meta-analysis and literature review were conducted to estimate the contribution of KIT mutations in prognostic parameters ...

Last Updated: 9 Sep 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 24 Jun 2016

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Serum Dickkopf-4 as a Biomarker for the Diagnosis and Treatment of Gastrointestinal Stromal Tumor
 

Status: Recruiting

Condition Summary: Gastrointestinal Stromal Tumor

 

Last Updated: 11 Oct 2016

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A Study of Sunitinib In Young Patients With Advanced Gastrointestinal Stromal Tumor
 

Status: Recruiting

Condition Summary: Gastrointestinal Stromal Tumors

 

Last Updated: 10 Feb 2017

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