Frontotemporal dementia and/or amyotrophic lateral sclerosis

Common Name(s)

Frontotemporal dementia and/or amyotrophic lateral sclerosis

Frontotemporal dementia (FTD) and/or amyotrophic lateral sclerosis (ALS) is an autosomal dominant neurodegenerative disorder characterized by adult onset of one or both of these features in an affected individual, with significant intrafamilial variation. The disorder is genetically and pathologically heterogeneous (summary by {37:Vance et al., 2006}). Patients with C9ORF72 repeat expansions tend to show a lower age of onset, shorter survival, bulbar symptom onset, increased incidence of neurodegenerative disease in relatives, and a propensity toward psychosis or hallucinations compared to patients with other forms of ALS and/or FTD (summary by {14:Harms et al., 2013}). Patients with C9ORF72 repeat expansions also show psychiatric disturbances that may predate the onset of dementia ({23:Meisler et al., 2013}; {12:Gomez-Tortosa et al., 2013}). For a general phenotypic description of frontotemporal dementia, also known as frontotemporal lobar degeneration (FTLD), see {600274}. For a general discussion of motor neuron disease (MND), see amyotrophic lateral sclerosis-1 (ALS1; {105400}). Genetic Heterogeneity of Frontotemporal Dementia and/or Amyotrophic Lateral Sclerosis See also FTDALS2 ({615911}), caused by mutation in the CHCHD10 gene ({615903}) on chromosome 22q11.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Frontotemporal dementia and/or amyotrophic lateral sclerosis" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Frontotemporal dementia and/or amyotrophic lateral sclerosis" returned 2 free, full-text research articles on human participants. First 3 results:

Association between extremely low-frequency electromagnetic fields occupations and amyotrophic lateral sclerosis: a meta-analysis.
 

Author(s): Hongjie Zhou, Guangdi Chen, Chunjing Chen, Yunxian Yu, Zhengping Xu

Journal: PLoS ONE. 2012 ;7(11):e48354.

 

To estimate the relationship between exposure to extremely low-frequency electromagnetic fields (ELF-EMF) and the risk of amyotrophic lateral sclerosis (ALS) by a meta-analysis.

Last Updated: 28 Nov 2012

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Revised medical criteria for evaluating amyotrophic lateral sclerosis. Final rules.
 

Author(s):

Journal: Fed Regist. 2003 Aug;68(167):51689-92.

 

We are revising the criteria in the Listing of Impairments (the listings) that we use to evaluate Amyotrophic Lateral Sclerosis (ALS). We apply these criteria when you claim benefits based on disability under title II or title XVI of the Social Security Act (the Act). The revision ...

Last Updated: 2 Sep 2003

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Frontotemporal dementia and/or amyotrophic lateral sclerosis" returned 0 free, full-text review articles on human participants.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Genetics of ALS: Identification of Genes With Roles in Familial and Sporadic Amyotrophic Lateral Sclerosis (ALS) and Amyotrophic Lateral Sclerosis (ALS) With Frontotemporal Dementia
 

Status: Recruiting

Condition Summary: Amyotrophic Lateral Sclerosis; Familial Amyotrophic Lateral Sclerosis; Amyotrophic Lateral Sclerosis With Frontotemporal Dementia; Lou Gehrig's Disease; Motor Neuron Disease; Primary Lateral Sclerosis

 

Last Updated: 1 Apr 2014

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Genetic Study of Familial and Sporadic ALS/Motor Neuron Disease, Miyoshi Myopathy and Other Neuromuscular Disorders
 

Status: Recruiting

Condition Summary: Amyotrophic Lateral Sclerosis; Frontotemporal Dementia; PLS; Motor Neuron Disease; Lou Gehrigs Disease; Familial Disease; Amyotrophic Lateral Sclerosis, Sporadic

 

Last Updated: 25 Jun 2014

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Last Updated: 25 Jun 2014

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