Frontotemporal dementia

Common Name(s)

Frontotemporal dementia

Frontotemporal dementia (FTD) is a term that describes a group of neurodegenerative conditions that affect the front and sides of the brain (the areas called the frontal and temporal lobes respectively). The cause of FTD is not fully understood at this time. However, scientists believe that genetics and environmental factors may have an influence. Additionally, many studies have shown unusually high levels of proteins in the nerve cells of individuals with the condition. Ultimately, FTD causes the frontal and temporal lobes of the brain to shrink over time (frontotemporal atrophy).

Symptoms of FTD are often categorized either as behavioral changes or as speech and language difficulties, which reflect the brain areas affected. In certain forms of FTD, motor symptoms may appear as well. Behavioral changes are often seen as a loss of empathy, increasing lack of judgment, and depression. Language problems are seen as an increased difficulty with speaking or understanding language. This disease is most often found in older individuals who are in their 50s or 60s. Sadly, once the process begins, symptoms tend to progressively worsen over time.

Although there is no conclusive test to diagnose FTD, a combination of blood tests, reasoning/memory tests, and various brain scans can aid in diagnosing the condition. With brain imaging scans like MRIs, it is sometimes even possible to see the shrinking of the frontal and temporal lobes. If you or your family member has been diagnosed with FTD, talk with your doctor and specialists about the most current treatment options. Support groups are also a good source of information and help connect you with other individuals and families affected by FTD.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Frontotemporal dementia" for support, advocacy or research.

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Association for Frontotemporal Degeneration

The Association for Frontotemporal Degeneration (AFTD) is a nationwide non-profit organization whose mission is to promote and fund research into finding the cause and cure for the frontotemporal dementias; to provide information, education, and support to persons diagnosed with frontotemporal dementias (FTD) and their families and caregivers; and to educate physicians and allied health professionals about FTD.

Last Updated: 8 Jul 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Frontotemporal dementia" for support, advocacy or research.

Logo
Association for Frontotemporal Degeneration

The Association for Frontotemporal Degeneration (AFTD) is a nationwide non-profit organization whose mission is to promote and fund research into finding the cause and cure for the frontotemporal dementias; to provide information, education, and support to persons diagnosed with frontotemporal dementias (FTD) and their families and caregivers; and to educate physicians and allied health professionals about FTD.

http://www.theaftd.org

Last Updated: 8 Jul 2015

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Frontotemporal dementia" returned 404 free, full-text research articles on human participants. First 3 results:

Cognitive reserve and TMEM106B genotype modulate brain damage in presymptomatic frontotemporal dementia: a GENFI study.
 

Author(s): Enrico Premi, Mario Grassi, John van Swieten, Daniela Galimberti, Caroline Graff, Mario Masellis, Carmela Tartaglia, Fabrizio Tagliavini, James B Rowe, Robert Laforce, Elizabeth Finger, Giovanni B Frisoni, Alexandre de Mendon├ža, Sandro Sorbi, Stefano Gazzina, Maura Cosseddu, Silvana Archetti, Roberto Gasparotti, Marta Manes, Antonella Alberici, Manuel J Cardoso, Martina Bocchetta, David M Cash, Sebastian Ourselin, Alessandro Padovani, Jonathan D Rohrer, Barbara Borroni,

Journal: Brain. 2017 Jun;140(6):1784-1791.

 

Frontotemporal dementia is a heterogeneous neurodegenerative disorder with around a third of cases having autosomal dominant inheritance. There is wide variability in phenotype even within affected families, raising questions about the determinants of the progression of disease and ...

Last Updated: 1 May 2017

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Genetic architecture of sporadic frontotemporal dementia and overlap with Alzheimer's and Parkinson's diseases.
 

Author(s): Raffaele Ferrari, Yunpeng Wang, Jana Vandrovcova, Sebastian Guelfi, Aree Witeolar, Celeste M Karch, Andrew J Schork, Chun C Fan, James B Brewer, , , , Parastoo Momeni, Gerard D Schellenberg, William P Dillon, Leo P Sugrue, Christopher P Hess, Jennifer S Yokoyama, Luke W Bonham, Gil D Rabinovici, Bruce L Miller, Ole A Andreassen, Anders M Dale, John Hardy, Rahul S Desikan

Journal: J. Neurol. Neurosurg. Psychiatr.. 2017 02;88(2):152-164.

 

Clinical, pathological and genetic overlap between sporadic frontotemporal dementia (FTD), Alzheimer's disease (AD) and Parkinson's disease (PD) has been suggested; however, the relationship between these disorders is still not well understood. Here we evaluated genetic overlap between ...

Last Updated: 30 Nov 2016

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Expression and purification of tau protein and its frontotemporal dementia variants using a cleavable histidine tag.
 

Author(s): Thomas K Karikari, Alexandra Turner, Robert Stass, Leonie C Y Lee, Bethany Wilson, David A Nagel, Eric J Hill, Kevin G Moffat

Journal: Protein Expr. Purif.. 2017 Feb;130():44-54.

 

Recombinant tau protein is widely used to study the biochemical, cellular and pathological aspects of tauopathies, including Alzheimer's disease and frontotemporal dementia with Parkinsonism linked to chromosome 17 (FTPD-17). Pure tau in high yield is a requirement for in vitro evaluation ...

Last Updated: 24 Sep 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Frontotemporal dementia" returned 76 free, full-text review articles on human participants. First 3 results:

Frontotemporal dementia as a comorbidity to idiopathic normal pressure hydrocephalus (iNPH): a short review of literature and an unusual case.
 

Author(s): V E Korhonen, E Solje, N M Suhonen, T Rauramaa, R Vanninen, A M Remes, V Leinonen

Journal:

 

Behavioural variant frontotemporal dementia (bvFTD) and idiopathic normal pressure hydrocephalus (iNPH) are neurodegenerative diseases that can present with similar symptoms. These include decline in executive functions, psychomotor slowness, and behavioural and personality changes. ...

Last Updated: 19 Apr 2017

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Therapy and clinical trials in frontotemporal dementia: past, present, and future.
 

Author(s): Richard M Tsai, Adam L Boxer

Journal: J. Neurochem.. 2016 Aug;138 Suppl 1():211-21.

 

Frontotemporal dementia (FTD) is a common form of dementia with heterogeneous clinical presentations and distinct clinical syndromes. This article will review currently available therapies for FTD, its related disorders and their clinical evidence. It will also discuss recent advancements ...

Last Updated: 9 Aug 2016

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The behavioural variant frontotemporal dementia (bvFTD) syndrome in psychiatry.
 

Author(s): Serggio C Lanata, Bruce L Miller

Journal: J. Neurol. Neurosurg. Psychiatr.. 2016 May;87(5):501-11.

 

The primary goal of this article is to critically discuss the syndromic overlap that exists between early behavioural variant frontotemporal dementia (bvFTD)--the most common clinical syndrome associated with frontotemporal lobar degeneration (FTLD)--and several primary psychiatric ...

Last Updated: 15 Apr 2016

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Impact of Emotional Mimicry and Oxytocin on Frontotemporal Dementia
 

Status: Recruiting

Condition Summary: Frontotemporal Dementia

 

Last Updated: 9 Mar 2017

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Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects
 

Status: Recruiting

Condition Summary: Familial Frontotemporal Dementia

 

Last Updated: 21 Mar 2017

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Low-Dose Lithium for the Treatment of Behavioral Symptoms in Frontotemporal Dementia
 

Status: Recruiting

Condition Summary: Frontotemporal Dementia (FTD)

 

Last Updated: 18 Apr 2017

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