Frontotemporal Dementia

Common Name(s)

Frontotemporal Dementia

Frontotemporal dementia describes a group of conditions associated with shrinking of the frontal and temporal anterior lobes of the brain. Symptoms include either variable changes in behavior (e.g., impulsive, bored, listless, lack of social contact, lack of empathy, distractibility, blunted emotions, compulsive behavior, decreased energy and motivation) or problems with language (e.g., difficulty making or understanding speech). Spatial skills and memory remain intact. There is a strong genetic component to the disease; it often runs in families. There is no cure for frontotemporal dementia at this time, as a result treatment remains supportive.

Although the name and classification of FTD has been a topic of discussion for over a century, the current classification of the syndrome groups together PickÕs disease, primary progressive aphasia, and semantic dementia as FTD. Some doctors propose adding corticobasal degeneration and progressive supranuclear palsy to FTD and calling the group Pick Complex. You can click on the links to view the GARD pages on these conditions.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Frontotemporal Dementia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Frontotemporal Dementia" returned 262 free, full-text research articles on human participants. First 3 results:

RAN proteins and RNA foci from antisense transcripts in C9ORF72 ALS and frontotemporal dementia.
 

Author(s): Tao Zu, Yuanjing Liu, Monica Bañez-Coronel, Tammy Reid, Olga Pletnikova, Jada Lewis, Timothy M Miller, Matthew B Harms, Annet E Falchook, S H Subramony, Lyle W Ostrow, Jeffrey D Rothstein, Juan C Troncoso, Laura P W Ranum

Journal: Proc. Natl. Acad. Sci. U.S.A.. 2013 Dec;110(51):E4968-77.

 

The finding that a GGGGCC (G4C2) hexanucleotide repeat expansion in the chromosome 9 ORF 72 (C9ORF72) gene is a common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) links ALS/FTD to a large group of unstable microsatellite diseases. Previously, we ...

Last Updated: 18 Dec 2013

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Diffusion tensor tractography versus volumetric imaging in the diagnosis of behavioral variant frontotemporal dementia.
 

Author(s): Alexander Frizell Santillo, Johanna Mårtensson, Olof Lindberg, Markus Nilsson, Amir Manzouri, Maria Landqvist Waldö, Danielle van Westen, Lars-Olof Wahlund, Jimmy Lätt, Christer Nilsson

Journal:

 

MRI diffusion tensor imaging (DTI) studies of white matter integrity in behavioral variant frontotemporal dementia have consistently shown involvement of frontal and temporal white matter, corresponding to regional loss of cortical volume. Volumetric imaging has a suboptimal sensitivity ...

Last Updated: 22 Jul 2013

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Modeling key pathological features of frontotemporal dementia with C9ORF72 repeat expansion in iPSC-derived human neurons.
 

Author(s): Sandra Almeida, Eduardo Gascon, Hélène Tran, Hsin Jung Chou, Tania F Gendron, Steven Degroot, Andrew R Tapper, Chantal Sellier, Nicolas Charlet-Berguerand, Anna Karydas, William W Seeley, Adam L Boxer, Leonard Petrucelli, Bruce L Miller, Fen-Biao Gao

Journal: Acta Neuropathol.. 2013 Sep;126(3):385-99.

 

The recently identified GGGGCC repeat expansion in the noncoding region of C9ORF72 is the most common pathogenic mutation in patients with frontotemporal dementia (FTD) or amyotrophic lateral sclerosis (ALS). We generated a human neuronal model and investigated the pathological phenotypes ...

Last Updated: 27 Aug 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Frontotemporal Dementia" returned 51 free, full-text review articles on human participants. First 3 results:

[Genetic coherence between hereditary amyotrophic lateral sclerosis and frontotemporal dementia].
 

Author(s): Kristian Varden Gjerde, Ole-Bjørn Tysnes

Journal: Tidsskr. Nor. Laegeforen.. 2014 Feb;134(3):302-6.

 

Amyotrophic lateral sclerosis (ALS) has traditionally been considered purely as a motor condition with a progressive loss of upper and lower motor neurons, and without cognitive or behavioural impairment. In 2011 a new genetic mutation that may cause both ALS and frontotemporal dementia ...

Last Updated: 12 Feb 2014

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Clinical review. Frontotemporal dementia.
 

Author(s): Jason D Warren, Jonathan D Rohrer, Martin N Rossor

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Last Updated: 7 Aug 2013

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Novel compound heterozygous mutation in TREM2 found in a Turkish frontotemporal dementia-like family.
 

Author(s): Rita Guerreiro, Basar Bilgic, Gamze Guven, José Brás, Jonathan Rohrer, Ebba Lohmann, Hasmet Hanagasi, Hakan Gurvit, Murat Emre

Journal: Neurobiol. Aging. 2013 Dec;34(12):2890.e1-5.

 

Triggering receptor expressed on myeloid cells 2 (TREM2) homozygous mutations cause Nasu-Hakola disease, an early-onset recessive form of dementia preceded by bone cysts and fractures. The same type of mutations has recently been shown to cause frontotemporal dementia (FTD) without ...

Last Updated: 20 Sep 2013

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Characterization of Inclusion Body Myopathy Associated With Paget's Disease of Bone and Frontotemporal Dementia (IBMPFD)
 

Status: Recruiting

Condition Summary: Inclusion Body Myopathy With Early-onset Paget Disease and Frontotemporal Dementia; Paget Disease of Bone; Frontotemporal Dementia; Myopathy

 

Last Updated: 12 May 2011

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Impact of Emotional Mimicry and Oxytocin on Frontotemporal Dementia
 

Status: Recruiting

Condition Summary: Frontotemporal Dementia

 

Last Updated: 24 Oct 2013

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Study of Social Behavior and Emotion in Frontotemporal Dementia, Alzheimer's Disease and Controls
 

Status: Recruiting

Condition Summary: Frontotemporal Dementia; Frontotemporal Degeneration; Alzheimer's Disease; Social Behavior

 

Last Updated: 27 Oct 2011

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