Frontotemporal Dementia

Common Name(s)

Frontotemporal Dementia

Frontotemporal dementia describes a group of conditions associated with shrinking of the frontal and temporal anterior lobes of the brain. Symptoms include either variable changes in behavior (e.g., impulsive, bored, listless, lack of social contact, lack of empathy, distractibility, blunted emotions, compulsive behavior, decreased energy and motivation) or problems with language (e.g., difficulty making or understanding speech). Spatial skills and memory remain intact. There is a strong genetic component to the disease; it often runs in families. There is no cure for frontotemporal dementia at this time, as a result treatment remains supportive.

Although the name and classification of FTD has been a topic of discussion for over a century, the current classification of the syndrome groups together PickÕs disease, primary progressive aphasia, and semantic dementia as FTD. Some doctors propose adding corticobasal degeneration and progressive supranuclear palsy to FTD and calling the group Pick Complex. You can click on the links to view the GARD pages on these conditions.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Frontotemporal Dementia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Frontotemporal Dementia" returned 280 free, full-text research articles on human participants. First 3 results:

RAN proteins and RNA foci from antisense transcripts in C9ORF72 ALS and frontotemporal dementia.
 

Author(s): Tao Zu, Yuanjing Liu, Monica Bañez-Coronel, Tammy Reid, Olga Pletnikova, Jada Lewis, Timothy M Miller, Matthew B Harms, Annet E Falchook, S H Subramony, Lyle W Ostrow, Jeffrey D Rothstein, Juan C Troncoso, Laura P W Ranum

Journal: Proc. Natl. Acad. Sci. U.S.A.. 2013 Dec;110(51):E4968-77.

 

The finding that a GGGGCC (G4C2) hexanucleotide repeat expansion in the chromosome 9 ORF 72 (C9ORF72) gene is a common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) links ALS/FTD to a large group of unstable microsatellite diseases. Previously, we ...

Last Updated: 18 Dec 2013

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C9ORF72 transcription in a frontotemporal dementia case with two expanded alleles.
 

Author(s): Johnathan Cooper-Knock, Adrian Higginbottom, Natalie Connor-Robson, Nadhim Bayatti, Joanna J Bury, Janine Kirby, Natalia Ninkina, Vladimir L Buchman, Pamela J Shaw

Journal: Neurology. 2013 Nov;81(19):1719-21.

 

Discovery of intronic hexanucleotide repeat expansions of the C9ORF72 gene in a significant proportion of patients with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD)(1,2) was an important step for research into these disorders. The C9ORF72 genetic variant is ...

Last Updated: 5 Nov 2013

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A novel MAPT mutation, G55R, in a frontotemporal dementia patient leads to altered Tau function.
 

Author(s): Abhinaya Iyer, Nichole E Lapointe, Krzysztof Zielke, Mariusz Berdynski, Elmer Guzman, Anna Barczak, Małgorzata Chodakowska-Żebrowska, Maria Barcikowska, Stuart Feinstein, Cezary Zekanowski

Journal:

 

Over two dozen mutations in the gene encoding the microtubule associated protein tau cause a variety of neurodegenerative dementias known as tauopathies, including frontotemporal dementia (FTD), PSP, CBD and Pick's disease. The vast majority of these mutations map to the C-terminal ...

Last Updated: 2 Oct 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Frontotemporal Dementia" returned 54 free, full-text review articles on human participants. First 3 results:

[Genetic coherence between hereditary amyotrophic lateral sclerosis and frontotemporal dementia].
 

Author(s): Kristian Varden Gjerde, Ole-Bjørn Tysnes

Journal: Tidsskr. Nor. Laegeforen.. 2014 Feb;134(3):302-6.

 

Amyotrophic lateral sclerosis (ALS) has traditionally been considered purely as a motor condition with a progressive loss of upper and lower motor neurons, and without cognitive or behavioural impairment. In 2011 a new genetic mutation that may cause both ALS and frontotemporal dementia ...

Last Updated: 12 Feb 2014

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Functional status in behavioral variant frontotemporal dementia: a systematic review.
 

Author(s): Thais Bento Lima-Silva, Valéria Santoro Bahia, Ricardo Nitrini, Mônica Sanches Yassuda

Journal: Biomed Res Int. 2013 ;2013():837120.

 

The aim was to conduct a systematic review of studies that described the functional profile of patients with behavioral variant frontotemporal dementia (bvFTD), published between 2000 and 2013. The bibliographic search was conducted using the terms "frontotemporal dementia" and "frontotemporal ...

Last Updated: 5 Dec 2013

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Clinical, genetic and neuropathological features of frontotemporal dementia: an update and guide.
 

Author(s): Jorge Pelicano Paulos, João Massano

Journal: Acta Med Port. ;26(4):392-401.

 

Frontotemporal Lobar Degeneration encompasses a group of heterogeneous disorders with shared behavioural and cognitive symptoms, as well as gross pathological features. The genetic underpinnings and histopathological aspects are quite diverse and form the basis of molecular classification, ...

Last Updated: 10 Sep 2013

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Impact of Emotional Mimicry and Oxytocin on Frontotemporal Dementia
 

Status: Recruiting

Condition Summary: Frontotemporal Dementia

 

Last Updated: 11 Sep 2014

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Study of Social Behavior and Emotion in Frontotemporal Dementia, Alzheimer's Disease and Controls
 

Status: Recruiting

Condition Summary: Frontotemporal Dementia; Frontotemporal Degeneration; Alzheimer's Disease; Social Behavior

 

Last Updated: 27 Oct 2011

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Safety and Efficacy Study Evaluating TRx0237 in Subjects With Behavioral Variant Frontotemporal Dementia (bvFTD)
 

Status: Recruiting

Condition Summary: Behavioral Variant Frontotemporal Dementia (bvFTD)

 

Last Updated: 4 Aug 2014

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