Frontotemporal dementia

Common Name(s)

Frontotemporal dementia

Frontotemporal dementia (FTD) is a term that describes a group of neurodegenerative conditions that affect the front and sides of the brain (the areas called the frontal and temporal lobes respectively). The cause of FTD is not fully understood at this time. However, scientists believe that genetics and environmental factors may have an influence. Additionally, many studies have shown unusually high levels of proteins in the nerve cells of individuals with the condition. Ultimately, FTD causes the frontal and temporal lobes of the brain to shrink over time (frontotemporal atrophy).

Symptoms of FTD are often categorized either as behavioral changes or as speech and language difficulties, which reflect the brain areas affected. In certain forms of FTD, motor symptoms may appear as well. Behavioral changes are often seen as a loss of empathy, increasing lack of judgment, and depression. Language problems are seen as an increased difficulty with speaking or understanding language. This disease is most often found in older individuals who are in their 50s or 60s. Sadly, once the process begins, symptoms tend to progressively worsen over time.

Although there is no conclusive test to diagnose FTD, a combination of blood tests, reasoning/memory tests, and various brain scans can aid in diagnosing the condition. With brain imaging scans like MRIs, it is sometimes even possible to see the shrinking of the frontal and temporal lobes. If you or your family member has been diagnosed with FTD, talk with your doctor and specialists about the most current treatment options. Support groups are also a good source of information and help connect you with other individuals and families affected by FTD.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Frontotemporal dementia" for support, advocacy or research.

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Association for Frontotemporal Degeneration

The Association for Frontotemporal Degeneration (AFTD) is a nationwide non-profit organization whose mission is to promote and fund research into finding the cause and cure for the frontotemporal dementias; to provide information, education, and support to persons diagnosed with frontotemporal dementias (FTD) and their families and caregivers; and to educate physicians and allied health professionals about FTD.

Last Updated: 8 Jul 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Frontotemporal dementia" for support, advocacy or research.

Logo
Association for Frontotemporal Degeneration

The Association for Frontotemporal Degeneration (AFTD) is a nationwide non-profit organization whose mission is to promote and fund research into finding the cause and cure for the frontotemporal dementias; to provide information, education, and support to persons diagnosed with frontotemporal dementias (FTD) and their families and caregivers; and to educate physicians and allied health professionals about FTD.

http://www.theaftd.org

Last Updated: 8 Jul 2015

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Frontotemporal dementia" returned 336 free, full-text research articles on human participants. First 3 results:

Functional MRI of music emotion processing in frontotemporal dementia.
 

Author(s): Jennifer L Agustus, Colin J Mahoney, Laura E Downey, Rohani Omar, Miriam Cohen, Mark J White, Sophie K Scott, Laura Mancini, Jason D Warren

Journal: Ann. N. Y. Acad. Sci.. 2015 Mar;1337():232-40.

 

Frontotemporal dementia is an important neurodegenerative disorder of younger life led by profound emotional and social dysfunction. Here we used fMRI to assess brain mechanisms of music emotion processing in a cohort of patients with frontotemporal dementia (n = 15) in relation to ...

Last Updated: 16 Mar 2015

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Presymptomatic cognitive and neuroanatomical changes in genetic frontotemporal dementia in the Genetic Frontotemporal dementia Initiative (GENFI) study: a cross-sectional analysis.
 

Author(s): Jonathan D Rohrer, Jennifer M Nicholas, David M Cash, John van Swieten, Elise Dopper, Lize Jiskoot, Rick van Minkelen, Serge A Rombouts, M Jorge Cardoso, Shona Clegg, Miklos Espak, Simon Mead, David L Thomas, Enrico De Vita, Mario Masellis, Sandra E Black, Morris Freedman, Ron Keren, Bradley J MacIntosh, Ekaterina Rogaeva, David Tang-Wai, Maria Carmela Tartaglia, Robert Laforce, Fabrizio Tagliavini, Pietro Tiraboschi, Veronica Redaelli, Sara Prioni, Marina Grisoli, Barbara Borroni, Alessandro Padovani, Daniela Galimberti, Elio Scarpini, Andrea Arighi, Giorgio Fumagalli, James B Rowe, Ian Coyle-Gilchrist, Caroline Graff, Marie Fallström, Vesna Jelic, Anne Kinhult Ståhlbom, Christin Andersson, Håkan Thonberg, Lena Lilius, Giovanni B Frisoni, Michela Pievani, Martina Bocchetta, Luisa Benussi, Roberta Ghidoni, Elizabeth Finger, Sandro Sorbi, Benedetta Nacmias, Gemma Lombardi, Cristina Polito, Jason D Warren, Sebastien Ourselin, Nick C Fox, Martin N Rossor

Journal: Lancet Neurol. 2015 Mar;14(3):253-62.

 

Frontotemporal dementia is a highly heritable neurodegenerative disorder. In about a third of patients, the disease is caused by autosomal dominant genetic mutations usually in one of three genes: progranulin (GRN), microtubule-associated protein tau (MAPT), or chromosome 9 open reading ...

Last Updated: 2 Mar 2015

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Frontotemporal dementia: a peek under its invisibility cloak.
 

Author(s): Keith A Josephs

Journal: Lancet Neurol. 2015 Mar;14(3):236-7.

 

Last Updated: 2 Mar 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Frontotemporal dementia" returned 62 free, full-text review articles on human participants. First 3 results:

Tale of two diseases: amyotrophic lateral sclerosis and frontotemporal dementia.
 

Author(s): Ashok Verma

Journal: Neurol India. ;62(4):347-51.

 

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) were independently described in clinical and pathological details more than a century ago. Recent breakthrough discoveries identifying common genes that are causal to either ALS or FTD or an overlapping ALS-FTD ...

Last Updated: 20 Sep 2014

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C9orf72 amyotrophic lateral sclerosis and frontotemporal dementia: gain or loss of function?
 

Author(s): Sarah Mizielinska, Adrian M Isaacs

Journal: Curr. Opin. Neurol.. 2014 Oct;27(5):515-23.

 

The molecular mechanisms that underlie chromosome 9 open reading frame 72 (C9orf72)-associated amyotrophic lateral sclerosis and frontotemporal dementia are rapidly emerging. Two potential disease mechanisms have been postulated - gain or loss of function. We provide an overview of ...

Last Updated: 5 Sep 2014

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Pathogenesis/genetics of frontotemporal dementia and how it relates to ALS.
 

Author(s): Janis Bennion Callister, Stuart M Pickering-Brown

Journal: Exp. Neurol.. 2014 Dec;262 Pt B():84-90.

 

One of the most interesting findings in the field of neurodegeneration in recent years is tfche discovery of a genetic mutation in the C9orf72 gene, the most common mutation found to be causative of sporadic and familial frontotemporal lobar degeneration (FTLD), amyotrophic lateral ...

Last Updated: 2 Dec 2014

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Impact of Emotional Mimicry and Oxytocin on Frontotemporal Dementia
 

Status: Recruiting

Condition Summary: Frontotemporal Dementia

 

Last Updated: 30 Mar 2015

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Study of Social Behavior and Emotion in Frontotemporal Dementia, Alzheimer's Disease and Controls
 

Status: Recruiting

Condition Summary: Frontotemporal Dementia; Frontotemporal Degeneration; Alzheimer's Disease; Social Behavior

 

Last Updated: 27 Oct 2011

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Efficacy of Web-Based Social-Cognitive Interventions in Right Hemisphere Stroke and Frontotemporal Dementia
 

Status: Not yet recruiting

Condition Summary: Frontotemporal Dementia; Right Sided Cerebral Hemisphere Cerebrovascular Accident

 

Last Updated: 30 Jul 2015

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