Frontotemporal dementia

Common Name(s)

Frontotemporal dementia

Frontotemporal dementia (FTD) is a term that describes a group of neurodegenerative conditions that affect the front and sides of the brain (the areas called the frontal and temporal lobes respectively). The cause of FTD is not fully understood at this time. However, scientists believe that genetics and environmental factors may have an influence. Additionally, many studies have shown unusually high levels of proteins in the nerve cells of individuals with the condition. Ultimately, FTD causes the frontal and temporal lobes of the brain to shrink over time (frontotemporal atrophy).

Symptoms of FTD are often categorized either as behavioral changes or as speech and language difficulties, which reflect the brain areas affected. In certain forms of FTD, motor symptoms may appear as well. Behavioral changes are often seen as a loss of empathy, increasing lack of judgment, and depression. Language problems are seen as an increased difficulty with speaking or understanding language. This disease is most often found in older individuals who are in their 50s or 60s. Sadly, once the process begins, symptoms tend to progressively worsen over time.

Although there is no conclusive test to diagnose FTD, a combination of blood tests, reasoning/memory tests, and various brain scans can aid in diagnosing the condition. With brain imaging scans like MRIs, it is sometimes even possible to see the shrinking of the frontal and temporal lobes. If you or your family member has been diagnosed with FTD, talk with your doctor and specialists about the most current treatment options. Support groups are also a good source of information and help connect you with other individuals and families affected by FTD.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Frontotemporal dementia" for support, advocacy or research.

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Association for Frontotemporal Degeneration

The Association for Frontotemporal Degeneration (AFTD) is a nationwide non-profit organization whose mission is to promote and fund research into finding the cause and cure for the frontotemporal dementias; to provide information, education, and support to persons diagnosed with frontotemporal dementias (FTD) and their families and caregivers; and to educate physicians and allied health professionals about FTD.

Last Updated: 8 Jul 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Frontotemporal dementia" for support, advocacy or research.

Logo
Association for Frontotemporal Degeneration

The Association for Frontotemporal Degeneration (AFTD) is a nationwide non-profit organization whose mission is to promote and fund research into finding the cause and cure for the frontotemporal dementias; to provide information, education, and support to persons diagnosed with frontotemporal dementias (FTD) and their families and caregivers; and to educate physicians and allied health professionals about FTD.

http://www.theaftd.org

Last Updated: 8 Jul 2015

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Frontotemporal dementia" returned 413 free, full-text research articles on human participants. First 3 results:

CCNF mutations in amyotrophic lateral sclerosis and frontotemporal dementia.
 

Author(s): Kelly L Williams, Simon Topp, Shu Yang, Bradley Smith, Jennifer A Fifita, Sadaf T Warraich, Katharine Y Zhang, Natalie Farrawell, Caroline Vance, Xun Hu, Alessandra Chesi, Claire S Leblond, Albert Lee, Stephanie L Rayner, Vinod Sundaramoorthy, Carol Dobson-Stone, Mark P Molloy, Marka van Blitterswijk, Dennis W Dickson, Ronald C Petersen, Neill R Graff-Radford, Bradley F Boeve, Melissa E Murray, Cyril Pottier, Emily Don, Claire Winnick, Emily P McCann, Alison Hogan, Hussein Daoud, Annie Levert, Patrick A Dion, Jun Mitsui, Hiroyuki Ishiura, Yuji Takahashi, Jun Goto, Jason Kost, Cinzia Gellera, Athina Soragia Gkazi, Jack Miller, Joanne Stockton, William S Brooks, Karyn Boundy, Meraida Polak, José Luis Muñoz-Blanco, Jesús Esteban-Pérez, Alberto Rábano, Orla Hardiman, Karen E Morrison, Nicola Ticozzi, Vincenzo Silani, Jacqueline de Belleroche, Jonathan D Glass, John B J Kwok, Gilles J Guillemin, Roger S Chung, Shoji Tsuji, Robert H Brown, Alberto García-Redondo, Rosa Rademakers, John E Landers, Aaron D Gitler, Guy A Rouleau, Nicholas J Cole, Justin J Yerbury, Julie D Atkin, Christopher E Shaw, Garth A Nicholson, Ian P Blair

Journal:

 

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are overlapping, fatal neurodegenerative disorders in which the molecular and pathogenic basis remains poorly understood. Ubiquitinated protein aggregates, of which TDP-43 is a major component, are a characteristic ...

Last Updated: 15 Apr 2016

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Profiling Speech and Pausing in Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD).
 

Author(s): Yana Yunusova, Naida L Graham, Sanjana Shellikeri, Kent Phuong, Madhura Kulkarni, Elizabeth Rochon, David F Tang-Wai, Tiffany W Chow, Sandra E Black, Lorne H Zinman, Jordan R Green

Journal:

 

This study examines reading aloud in patients with amyotrophic lateral sclerosis (ALS) and those with frontotemporal dementia (FTD) in order to determine whether differences in patterns of speaking and pausing exist between patients with primary motor vs. primary cognitive-linguistic ...

Last Updated: 21 Jan 2016

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TMEM106B, a frontotemporal lobar dementia (FTLD) modifier, associates with FTD-3-linked CHMP2B, a complex of ESCRT-III.
 

Author(s): Mi-Hee Jun, Jeong-Ho Han, Yu-Kyung Lee, Deok-Jin Jang, Bong-Kiun Kaang, Jin-A Lee

Journal:

 

Transmembrane protein 106B (TMEM106B) has been identified as a risk factor for frontotemporal lobar degeneration, which is the second most common form of progressive dementia in people under 65 years of age. Mutations in charged multivesicular body protein 2B (CHMP2B), which is involved ...

Last Updated: 15 Dec 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Frontotemporal dementia" returned 73 free, full-text review articles on human participants. First 3 results:

The behavioural variant frontotemporal dementia (bvFTD) syndrome in psychiatry.
 

Author(s): Serggio C Lanata, Bruce L Miller

Journal: J. Neurol. Neurosurg. Psychiatr.. 2016 May;87(5):501-11.

 

The primary goal of this article is to critically discuss the syndromic overlap that exists between early behavioural variant frontotemporal dementia (bvFTD)--the most common clinical syndrome associated with frontotemporal lobar degeneration (FTLD)--and several primary psychiatric ...

Last Updated: 15 Apr 2016

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Mapping neuroinflammation in frontotemporal dementia with molecular PET imaging.
 

Author(s): Jing Zhang

Journal:

 

Recent findings have led to a renewed interest and support for an active role of inflammation in neurodegenerative dementias and related neurologic disorders. Detection of neuroinflammation in vivo throughout the course of neurodegenerative diseases is of great clinical interest. ...

Last Updated: 2 Jun 2015

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Cerebrospinal Fluid Biomarkers in Familial Forms of Alzheimer's Disease and Frontotemporal Dementia.
 

Author(s): Nina Rostgaard, Gunhild Waldemar, Jørgen Erik Nielsen, Anja Hviid Simonsen

Journal: Dement Geriatr Cogn Disord. 2015 ;40(1-2):54-62.

 

As dementia is a fast-growing health care problem, it is becoming an increasingly urgent need to provide an early diagnosis in order to offer patients the best medical treatment and care. Validated biomarkers which reflect the pathology and disease progression are essential for diagnosis ...

Last Updated: 3 Jul 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Impact of Emotional Mimicry and Oxytocin on Frontotemporal Dementia
 

Status: Recruiting

Condition Summary: Frontotemporal Dementia

 

Last Updated: 3 Mar 2016

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Study of Social Behavior and Emotion in Frontotemporal Dementia, Alzheimer's Disease and Controls
 

Status: Recruiting

Condition Summary: Frontotemporal Dementia; Frontotemporal Degeneration; Alzheimer's Disease; Social Behavior

 

Last Updated: 27 Oct 2011

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Efficacy of Web-Based Social-Cognitive Interventions in Right Hemisphere Stroke and Frontotemporal Dementia
 

Status: Recruiting

Condition Summary: Frontotemporal Dementia; Right Sided Cerebral Hemisphere Cerebrovascular Accident

 

Last Updated: 7 Apr 2016

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