Frontotemporal dementia

Common Name(s)

Frontotemporal dementia

Frontotemporal dementia (FTD) is a term that describes a group of neurodegenerative conditions that affect the front and sides of the brain (the areas called the frontal and temporal lobes respectively). The cause of FTD is not fully understood at this time. However, scientists believe that genetics and environmental factors may have an influence. Additionally, many studies have shown unusually high levels of proteins in the nerve cells of individuals with the condition. Ultimately, FTD causes the frontal and temporal lobes of the brain to shrink over time (frontotemporal atrophy).

Symptoms of FTD are often categorized either as behavioral changes or as speech and language difficulties, which reflect the brain areas affected. In certain forms of FTD, motor symptoms may appear as well. Behavioral changes are often seen as a loss of empathy, increasing lack of judgment, and depression. Language problems are seen as an increased difficulty with speaking or understanding language. This disease is most often found in older individuals who are in their 50s or 60s. Sadly, once the process begins, symptoms tend to progressively worsen over time.

Although there is no conclusive test to diagnose FTD, a combination of blood tests, reasoning/memory tests, and various brain scans can aid in diagnosing the condition. With brain imaging scans like MRIs, it is sometimes even possible to see the shrinking of the frontal and temporal lobes. If you or your family member has been diagnosed with FTD, talk with your doctor and specialists about the most current treatment options. Support groups are also a good source of information and help connect you with other individuals and families affected by FTD.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Frontotemporal dementia" for support, advocacy or research.

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Association for Frontotemporal Degeneration

The Association for Frontotemporal Degeneration (AFTD) is a nationwide non-profit organization whose mission is to promote and fund research into finding the cause and cure for the frontotemporal dementias; to provide information, education, and support to persons diagnosed with frontotemporal dementias (FTD) and their families and caregivers; and to educate physicians and allied health professionals about FTD.

Last Updated: 8 Jul 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Frontotemporal dementia" for support, advocacy or research.

Logo
Association for Frontotemporal Degeneration

The Association for Frontotemporal Degeneration (AFTD) is a nationwide non-profit organization whose mission is to promote and fund research into finding the cause and cure for the frontotemporal dementias; to provide information, education, and support to persons diagnosed with frontotemporal dementias (FTD) and their families and caregivers; and to educate physicians and allied health professionals about FTD.

http://www.theaftd.org

Last Updated: 8 Jul 2015

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Frontotemporal dementia" returned 372 free, full-text research articles on human participants. First 3 results:

Temporal Variant Frontotemporal Dementia is Associated with Globular Glial Tauopathy.
 

Author(s): Camilla N Clark, Tammaryn Lashley, Colin J Mahoney, Jason D Warren, Tamas Revesz, Jonathan D Rohrer

Journal: Cogn Behav Neurol. 2015 Jun;28(2):92-7.

 

Frontotemporal dementia (FTD) is a clinically and pathologically heterogeneous neurodegenerative disorder associated with atrophy of the frontal and temporal lobes. Most patients with focal temporal lobe atrophy present with either the semantic dementia subtype of FTD or the behavioral ...

Last Updated: 24 Jun 2015

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Improving response inhibition systems in frontotemporal dementia with citalopram.
 

Author(s): Laura E Hughes, Timothy Rittman, Ralf Regenthal, Trevor W Robbins, James B Rowe

Journal: Brain. 2015 Jul;138(Pt 7):1961-75.

 

Disinhibition is a cardinal feature of the behavioural variant of frontotemporal dementia, presenting as impulsive and impetuous behaviours that are often difficult to manage. The options for symptomatic treatments are limited, but a potential target for therapy is the restoration ...

Last Updated: 24 Jun 2015

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Functional MRI of music emotion processing in frontotemporal dementia.
 

Author(s): Jennifer L Agustus, Colin J Mahoney, Laura E Downey, Rohani Omar, Miriam Cohen, Mark J White, Sophie K Scott, Laura Mancini, Jason D Warren

Journal: Ann. N. Y. Acad. Sci.. 2015 Mar;1337():232-40.

 

Frontotemporal dementia is an important neurodegenerative disorder of younger life led by profound emotional and social dysfunction. Here we used fMRI to assess brain mechanisms of music emotion processing in a cohort of patients with frontotemporal dementia (n = 15) in relation to ...

Last Updated: 16 Mar 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Frontotemporal dementia" returned 65 free, full-text review articles on human participants. First 3 results:

Cerebrospinal Fluid Biomarkers in Familial Forms of Alzheimer's Disease and Frontotemporal Dementia.
 

Author(s): Nina Rostgaard, Gunhild Waldemar, Jørgen Erik Nielsen, Anja Hviid Simonsen

Journal: Dement Geriatr Cogn Disord. 2015 ;40(1-2):54-62.

 

As dementia is a fast-growing health care problem, it is becoming an increasingly urgent need to provide an early diagnosis in order to offer patients the best medical treatment and care. Validated biomarkers which reflect the pathology and disease progression are essential for diagnosis ...

Last Updated: 3 Jul 2015

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[Overlapping features of frontotemporal dementia and amyotrophic lateral sclerosis].
 

Author(s): Patricia Lillo, José Manuel Matamala, Daniel Valenzuela, Renato Verdugo, José Luis Castillo, Agustín Ibáñez, Andrea Slachevsky

Journal: Rev Med Chil. 2014 Jul;142(7):867-79.

 

Recent genetic and neuropathologic advances support the concept that frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are overlapping multisystem disorders. While 10-15% of ALS patients fulfil criteria for FTD, features of motor neuron disease appear in approximately ...

Last Updated: 7 Nov 2014

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Tale of two diseases: amyotrophic lateral sclerosis and frontotemporal dementia.
 

Author(s): Ashok Verma

Journal: Neurol India. ;62(4):347-51.

 

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) were independently described in clinical and pathological details more than a century ago. Recent breakthrough discoveries identifying common genes that are causal to either ALS or FTD or an overlapping ALS-FTD ...

Last Updated: 20 Sep 2014

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Impact of Emotional Mimicry and Oxytocin on Frontotemporal Dementia
 

Status: Recruiting

Condition Summary: Frontotemporal Dementia

 

Last Updated: 30 Mar 2015

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Study of Social Behavior and Emotion in Frontotemporal Dementia, Alzheimer's Disease and Controls
 

Status: Recruiting

Condition Summary: Frontotemporal Dementia; Frontotemporal Degeneration; Alzheimer's Disease; Social Behavior

 

Last Updated: 27 Oct 2011

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Efficacy of Web-Based Social-Cognitive Interventions in Right Hemisphere Stroke and Frontotemporal Dementia
 

Status: Recruiting

Condition Summary: Frontotemporal Dementia; Right Sided Cerebral Hemisphere Cerebrovascular Accident

 

Last Updated: 13 Sep 2015

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