Frontotemporal Dementia

Common Name(s)

Frontotemporal Dementia

Frontotemporal dementia describes a group of conditions associated with shrinking of the frontal and temporal anterior lobes of the brain. Symptoms include either variable changes in behavior (e.g., impulsive, bored, listless, lack of social contact, lack of empathy, distractibility, blunted emotions, compulsive behavior, decreased energy and motivation) or problems with language (e.g., difficulty making or understanding speech). Spatial skills and memory remain intact. There is a strong genetic component to the disease; it often runs in families. There is no cure for frontotemporal dementia at this time, as a result treatment remains supportive.

Although the name and classification of FTD has been a topic of discussion for over a century, the current classification of the syndrome groups together PickÕs disease, primary progressive aphasia, and semantic dementia as FTD. Some doctors propose adding corticobasal degeneration and progressive supranuclear palsy to FTD and calling the group Pick Complex. You can click on the links to view the GARD pages on these conditions.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Frontotemporal Dementia" for support, advocacy or research.

Logo
Association for Frontotemporal Degeneration

The Association for Frontotemporal Degeneration (AFTD) is a nationwide non-profit organization whose mission is to promote and fund research into finding the cause and cure for the frontotemporal dementias; to provide information, education, and support to persons diagnosed with frontotemporal dementias (FTD) and their families and caregivers; and to educate physicians and allied health professionals about FTD.

Last Updated: 10 Dec 2014

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Frontotemporal Dementia" for support, advocacy or research.

Logo
Association for Frontotemporal Degeneration

The Association for Frontotemporal Degeneration (AFTD) is a nationwide non-profit organization whose mission is to promote and fund research into finding the cause and cure for the frontotemporal dementias; to provide information, education, and support to persons diagnosed with frontotemporal dementias (FTD) and their families and caregivers; and to educate physicians and allied health professionals about FTD.

http://www.theaftd.org

Last Updated: 10 Dec 2014

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Frontotemporal Dementia" returned 290 free, full-text research articles on human participants. First 3 results:

Music, reward and frontotemporal dementia.
 

Author(s): Phillip D Fletcher, Camilla N Clark, Jason D Warren

Journal: Brain. 2014 Oct;137(Pt 10):e300.

 

Last Updated: 14 Sep 2014

Go To URL
Biomarkers in frontotemporal dementia.
 

Author(s): Jonathan D Rohrer, Henrik Zetterberg

Journal: Biomark Med. 2014 ;8(4):519-21.

 

Last Updated: 6 May 2014

Go To URL
Longitudinal grey and white matter changes in frontotemporal dementia and Alzheimer's disease.
 

Author(s): Lars Frings, Belinda Yew, Emma Flanagan, Bonnie Y K Lam, Michael Hüll, Hans-Jürgen Huppertz, John R Hodges, Michael Hornberger

Journal:

 

Behavioural variant frontotemporal dementia (bvFTD) and Alzheimer's disease (AD) dementia are characterised by progressive brain atrophy. Longitudinal MRI volumetry may help to characterise ongoing structural degeneration and support the differential diagnosis of dementia subtypes. ...

Last Updated: 5 Mar 2014

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Frontotemporal Dementia" returned 56 free, full-text review articles on human participants. First 3 results:

Tale of two diseases: amyotrophic lateral sclerosis and frontotemporal dementia.
 

Author(s): Ashok Verma

Journal: Neurol India. ;62(4):347-51.

 

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) were independently described in clinical and pathological details more than a century ago. Recent breakthrough discoveries identifying common genes that are causal to either ALS or FTD or an overlapping ALS-FTD ...

Last Updated: 20 Sep 2014

Go To URL
[Genetic coherence between hereditary amyotrophic lateral sclerosis and frontotemporal dementia].
 

Author(s): Kristian Varden Gjerde, Ole-Bjørn Tysnes

Journal: Tidsskr. Nor. Laegeforen.. 2014 Feb;134(3):302-6.

 

Amyotrophic lateral sclerosis (ALS) has traditionally been considered purely as a motor condition with a progressive loss of upper and lower motor neurons, and without cognitive or behavioural impairment. In 2011 a new genetic mutation that may cause both ALS and frontotemporal dementia ...

Last Updated: 12 Feb 2014

Go To URL
Functional status in behavioral variant frontotemporal dementia: a systematic review.
 

Author(s): Thais Bento Lima-Silva, Valéria Santoro Bahia, Ricardo Nitrini, Mônica Sanches Yassuda

Journal: Biomed Res Int. 2013 ;2013():837120.

 

The aim was to conduct a systematic review of studies that described the functional profile of patients with behavioral variant frontotemporal dementia (bvFTD), published between 2000 and 2013. The bibliographic search was conducted using the terms "frontotemporal dementia" and "frontotemporal ...

Last Updated: 5 Dec 2013

Go To URL
 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Impact of Emotional Mimicry and Oxytocin on Frontotemporal Dementia
 

Status: Recruiting

Condition Summary: Frontotemporal Dementia

 

Last Updated: 11 Sep 2014

Go to URL
Study of Social Behavior and Emotion in Frontotemporal Dementia, Alzheimer's Disease and Controls
 

Status: Recruiting

Condition Summary: Frontotemporal Dementia; Frontotemporal Degeneration; Alzheimer's Disease; Social Behavior

 

Last Updated: 27 Oct 2011

Go to URL
Safety and Efficacy Study Evaluating TRx0237 in Subjects With Behavioral Variant Frontotemporal Dementia (bvFTD)
 

Status: Recruiting

Condition Summary: Behavioral Variant Frontotemporal Dementia (bvFTD)

 

Last Updated: 4 Aug 2014

Go to URL