Frontotemporal Dementia

Common Name(s)

Frontotemporal Dementia

Frontotemporal dementia describes a group of conditions associated with shrinking of the frontal and temporal anterior lobes of the brain. Symptoms include either variable changes in behavior (e.g., impulsive, bored, listless, lack of social contact, lack of empathy, distractibility, blunted emotions, compulsive behavior, decreased energy and motivation) or problems with language (e.g., difficulty making or understanding speech). Spatial skills and memory remain intact. There is a strong genetic component to the disease; it often runs in families. There is no cure for frontotemporal dementia at this time, as a result treatment remains supportive.

Although the name and classification of FTD has been a topic of discussion for over a century, the current classification of the syndrome groups together PickÕs disease, primary progressive aphasia, and semantic dementia as FTD. Some doctors propose adding corticobasal degeneration and progressive supranuclear palsy to FTD and calling the group Pick Complex. You can click on the links to view the GARD pages on these conditions.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Frontotemporal Dementia" for support, advocacy or research.

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Association for Frontotemporal Degeneration

The Association for Frontotemporal Degeneration (AFTD) is a nationwide non-profit organization whose mission is to promote and fund research into finding the cause and cure for the frontotemporal dementias; to provide information, education, and support to persons diagnosed with frontotemporal dementias (FTD) and their families and caregivers; and to educate physicians and allied health professionals about FTD.

Last Updated: 10 Dec 2014

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Frontotemporal Dementia" for support, advocacy or research.

Logo
Association for Frontotemporal Degeneration

The Association for Frontotemporal Degeneration (AFTD) is a nationwide non-profit organization whose mission is to promote and fund research into finding the cause and cure for the frontotemporal dementias; to provide information, education, and support to persons diagnosed with frontotemporal dementias (FTD) and their families and caregivers; and to educate physicians and allied health professionals about FTD.

http://www.theaftd.org

Last Updated: 10 Dec 2014

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Frontotemporal Dementia" returned 307 free, full-text research articles on human participants. First 3 results:

Longitudinal diffusion tensor imaging in frontotemporal dementia.
 

Author(s): Colin J Mahoney, Ivor J A Simpson, Jennifer M Nicholas, Phillip D Fletcher, Laura E Downey, Hannah L Golden, Camilla N Clark, Nicole Schmitz, Jonathan D Rohrer, Jonathan M Schott, Hui Zhang, Sebastian Ourselin, Jason D Warren, Nick C Fox

Journal: Ann. Neurol.. 2015 Jan;77(1):33-46.

 

Novel biomarkers for monitoring progression in neurodegenerative conditions are needed. Measurement of microstructural changes in white matter (WM) using diffusion tensor imaging (DTI) may be a useful outcome measure. Here we report trajectories of WM change using serial DTI in a ...

Last Updated: 13 Jan 2015

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[Obsessive-compulsive behaviour in two patients with right temporal variant frontotemporal dementia].
 

Author(s): T Sabbe, M Vandenbulcke

Journal: Tijdschr Psychiatr. 2014 ;56(10):685-8.

 

There is often a long delay before right temporal variant of frontotemporal dementia (rtlv) is correctly diagnosed. The late diagnosis is usually due to the occurrence of psychiatric symptoms as the first signs of disease and to the relatively young age of the patient. We report two ...

Last Updated: 20 Oct 2014

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A 6.4 Mb duplication of the α-synuclein locus causing frontotemporal dementia and Parkinsonism: phenotype-genotype correlations.
 

Author(s): Eleanna Kara, Aoife P Kiely, Christos Proukakis, Nicola Giffin, Seth Love, Jason Hehir, Khadija Rantell, Amelie Pandraud, Dena G Hernandez, Elizabeth Nacheva, Alan M Pittman, Mike A Nalls, Andrew B Singleton, Tamas Revesz, Kailash P Bhatia, Niall Quinn, John Hardy, Janice L Holton, Henry Houlden

Journal: JAMA Neurol. 2014 Sep;71(9):1162-71.

 

α-Synuclein (SNCA) locus duplications are associated with variable clinical features and reduced penetrance but the reasons underlying this variability are unknown.

Last Updated: 9 Sep 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Frontotemporal Dementia" returned 58 free, full-text review articles on human participants. First 3 results:

Tale of two diseases: amyotrophic lateral sclerosis and frontotemporal dementia.
 

Author(s): Ashok Verma

Journal: Neurol India. ;62(4):347-51.

 

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) were independently described in clinical and pathological details more than a century ago. Recent breakthrough discoveries identifying common genes that are causal to either ALS or FTD or an overlapping ALS-FTD ...

Last Updated: 20 Sep 2014

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Pathogenesis/genetics of frontotemporal dementia and how it relates to ALS.
 

Author(s): Janis Bennion Callister, Stuart M Pickering-Brown

Journal: Exp. Neurol.. 2014 Dec;262 Pt B():84-90.

 

One of the most interesting findings in the field of neurodegeneration in recent years is tfche discovery of a genetic mutation in the C9orf72 gene, the most common mutation found to be causative of sporadic and familial frontotemporal lobar degeneration (FTLD), amyotrophic lateral ...

Last Updated: 2 Dec 2014

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[Genetic coherence between hereditary amyotrophic lateral sclerosis and frontotemporal dementia].
 

Author(s): Kristian Varden Gjerde, Ole-Bjørn Tysnes

Journal: Tidsskr. Nor. Laegeforen.. 2014 Feb;134(3):302-6.

 

Amyotrophic lateral sclerosis (ALS) has traditionally been considered purely as a motor condition with a progressive loss of upper and lower motor neurons, and without cognitive or behavioural impairment. In 2011 a new genetic mutation that may cause both ALS and frontotemporal dementia ...

Last Updated: 12 Feb 2014

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Impact of Emotional Mimicry and Oxytocin on Frontotemporal Dementia
 

Status: Recruiting

Condition Summary: Frontotemporal Dementia

 

Last Updated: 11 Sep 2014

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Study of Social Behavior and Emotion in Frontotemporal Dementia, Alzheimer's Disease and Controls
 

Status: Recruiting

Condition Summary: Frontotemporal Dementia; Frontotemporal Degeneration; Alzheimer's Disease; Social Behavior

 

Last Updated: 27 Oct 2011

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Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects
 

Status: Not yet recruiting

Condition Summary: Familial Frontotemporal Dementia

 

Last Updated: 25 Feb 2015

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